ENTRY       hsa00380                    Pathway
NAME        Tryptophan metabolism - Homo sapiens (human)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP hsa00380  Tryptophan metabolism
MODULE      hsa_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:hsa00380]
            hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:hsa00380]
            hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00380]
NETWORK     nt06028  Dopamine and serotonin metabolism
  ELEMENT   N01551  Serotonin metabolism
DRUG        D00505  Phenelzine sulfate (USP)
            D00826  Tranylcypromine sulfate (USP)
            D01888  Safrazine hydrochloride (JAN)
            D02559  Toloxatone (INN)
            D02560  Brofaromine (INN)
            D02561  Moclobemide (USAN/INN)
            D02563  Befloxatone (INN)
            D02579  Iproniazid (INN)
            D02580  Isocarboxazid (INN)
            D03248  Clorgiline (INN)
            D03409  Caroxazone (USAN/INN)
            D07337  Nialamide (INN)
            D07338  Iproclozide (INN)
            D08085  Iproniazid phosphate
            D08349  Phenelzine (BAN)
            D08392  Pirlindole (INN)
            D08393  Pirlindole hydrochloride
            D08625  Tranylcypromine (INN)
            D09973  Telotristat (USAN/INN)
            D09975  Telotristat etiprate (USAN)
            D10640  Indoximod (USAN/INN)
            D11049  Epacadostat (JAN/USAN/INN)
            D11255  Navoximod (USAN/INN)
            D11317  Rodatristat (USAN)
            D11318  Rodatristat ethyl (USAN)
            D11412  Linrodostat (USAN)
            D11413  Linrodostat mesylate (USAN)
            D12407  Eladocagene exuparvovec (USAN/INN)
DBLINKS     GO: 0006568 0009851
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        6999  TDO2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
            3620  IDO1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
            169355  IDO2; indoleamine 2,3-dioxygenase 2 [KO:K00463] [EC:1.13.11.52]
            125061  AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]
            8564  KMO; kynurenine 3-monooxygenase [KO:K00486] [EC:1.14.13.9]
            8942  KYNU; kynureninase [KO:K01556] [EC:3.7.1.3]
            23498  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
            130013  ACMSD; aminocarboxymuconate semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]
            64577  ALDH8A1; aldehyde dehydrogenase 8 family member A1 [KO:K23234] [EC:1.2.1.32]
            55526  DHTKD1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.2]
            1743  DLST; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
            1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
            2639  GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
            3030  HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
            1962  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
            1892  ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
            3033  HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
            39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
            38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
            56267  KYAT3; kynurenine aminotransferase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
            883  KYAT1; kynurenine aminotransferase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
            51166  AADAT; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
            121278  TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
            7166  TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
            1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
            4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
            4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
            217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
            224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
            219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
            501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
            316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
            438  ASMT; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
            15  AANAT; aralkylamine N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
            1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
            1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
            1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
            11185  INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
            259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
            26  AOC1; amine oxidase copper containing 1 [KO:K11182] [EC:1.4.3.22]
            847  CAT; catalase [KO:K03781] [EC:1.11.1.6]
COMPOUND    C00024  Acetyl-CoA
            C00078  L-Tryptophan
            C00108  Anthranilate
            C00322  2-Oxoadipate
            C00328  L-Kynurenine
            C00331  Indolepyruvate
            C00332  Acetoacetyl-CoA
            C00398  Tryptamine
            C00463  Indole
            C00527  Glutaryl-CoA
            C00632  3-Hydroxyanthranilate
            C00637  Indole-3-acetaldehyde
            C00643  5-Hydroxy-L-tryptophan
            C00780  Serotonin
            C00877  Crotonoyl-CoA
            C00954  Indole-3-acetate
            C00955  Indole-3-ethanol
            C00978  N-Acetylserotonin
            C01111  7,8-Dihydroxykynurenate
            C01144  (S)-3-Hydroxybutanoyl-CoA
            C01249  7,8-Dihydro-7,8-dihydroxykynurenate
            C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
            C01598  Melatonin
            C01717  4-Hydroxy-2-quinolinecarboxylic acid
            C01987  2-Aminophenol
            C02161  2-Aminophenoxazin-3-one
            C02172  N-Acetylisatin
            C02220  2-Aminomuconate
            C02298  N-Acetylindoxyl
            C02470  Xanthurenic acid
            C02693  (Indol-3-yl)acetamide
            C02700  L-Formylkynurenine
            C02775  2,3-Dihydroxyindole
            C02937  Indole-3-acetaldehyde oxime
            C02938  3-Indoleacetonitrile
            C03227  3-Hydroxy-L-kynurenine
            C03230  (Indol-3-yl)glycolaldehyde
            C03453  gamma-Oxalocrotonate
            C03574  2-Formylaminobenzaldehyde
            C03722  Quinolinate
            C03824  2-Aminomuconate semialdehyde
            C04409  2-Amino-3-carboxymuconate semialdehyde
            C05634  5-Hydroxyindoleacetaldehyde
            C05635  5-Hydroxyindoleacetate
            C05636  3-Hydroxykynurenamine
            C05637  4,8-Dihydroxyquinoline
            C05638  5-Hydroxykynurenamine
            C05639  4,6-Dihydroxyquinoline
            C05640  Cinnavalininate
            C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
            C05642  Formyl-N-acetyl-5-methoxykynurenamine
            C05643  6-Hydroxymelatonin
            C05644  3-Methylindolepyruvate
            C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
            C05646  5-Hydroxyindolepyruvate
            C05647  Formyl-5-hydroxykynurenamine
            C05648  5-Hydroxy-N-formylkynurenine
            C05651  5-Hydroxykynurenine
            C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
            C05653  Formylanthranilate
            C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
            C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
            C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
            C05658  Indoxyl
            C05659  5-Methoxytryptamine
            C05660  5-Methoxyindoleacetate
            C05663  6-Hydroxykynurenate
            C05830  8-Methoxykynurenate
            C05831  3-Methoxyanthranilate
            C05832  5-Hydroxyindoleacetylglycine
            C05834  3-Methyldioxyindole
            C05835  2-Formaminobenzoylacetate
            C05837  Glucobrassicin
            C06212  N-Methylserotonin
            C06213  N-Methyltryptamine
            C08313  Skatole
            C10164  Picolinic acid
            C16516  Indolylmethylthiohydroximate
            C16517  Indolylmethyl-desulfoglucosinolate
            C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
            C17203  N-Hydroxyl-tryptamine
            C22006  (R)-(Indol-3-yl)lactate
            C22202  2-Oxoindole-3-acetate
REFERENCE   PMID:15749753
  AUTHORS   Woodward AW, Bartel B
  TITLE     Auxin: regulation, action, and interaction.
  JOURNAL   Ann Bot 95:707-35 (2005)
            DOI:10.1093/aob/mci083
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            hsa00760  Nicotinate and nicotinamide metabolism
KO_PATHWAY  ko00380
///
