ENTRY       hsa00620                    Pathway
NAME        Pyruvate metabolism - Homo sapiens (human)
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP hsa00620  Pyruvate metabolism
MODULE      hsa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00620]
DRUG        D00123  Cyanamide (JP18)
            D00131  Disulfiram (JP18/USP/INN)
            D11408  Mitapivat sulfate (USAN)
            D12362  Etavopivat (USAN/INN)
DBLINKS     GO: 0006090
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
            55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
            5161  PDHA2; pyruvate dehydrogenase E1 subunit alpha 2 [KO:K00161] [EC:1.2.4.1]
            5160  PDHA1; pyruvate dehydrogenase E1 subunit alpha 1 [KO:K00161] [EC:1.2.4.1]
            5162  PDHB; pyruvate dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]
            1737  DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
            1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
            124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
            125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
            126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
            131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
            127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
            130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
            128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
            5315  PKM; pyruvate kinase M1/2 [KO:K00873] [EC:2.7.1.40]
            5313  PKLR; pyruvate kinase L/R [KO:K12406] [EC:2.7.1.40]
            31  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            32  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            98  ACYP2; acylphosphatase 2 [KO:K01512] [EC:3.6.1.7]
            97  ACYP1; acylphosphatase 1 [KO:K01512] [EC:3.6.1.7]
            217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
            224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
            219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
            501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
            134526  ACOT12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
            160287  LDHAL6A; lactate dehydrogenase A like 6A [KO:K00016] [EC:1.1.1.27]
            92483  LDHAL6B; lactate dehydrogenase A like 6B [KO:K00016] [EC:1.1.1.27]
            3939  LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
            3945  LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
            3948  LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
            197257  LDHD; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
            2739  GLO1; glyoxalase I [KO:K01759] [EC:4.4.1.5]
            3029  HAGH; hydroxyacylglutathione hydrolase [KO:K01069] [EC:3.1.2.6]
            9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
            4200  ME2; malic enzyme 2 [KO:K00027] [EC:1.1.1.38]
            10873  ME3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
            4199  ME1; malic enzyme 1 [KO:K00029] [EC:1.1.1.40]
            5091  PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
            4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
            4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
            2271  FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
            5105  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
            5106  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
            39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
            38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00033  Acetate
            C00036  Oxaloacetate
            C00042  Succinate
            C00058  Formate
            C00068  Thiamin diphosphate
            C00074  Phosphoenolpyruvate
            C00083  Malonyl-CoA
            C00084  Acetaldehyde
            C00122  Fumarate
            C00149  (S)-Malate
            C00186  (S)-Lactate
            C00227  Acetyl phosphate
            C00256  (R)-Lactate
            C00332  Acetoacetyl-CoA
            C00424  (S)-Lactaldehyde
            C00469  Ethanol
            C00546  Methylglyoxal
            C00937  (R)-Lactaldehyde
            C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
            C02488  (R)-2-Ethylmalate
            C02504  alpha-Isopropylmalate
            C03248  Acetylenedicarboxylate
            C03451  (R)-S-Lactoylglutathione
            C03981  2-Hydroxyethylenedicarboxylate
            C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
            C05993  Acetyl adenylate
            C05994  2-Propylmalate
            C15972  Enzyme N6-(lipoyl)lysine
            C15973  Enzyme N6-(dihydrolipoyl)lysine
            C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00020  Citrate cycle (TCA cycle)
            hsa00061  Fatty acid biosynthesis
            hsa00260  Glycine, serine and threonine metabolism
            hsa00290  Valine, leucine and isoleucine biosynthesis
            hsa00630  Glyoxylate and dicarboxylate metabolism
            hsa00640  Propanoate metabolism
            hsa00650  Butanoate metabolism
            hsa00760  Nicotinate and nicotinamide metabolism
KO_PATHWAY  ko00620
///
