ENTRY       hsa00232                    Pathway
NAME        Caffeine metabolism - Homo sapiens (human)
CLASS       Metabolism; Biosynthesis of other secondary metabolites
PATHWAY_MAP hsa00232  Caffeine metabolism
DRUG        D09786  Topiroxostat (JAN/INN)
DBLINKS     UMBBD: caf caf2
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
            10  NAT2; N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
            9  NAT1; N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
            1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-]
            1549  CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-]
            7498  XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
COMPOUND    C00048  Glyoxylate
            C00385  Xanthine
            C01762  Xanthosine
            C07130  Theophylline
            C07480  Theobromine
            C07481  Caffeine
            C13747  1,7-Dimethylxanthine
            C16352  7-Methylxanthosine
            C16353  7-Methylxanthine
            C16355  7-Methyluric acid
            C16356  1,7-Dimethyluric acid
            C16357  3-Methylxanthine
            C16358  1-Methylxanthine
            C16359  1-Methyluric acid
            C16360  3,7-Dimethyluric acid
            C16361  1,3,7-Trimethyluric acid
            C16362  3,6,8-Trimethylallantoin
            C16363  N-Methylurea
            C16364  N,N'-Dimethylurea
            C16365  5-Acetylamino-6-formylamino-3-methyluracil
            C16366  5-Acetylamino-6-amino-3-methyluracil
            C21144  1,3,7-Trimethyl-5-hydroxyisourate
REFERENCE   PMID:9705852
  AUTHORS   Madyastha KM, Sridhar GR.
  TITLE     A novel pathway for the metabolism of caffeine by a mixed culture consortium.
  JOURNAL   Biochem Biophys Res Commun 249:178-81 (1998)
            DOI:10.1006/bbrc.1998.9102
REFERENCE   PMID:14977550
  AUTHORS   Mazzafera P.
  TITLE     Catabolism of caffeine in plants and microorganisms.
  JOURNAL   Front Biosci 9:1348-59 (2004)
            DOI:10.2741/1339
REFERENCE   PMID:11393735
  AUTHORS   Nyeki A, Biollaz J, Kesselring UW, Decosterd LA.
  TITLE     Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.
  JOURNAL   J Chromatogr B Biomed Sci Appl 755:73-84 (2001)
            DOI:10.1016/S0378-4347(00)00616-2
REFERENCE   PMID:11544129
  AUTHORS   Ashihara H, Crozier A.
  TITLE     Caffeine: a well known but little mentioned compound in plant science.
  JOURNAL   Trends Plant Sci 6:407-13 (2001)
            DOI:10.1016/S1360-1385(01)02055-6
REFERENCE   PMID:16333668
  AUTHORS   Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M.
  TITLE     Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.
  JOURNAL   Mol Genet Genomics 275:125-35 (2006)
            DOI:10.1007/s00438-005-0070-z
REL_PATHWAY hsa00230  Purine metabolism
            hsa00630  Glyoxylate and dicarboxylate metabolism
KO_PATHWAY  ko00232
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