ENTRY       hsa00330                    Pathway
NAME        Arginine and proline metabolism - Homo sapiens (human)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP hsa00330  Arginine and proline metabolism
MODULE      hsa_M00015  Proline biosynthesis, glutamate => proline [PATH:hsa00330]
            hsa_M00047  Creatine pathway [PATH:hsa00330]
            hsa_M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:hsa00330]
            hsa_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:hsa00330]
            hsa_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:hsa00330]
DRUG        D00505  Phenelzine sulfate (USP)
            D00826  Tranylcypromine sulfate (USP)
            D00829  Eflornithine hydrochloride (USAN)
            D01888  Safrazine hydrochloride (JAN)
            D02559  Toloxatone (INN)
            D02560  Brofaromine (INN)
            D02561  Moclobemide (USAN/INN)
            D02563  Befloxatone (INN)
            D02579  Iproniazid (INN)
            D02580  Isocarboxazid (INN)
            D03248  Clorgiline (INN)
            D03409  Caroxazone (USAN/INN)
            D04793  Lufironil (USAN/INN)
            D07258  Mitoguazone (INN)
            D07337  Nialamide (INN)
            D07338  Iproclozide (INN)
            D07883  Eflornithine (INN)
            D08085  Iproniazid phosphate
            D08349  Phenelzine (BAN)
            D08392  Pirlindole (INN)
            D08393  Pirlindole hydrochloride
            D08625  Tranylcypromine (INN)
            D09018  Tilarginine acetate (USAN)
            D11695  Pegzilarginase (USAN/INN)
DBLINKS     GO: 0006525 0006560
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2628  GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
            2593  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
            1158  CKM; creatine kinase, M-type [KO:K00933] [EC:2.7.3.2]
            548596  CKMT1A; creatine kinase, mitochondrial 1A [KO:K00933] [EC:2.7.3.2]
            1160  CKMT2; creatine kinase, mitochondrial 2 [KO:K00933] [EC:2.7.3.2]
            1152  CKB; creatine kinase B [KO:K00933] [EC:2.7.3.2]
            1159  CKMT1B; creatine kinase, mitochondrial 1B [KO:K00933] [EC:2.7.3.2]
            113451  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
            79814  AGMAT; agmatinase [KO:K01480] [EC:3.5.3.11]
            4953  ODC1; ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
            6723  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
            6611  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
            262  AMD1; adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
            26  AOC1; amine oxidase copper containing 1 [KO:K11182] [EC:1.4.3.22]
            54498  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
            217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
            224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
            219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
            501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
            84735  CNDP1; carnosine dipeptidase 1 [KO:K05604] [EC:3.4.13.20]
            55748  CNDP2; carnosine dipeptidase 2 [KO:K08660] [EC:3.4.13.18]
            57571  CARNS1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
            112483  SAT2; spermidine/spermine N1-acetyltransferase family member 2 [KO:K00657] [EC:2.3.1.57]
            6303  SAT1; spermidine/spermine N1-acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
            4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
            4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
            4842  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
            4843  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
            4846  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
            384  ARG2; arginase 2 [KO:K01476] [EC:3.5.3.1]
            383  ARG1; arginase 1 [KO:K01476] [EC:3.5.3.1]
            4942  OAT; ornithine aminotransferase [KO:K00819] [EC:2.6.1.13]
            65263  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
            29920  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
            5831  PYCR1; pyrroline-5-carboxylate reductase 1 [KO:K00286] [EC:1.5.1.2]
            5625  PRODH; proline dehydrogenase 1 [KO:K00318] [EC:1.5.5.2]
            8659  ALDH4A1; aldehyde dehydrogenase 4 family member A1 [KO:K00294] [EC:1.2.1.88]
            5832  ALDH18A1; aldehyde dehydrogenase 18 family member A1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
            51056  LAP3; leucine aminopeptidase 3 [KO:K11142] [EC:3.4.11.1 3.4.11.5]
            8974  P4HA2; prolyl 4-hydroxylase subunit alpha 2 [KO:K00472] [EC:1.14.11.2]
            283208  P4HA3; prolyl 4-hydroxylase subunit alpha 3 [KO:K00472] [EC:1.14.11.2]
            5033  P4HA1; prolyl 4-hydroxylase subunit alpha 1 [KO:K00472] [EC:1.14.11.2]
            58510  PRODH2; proline dehydrogenase 2 [KO:K11394] [EC:1.5.5.3]
            2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
            137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
            2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
            112817  HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
            1610  DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
            112849  L3HYPDH; trans-L-3-hydroxyproline dehydratase [KO:K18384] [EC:4.2.1.77]
COMPOUND    C00012  Peptide
            C00019  S-Adenosyl-L-methionine
            C00022  Pyruvate
            C00025  L-Glutamate
            C00048  Glyoxylate
            C00062  L-Arginine
            C00077  L-Ornithine
            C00086  Urea
            C00134  Putrescine
            C00148  L-Proline
            C00179  Agmatine
            C00213  Sarcosine
            C00223  p-Coumaroyl-CoA
            C00300  Creatine
            C00315  Spermidine
            C00334  4-Aminobutanoate
            C00406  Feruloyl-CoA
            C00431  5-Aminopentanoate
            C00436  N-Carbamoylputrescine
            C00441  L-Aspartate 4-semialdehyde
            C00533  Nitric oxide
            C00555  4-Aminobutyraldehyde
            C00581  Guanidinoacetate
            C00750  Spermine
            C00763  D-Proline
            C00791  Creatinine
            C00884  Homocarnosine
            C00986  1,3-Diaminopropane
            C01035  4-Guanidinobutanoate
            C01043  N-Carbamoylsarcosine
            C01110  5-Amino-2-oxopentanoic acid
            C01137  S-Adenosylmethioninamine
            C01157  Hydroxyproline
            C01165  L-Glutamate 5-semialdehyde
            C01250  N-Acetyl-L-glutamate 5-semialdehyde
            C01682  Nopaline
            C02305  Phosphocreatine
            C02565  N-Methylhydantoin
            C02647  4-Guanidinobutanal
            C02714  N-Acetylputrescine
            C02946  4-Acetamidobutanoate
            C03078  4-Guanidinobutanamide
            C03166  Phosphoguanidinoacetate
            C03287  L-Glutamyl 5-phosphate
            C03296  N2-Succinyl-L-arginine
            C03375  Norspermidine
            C03415  N2-Succinyl-L-ornithine
            C03564  1-Pyrroline-2-carboxylate
            C03771  5-Guanidino-2-oxopentanoate
            C03912  (S)-1-Pyrroline-5-carboxylate
            C04137  Octopine
            C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
            C05147  trans-3-Hydroxy-L-proline
            C05931  N-Succinyl-L-glutamate
            C05932  N-Succinyl-L-glutamate 5-semialdehyde
            C05933  N(omega)-Hydroxyarginine
            C05936  N4-Acetylaminobutanal
            C05938  L-4-Hydroxyglutamate semialdehyde
            C05945  L-Arginine phosphate
            C05946  (4R)-4-Hydroxy-2-oxoglutarate
            C05947  L-erythro-4-Hydroxyglutamate
            C10497  Feruloylputrescine
            C15699  gamma-L-Glutamylputrescine
            C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
            C15767  4-(L-gamma-Glutamylamino)butanoate
            C18172  Carboxyspermidine
            C18174  Carboxynorspermidine
            C18326  p-Coumaroylputrescine
            C19706  cis-3-Hydroxy-L-proline
REFERENCE   PMID:5288244
  AUTHORS   Haake P, Allen GW.
  TITLE     Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  JOURNAL   Proc Natl Acad Sci U S A 68:2691-3 (1971)
            DOI:10.1073/pnas.68.11.2691
REFERENCE   PMID:16499623
  AUTHORS   Kurihara S, Oda S, Kumagai H, Suzuki H.
  TITLE     Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  JOURNAL   FEMS Microbiol Lett 256:318-23 (2006)
            DOI:10.1111/j.1574-6968.2006.00137.x
REFERENCE   PMID:15590624
  AUTHORS   Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  TITLE     A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  JOURNAL   J Biol Chem 280:4602-8 (2005)
            DOI:10.1074/jbc.M411114200
REL_PATHWAY hsa00020  Citrate cycle (TCA cycle)
            hsa00220  Arginine biosynthesis
            hsa00250  Alanine, aspartate and glutamate metabolism
            hsa00260  Glycine, serine and threonine metabolism
            hsa00270  Cysteine and methionine metabolism
            hsa00310  Lysine degradation
            hsa00410  beta-Alanine metabolism
            hsa00470  D-Amino acid metabolism
            hsa00480  Glutathione metabolism
            hsa00630  Glyoxylate and dicarboxylate metabolism
            hsa00650  Butanoate metabolism
            hsa00770  Pantothenate and CoA biosynthesis
KO_PATHWAY  ko00330
///
