ENTRY       hsa00630                    Pathway
NAME        Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP hsa00630  Glyoxylate and dicarboxylate metabolism
MODULE      hsa_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hsa00630]
DRUG        D11925  Lumasiran (USAN/INN)
            D11926  Lumasiran sodium
DBLINKS     GO: 0046487 0043648
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
            55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
            4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
            4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
            1431  CS; citrate synthase [KO:K01647] [EC:2.3.3.1]
            50  ACO2; aconitase 2 [KO:K01681] [EC:4.2.1.3]
            48  ACO1; aconitase 1 [KO:K01681] [EC:4.2.1.3]
            39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
            38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
            84693  MCEE; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
            5095  PCCA; propionyl-CoA carboxylase subunit alpha [KO:K01965] [EC:6.4.1.3]
            5096  PCCB; propionyl-CoA carboxylase subunit beta [KO:K01966] [EC:6.4.1.3 2.1.3.15]
            4594  MMUT; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
            51179  HAO2; hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
            54363  HAO1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
            847  CAT; catalase [KO:K03781] [EC:1.11.1.6]
            9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
            283871  PGP; phosphoglycolate phosphatase [KO:K19269] [EC:3.1.3.18 3.1.3.48]
            189  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            2752  GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
            6472  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
            6470  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
            2731  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
            275  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
            1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
            2653  GCSH; glycine cleavage system protein H [KO:K02437]
            81888  HYI; hydroxypyruvate isomerase (putative) [KO:K01816] [EC:5.3.1.22]
            132158  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
            112817  HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
            125061  AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]
COMPOUND    C00007  Oxygen
            C00011  CO2
            C00014  Ammonia
            C00022  Pyruvate
            C00024  Acetyl-CoA
            C00025  L-Glutamate
            C00026  2-Oxoglutarate
            C00027  Hydrogen peroxide
            C00033  Acetate
            C00036  Oxaloacetate
            C00037  Glycine
            C00042  Succinate
            C00048  Glyoxylate
            C00058  Formate
            C00064  L-Glutamine
            C00065  L-Serine
            C00091  Succinyl-CoA
            C00100  Propanoyl-CoA
            C00111  Glycerone phosphate
            C00136  Butanoyl-CoA
            C00149  (S)-Malate
            C00158  Citrate
            C00160  Glycolate
            C00168  Hydroxypyruvate
            C00197  3-Phospho-D-glycerate
            C00209  Oxalate
            C00258  D-Glycerate
            C00266  Glycolaldehyde
            C00311  Isocitrate
            C00313  Oxalyl-CoA
            C00332  Acetoacetyl-CoA
            C00417  cis-Aconitate
            C00552  meso-Tartaric acid
            C00631  2-Phospho-D-glycerate
            C00683  (S)-Methylmalonyl-CoA
            C00798  Formyl-CoA
            C00877  Crotonoyl-CoA
            C00888  Pentanoyl-CoA
            C00898  (R,R)-Tartaric acid
            C00975  Dihydroxyfumarate
            C00988  2-Phosphoglycolate
            C01127  4-Hydroxy-2-oxoglutarate
            C01146  2-Hydroxy-3-oxopropanoate
            C01182  D-Ribulose 1,5-bisphosphate
            C01213  (R)-Methylmalonyl-CoA
            C01380  Ethylene glycol
            C01732  Mesaconate
            C01989  3-Ethylmalate
            C01990  3-Oxalomalate
            C02123  3-Propylmalate
            C02405  Formyl phosphate
            C03217  2-Hydroxy-3-oxoadipate
            C03459  2-Hydroxy-3-oxosuccinate
            C03548  trans-2,3-Epoxysuccinate
            C03561  (R)-3-Hydroxybutanoyl-CoA
            C03618  L-threo-3-Methylaspartate
            C04348  L-Malyl-CoA
            C06027  L-erythro-3-Methylmalyl-CoA
            C06028  2-Methylfumaryl-CoA
            C06049  N-Formylderivatives
            C18026  (2S)-Ethylmalonyl-CoA
            C18324  (2S)-Methylsuccinyl-CoA
            C20238  (2R)-Ethylmalonyl-CoA
            C22337  D-Ribulose 1-phosphate
REFERENCE   PMID:10978349
  AUTHORS   Njau RK, Herndon CA, Hawes JW.
  TITLE     Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  JOURNAL   J Biol Chem 275:38780-6 (2000)
            DOI:10.1074/jbc.M007432200
REFERENCE   PMID:18065535
  AUTHORS   Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  TITLE     Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  JOURNAL   J Bacteriol 190:1366-74 (2008)
            DOI:10.1128/JB.01621-07
REFERENCE   PMID:18819910
  AUTHORS   Erb TJ, Retey J, Fuchs G, Alber BE
  TITLE     Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  JOURNAL   J Biol Chem 283:32283-93 (2008)
            DOI:10.1074/jbc.M805527200
REFERENCE   PMID:9596633
  AUTHORS   Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  TITLE     Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  JOURNAL   Plant Cell 10:741-52 (1998)
            DOI:10.1105/tpc.10.5.741
REFERENCE   PMID:16407450
  AUTHORS   Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  TITLE     Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  JOURNAL   Plant Physiol 140:444-56 (2006)
            DOI:10.1104/pp.105.071910
REFERENCE   PMID:21252347
  AUTHORS   Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  TITLE     A methylaspartate cycle in haloarchaea.
  JOURNAL   Science 331:334-7 (2011)
            DOI:10.1126/science.1196544
REFERENCE   PMID:11513957
  AUTHORS   Serrano JA, Bonete MJ
  TITLE     Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  JOURNAL   Biochim Biophys Acta 1520:154-62 (2001)
            DOI:10.1016/S0167-4781(01)00263-9
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00020  Citrate cycle (TCA cycle)
            hsa00030  Pentose phosphate pathway
            hsa00053  Ascorbate and aldarate metabolism
            hsa00071  Fatty acid degradation
            hsa00230  Purine metabolism
            hsa00250  Alanine, aspartate and glutamate metabolism
            hsa00260  Glycine, serine and threonine metabolism
            hsa00620  Pyruvate metabolism
            hsa00750  Vitamin B6 metabolism
            hsa00910  Nitrogen metabolism
KO_PATHWAY  ko00630
///
