ENTRY       hsa00100                    Pathway
NAME        Steroid biosynthesis - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00100  Steroid biosynthesis
MODULE      hsa_M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol [PATH:hsa00100]
            hsa_M00103  Cholecalciferol biosynthesis [PATH:hsa00100]
DRUG        D01202  Melinamide (JAN)
            D03012  Avasimibe (USAN/INN)
            D03025  Azalanstat dihydrochloride (USAN)
            D03447  Cetaben sodium (USAN)
            D03734  Eldacimibe (USAN/INN)
            D03735  Lecimibide (USAN)
            D06609  Lapaquistat acetate (JAN/USAN)
DBLINKS     GO: 0016126
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2222  FDFT1; farnesyl-diphosphate farnesyltransferase 1 [KO:K00801] [EC:2.5.1.21]
            6713  SQLE; squalene epoxidase [KO:K00511] [EC:1.14.14.17]
            4047  LSS; lanosterol synthase [KO:K01852] [EC:5.4.99.7]
            1595  CYP51A1; cytochrome P450 family 51 subfamily A member 1 [KO:K05917] [EC:1.14.14.154 1.14.15.36]
            7108  TM7SF2; transmembrane 7 superfamily member 2 [KO:K00222] [EC:1.3.1.70]
            3930  LBR; lamin B receptor [KO:K19532] [EC:1.3.1.70]
            6307  MSMO1; methylsterol monooxygenase 1 [KO:K07750] [EC:1.14.18.9]
            50814  NSDHL; NAD(P) dependent steroid dehydrogenase-like [KO:K07748] [EC:1.1.1.170]
            51478  HSD17B7; hydroxysteroid 17-beta dehydrogenase 7 [KO:K13373] [EC:1.1.1.62 1.1.1.270]
            10682  EBP; EBP cholestenol delta-isomerase [KO:K01824] [EC:5.3.3.5]
            1718  DHCR24; 24-dehydrocholesterol reductase [KO:K09828] [EC:1.3.1.72 1.3.1.-]
            6309  SC5D; sterol-C5-desaturase [KO:K00227] [EC:1.14.19.20]
            1717  DHCR7; 7-dehydrocholesterol reductase [KO:K00213] [EC:1.3.1.21]
            3988  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
            1056  CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
            8435  SOAT2; sterol O-acyltransferase 2 [KO:K00637] [EC:2.3.1.26]
            6646  SOAT1; sterol O-acyltransferase 1 [KO:K00637] [EC:2.3.1.26]
            120227  CYP2R1; cytochrome P450 family 2 subfamily R member 1 [KO:K07419] [EC:1.14.14.24]
            1594  CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438] [EC:1.14.15.18]
            1591  CYP24A1; cytochrome P450 family 24 subfamily A member 1 [KO:K07436] [EC:1.14.15.16]
COMPOUND    C00187  Cholesterol
            C00448  trans,trans-Farnesyl diphosphate
            C00751  Squalene
            C01054  (S)-2,3-Epoxysqualene
            C01164  7-Dehydrocholesterol
            C01189  Lathosterol
            C01561  Calcidiol
            C01673  Calcitriol
            C01694  Ergosterol
            C01724  Lanosterol
            C01753  beta-Sitosterol
            C01789  Campesterol
            C01802  Desmosterol
            C01902  Cycloartenol
            C01943  Obtusifoliol
            C02141  Cycloeucalenol
            C02530  Cholesterol ester
            C03428  Presqualene diphosphate
            C03845  5alpha-Cholest-8-en-3beta-ol
            C04525  Fecosterol
            C05103  4alpha-Methylzymosterol
            C05107  7-Dehydrodesmosterol
            C05108  14-Demethyllanosterol
            C05109  24,25-Dihydrolanosterol
            C05437  Zymosterol
            C05439  5alpha-Cholesta-7,24-dien-3beta-ol
            C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
            C05441  Vitamin D2
            C05442  Stigmasterol
            C05443  Vitamin D3
            C07712  Secalciferol
            C08813  Brassicasterol
            C08821  Isofucosterol
            C08830  24-Methylidenecycloartanol
            C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
            C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
            C11522  24-Methylenelophenol
            C11523  24-Ethylidenelophenol
            C15776  4alpha-Methylfecosterol
            C15777  Episterol
            C15780  5-Dehydroepisterol
            C15781  24-Methylenecholesterol
            C15782  Delta7-Avenasterol
            C15783  5-Dehydroavenasterol
            C15808  4alpha-Methylzymosterol-4-carboxylate
            C15816  3-Keto-4-methylzymosterol
            C15915  4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
            C18231  Calcitetrol
            C21106  24-epi-Campesterol
            C22112  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol
            C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
            C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
            C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
            C22121  Cycloeucalenone
            C22122  Episterone
            C22123  Avenastenone
            C22136  Zymosterone
REFERENCE   
  AUTHORS   Koshiba K, Kamiya Y.
  TITLE     [Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  JOURNAL   Koudansya saientific:199-138 (2002)
REFERENCE   PMID:16531502
  AUTHORS   Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  TITLE     Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  JOURNAL   Plant Cell 18:1008-22 (2006)
            DOI:10.1105/tpc.105.036012
REFERENCE   PMID:12777052
  AUTHORS   Lange BM, Ghassemian M.
  TITLE     Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  JOURNAL   Plant Mol Biol 51:925-48 (2003)
            DOI:10.1023/A:1023005504702
REL_PATHWAY hsa00120  Primary bile acid biosynthesis
            hsa00140  Steroid hormone biosynthesis
            hsa00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko00100
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