ENTRY       hsa00072                    Pathway
NAME        Synthesis and degradation of ketone bodies - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00072  Synthesis and degradation of ketone bodies
DISEASE     H01076  Alpha-methylacetoacetic aciduria
            H01121  Succinyl CoA:3-oxoacid CoA transferase (SCOT) deficiency
            H01123  HMG-CoA synthase deficiency
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        3157  HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 [KO:K01641] [EC:2.3.3.10]
            3158  HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 [KO:K01641] [EC:2.3.3.10]
            3155  HMGCL; 3-hydroxy-3-methylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
            54511  HMGCLL1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 [KO:K01640] [EC:4.1.3.4]
            5019  OXCT1; 3-oxoacid CoA-transferase 1 [KO:K01027] [EC:2.8.3.5]
            64064  OXCT2; 3-oxoacid CoA-transferase 2 [KO:K01027] [EC:2.8.3.5]
            39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
            38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
            622  BDH1; 3-hydroxybutyrate dehydrogenase 1 [KO:K00019] [EC:1.1.1.30]
            56898  BDH2; 3-hydroxybutyrate dehydrogenase 2 [KO:K00019] [EC:1.1.1.30]
COMPOUND    C00024  Acetyl-CoA
            C00164  Acetoacetate
            C00207  Acetone
            C00332  Acetoacetyl-CoA
            C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
            C01089  (R)-3-Hydroxybutanoate
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00071  Fatty acid degradation
            hsa00620  Pyruvate metabolism
            hsa00650  Butanoate metabolism
KO_PATHWAY  ko00072
///
