ENTRY       hsa00350                    Pathway
NAME        Tyrosine metabolism - Homo sapiens (human)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP hsa00350  Tyrosine metabolism
MODULE      hsa_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:hsa00350]
            hsa_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:hsa00350]
            hsa_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:hsa00350]
NETWORK     nt06016  Phenylalanine and tyrosine metabolism
            nt06028  Dopamine and serotonin metabolism
            nt06322  TRH-TSH-TH signaling
            nt06422  Dopamine metabolism
            nt06463  Parkinson disease
  ELEMENT   N00708  Tyrosine degradation
            N00803  Iodide organification/coupling reactions
            N01530  Dopamine metabolism
            N01550  Adrenaline metabolism
            N01552  Eumelanin biosynthesis
DRUG        D00152  Phloroglucinol (JAN)
            D00505  Phenelzine sulfate (USP)
            D00762  Metyrosine (USP)
            D00826  Tranylcypromine sulfate (USP)
            D01259  Flopropione (JP18/INN)
            D01888  Safrazine hydrochloride (JAN)
            D02559  Toloxatone (INN)
            D02560  Brofaromine (INN)
            D02561  Moclobemide (USAN/INN)
            D02563  Befloxatone (INN)
            D02579  Iproniazid (INN)
            D02580  Isocarboxazid (INN)
            D03248  Clorgiline (INN)
            D03409  Caroxazone (USAN/INN)
            D05177  Nitisinone (JAN/USAN/INN)
            D07337  Nialamide (INN)
            D07338  Iproclozide (INN)
            D08085  Iproniazid phosphate
            D08349  Phenelzine (BAN)
            D08369  Polyphloroglucinol phosphate
            D08392  Pirlindole (INN)
            D08393  Pirlindole hydrochloride
            D08625  Tranylcypromine (INN)
            D12407  Eladocagene exuparvovec (USAN/INN)
DBLINKS     GO: 0006570
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
            137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
            2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
            6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
            259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
            3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
            3081  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
            2954  GSTZ1; glutathione S-transferase zeta 1 [KO:K01800] [EC:5.2.1.2]
            2184  FAH; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
            7299  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
            7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
            1638  DCT; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
            7306  TYRP1; tyrosinase related protein 1 [KO:K00506] [EC:1.14.18.-]
            1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
            1621  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
            5409  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
            1312  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
            220074  LRTOMT; leucine rich transmembrane and O-methyltransferase domain containing [KO:K00545] [EC:2.1.1.6]
            4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
            4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
            8639  AOC3; amine oxidase copper containing 3 [KO:K00276] [EC:1.4.3.21]
            314  AOC2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
            221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
            222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
            218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
            124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
            125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
            126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
            131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
            127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
            128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
            130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
            7173  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
            316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
            81889  FAHD1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
            4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
COMPOUND    C00022  Pyruvate
            C00042  Succinate
            C00082  L-Tyrosine
            C00122  Fumarate
            C00146  Phenol
            C00164  Acetoacetate
            C00232  Succinate semialdehyde
            C00355  3,4-Dihydroxy-L-phenylalanine
            C00483  Tyramine
            C00530  Hydroquinone
            C00544  Homogentisate
            C00547  L-Noradrenaline
            C00628  2,5-Dihydroxybenzoate
            C00642  4-Hydroxyphenylacetate
            C00788  L-Adrenaline
            C00811  4-Coumarate
            C00822  Dopaquinone
            C01036  4-Maleylacetoacetate
            C01060  3,5-Diiodo-L-tyrosine
            C01061  4-Fumarylacetoacetate
            C01161  3,4-Dihydroxyphenylacetate
            C01179  3-(4-Hydroxyphenyl)pyruvate
            C01384  Maleic acid
            C01693  L-Dopachrome
            C01829  Thyroxine
            C01850  Rosmarinate
            C02167  Maleylpyruvate
            C02442  N-Methyltyramine
            C02465  Triiodothyronine
            C02514  3-Fumarylpyruvate
            C02515  3-Iodo-L-tyrosine
            C03063  2-Oxohept-3-enedioate
            C03077  4-Chlorophenylacetate
            C03758  Dopamine
            C03765  4-Hydroxyphenylacetaldehyde
            C03964  (R)-3-(4-Hydroxyphenyl)lactate
            C04043  3,4-Dihydroxyphenylacetaldehyde
            C04045  3-(3,4-Dihydroxyphenyl)pyruvate
            C04052  5-Carboxy-2-oxohept-3-enedioate
            C04185  5,6-Dihydroxyindole-2-carboxylate
            C04186  5-Carboxymethyl-2-hydroxymuconate
            C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
            C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
            C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
            C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
            C05338  4-Hydroxyphenylacetyl-CoA
            C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
            C05576  3,4-Dihydroxyphenylethyleneglycol
            C05577  3,4-Dihydroxymandelaldehyde
            C05578  5,6-Dihydroxyindole
            C05579  Indole-5,6-quinone
            C05580  3,4-Dihydroxymandelate
            C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
            C05582  Homovanillate
            C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
            C05584  3-Methoxy-4-hydroxymandelate
            C05585  Gentisate aldehyde
            C05587  3-Methoxytyramine
            C05588  L-Metanephrine
            C05589  L-Normetanephrine
            C05593  3-Hydroxyphenylacetate
            C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
            C05595  4-Hydroxyphenylacetylglutamic acid
            C05596  p-Hydroxyphenylacetylglycine
            C05600  2-Hydroxyhepta-2,4-dienedioate
            C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
            C06044  4-Hydroxyphenylethanol
            C06046  Salidroside
            C06047  Stizolobate
            C06048  Stizolobinate
            C06199  Hordenine
            C06201  2,4-Dihydroxyhept-2-enedioate
            C10447  3,4-Dihydroxyphenylpropanoate
            C17935  Cysteinyldopa
            C17936  Phaeomelanin
            C17937  Eumelanin
            C17938  5,6-Indolequinone-2-carboxylic acid
            C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
REFERENCE   PMID:8550403
  AUTHORS   Prieto MA, Diaz E, Garcia JL.
  TITLE     Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  JOURNAL   J Bacteriol 178:111-20 (1996)
            DOI:10.1128/JB.178.1.111-120.1996
REFERENCE   PMID:1194238
  AUTHORS   Sparnins VL, Dagley S.
  TITLE     Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  JOURNAL   J Bacteriol 124:1374-81 (1975)
            DOI:10.1128/JB.124.3.1374-1381.1975
REFERENCE   PMID:18435614
  AUTHORS   Ito S, Wakamatsu K
  TITLE     Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  JOURNAL   Photochem Photobiol 84:582-92 (2008)
            DOI:10.1111/j.1751-1097.2007.00238.x
REFERENCE   PMID:11171088
  AUTHORS   Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  TITLE     The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  JOURNAL   Biochem J 354:131-9 (2001)
            DOI:10.1042/bj3540131
REL_PATHWAY hsa00020  Citrate cycle (TCA cycle)
            hsa00360  Phenylalanine metabolism
            hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            hsa00620  Pyruvate metabolism
            hsa00650  Butanoate metabolism
KO_PATHWAY  ko00350
///
