ENTRY       hsa00591                    Pathway
NAME        Linoleic acid metabolism - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00591  Linoleic acid metabolism
DRUG        D12510  Utreloxastat (USAN/INN)
DBLINKS     GO: 0043651
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        8399  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
            26279  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
            30814  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
            50487  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
            64600  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
            81579  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
            84647  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
            5319  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
            5322  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
            5320  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
            391013  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
            123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
            5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
            8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
            100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
            8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
            283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
            255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
            8398  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
            151056  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
            11145  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            54979  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            246  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
            1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
            1558  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
            1559  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
            1557  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17721] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
            1573  CYP2J2; cytochrome P450 family 2 subfamily J member 2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
            1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
            1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
COMPOUND    C00157  Phosphatidylcholine
            C00219  Arachidonate
            C01595  Linoleate
            C03242  Dihomo-gamma-linolenate
            C04056  Rumenic acid
            C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
            C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
            C07289  Crepenynate
            C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
            C07354  (7S,8S)-DiHODE
            C14762  13(S)-HODE
            C14765  13-OxoODE
            C14766  9-OxoODE
            C14767  9(S)-HODE
            C14825  9(10)-EpOME
            C14826  12(13)-EpOME
            C14827  9(S)-HPODE
            C14828  9,10-DHOME
            C14829  12,13-DHOME
            C14831  8(R)-HPODE
            C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
            C14833  9,12,13-TriHOME
            C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
            C14835  9,10,13-TriHOME
            C14836  9,10-12,13-Diepoxyoctadecanoate
            C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
            C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
            C20186  5S,8R-DiHODE
REFERENCE   PMID:14757320
  AUTHORS   Nowak G, Grant DF, Moran JH.
  TITLE     Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  JOURNAL   Toxicol Lett 147:161-75 (2004)
            DOI:10.1016/j.toxlet.2003.11.002
REFERENCE   PMID:12909723
  AUTHORS   Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  TITLE     The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  JOURNAL   Proc Natl Acad Sci U S A 100:9968-73 (2003)
            DOI:10.1073/pnas.1631086100
REFERENCE   PMID:12324235
  AUTHORS   Spiteller G.
  TITLE     Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
            DOI:10.1054/plef.2002.0413
REFERENCE   PMID:11302930
  AUTHORS   Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  TITLE     13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  JOURNAL   Drug Metab Dispos 29:652-5 (2001)
REFERENCE   PMID:9694817
  AUTHORS   Su C, Sahlin M, Oliw EH.
  TITLE     A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  JOURNAL   J Biol Chem 273:20744-51 (1998)
            DOI:10.1074/jbc.273.33.20744
REFERENCE   PMID:1634517
  AUTHORS   Brodowsky ID, Hamberg M, Oliw EH.
  TITLE     A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  JOURNAL   J Biol Chem 267:14738-45 (1992)
REFERENCE   PMID:12226220
  AUTHORS   Hamberg M, Hamberg G.
  TITLE     Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  JOURNAL   Plant Physiol 110:807-815 (1996)
            DOI:10.1104/pp.110.3.807
REFERENCE   PMID:8765137
  AUTHORS   Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  TITLE     Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  JOURNAL   Biochim Biophys Acta 1290:327-39 (1996)
            DOI:10.1016/0304-4165(96)00037-2
REL_PATHWAY hsa00590  Arachidonic acid metabolism
KO_PATHWAY  ko00591
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