ENTRY       hsa00360                    Pathway
NAME        Phenylalanine metabolism - Homo sapiens (human)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP hsa00360  Phenylalanine metabolism
DRUG        D00505  Phenelzine sulfate (USP)
            D00826  Tranylcypromine sulfate (USP)
            D01888  Safrazine hydrochloride (JAN)
            D02559  Toloxatone (INN)
            D02560  Brofaromine (INN)
            D02561  Moclobemide (USAN/INN)
            D02563  Befloxatone (INN)
            D02579  Iproniazid (INN)
            D02580  Isocarboxazid (INN)
            D03248  Clorgiline (INN)
            D03409  Caroxazone (USAN/INN)
            D05177  Nitisinone (JAN/USAN/INN)
            D07337  Nialamide (INN)
            D07338  Iproclozide (INN)
            D08085  Iproniazid phosphate
            D08349  Phenelzine (BAN)
            D08392  Pirlindole (INN)
            D08393  Pirlindole hydrochloride
            D08625  Tranylcypromine (INN)
DBLINKS     GO: 0006558
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        5053  PAH; phenylalanine hydroxylase [KO:K00500] [EC:1.14.16.1]
            1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
            8639  AOC3; amine oxidase copper containing 3 [KO:K00276] [EC:1.4.3.21]
            314  AOC2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
            4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
            4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
            221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
            222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
            218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
            2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
            137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
            2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
            6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
            259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
            3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
            4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
COMPOUND    C00022  Pyruvate
            C00024  Acetyl-CoA
            C00042  Succinate
            C00079  L-Phenylalanine
            C00082  L-Tyrosine
            C00084  Acetaldehyde
            C00091  Succinyl-CoA
            C00122  Fumarate
            C00166  Phenylpyruvate
            C00423  trans-Cinnamate
            C00512  Benzoyl-CoA
            C00582  Phenylacetyl-CoA
            C00596  2-Hydroxy-2,4-pentadienoate
            C00601  Phenylacetaldehyde
            C00642  4-Hydroxyphenylacetate
            C01198  3-(2-Hydroxyphenyl)propanoate
            C01772  trans-2-Hydroxycinnamate
            C02137  alpha-Oxo-benzeneacetic acid
            C02232  3-Oxoadipyl-CoA
            C02265  D-Phenylalanine
            C02505  2-Phenylacetamide
            C02763  2-Hydroxy-3-phenylpropenoate
            C03519  N-Acetyl-L-phenylalanine
            C03589  4-Hydroxy-2-oxopentanoate
            C04044  3-(2,3-Dihydroxyphenyl)propanoate
            C04148  Phenylacetylglutamine
            C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
            C05332  Phenethylamine
            C05593  3-Hydroxyphenylacetate
            C05598  Phenylacetylglycine
            C05607  Phenyllactate
            C05629  Phenylpropanoate
            C05852  2-Hydroxyphenylacetate
            C05853  Phenylethyl alcohol
            C06207  2,6-Dihydroxyphenylacetate
            C07086  Phenylacetic acid
            C11457  3-(3-Hydroxyphenyl)propanoic acid
            C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
            C12621  trans-3-Hydroxycinnamate
            C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
            C12623  trans-2,3-Dihydroxycinnamate
            C12624  2-Hydroxy-6-ketononatrienedioate
            C14144  5-Carboxy-2-pentenoyl-CoA
            C14145  (3S)-3-Hydroxyadipyl-CoA
            C15524  Phenylglyoxylyl-CoA
            C19945  3-Oxo-5,6-dehydrosuberyl-CoA
            C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
            C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
            C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:10537203
  AUTHORS   Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  TITLE     Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  JOURNAL   Microbiology 145 ( Pt 10):2813-20 (1999)
            DOI:10.1099/00221287-145-10-2813
REFERENCE   PMID:9603882
  AUTHORS   Diaz E, Ferrandez A, Garcia JL.
  TITLE     Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  JOURNAL   J Bacteriol 180:2915-23 (1998)
            DOI:10.1128/JB.180.11.2915-2923.1998
REFERENCE   PMID:9098055
  AUTHORS   Ferrandez A, Garcia JL, Diaz E.
  TITLE     Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  JOURNAL   J Bacteriol 179:2573-81 (1997)
            DOI:10.1128/JB.179.8.2573-2581.1997
REFERENCE   PMID:19016485
  AUTHORS   Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  TITLE     Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  JOURNAL   Biotechnol Bioeng 102:1323-9 (2009)
            DOI:10.1002/bit.22178
REFERENCE   PMID:20660314
  AUTHORS   Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  TITLE     Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  JOURNAL   Proc Natl Acad Sci U S A 107:14390-5 (2010)
            DOI:10.1073/pnas.1005399107
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00020  Citrate cycle (TCA cycle)
            hsa00350  Tyrosine metabolism
            hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO_PATHWAY  ko00360
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