ENTRY       hsa00760                    Pathway
NAME        Nicotinate and nicotinamide metabolism - Homo sapiens (human)
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP hsa00760  Nicotinate and nicotinamide metabolism
MODULE      hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00760]
DRUG        D04245  Forodesine hydrochloride (JAN/USAN)
            D05396  Peldesine (USAN)
            D06596  Forodesine (USAN/INN)
            D09678  Teglarinad chloride (USAN/INN)
            D10431  Ulodesine (USAN)
            D10432  Ulodesine succinate (USAN)
            D12373  Quemliclustat (USAN/INN)
            D12401  Uliledlimab (USAN/INN)
DBLINKS     UMBBD: nic
            GO: 0046497 0006769
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        554235  ASPDH; aspartate dehydrogenase domain containing [KO:K06989] [EC:1.4.1.21]
            23475  QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]
            93100  NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
            4860  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
            54981  NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
            27231  NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
            22978  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
            84618  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
            93034  NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
            30833  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
            56953  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
            100526794  NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
            284958  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
            4907  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
            349565  NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
            64802  NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
            23057  NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
            5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
            5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
            83594  NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]
            55191  NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]
            10135  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
            952  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
            683  BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
            23411  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
            22933  SIRT2; sirtuin 2 [KO:K11412] [EC:2.3.1.286]
            23410  SIRT3; sirtuin 3 [KO:K11413] [EC:2.3.1.286]
            23409  SIRT4; sirtuin 4 [KO:K11414] [EC:2.3.1.286]
            23408  SIRT5; sirtuin 5 [KO:K11415] [EC:2.3.1.286]
            51548  SIRT6; sirtuin 6 [KO:K11416] [EC:2.3.1.286]
            51547  SIRT7; sirtuin 7 [KO:K11417] [EC:2.3.1.286]
            65220  NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]
            133686  NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
            23530  NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:1.6.1.2 7.1.1.1]
            4837  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
            316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
COMPOUND    C00003  NAD+
            C00006  NADP+
            C00022  Pyruvate
            C00042  Succinate
            C00049  L-Aspartate
            C00111  Glycerone phosphate
            C00122  Fumarate
            C00153  Nicotinamide
            C00163  Propanoate
            C00232  Succinate semialdehyde
            C00253  Nicotinate
            C00334  4-Aminobutanoate
            C00455  Nicotinamide D-ribonucleotide
            C00745  Nicotine
            C00857  Deamino-NAD+
            C00922  2,3-Dimethylmaleate
            C01020  6-Hydroxynicotinate
            C01056  (S)-6-Hydroxynicotine
            C01059  2,5-Dihydroxypyridine
            C01185  Nicotinate D-ribonucleotide
            C01297  6-Hydroxypseudooxynicotine
            C01384  Maleic acid
            C01596  Maleamate
            C02295  Methylitaconate
            C02918  1-Methylnicotinamide
            C02930  2-Methyleneglutarate
            C03043  (R)-6-Hydroxynicotine
            C03056  2,6-Dihydroxypyridine
            C03150  Nicotinamide-beta-riboside
            C03458  2,3,6-Trihydroxypyridine
            C03652  (2R,3S)-2,3-Dimethylmalate
            C03722  Quinolinate
            C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
            C05380  Nicotinurate
            C05840  Iminoaspartate
            C05841  Nicotinate D-ribonucleoside
            C05842  N1-Methyl-2-pyridone-5-carboxamide
            C05843  N1-Methyl-4-pyridone-5-carboxamide
            C06178  1-Methylpyrrolinium
            C15523  2,6-Dihydroxynicotinate
            C15986  2,6-Dihydroxypseudooxynicotine
            C15987  4-Methylaminobutyrate
            C16151  2,6-Dihydroxy-N-methylmyosmine
            C16152  Blue pigment
            C16159  2-Formylglutarate
            C16386  (R)-Nicotine
            C16390  (S)-2-(Hydroxymethyl)glutarate
            C18232  N-Formylmaleamic acid
            C19567  4-Oxo-1-(3-pyridyl)-1-butanone
            C19569  3-Succinoylpyridine
            C19631  6-Hydroxy-3-succinoylpyridine
            C20361  Pseudooxynicotine
            C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
            C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
            C21154  N-Methylmyosmine
REFERENCE   PMID:13475371
  AUTHORS   BEHRMAN EJ, STANIER RY.
  TITLE     The bacterial oxidation of nicotinic acid.
  JOURNAL   J Biol Chem 228:923-45 (1957)
REFERENCE   PMID:16894175
  AUTHORS   Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  TITLE     Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  JOURNAL   Proc Natl Acad Sci U S A 103:12341-6 (2006)
            DOI:10.1073/pnas.0601635103
REFERENCE   PMID:11514508
  AUTHORS   Baitsch D, Sandu C, Brandsch R, Igloi GL.
  TITLE     Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  JOURNAL   J Bacteriol 183:5262-7 (2001)
            DOI:10.1128/JB.183.18.5262-5267.2001
REFERENCE   PMID:16321959
  AUTHORS   Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  TITLE     An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  JOURNAL   J Bacteriol 187:8516-9 (2005)
            DOI:10.1128/JB.187.24.8516-8519.2005
REFERENCE   PMID:5835946
  AUTHORS   Gherna RL, Richardson SH, Rittenberg SC
  TITLE     The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  JOURNAL   J Biol Chem 240:3669-74 (1965)
REFERENCE   PMID:21953451
  AUTHORS   Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  TITLE     Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  JOURNAL   J Biol Chem 286:40365-75 (2011)
            DOI:10.1074/jbc.M111.275818
REL_PATHWAY hsa00020  Citrate cycle (TCA cycle)
            hsa00250  Alanine, aspartate and glutamate metabolism
            hsa00380  Tryptophan metabolism
            hsa00620  Pyruvate metabolism
KO_PATHWAY  ko00760
///
