ENTRY       hsa00040                    Pathway
NAME        Pentose and glucuronate interconversions - Homo sapiens (human)
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP hsa00040  Pentose and glucuronate interconversions
MODULE      hsa_M00014  Glucuronate pathway (uronate pathway) [PATH:hsa00040]
DRUG        D01805  Aceglatone (JAN/INN)
ORGANISM    Homo sapiens (human) [GN:hsa]
GENE        2990  GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
            9365  KL; klotho [KO:K14756] [EC:3.2.1.31]
            10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
            79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
            7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
            10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
            54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
            54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
            54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
            54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
            54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
            7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
            54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
            7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
            54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
            54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
            54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
            7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
            54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
            7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
            574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
            7358  UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
            7360  UGP2; UDP-glucose pyrophosphorylase 2 [KO:K00963] [EC:2.7.7.9]
            10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
            51084  CRYL1; crystallin lambda 1 [KO:K13247] [EC:1.1.1.45]
            6120  RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]
            729020  RPEL1; ribulose-5-phosphate-3-epimerase like 1 [KO:K01783] [EC:5.1.3.1]
            9942  XYLB; xylulokinase [KO:K00854] [EC:2.7.1.17]
            231  AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]
            57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
            51181  DCXR; dicarbonyl and L-xylulose reductase [KO:K03331] [EC:1.1.1.10]
            6652  SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]
            27294  DHDH; dihydrodiol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
            55277  FGGY; FGGY carbohydrate kinase domain containing [KO:K00875] [EC:2.7.1.47]
            729920  CRPPA; CDP-L-ribitol pyrophosphorylase A [KO:K21031] [EC:2.7.7.40]
COMPOUND    C00022  Pyruvate
            C00026  2-Oxoglutarate
            C00029  UDP-glucose
            C00103  D-Glucose 1-phosphate
            C00111  Glycerone phosphate
            C00116  Glycerol
            C00167  UDP-glucuronate
            C00181  D-Xylose
            C00191  D-Glucuronate
            C00199  D-Ribulose 5-phosphate
            C00204  2-Dehydro-3-deoxy-D-gluconate
            C00216  D-Arabinose
            C00231  D-Xylulose 5-phosphate
            C00259  L-Arabinose
            C00266  Glycolaldehyde
            C00309  D-Ribulose
            C00310  D-Xylulose
            C00312  L-Xylulose
            C00333  D-Galacturonate
            C00379  Xylitol
            C00433  2,5-Dioxopentanoate
            C00470  Pectate
            C00474  Ribitol
            C00476  D-Lyxose
            C00502  D-Xylonate
            C00508  L-Ribulose
            C00514  D-Mannonate
            C00532  L-Arabitol
            C00558  D-Tagaturonate
            C00618  3-Dehydro-L-gulonate
            C00714  Pectin
            C00789  CDP-ribitol
            C00800  L-Gulonate
            C00817  D-Altronate
            C00905  D-Fructuronate
            C01068  D-Ribitol 5-phosphate
            C01101  L-Ribulose 5-phosphate
            C01508  L-Lyxose
            C01904  D-Arabitol
            C02266  D-Xylonolactone
            C02273  Digalacturonate
            C02426  L-Glyceraldehyde
            C02753  D-Xylono-1,4-lactone
            C03033  beta-D-Glucuronoside
            C03291  L-Xylulose 5-phosphate
            C03826  2-Dehydro-3-deoxy-D-xylonate
            C04053  5-Dehydro-4-deoxy-D-glucuronate
            C04349  (4S)-4,6-Dihydroxy-2,5-dioxohexanoate
            C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
            C05385  D-Glucuronate 1-phosphate
            C05411  L-Xylonate
            C05412  L-Lyxonate
            C06118  4-(4-Deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate
            C06441  L-Xylulose 1-phosphate
            C14899  3-Dehydro-L-gulonate 6-phosphate
            C15930  L-Galactonate
            C20680  2-Dehydro-3-deoxy-L-galactonate
            C22337  D-Ribulose 1-phosphate
REFERENCE   PMID:11741871
  AUTHORS   Yew WS, Gerlt JA.
  TITLE     Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.
  JOURNAL   J Bacteriol 184:302-6 (2002)
            DOI:10.1128/JB.184.1.302-306.2002
REFERENCE   PMID:15697206
  AUTHORS   Yew WS, Akana J, Wise EL, Rayment I, Gerlt JA
  TITLE     Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
  JOURNAL   Biochemistry 44:1807-15 (2005)
            DOI:10.1021/bi047815v
REFERENCE   PMID:10572115
  AUTHORS   Yasueda H, Kawahara Y, Sugimoto S.
  TITLE     Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  JOURNAL   J Bacteriol 181:7154-60 (1999)
            DOI:10.1128/JB.181.23.7154-7160.1999
REFERENCE   PMID:10913097
  AUTHORS   Ibanez E, Gimenez R, Pedraza T, Baldoma L, Aguilar J, Badia J
  TITLE     Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.
  JOURNAL   J Bacteriol 182:4625-7 (2000)
            DOI:10.1128/JB.182.16.4625-4627.2000
REFERENCE   PMID:15901685
  AUTHORS   Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  TITLE     The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  JOURNAL   J Bacteriol 187:3636-42 (2005)
            DOI:10.1128/JB.187.11.3636-3642.2005
REL_PATHWAY hsa00010  Glycolysis / Gluconeogenesis
            hsa00020  Citrate cycle (TCA cycle)
            hsa00030  Pentose phosphate pathway
            hsa00052  Galactose metabolism
            hsa00053  Ascorbate and aldarate metabolism
            hsa00500  Starch and sucrose metabolism
            hsa00520  Amino sugar and nucleotide sugar metabolism
            hsa00561  Glycerolipid metabolism
            hsa00562  Inositol phosphate metabolism
            hsa00740  Riboflavin metabolism
KO_PATHWAY  ko00040
///
