ENTRY       hsa00564                    Pathway
NAME        Glycerophospholipid metabolism - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00564  Glycerophospholipid metabolism
MODULE      hsa_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:hsa00564]
            hsa_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:hsa00564]
            hsa_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:hsa00564]
DRUG        D00469  Pralidoxime chloride (USP)
            D00487  Pyridostigmine bromide (JP18/USP/INN)
            D00670  Donepezil hydrochloride (JP18/USP)
            D00995  Neostigmine bromide (JAN/USP/INN)
            D00998  Neostigmine methylsulfate (JP18/USP)
            D01001  Ambenonium chloride (JP18/INN)
            D01228  Distigmine bromide (JP18/INN)
            D01572  Pralidoxime iodide (JAN/USAN)
            D02068  Tacrine hydrochloride (USP)
            D02173  Galantamine hydrobromide (JAN/USP)
            D02558  Rivastigmine tartrate
            D02565  Dimetacrine (INN)
            D03822  Rivastigmine (JAN/USP/INN)
            D04292  Galantamine (USAN/INN)
            D05590  Pralidoxime mesylate (USAN)
            D07869  Donepezil (JAN/INN)
            D08261  Neostigmine (BAN)
            D08555  Tacrine (INN)
            D09750  Ipidacrine hydrochloride hydrate (JAN)
            D12318  Buntanetap (USAN)
            D12319  Buntanetap tartrate (USAN)
DBLINKS     GO: 0006650
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        23171  GPD1L; glycerol-3-phosphate dehydrogenase 1 like [KO:K00006] [EC:1.1.1.8]
            2819  GPD1; glycerol-3-phosphate dehydrogenase 1 [KO:K00006] [EC:1.1.1.8]
            2820  GPD2; glycerol-3-phosphate dehydrogenase 2 [KO:K00111] [EC:1.1.5.3]
            57678  GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
            150763  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
            137964  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
            84803  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
            10554  AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
            10555  AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
            56894  AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
            56895  AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
            55326  AGPAT5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
            253558  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
            154141  MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
            129642  MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
            8443  GNPAT; glyceronephosphate O-acyltransferase [KO:K00649] [EC:2.3.1.42]
            56985  ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
            8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
            8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
            8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
            23175  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
            64900  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
            9663  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
            84513  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
            196051  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
            8525  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
            8527  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
            9162  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
            1606  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
            8526  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
            1607  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
            160851  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
            1608  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
            1609  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
            139189  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
            56994  CHPT1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
            10390  CEPT1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
            5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
            5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
            23646  PLD3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
            122618  PLD4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
            3931  LCAT; lecithin-cholesterol acyltransferase [KO:K00650] [EC:2.3.1.43]
            8399  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
            26279  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
            30814  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
            50487  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
            64600  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
            81579  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
            84647  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
            5319  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
            5322  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
            5320  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
            391013  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
            123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
            5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
            8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
            100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
            8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
            283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
            255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
            8398  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
            151056  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
            11145  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            54979  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
            54947  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
            79888  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
            254531  LPCAT4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
            10162  LPCAT3; lysophosphatidylcholine acyltransferase 3 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
            10434  LYPLA1; lysophospholipase 1 [KO:K06128] [EC:3.1.1.5]
            23659  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
            11313  LYPLA2; lysophospholipase 2 [KO:K06130] [EC:3.1.1.5]
            10908  PNPLA6; patatin like phospholipase domain containing 6 [KO:K14676] [EC:3.1.1.5]
            375775  PNPLA7; patatin like phospholipase domain containing 7 [KO:K14676] [EC:3.1.1.5]
            56261  GPCPD1; glycerophosphocholine phosphodiesterase 1 [KO:K18695] [EC:3.1.4.2]
            1103  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
            43  ACHE; acetylcholinesterase (Cartwright blood group) [KO:K01049] [EC:3.1.1.7]
            1119  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
            1120  CHKB; choline kinase beta [KO:K14156] [EC:2.7.1.32 2.7.1.82]
            162466  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase 1 [KO:K06124] [EC:3.1.3.75]
            9468  PCYT1B; phosphate cytidylyltransferase 1B, choline [KO:K00968] [EC:2.7.7.15]
            5130  PCYT1A; phosphate cytidylyltransferase 1A, choline [KO:K00968] [EC:2.7.7.15]
            85465  SELENOI; selenoprotein I [KO:K00993] [EC:2.7.8.1]
            55500  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
            55224  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
            5833  PCYT2; phosphate cytidylyltransferase 2, ethanolamine [KO:K00967] [EC:2.7.7.14]
            64850  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
            10400  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
            1040  CDS1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
            8760  CDS2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
            51365  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
            9791  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
            81490  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
            23761  PISD; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
            9489  PGS1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
            54675  CRLS1; cardiolipin synthase 1 [KO:K08744] [EC:2.7.8.41]
            6901  TAFAZZIN; tafazzin, phospholipid-lysophospholipid transacylase [KO:K13511] [EC:2.3.1.-]
            9926  LPGAT1; lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
            10423  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
            79143  MBOAT7; membrane bound O-acyltransferase domain containing 7 [KO:K13516] [EC:2.3.1.-]
COMPOUND    C00040  Acyl-CoA
            C00065  L-Serine
            C00084  Acetaldehyde
            C00093  sn-Glycerol 3-phosphate
            C00111  Glycerone phosphate
            C00114  Choline
            C00157  Phosphatidylcholine
            C00189  Ethanolamine
            C00269  CDP-diacylglycerol
            C00307  CDP-choline
            C00344  Phosphatidylglycerol
            C00346  Ethanolamine phosphate
            C00350  Phosphatidylethanolamine
            C00416  Phosphatidate
            C00513  CDP-glycerol
            C00570  CDP-ethanolamine
            C00588  Choline phosphate
            C00623  sn-Glycerol 1-phosphate
            C00641  1,2-Diacyl-sn-glycerol
            C00670  sn-Glycero-3-phosphocholine
            C00681  1-Acyl-sn-glycerol 3-phosphate
            C01194  1-Phosphatidyl-D-myo-inositol
            C01210  N-Methylethanolamine phosphate
            C01233  sn-Glycero-3-phosphoethanolamine
            C01241  Phosphatidyl-N-methylethanolamine
            C01996  Acetylcholine
            C02737  Phosphatidylserine
            C03372  Acylglycerone phosphate
            C03819  1-Acylglycerophosphoinositol
            C03872  L-Serine-phosphoethanolamine
            C03892  Phosphatidylglycerophosphate
            C03974  2-Acyl-sn-glycerol 3-phosphate
            C04230  1-Acyl-sn-glycero-3-phosphocholine
            C04233  2-Acyl-sn-glycero-3-phosphocholine
            C04308  Phosphatidyl-N-dimethylethanolamine
            C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
            C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
            C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
            C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
            C05974  2-Acyl-sn-glycero-3-phosphoserine
            C05976  Aminoacyl-phosphatidylglycerol
            C05980  Cardiolipin
            C06771  Triethanolamine
            C06772  Diethanolamine
            C13482  Phosphodimethylethanolamine
            C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
            C18125  1-Acyl-sn-glycero-3-phosphoserine
            C18126  1-Acyl-sn-glycero-3-phosphoglycerol
            C18129  Monolysocardiolipin
            C18168  Diacylglycerylhomoserine
            C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
            C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
            C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
            C22340  Heptaprenylglyceryl phosphate
            C22341  Heptaprenylglycerol
            C22342  Diacetylheptaprenylglycerol
REFERENCE   PMID:1512203
  AUTHORS   Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  TITLE     The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  JOURNAL   J Bacteriol 174:5702-10 (1992)
            DOI:10.1128/JB.174.17.5702-5710.1992
REFERENCE   PMID:10092508
  AUTHORS   Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  TITLE     Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  JOURNAL   Biochem Biophys Res Commun 257:50-6 (1999)
            DOI:10.1006/bbrc.1999.0411
REFERENCE   PMID:10542045
  AUTHORS   Athenstaedt K, Daum G.
  TITLE     Phosphatidic acid, a key intermediate in lipid metabolism.
  JOURNAL   Eur J Biochem 266:1-16 (1999)
            DOI:10.1046/j.1432-1327.1999.00822.x
REFERENCE   PMID:12431977
  AUTHORS   Shields DJ, Lehner R, Agellon LB, Vance DE.
  TITLE     Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  JOURNAL   J Biol Chem 278:2956-62 (2003)
            DOI:10.1074/jbc.M210904200
REFERENCE   PMID:14663079
  AUTHORS   Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  TITLE     Pathways for phosphatidylcholine biosynthesis in bacteria.
  JOURNAL   Microbiology 149:3461-71 (2003)
            DOI:10.1099/mic.0.26522-0
REFERENCE   PMID:15522832
  AUTHORS   Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  TITLE     Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  JOURNAL   Biochim Biophys Acta 1686:161-8 (2004)
            DOI:10.1016/j.bbalip.2004.09.007
REFERENCE   PMID:1649829
  AUTHORS   Hsu L, Jackowski S, Rock CO
  TITLE     Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  JOURNAL   J Biol Chem 266:13783-8 (1991)
REFERENCE   PMID:10938271
  AUTHORS   Stone SJ, Vance JE.
  TITLE     Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  JOURNAL   J Biol Chem 275:34534-40 (2000)
            DOI:10.1074/jbc.M002865200
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00260  Glycine, serine and threonine metabolism
            hsa00561  Glycerolipid metabolism
            hsa00562  Inositol phosphate metabolism
            hsa00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
            hsa00565  Ether lipid metabolism
            hsa00620  Pyruvate metabolism
KO_PATHWAY  ko00564
///
