ENTRY       hsa00061                    Pathway
NAME        Fatty acid biosynthesis - Homo sapiens (human)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP hsa00061  Fatty acid biosynthesis
MODULE      hsa_M00082  Fatty acid biosynthesis, initiation [PATH:hsa00061]
            hsa_M00083  Fatty acid biosynthesis, elongation [PATH:hsa00061]
            hsa_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:hsa00061]
            hsa_M00873  Fatty acid biosynthesis in mitochondria, animals [PATH:hsa00061]
DRUG        D11186  Olumacostat glasaretil (USAN/INN)
            D11640  Firsocostat (USAN/INN)
            D11902  Clesacostat (USAN)
            D11903  Clesacostat tromethamine (USAN)
            D12391  Denifanstat (USAN)
DBLINKS     GO: 0006633
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        31  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            32  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
            197322  ACSF3; acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
            27349  MCAT; malonyl-CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
            2194  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
            54995  OXSM; 3-oxoacyl-ACP synthase, mitochondrial [KO:K09458] [EC:2.3.1.179]
            84869  CBR4; carbonyl reductase 4 [KO:K11539] [EC:1.1.1.-]
            7923  HSD17B8; hydroxysteroid 17-beta dehydrogenase 8 [KO:K13370] [EC:1.1.1.62 1.1.1.239]
            109703458  HTD2; hydroxyacyl-thioester dehydratase type 2 [KO:K22540] [EC:4.2.1.-]
            51102  MECR; mitochondrial trans-2-enoyl-CoA reductase [KO:K07512] [EC:1.3.1.- 1.3.1.38]
            55301  OLAH; oleoyl-ACP hydrolase [KO:K01071] [EC:3.1.2.21]
            23305  ACSL6; acyl-CoA synthetase long chain family member 6 [KO:K01897] [EC:6.2.1.3]
            2182  ACSL4; acyl-CoA synthetase long chain family member 4 [KO:K01897] [EC:6.2.1.3]
            2180  ACSL1; acyl-CoA synthetase long chain family member 1 [KO:K01897] [EC:6.2.1.3]
            51703  ACSL5; acyl-CoA synthetase long chain family member 5 [KO:K01897] [EC:6.2.1.3]
            2181  ACSL3; acyl-CoA synthetase long chain family member 3 [KO:K01897] [EC:6.2.1.3]
            23205  ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
            81616  ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
COMPOUND    C00024  Acetyl-CoA
            C00083  Malonyl-CoA
            C00154  Palmitoyl-CoA
            C00173  Acyl-[acyl-carrier protein]
            C00229  Acyl-carrier protein
            C00249  Hexadecanoic acid
            C00383  Malonate
            C00638  Long-chain fatty acid
            C00685  3-Oxoacyl-[acyl-carrier protein]
            C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
            C00712  (9Z)-Octadecenoic acid
            C01203  Oleoyl-[acyl-carrier protein]
            C01209  Malonyl-[acyl-carrier protein]
            C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
            C01530  Octadecanoic acid
            C01571  Decanoic acid
            C02679  Dodecanoic acid
            C02843  Long-chain acyl-CoA
            C03939  Acetyl-[acyl-carrier protein]
            C04088  Octadecanoyl-[acyl-carrier protein]
            C04180  cis-Dec-3-enoyl-[acp]
            C04246  But-2-enoyl-[acyl-carrier protein]
            C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
            C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
            C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
            C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
            C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
            C05223  Dodecanoyl-[acyl-carrier protein]
            C05744  Acetoacetyl-[acp]
            C05745  Butyryl-[acp]
            C05746  3-Oxohexanoyl-[acp]
            C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
            C05748  trans-Hex-2-enoyl-[acp]
            C05749  Hexanoyl-[acp]
            C05750  3-Oxooctanoyl-[acp]
            C05751  trans-Oct-2-enoyl-[acp]
            C05752  Octanoyl-[acp]
            C05753  3-Oxodecanoyl-[acp]
            C05754  trans-Dec-2-enoyl-[acp]
            C05755  Decanoyl-[acp]
            C05756  3-Oxododecanoyl-[acp]
            C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
            C05758  trans-Dodec-2-enoyl-[acp]
            C05759  3-Oxotetradecanoyl-[acp]
            C05760  trans-Tetradec-2-enoyl-[acp]
            C05761  Tetradecanoyl-[acp]
            C05762  3-Oxohexadecanoyl-[acp]
            C05763  trans-Hexadec-2-enoyl-[acp]
            C05764  Hexadecanoyl-[acp]
            C06423  Octanoic acid
            C06424  Tetradecanoic acid
            C08362  (9Z)-Hexadecenoic acid
            C16219  3-Oxostearoyl-[acp]
            C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
            C16221  (2E)-Octadecenoyl-[acp]
            C16520  Hexadecenoyl-[acyl-carrier protein]
            C20683  Long-chain acyl-[acyl-carrier protein]
            C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
REFERENCE   PMID:12061798
  AUTHORS   Salas JJ, Ohlrogge JB.
  TITLE     Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  JOURNAL   Arch Biochem Biophys 403:25-34 (2002)
            DOI:10.1016/S0003-9861(02)00017-6
REFERENCE   PMID:12518017
  AUTHORS   Zhang YM, Marrakchi H, White SW, Rock CO.
  TITLE     The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  JOURNAL   J Lipid Res 44:1-10 (2003)
            DOI:10.1194/jlr.R200016-JLR200
REFERENCE   PMID:11337402
  AUTHORS   Voelker T, Kinney AJ.
  TITLE     VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  JOURNAL   Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
            DOI:10.1146/annurev.arplant.52.1.335
REFERENCE   PMID:17573542
  AUTHORS   Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  TITLE     Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  JOURNAL   Plant Physiol 144:1827-42 (2007)
            DOI:10.1104/pp.107.096172
REFERENCE   PMID:30201289
  AUTHORS   Bowman CE, Wolfgang MJ
  TITLE     Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  JOURNAL   Adv Biol Regul 71:34-40 (2019)
            DOI:10.1016/j.jbior.2018.09.002
REFERENCE   PMID:25203508
  AUTHORS   Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  TITLE     Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  JOURNAL   Nat Commun 5:4805 (2014)
            DOI:10.1038/ncomms5805
REFERENCE   PMID:19686777
  AUTHORS   Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  TITLE     Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  JOURNAL   Prog Lipid Res 49:27-45 (2010)
            DOI:10.1016/j.plipres.2009.08.001
REFERENCE   PMID:27553474
  AUTHORS   Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  TITLE     Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
            DOI:10.1016/j.bbalip.2016.08.011
REL_PATHWAY hsa00020  Citrate cycle (TCA cycle)
            hsa00062  Fatty acid elongation
            hsa00071  Fatty acid degradation
            hsa00410  beta-Alanine metabolism
            hsa00561  Glycerolipid metabolism
            hsa00564  Glycerophospholipid metabolism
            hsa00620  Pyruvate metabolism
            hsa00785  Lipoic acid metabolism
KO_PATHWAY  ko00061
///
