ENTRY       hsa00250                    Pathway
NAME        Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP hsa00250  Alanine, aspartate and glutamate metabolism
MODULE      hsa_M00027  GABA (gamma-Aminobutyrate) shunt [PATH:hsa00250]
DRUG        D07130  Carglumic acid (JAN/USAN/INN)
DBLINKS     GO: 0006522 0006531 0006536
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
            137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
            2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
            259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
            8528  DDO; D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
            80150  ASRGL1; asparaginase and isoaspartyl peptidase 1 [KO:K13051] [EC:3.5.1.1 3.4.19.5]
            440  ASNS; asparagine synthetase (glutamine-hydrolyzing) [KO:K01953] [EC:6.3.5.4]
            56954  NIT2; nitrilase family member 2 [KO:K13566] [EC:3.5.1.3]
            84706  GPT2; glutamic--pyruvic transaminase 2 [KO:K00814] [EC:2.6.1.2]
            2875  GPT; glutamic--pyruvic transaminase [KO:K00814] [EC:2.6.1.2]
            189  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            64902  AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            445  ASS1; argininosuccinate synthase 1 [KO:K01940] [EC:6.3.4.5]
            435  ASL; argininosuccinate lyase [KO:K01755] [EC:4.3.2.1]
            122622  ADSS1; adenylosuccinate synthase 1 [KO:K01939] [EC:6.3.4.4]
            159  ADSS2; adenylosuccinate synthase 2 [KO:K01939] [EC:6.3.4.4]
            158  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
            339983  NAT8L; N-acetyltransferase 8 like [KO:K18309] [EC:2.3.1.17]
            57494  RIMKLB; ribosomal modification protein rimK like family member B [KO:K18310] [EC:6.3.1.17 6.3.2.41]
            284716  RIMKLA; ribosomal modification protein rimK like family member A [KO:K18311] [EC:6.3.2.41 6.3.2.42]
            2346  FOLH1; folate hydrolase 1 [KO:K14592] [EC:3.4.17.21]
            443  ASPA; aspartoacylase [KO:K01437] [EC:3.5.1.15]
            2571  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
            2572  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
            18  ABAT; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.19 2.6.1.22]
            7915  ALDH5A1; aldehyde dehydrogenase 5 family member A1 [KO:K00139] [EC:1.2.1.24]
            2747  GLUD2; glutamate dehydrogenase 2 [KO:K00261] [EC:1.4.1.3]
            2746  GLUD1; glutamate dehydrogenase 1 [KO:K00261] [EC:1.4.1.3]
            8659  ALDH4A1; aldehyde dehydrogenase 4 family member A1 [KO:K00294] [EC:1.2.1.88]
            2752  GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
            790  CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [KO:K11540] [EC:6.3.5.5 2.1.3.2 3.5.2.3]
            27165  GLS2; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
            2744  GLS; glutaminase [KO:K01425] [EC:3.5.1.2]
            1373  CPS1; carbamoyl-phosphate synthase 1 [KO:K01948] [EC:6.3.4.16]
            9945  GFPT2; glutamine-fructose-6-phosphate transaminase 2 [KO:K00820] [EC:2.6.1.16]
            2673  GFPT1; glutamine--fructose-6-phosphate transaminase 1 [KO:K00820] [EC:2.6.1.16]
            5471  PPAT; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
COMPOUND    C00014  Ammonia
            C00022  Pyruvate
            C00025  L-Glutamate
            C00026  2-Oxoglutarate
            C00036  Oxaloacetate
            C00041  L-Alanine
            C00042  Succinate
            C00049  L-Aspartate
            C00064  L-Glutamine
            C00122  Fumarate
            C00152  L-Asparagine
            C00158  Citrate
            C00169  Carbamoyl phosphate
            C00232  Succinate semialdehyde
            C00334  4-Aminobutanoate
            C00352  D-Glucosamine 6-phosphate
            C00402  D-Aspartate
            C00438  N-Carbamoyl-L-aspartate
            C00940  2-Oxoglutaramate
            C01042  N-Acetyl-L-aspartate
            C02362  2-Oxosuccinamate
            C03090  5-Phosphoribosylamine
            C03406  N-(L-Arginino)succinate
            C03794  N6-(1,2-Dicarboxyethyl)-AMP
            C03912  (S)-1-Pyrroline-5-carboxylate
            C12270  N-Acetylaspartylglutamate
            C20775  beta-Citryl-L-glutamate
            C20776  N-Acetylaspartylglutamylglutamate
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:9687539
  AUTHORS   Wu G
  TITLE     Intestinal mucosal amino acid catabolism.
  JOURNAL   J Nutr 128:1249-52 (1998)
            DOI:10.1093/jn/128.8.1249
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00020  Citrate cycle (TCA cycle)
            hsa00220  Arginine biosynthesis
            hsa00230  Purine metabolism
            hsa00240  Pyrimidine metabolism
            hsa00260  Glycine, serine and threonine metabolism
            hsa00330  Arginine and proline metabolism
            hsa00340  Histidine metabolism
            hsa00410  beta-Alanine metabolism
            hsa00470  D-Amino acid metabolism
            hsa00480  Glutathione metabolism
            hsa00520  Amino sugar and nucleotide sugar metabolism
            hsa00630  Glyoxylate and dicarboxylate metabolism
            hsa00650  Butanoate metabolism
            hsa00760  Nicotinate and nicotinamide metabolism
            hsa00770  Pantothenate and CoA biosynthesis
            hsa00860  Porphyrin metabolism
            hsa00910  Nitrogen metabolism
KO_PATHWAY  ko00250
///
