ENTRY       hsa00740                    Pathway
NAME        Riboflavin metabolism - Homo sapiens (human)
CLASS       Metabolism; Metabolism of cofactors and vitamins
PATHWAY_MAP hsa00740  Riboflavin metabolism
DBLINKS     GO: 0006771
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        55312  RFK; riboflavin kinase [KO:K00861] [EC:2.7.1.26]
            54  ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
            52  ACP1; acid phosphatase 1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
            53  ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
            80308  FLAD1; flavin adenine dinucleotide synthetase 1 [KO:K00953] [EC:2.7.7.2]
            5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
            5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
            645  BLVRB; biliverdin reductase B [KO:K05901] [EC:1.3.1.24 1.5.1.30]
COMPOUND    C00016  FAD
            C00044  GTP
            C00061  FMN
            C00199  D-Ribulose 5-phosphate
            C00235  Dimethylallyl diphosphate
            C00255  Riboflavin
            C00474  Ribitol
            C01007  Reduced riboflavin
            C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
            C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
            C01352  FADH2
            C01390  Prenol
            C01727  Lumichrome
            C01847  Reduced FMN
            C03114  Dimethylbenzimidazole
            C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
            C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
            C04732  5-Amino-6-(1-D-ribitylamino)uracil
            C05995  7-Hydroxy-6-methyl-8-ribityllumazine
            C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
            C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
            C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
            C21214  Dimethylallyl phosphate
            C21215  Prenylated FMNH2
REFERENCE   PMID:12136096
  AUTHORS   Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  TITLE     Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  JOURNAL   Nucleic Acids Res 30:3141-51 (2002)
            DOI:10.1093/nar/30.14.3141
REFERENCE   PMID:11856310
  AUTHORS   Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  TITLE     Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  JOURNAL   Eur J Biochem 269:519-26 (2002)
            DOI:10.1046/j.0014-2956.2001.02674.x
REFERENCE   PMID:12867427
  AUTHORS   Haase I, Fischer M, Bacher A, Schramek N.
  TITLE     Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  JOURNAL   J Biol Chem 278:37909-15 (2003)
            DOI:10.1074/jbc.M303090200
REFERENCE   PMID:16042598
  AUTHORS   Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  TITLE     Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  JOURNAL   Biochem Soc Trans 33:780-4 (2005)
            DOI:10.1042/BST0330780
REL_PATHWAY hsa00030  Pentose phosphate pathway
            hsa00040  Pentose and glucuronate interconversions
            hsa00230  Purine metabolism
            hsa00860  Porphyrin metabolism
            hsa00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko00740
///
