ENTRY       hsa00565                    Pathway
NAME        Ether lipid metabolism - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00565  Ether lipid metabolism
MODULE      hsa_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:hsa00565]
DRUG        D03650  Darapladib (JAN/USAN)
            D04368  Goxalapladib (USAN)
            D05728  Rilapladib (USAN)
            D08107  Varespladib (USAN/INN)
            D08221  Varespladib methyl (USAN)
            D11844  Ziritaxestat (USAN/INN)
DBLINKS     GO: 0046485
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        8540  AGPS; alkylglycerone phosphate synthase [KO:K00803] [EC:2.5.1.26]
            8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
            8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
            8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
            85465  SELENOI; selenoprotein I [KO:K00993] [EC:2.7.8.1]
            56994  CHPT1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
            10390  CEPT1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
            387521  PEDS1; plasmanylethanolamine desaturase 1 [KO:K20656] [EC:1.14.19.77]
            387522  PEDS1-UBE2V1; PEDS1-UBE2V1 readthrough [KO:K20656] [EC:1.14.19.77]
            8399  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
            26279  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
            30814  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
            50487  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
            64600  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
            81579  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
            84647  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
            5319  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
            5322  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
            5320  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
            391013  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
            123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
            5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
            8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
            100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
            8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
            283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
            255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
            8398  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
            151056  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
            11145  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            54979  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            254531  LPCAT4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
            133121  ENPP6; ectonucleotide pyrophosphatase/phosphodiesterase 6 [KO:K08743] [EC:3.1.4.-]
            5168  ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2 [KO:K01122] [EC:3.1.4.39]
            79153  GDPD3; glycerophosphodiester phosphodiesterase domain containing 3 [KO:K22387] [EC:3.1.4.39]
            284161  GDPD1; glycerophosphodiester phosphodiesterase domain containing 1 [KO:K22387] [EC:3.1.4.39]
            255043  TMEM86B; transmembrane protein 86B [KO:K18575] [EC:3.3.2.2]
            5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
            5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
            23646  PLD3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
            122618  PLD4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
            7368  UGT8; UDP glycosyltransferase 8 [KO:K04628] [EC:2.4.1.47]
            9514  GAL3ST1; galactose-3-O-sulfotransferase 1 [KO:K01019] [EC:2.8.2.11]
            54947  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
            79888  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
            5048  PAFAH1B1; platelet activating factor acetylhydrolase 1b regulatory subunit 1 [KO:K16794]
            5049  PAFAH1B2; platelet activating factor acetylhydrolase 1b catalytic subunit 2 [KO:K16795] [EC:3.1.1.47]
            5050  PAFAH1B3; platelet activating factor acetylhydrolase 1b catalytic subunit 3 [KO:K16795] [EC:3.1.1.47]
            7941  PLA2G7; phospholipase A2 group VII [KO:K01062] [EC:3.1.1.47]
            5051  PAFAH2; platelet activating factor acetylhydrolase 2 [KO:K01062] [EC:3.1.1.47]
COMPOUND    C00670  sn-Glycero-3-phosphocholine
            C00958  Plasmenylcholine
            C01233  sn-Glycero-3-phosphoethanolamine
            C01264  2-Acetyl-1-alkyl-sn-glycero-3-phosphate
            C02773  1-Alkyl-sn-glycerol
            C03201  1-Alkyl-2-acylglycerol
            C03372  Acylglycerone phosphate
            C03454  1-Alkenyl-2-acylglycerol
            C03715  O-Alkylglycerone phosphate
            C03820  1-Alkyl-2-acetyl-sn-glycerol
            C03968  1-Alkyl-sn-glycero-3-phosphate
            C04317  1-Organyl-2-lyso-sn-glycero-3-phosphocholine
            C04361  1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol
            C04475  1-Alkyl-2-acylglycerophosphoethanolamine
            C04517  1-(1-Alkenyl)-sn-glycero-3-phosphocholine
            C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
            C04635  1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine
            C04756  O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine
            C05212  1-Radyl-2-acyl-sn-glycero-3-phosphocholine
            C05977  2-Acyl-1-alkyl-sn-glycero-3-phosphate
            C15645  1-(1-Alkenyl)-sn-glycerol
            C15646  1-(1-Alkenyl)-sn-glycero-3-phosphate
            C15647  2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate
            C20825  Seminolipid
            C20859  Galactosyl-1-alkyl-2-acylglycerol
REFERENCE   PMID:11275267
  AUTHORS   Nagan N, Zoeller RA.
  TITLE     Plasmalogens: biosynthesis and functions.
  JOURNAL   Prog Lipid Res 40:199-229 (2001)
            DOI:10.1016/S0163-7827(01)00003-0
REFERENCE   PMID:11015622
  AUTHORS   Montrucchio G, Alloatti G, Camussi G.
  TITLE     Role of platelet-activating factor in cardiovascular pathophysiology.
  JOURNAL   Physiol Rev 80:1669-99 (2000)
            DOI:10.1152/physrev.2000.80.4.1669
REFERENCE   PMID:15788404
  AUTHORS   Sakagami H, Aoki J, Natori Y, Nishikawa K, Kakehi Y, Natori Y, Arai H.
  TITLE     Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
  JOURNAL   J Biol Chem 280:23084-93 (2005)
            DOI:10.1074/jbc.M413438200
REL_PATHWAY hsa00564  Glycerophospholipid metabolism
KO_PATHWAY  ko00565
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