ENTRY       gmx04146                    Pathway
NAME        Peroxisome - Glycine max (soybean)
DESCRIPTION Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP gmx04146  Peroxisome
DBLINKS     GO: 0005777
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100793724  peroxisome biogenesis protein 16 [KO:K13335]
            100804234  peroxisome biogenesis protein 16 [KO:K13335]
            113001421  peroxisome biogenesis protein 16 [KO:K13335]
            100778748  peroxisome biogenesis protein 3-2 [KO:K13336]
            100782816  peroxisome biogenesis protein 3-2 [KO:K13336]
            100500051  uncharacterized protein LOC100500051 [KO:K13337]
            100527390  putative peroxisome biogenesis protein 19 [KO:K13337]
            100803882  peroxisome biogenesis protein 1 [KO:K13338]
            100820183  peroxisome biogenesis protein 6 [KO:K13339]
            100817902  peroxisome biogenesis protein 7 [KO:K13341]
            100789878  peroxisome biogenesis protein 5 [KO:K13342]
            100527272  TPR repeat superfamily protein [KO:K13342]
            100786361  peroxisomal membrane protein PEX14 [KO:K13343]
            100784152  peroxisomal membrane protein PEX14 isoform X1 [KO:K13343]
            100807229  PEX14; peroxisomal membrane protein PEX14 [KO:K13343]
            100775500  peroxisomal membrane protein 13 [KO:K13344]
            100820349  peroxisomal membrane protein 13 isoform X1 [KO:K13344]
            100788885  peroxisomal membrane protein 13 isoform X1 [KO:K13344]
            100804330  peroxisome biogenesis protein 12 [KO:K13345]
            100814145  peroxisome biogenesis protein 12 [KO:K13345]
            100783914  peroxisome biogenesis factor 10 [KO:K13346]
            100816042  peroxisome biogenesis factor 10 [KO:K13346]
            100800681  peroxisome biogenesis protein 2 isoform X3 [KO:K06664]
            100805856  peroxisome biogenesis protein 2 isoform X1 [KO:K06664]
            100775933  peroxisomal membrane protein PMP22 [KO:K13347]
            100499909  uncharacterized protein LOC100499909 [KO:K13347]
            100801717  peroxisomal membrane protein PMP22-like [KO:K13347]
            100527292  peroxisomal membrane protein PMP22-like [KO:K13347]
            100790392  protein sym-1 [KO:K13347]
            100781852  peroxisomal membrane protein 2 [KO:K13347]
            100796872  PXMP2/4 family protein 4 [KO:K13348]
            100801389  protein Mpv17 isoform X2 [KO:K13348]
            100789384  protein SYM1 [KO:K13348]
            100805057  uncharacterized protein LOC100805057 [KO:K13348]
            100786706  uncharacterized protein LOC100786706 [KO:K13348]
            100810534  PXMP2/4 family protein 4-like [KO:K13348]
            100805283  protein Mpv17 [KO:K13348]
            100816797  PXMP2/4 family protein 4 [KO:K13348]
            100796063  protein sym-1 [KO:K13348]
            100775304  peroxisomal nicotinamide adenine dinucleotide carrier-like [KO:K13354]
            100789858  peroxisomal nicotinamide adenine dinucleotide carrier isoform X1 [KO:K13354]
            100775784  peroxisomal nicotinamide adenine dinucleotide carrier isoform X1 [KO:K13354]
            100778257  2-hydroxyacyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
            100781584  2-hydroxyacyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
            100788875  uncharacterized protein LOC100788875 [KO:K00477] [EC:1.14.11.18]
            100790934  phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
            547625  ACX1;1; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
            547626  ACX1;2; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
            100810829  peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
            100790627  acyl-coenzyme A oxidase 3, peroxisomal [KO:K00232] [EC:1.3.3.6]
            100784451  acyl-coenzyme A oxidase 4, peroxisomal [KO:K00232] [EC:1.3.3.6]
            100125585  acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
            100799226  acyl-coenzyme A oxidase 2, peroxisomal [KO:K00232] [EC:1.3.3.6]
            100780811  acyl-coenzyme A oxidase 3, peroxisomal isoform X1 [KO:K00232] [EC:1.3.3.6]
            100802115  putative peroxisomal acyl-coenzyme A oxidase 1.2 [KO:K00232] [EC:1.3.3.6]
            100777033  acyl-coenzyme A oxidase 4, peroxisomal [KO:K00232] [EC:1.3.3.6]
            547735  3-ketoacyl-CoA thiolase [KO:K07513] [EC:2.3.1.16]
            100170734  peroxisomal 3-ketoacyl-CoA thiolase [KO:K07513] [EC:2.3.1.16]
            100789930  putative 3-ketoacyl-CoA thiolase 2 [KO:K07513] [EC:2.3.1.16]
            100807194  3-ketoacyl-CoA thiolase 2, peroxisomal isoform X1 [KO:K07513] [EC:2.3.1.16]
            100793630  uncharacterized protein LOC100793630 [KO:K13237] [EC:1.3.1.124]
            100800885  uncharacterized protein LOC100800885 [KO:K13237] [EC:1.3.1.124]
            100804855  uncharacterized protein LOC100804855 [KO:K12663] [EC:5.3.3.21]
            100791623  ABC transporter D family member 1 [KO:K25819] [EC:7.6.2.4]
            100813765  ABC transporter D family member 1 [KO:K25819] [EC:7.6.2.4]
            100786592  ABC transporter D family member 1 isoform X2 [KO:K25819] [EC:7.6.2.4]
            100796571  ABC transporter D family member 1 isoform X1 [KO:K25819] [EC:7.6.2.4]
            100779735  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            100807687  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
            100803677  long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
            100301904  long chain acyl-CoA synthetase 6, peroxisomal [KO:K01897] [EC:6.2.1.3]
            100785229  long chain acyl-CoA synthetase 6, peroxisomal [KO:K01897] [EC:6.2.1.3]
            100778889  long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
            100802266  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
            100818394  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
            100812745  ACSL2; long-chain acyl-CoA synthetase ACSL2 [KO:K01897] [EC:6.2.1.3]
            100782583  probable acyl-activating enzyme 16, chloroplastic isoform X1 [KO:K01897] [EC:6.2.1.3]
            100803126  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
            100806645  long chain acyl-CoA synthetase 2 isoform X1 [KO:K01897] [EC:6.2.1.3]
            100816578  long chain acyl-CoA synthetase 1 [KO:K01897] [EC:6.2.1.3]
            100790068  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            100814965  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            100795926  long chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
            100797826  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
            100790536  long chain acyl-CoA synthetase 1 isoform X2 [KO:K01897] [EC:6.2.1.3]
            100811306  long chain acyl-CoA synthetase 4 [KO:K01897] [EC:6.2.1.3]
            100807875  long chain acyl-CoA synthetase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
            100814219  nudix hydrolase 15, mitochondrial [KO:K17879] [EC:3.6.1.-]
            100814748  nudix hydrolase 15, mitochondrial-like [KO:K17879] [EC:3.6.1.-]
            100527349  nudix hydrolase [KO:K17879] [EC:3.6.1.-]
            100785664  nudix hydrolase superfamily protein [KO:K17879] [EC:3.6.1.-]
            100780473  nudix hydrolase 19, chloroplastic [KO:K03426] [EC:3.6.1.22]
            100793335  nudix hydrolase 19, chloroplastic isoform X1 [KO:K03426] [EC:3.6.1.22]
            100807487  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
            100802836  malonyl-CoA decarboxylase, mitochondrial isoform X2 [KO:K01578] [EC:4.1.1.9]
            100798338  alcohol-forming fatty acyl-CoA reductase [KO:K13356] [EC:1.2.1.84]
            100776505  fatty acyl-CoA reductase 2, chloroplastic [KO:K13356] [EC:1.2.1.84]
            100788994  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            100793197  fatty acyl-CoA reductase 3 isoform X1 [KO:K13356] [EC:1.2.1.84]
            100793736  alcohol-forming fatty acyl-CoA reductase isoform X1 [KO:K13356] [EC:1.2.1.84]
            100801815  fatty acyl-CoA reductase 2, chloroplastic [KO:K13356] [EC:1.2.1.84]
            100805240  fatty acyl-CoA reductase 3 isoform X2 [KO:K13356] [EC:1.2.1.84]
            100805776  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
            100788680  alcohol-forming fatty acyl-CoA reductase [KO:K13356] [EC:1.2.1.84]
            100789566  fatty acyl-CoA reductase 3 isoform X1 [KO:K13356] [EC:1.2.1.84]
            100787403  alcohol-forming fatty acyl-CoA reductase [KO:K13356] [EC:1.2.1.84]
            100804063  probable fatty acyl-CoA reductase 5 [KO:K13356] [EC:1.2.1.84]
            100820343  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
            100810739  mevalonate kinase isoform X1 [KO:K00869] [EC:2.7.1.36]
            732565  serine glyoxylate aminotransferase 3 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            100786630  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            606295  IDH1; NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
            100791166  IDH; isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            100819151  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            100786103  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
            100816688  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
            100789864  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            100788349  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            100777073  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            100817457  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            100791169  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
            100801507  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
            102666369  L-lactate dehydrogenase [KO:K11517] [EC:1.1.3.15]
            100777153  peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            100170730  peroxisomal glycolate oxidase [KO:K11517] [EC:1.1.3.15]
            100782977  uncharacterized protein LOC100782977 [KO:K11517] [EC:1.1.3.15]
            100800520  peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            102670034  (S)-2-hydroxy-acid oxidase GLO1 [KO:K11517] [EC:1.1.3.15]
            100170736  (S)-2-hydroxy-acid oxidase GLO1 [KO:K11517] [EC:1.1.3.15]
            100798419  (S)-2-hydroxy-acid oxidase GLO1 [KO:K11517] [EC:1.1.3.15]
            100798937  peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            121173714  peroxisomal (S)-2-hydroxy-acid oxidase GLO5-like [KO:K11517] [EC:1.1.3.15]
            121172669  (S)-2-hydroxy-acid oxidase GLO1-like [KO:K11517] [EC:1.1.3.15]
            100037447  CAT3; catalase-3 [KO:K03781] [EC:1.11.1.6]
            547510  CAT1; catalase-1/2 [KO:K03781] [EC:1.11.1.6]
            547511  CAT4; catalase-4 [KO:K03781] [EC:1.11.1.6]
            100037448  CAT5; catalase [KO:K03781] [EC:1.11.1.6]
            100499991  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
            100527058  uncharacterized protein LOC100527058 [KO:K04565] [EC:1.15.1.1]
            100815376  superoxide dismutase [Cu-Zn], chloroplastic [KO:K04565] [EC:1.15.1.1]
            100784752  superoxide dismutase [Cu-Zn], chloroplastic [KO:K04565] [EC:1.15.1.1]
            100305732  superoxide dismutase [KO:K04565] [EC:1.15.1.1]
            100780008  uncharacterized protein LOC100780008 [KO:K04565] [EC:1.15.1.1]
            100101896  MnSOD [KO:K04564] [EC:1.15.1.1]
            547531  SODB2; iron-superoxide dismutase [KO:K04564] [EC:1.15.1.1]
            100814802  superoxide dismutase [Fe], chloroplastic isoform X2 [KO:K04564] [EC:1.15.1.1]
            100785490  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
            547823  SODB; superoxide dismutase [Fe], chloroplastic precursor [KO:K04564] [EC:1.15.1.1]
            100813221  superoxide dismutase [Fe], chloroplastic isoform X2 [KO:K04564] [EC:1.15.1.1]
            100778673  superoxide dismutase [Fe] 3, chloroplastic isoform X3 [KO:K04564] [EC:1.15.1.1]
            100800309  xanthine dehydrogenase 1 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
            100816689  xanthine dehydrogenase 1 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
            100527263  SDR domain-containing protein [KO:K11147] [EC:1.1.-.-]
            100170726  peroxisomal short-chain dehydrogenase/reductase family protein [KO:K11147] [EC:1.1.-.-]
            100809582  uncharacterized protein LOC100809582 [KO:K11147] [EC:1.1.-.-]
REFERENCE   PMID:17055078
  AUTHORS   Wanders RJ, Waterham HR
  TITLE     Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  JOURNAL   Biochim Biophys Acta 1763:1707-20 (2006)
            DOI:10.1016/j.bbamcr.2006.08.010
REFERENCE   PMID:17055079
  AUTHORS   Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  TITLE     Peroxisome biogenesis disorders.
  JOURNAL   Biochim Biophys Acta 1763:1733-48 (2006)
            DOI:10.1016/j.bbamcr.2006.09.010
REFERENCE   PMID:17010456
  AUTHORS   Rottensteiner H, Theodoulou FL
  TITLE     The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  JOURNAL   Biochim Biophys Acta 1763:1527-40 (2006)
            DOI:10.1016/j.bbamcr.2006.08.012
REFERENCE   PMID:16631601
  AUTHORS   Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  TITLE     Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  JOURNAL   Biochem Biophys Res Commun 344:948-54 (2006)
            DOI:10.1016/j.bbrc.2006.04.008
REL_PATHWAY gmx00071  Fatty acid degradation
            gmx00230  Purine metabolism
            gmx00564  Glycerophospholipid metabolism
            gmx00565  Ether lipid metabolism
            gmx00900  Terpenoid backbone biosynthesis
KO_PATHWAY  ko04146
///
