ENTRY       gmx04145                    Pathway
NAME        Phagosome - Glycine max (soybean)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP gmx04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100801587  uncharacterized protein LOC100801587 [KO:K08492]
            100778011  syntaxin-81 [KO:K08492]
            100795552  uncharacterized protein LOC100795552 [KO:K08517]
            100779110  25.3 kDa vesicle transport protein [KO:K08517]
            100781527  25.3 kDa vesicle transport protein [KO:K08517]
            100782628  ras-related protein RHN1 isoform X1 [KO:K07888]
            100813519  ras-related protein RHN1 isoform X1 [KO:K07888]
            100791620  uncharacterized protein LOC100791620 [KO:K07889]
            100788883  ras-related protein RABF2b isoform X1 [KO:K07889]
            100810011  ras-related protein RHN1 isoform X2 [KO:K07889]
            547983  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            100778348  phosphatidylinositol 3-kinase, nodule isoform [KO:K00914] [EC:2.7.1.137]
            100814929  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
            100775727  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
            100814088  V-type proton ATPase subunit B 2 [KO:K02147]
            100791429  V-type proton ATPase subunit B 2 [KO:K02147]
            100793764  V-type proton ATPase subunit B 2 [KO:K02147]
            100804483  V-type proton ATPase subunit B 2 [KO:K02147]
            100790694  V-type proton ATPase subunit C [KO:K02148]
            100780187  V-type proton ATPase subunit C [KO:K02148]
            100803728  V-type proton ATPase subunit C [KO:K02148]
            100813963  V-type proton ATPase subunit C [KO:K02148]
            100801612  V-type proton ATPase subunit D [KO:K02149]
            100808847  V-type proton ATPase subunit D [KO:K02149]
            100500452  uncharacterized LOC100500452 [KO:K02150]
            100795235  V-type proton ATPase subunit E [KO:K02150]
            100779392  V-type proton ATPase subunit E2 [KO:K02150]
            100791813  V-type proton ATPase subunit E2 [KO:K02150]
            106794127  V-type proton ATPase subunit E [KO:K02150]
            111064655  V-type proton ATPase subunit E family protein [KO:K02150]
            100499818  V-type proton ATPase subunit E [KO:K02150]
            100305531  uncharacterized protein LOC100305531 [KO:K02151]
            100780523  V-type proton ATPase subunit F isoform X1 [KO:K02151]
            100305477  V-type proton ATPase subunit G-like protein [KO:K02152]
            100499803  uncharacterized protein LOC100499803 [KO:K02152]
            100306550  uncharacterized protein LOC100306550 [KO:K02152]
            100818549  V-type proton ATPase subunit G 1 [KO:K02152]
            100527042  V-type proton ATPase subunit e2 [KO:K02153]
            100527598  V-type proton ATPase subunit e1 [KO:K02153]
            100798558  V-type proton ATPase subunit e2 [KO:K02153]
            100781475  V-type proton ATPase subunit e1 [KO:K02153]
            100805813  V-type proton ATPase subunit a3 [KO:K02154]
            100786845  V-type proton ATPase subunit a1 [KO:K02154]
            100783125  V-type proton ATPase subunit a3 [KO:K02154]
            100800799  V-type proton ATPase subunit a1 [KO:K02154]
            100793301  V-type proton ATPase subunit a1 [KO:K02154]
            100810062  V-type proton ATPase subunit a3 [KO:K02154]
            100776037  V-type proton ATPase subunit a1 [KO:K02154]
            100800553  V-type proton ATPase subunit d2 [KO:K02146]
            100780773  V-type proton ATPase subunit d2-like [KO:K02146]
            100788723  V-type proton ATPase subunit H [KO:K02144]
            100796479  V-type proton ATPase subunit H [KO:K02144]
            100798638  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100779290  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100787215  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100804255  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100815182  uncharacterized protein LOC100815182 [KO:K02155]
            100777816  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100776231  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100812380  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100796361  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            102661642  uncharacterized protein LOC102661642 isoform X1 [KO:K02155]
            100500014  ATP synthase subunit C superfamily protein [KO:K02155]
            100527177  uncharacterized protein LOC100527177 [KO:K03661]
            100778175  V-type proton ATPase subunit c''1 [KO:K03661]
            100783389  ras-related protein Rab7 isoform X2 [KO:K07897]
            100305642  uncharacterized protein LOC100305642 [KO:K07897]
            100499740  uncharacterized protein LOC100499740 [KO:K07897]
            100795309  ras-related protein Rab7 isoform X1 [KO:K07897]
            100810766  ras-related protein Rab7 isoform X1 [KO:K07897]
            100305824  uncharacterized protein LOC100305824 [KO:K07897]
            100785104  ras-related protein Rab7 [KO:K07897]
            100787120  uncharacterized protein LOC100787120 [KO:K07897]
            732582  tubulin A [KO:K07374]
            100786598  tubulin alpha-2 chain [KO:K07374]
            100806907  uncharacterized protein LOC100806907 [KO:K07374]
            100799688  tubulin alpha chain [KO:K07374]
            100785622  tubulin alpha-2 chain [KO:K07374]
            100787058  tubulin alpha-3 chain [KO:K07374]
            100779027  tubulin alpha-1 chain [KO:K07374]
            100780531  tubulin alpha-3 chain isoform X1 [KO:K07374]
            100796371  tubulin alpha-6 chain [KO:K07374]
            100781185  tubulin alpha-4 chain [KO:K07374]
            100784487  tubulin alpha-3 chain [KO:K07374]
            100807401  tubulin alpha-1 chain [KO:K07374]
            100789289  tubulin alpha-3 chain [KO:K07374]
            547917  TUBB; tubulin beta chain [KO:K07375]
            100811275  TUBB2; tubulin beta-2 chain [KO:K07375]
            100776983  TUBB1; tubulin beta-1 chain [KO:K07375]
            100819883  tubulin beta chain [KO:K07375]
            100816898  tubulin beta-2 chain-like [KO:K07375]
            100801608  tubulin beta chain [KO:K07375]
            100797894  tubulin beta chain [KO:K07375]
            100788253  tubulin beta-1 chain [KO:K07375]
            100818878  tubulin beta chain [KO:K07375]
            100797652  tubulin beta-1 chain-like [KO:K07375]
            100781525  tubulin beta chain [KO:K07375]
            100781043  uncharacterized protein LOC100781043 [KO:K07375]
            547844  TUBB3; beta-tubulin [KO:K07375]
            100793406  tubulin beta-1 chain [KO:K07375]
            100784236  tubulin beta chain [KO:K07375]
            100798849  tubulin beta-4 chain [KO:K07375]
            100819408  tubulin beta chain [KO:K07375]
            100815340  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D isoform X1 [KO:K00921] [EC:2.7.1.150]
            100809696  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D isoform X1 [KO:K00921] [EC:2.7.1.150]
            100782480  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            100776916  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            100819364  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            100777340  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            100779147  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]
            100811146  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            100810430  preprotein translocase subunit SECY, chloroplastic isoform X1 [KO:K10956]
            100817566  protein transport protein Sec61 subunit alpha [KO:K10956]
            100798372  uncharacterized protein LOC100798372 [KO:K10956]
            100809703  protein transport protein Sec61 subunit alpha [KO:K10956]
            100795147  protein transport protein Sec61 subunit alpha [KO:K10956]
            100500335  protein transport protein Sec61 subunit beta [KO:K09481]
            100795313  protein transport protein Sec61 subunit beta-like [KO:K09481]
            100790740  protein transport protein Sec61 subunit beta [KO:K09481]
            100815435  protein transport protein Sec61 subunit beta-like [KO:K09481]
            100814692  protein transport protein Sec61 subunit beta [KO:K09481]
            100795094  LOW QUALITY PROTEIN: protein transport protein Sec61 subunit beta [KO:K09481]
            106795243  protein transport protein Sec61 subunit beta [KO:K09481]
            100789824  protein transport protein Sec61 subunit gamma [KO:K07342]
            100805604  protein transport protein Sec61 subunit gamma [KO:K07342]
            100306386  protein transport protein Sec61 subunit gamma [KO:K07342]
            100527335  transport protein Sec61 subunit gamma [KO:K07342]
            100037475  calreticulin-1 precursor [KO:K08057]
            100776524  calreticulin-3 [KO:K08057]
            100802428  calreticulin-3 [KO:K08057]
            100801827  calreticulin-3 [KO:K08057]
            100776652  calreticulin-3 [KO:K08057]
            100811997  calreticulin isoform X2 [KO:K08057]
            100802236  calnexin homolog [KO:K08054]
            100785901  calnexin homolog [KO:K08054]
            547851  calnexin homolog precursor [KO:K08054]
            100810595  calnexin homolog [KO:K08054]
            100499774  ROP10; Rho-related protein ROP10 [KO:K04392]
            100527464  ROP GTPase family protein [KO:K04392]
            100798550  uncharacterized protein LOC100798550 [KO:K04392]
            100801284  rac-like GTP-binding protein RHO1 [KO:K04392]
            100790459  rac-like GTP-binding protein ARAC7 isoform X1 [KO:K04392]
            100799091  rac-like GTP-binding protein RAC13 [KO:K04392]
            100803222  rac-like GTP-binding protein ARAC7 isoform X1 [KO:K04392]
            100808748  rac-like GTP-binding protein ARAC1-like [KO:K04392]
            100527158  Rho-related protein [KO:K04392]
            100499696  uncharacterized protein LOC100499696 [KO:K04392]
            100791566  Rho-related GTPase [KO:K04392]
            100805035  rac-like GTP-binding protein RAC1-like [KO:K04392]
            100782967  rac-like GTP-binding protein RAC2 [KO:K04392]
            100785464  rac-like GTP-binding protein RAC1 isoform X1 [KO:K04392]
            100805460  rac-like GTP-binding protein RAC13 [KO:K04392]
            100816833  rac-like GTP-binding protein RAC2 [KO:K04392]
            100794287  rac-like GTP-binding protein RAC2 isoform X1 [KO:K04392]
            100787827  rac-like GTP-binding protein RHO1 [KO:K04392]
            100812451  rac-like GTP-binding protein RHO1 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY gmx04144  Endocytosis
KO_PATHWAY  ko04145
///
