ENTRY       hsa00513                    Pathway
NAME        Various types of N-glycan biosynthesis - Homo sapiens (human)
CLASS       Metabolism; Glycan biosynthesis and metabolism
PATHWAY_MAP hsa00513  Various types of N-glycan biosynthesis
MODULE      hsa_M00072  N-glycosylation by oligosaccharyltransferase [PATH:hsa00513]
DBLINKS     GO: 0006487
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        79868  ALG13; ALG13 UDP-N-acetylglucosaminyltransferase subunit [KO:K07432] [EC:2.4.1.141]
            199857  ALG14; ALG14 UDP-N-acetylglucosaminyltransferase subunit [KO:K07441] [EC:2.4.1.141]
            56052  ALG1; ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [KO:K03842] [EC:2.4.1.142]
            85365  ALG2; ALG2 alpha-1,3/1,6-mannosyltransferase [KO:K03843] [EC:2.4.1.132 2.4.1.257]
            440138  ALG11; ALG11 alpha-1,2-mannosyltransferase [KO:K03844] [EC:2.4.1.131]
            10195  ALG3; ALG3 alpha-1,3- mannosyltransferase [KO:K03845] [EC:2.4.1.258]
            79796  ALG9; ALG9 alpha-1,2-mannosyltransferase [KO:K03846] [EC:2.4.1.259 2.4.1.261]
            79087  ALG12; ALG12 alpha-1,6-mannosyltransferase [KO:K03847] [EC:2.4.1.260]
            3703  STT3A; STT3 oligosaccharyltransferase complex catalytic subunit A [KO:K07151] [EC:2.4.99.18]
            201595  STT3B; STT3 oligosaccharyltransferase complex catalytic subunit B [KO:K07151] [EC:2.4.99.18]
            6184  RPN1; ribophorin I [KO:K12666]
            6185  RPN2; ribophorin II [KO:K12667]
            1603  DAD1; defender against cell death 1 [KO:K12668]
            7991  TUSC3; tumor suppressor candidate 3 [KO:K12669]
            1650  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [KO:K12670]
            11253  MAN1B1; mannosidase alpha class 1B member 1 [KO:K23741] [EC:3.2.1.209]
            10905  MAN1A2; mannosidase alpha class 1A member 2 [KO:K01230] [EC:3.2.1.113]
            57134  MAN1C1; mannosidase alpha class 1C member 1 [KO:K01230] [EC:3.2.1.113]
            4121  MAN1A1; mannosidase alpha class 1A member 1 [KO:K01230] [EC:3.2.1.113]
            4245  MGAT1; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [KO:K00726] [EC:2.4.1.101]
            4124  MAN2A1; mannosidase alpha class 2A member 1 [KO:K01231] [EC:3.2.1.114]
            4122  MAN2A2; mannosidase alpha class 2A member 2 [KO:K01231] [EC:3.2.1.114]
            4247  MGAT2; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [KO:K00736] [EC:2.4.1.143]
            3073  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
            3074  HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
            2530  FUT8; fucosyltransferase 8 [KO:K00717] [EC:2.4.1.68]
            284004  HEXD; hexosaminidase D [KO:K14459] [EC:3.2.1.52]
            25834  MGAT4C; MGAT4 family member C [KO:K13748] [EC:2.4.1.201 2.4.1.145]
            11320  MGAT4A; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A [KO:K00738] [EC:2.4.1.145]
            11282  MGAT4B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [KO:K00738] [EC:2.4.1.145]
            152586  MGAT4D; MGAT4 family member D [KO:K00738] [EC:2.4.1.145]
            2683  B4GALT1; beta-1,4-galactosyltransferase 1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
            8704  B4GALT2; beta-1,4-galactosyltransferase 2 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
            8703  B4GALT3; beta-1,4-galactosyltransferase 3 [KO:K07968] [EC:2.4.1.90 2.4.1.38 2.4.1.-]
            6487  ST3GAL3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [KO:K00781] [EC:2.4.3.6]
            283358  B4GALNT3; beta-1,4-N-acetyl-galactosaminyltransferase 3 [KO:K09656] [EC:2.4.1.244]
            338707  B4GALNT4; beta-1,4-N-acetyl-galactosaminyltransferase 4 [KO:K09657] [EC:2.4.1.244]
            64377  CHST8; carbohydrate sulfotransferase 8 [KO:K09672] [EC:2.8.2.-]
            83539  CHST9; carbohydrate sulfotransferase 9 [KO:K09673] [EC:2.8.2.-]
COMPOUND    G00011
            G00012
            G00013
            G00014
            G00015
            G00016
            G00017
            G00179
            G01813
            G05477
            G10665
            G10694
            G10716
            G10770
            G10841
            G10920
            G11000
            G11040
            G11933
            G12617
            G12625
            G12626
            G13047
            G13048
            G13049
            G13050
            G13055
            G13056
            G13057
            G13058
            G13059
REFERENCE   PMID:11412862
  AUTHORS   Munro S.
  TITLE     What can yeast tell us about N-linked glycosylation in the Golgi apparatus?
  JOURNAL   FEBS Lett 498:223-7 (2001)
            DOI:10.1016/S0014-5793(01)02488-7
REFERENCE   PMID:9878803
  AUTHORS   Dean N.
  TITLE     Asparagine-linked glycosylation in the yeast Golgi.
  JOURNAL   Biochim Biophys Acta 1426:309-22 (1999)
            DOI:10.1016/S0304-4165(98)00132-9
REFERENCE   PMID:9878780
  AUTHORS   Herscovics A.
  TITLE     Processing glycosidases of Saccharomyces cerevisiae.
  JOURNAL   Biochim Biophys Acta 1426:275-85 (1999)
            DOI:10.1016/S0304-4165(98)00129-9
REFERENCE   PMID:9218445
  AUTHORS   Wang XH, Nakayama K, Shimma Y, Tanaka A, Jigami Y.
  TITLE     MNN6, a member of the KRE2/MNT1 family, is the gene for mannosylphosphate transfer in Saccharomyces cerevisiae.
  JOURNAL   J Biol Chem 272:18117-24 (1997)
            DOI:10.1074/jbc.272.29.18117
REFERENCE   PMID:9756928
  AUTHORS   Rayner JC, Munro S.
  TITLE     Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae.
  JOURNAL   J Biol Chem 273:26836-43 (1998)
            DOI:10.1074/jbc.273.41.26836
REFERENCE   PMID:10037752
  AUTHORS   Jungmann J, Rayner JC, Munro S.
  TITLE     The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex.
  JOURNAL   J Biol Chem 274:6579-85 (1999)
            DOI:10.1074/jbc.274.10.6579
REFERENCE   PMID:8253757
  AUTHORS   Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y.
  TITLE     Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.
  JOURNAL   J Biol Chem 268:26338-45 (1993)
REFERENCE   PMID:20233335
  AUTHORS   Gomord V, Fitchette AC, Menu-Bouaouiche L, Saint-Jore-Dupas C, Plasson C, Michaud D, Faye L
  TITLE     Plant-specific glycosylation patterns in the context of therapeutic protein production.
  JOURNAL   Plant Biotechnol J 8:564-87 (2010)
            DOI:10.1111/j.1467-7652.2009.00497.x
REL_PATHWAY hsa00510  N-Glycan biosynthesis
KO_PATHWAY  ko00513
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