ENTRY       gmx04141                    Pathway
NAME        Protein processing in endoplasmic reticulum - Glycine max (soybean)
DESCRIPTION The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP gmx04141  Protein processing in endoplasmic reticulum
DBLINKS     GO: 0030433 0034976
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100810430  preprotein translocase subunit SECY, chloroplastic isoform X1 [KO:K10956]
            100817566  protein transport protein Sec61 subunit alpha [KO:K10956]
            100798372  uncharacterized protein LOC100798372 [KO:K10956]
            100809703  protein transport protein Sec61 subunit alpha [KO:K10956]
            100795147  protein transport protein Sec61 subunit alpha [KO:K10956]
            100500335  protein transport protein Sec61 subunit beta [KO:K09481]
            100795313  protein transport protein Sec61 subunit beta-like [KO:K09481]
            100790740  protein transport protein Sec61 subunit beta [KO:K09481]
            100815435  protein transport protein Sec61 subunit beta-like [KO:K09481]
            100814692  protein transport protein Sec61 subunit beta [KO:K09481]
            100795094  LOW QUALITY PROTEIN: protein transport protein Sec61 subunit beta [KO:K09481]
            106795243  protein transport protein Sec61 subunit beta [KO:K09481]
            100789824  protein transport protein Sec61 subunit gamma [KO:K07342]
            100805604  protein transport protein Sec61 subunit gamma [KO:K07342]
            100306386  protein transport protein Sec61 subunit gamma [KO:K07342]
            100527335  transport protein Sec61 subunit gamma [KO:K07342]
            100784481  uncharacterized protein LOC100784481 [KO:K12275]
            100809457  uncharacterized protein LOC100809457 [KO:K12275]
            100776439  dnaJ protein ERDJ2A isoform X1 [KO:K09540]
            100809969  dnaJ protein ERDJ2A [KO:K09540]
            100817203  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
            100814638  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
            100796192  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
            100817179  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
            100780415  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
            100814831  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
            100806815  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
            100306016  oligosaccharyl transferase subunit DAD1-like protein isoform 2 [KO:K12668]
            100814967  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
            100499801  DAD1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
            100789480  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K12669]
            100793228  oligosaccharide transmembrane transporter precursor [KO:K12669]
            100806848  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
            100805873  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
            100780916  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
            100782502  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
            100816018  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
            100795161  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
            100795691  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
            100788296  heat shock 70 kDa protein 17 precursor [KO:K09486]
            100786898  heat shock 70 kDa protein 17 [KO:K09486]
            547839  BIP4; ER-binding immunoglobulin protein BiP4 precursor [KO:K09490] [EC:3.6.4.10]
            547840  BIP2; ER-binding immunoglobulin protein BIP2 precursor [KO:K09490] [EC:3.6.4.10]
            547838  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
            100803843  Hsp 70 family protein precursor [KO:K09490] [EC:3.6.4.10]
            100799151  dnaJ protein ERDJ3B [KO:K09517]
            100799701  dnaJ protein ERDJ3B [KO:K09517]
            100782105  dnaJ protein ERDJ3B [KO:K09517]
            100807885  dnaJ protein ERDJ3B [KO:K09517]
            100781496  dnaJ protein P58IPK homolog [KO:K09523]
            100804685  dnaJ protein P58IPK homolog [KO:K09523]
            100819942  HSP90 superfamily protein precursor [KO:K09487]
            100806710  heat shock protein 90-6, mitochondrial [KO:K09487]
            100794913  heat shock protein 90-6, mitochondrial [KO:K09487]
            100819778  heat shock protein 90-5, chloroplastic [KO:K09487]
            100785017  heat shock protein 90-5, chloroplastic [KO:K09487]
            100779976  endoplasmin homolog isoform X2 [KO:K09487]
            100817168  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
            100811132  glucosidase 2 subunit beta [KO:K08288]
            100807083  glucosidase 2 subunit beta [KO:K08288]
            100802236  calnexin homolog [KO:K08054]
            100785901  calnexin homolog [KO:K08054]
            547851  calnexin homolog precursor [KO:K08054]
            100810595  calnexin homolog [KO:K08054]
            100037475  calreticulin-1 precursor [KO:K08057]
            100776524  calreticulin-3 [KO:K08057]
            100802428  calreticulin-3 [KO:K08057]
            100801827  calreticulin-3 [KO:K08057]
            100776652  calreticulin-3 [KO:K08057]
            100811997  calreticulin isoform X2 [KO:K08057]
            547540  MAN1; mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K01230] [EC:3.2.1.113]
            100819189  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
            100816571  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
            100789211  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
            100806551  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
            100786727  SEC12-like protein 2 isoform X1 [KO:K14003]
            100803472  SEC12-like protein 1 isoform X2 [KO:K14003]
            100787360  SEC12-like protein 1 isoform X1 [KO:K14003]
            100810637  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            100306687  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
            100500031  uncharacterized protein LOC100500031 [KO:K07953] [EC:3.6.5.-]
            100815670  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
            100811178  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
            100305632  uncharacterized protein LOC100305632 [KO:K07953] [EC:3.6.5.-]
            100788066  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            100305650  ARF-like GTPase family protein Sar1c-like protein [KO:K07953] [EC:3.6.5.-]
            100526929  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
            100787533  protein transport protein SEC13 homolog B-like [KO:K14004]
            100798414  protein transport protein SEC13 homolog B-like [KO:K14004]
            100794696  protein transport protein SEC13 homolog B [KO:K14004]
            100783637  protein transport protein SEC13 homolog B [KO:K14004]
            100803927  protein transport protein SEC31 homolog B [KO:K14005]
            100788642  protein transport protein SEC31 homolog B [KO:K14005]
            100803793  protein transport protein SEC23 [KO:K14006]
            100789860  protein transport protein SEC23 [KO:K14006]
            100784000  protein transport protein SEC23 [KO:K14006]
            100791527  protein transport protein SEC23 [KO:K14006]
            100813940  protein transport protein SEC23 [KO:K14006]
            100810009  protein transport protein Sec24-like At3g07100 [KO:K14007]
            100797752  protein transport protein Sec24-like At4g32640 [KO:K14007]
            100813263  protein transport protein Sec24-like At4g32640 [KO:K14007]
            100791083  protein transport protein Sec24-like At3g07100 isoform X2 [KO:K14007]
            100781347  UDP-glucose:glycoprotein glucosyltransferase isoform X2 [KO:K11718] [EC:2.4.1.-]
            100811899  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
            100797897  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
            100793674  alpha-mannosidase I MNS5 [KO:K10084]
            100785235  alpha-mannosidase I MNS4 [KO:K10085]
            100170706  PDIL-2; protein disulfide isomerase-like protein precursor [KO:K09580] [EC:5.3.4.1]
            100526845  protein disulfide isomerase like protein precursor [KO:K09580] [EC:5.3.4.1]
            100305460  disulfide isomerase-like protein isoform 1 precursor [KO:K09580] [EC:5.3.4.1]
            100790223  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
            100804924  protein disulfide isomerase-like 1-4 isoform X2 [KO:K09580] [EC:5.3.4.1]
            100170705  protein disulfide isomerase-like protein precursor [KO:K09580] [EC:5.3.4.1]
            100791778  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
            100785630  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
            100788702  protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
            100788687  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
            100789569  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
            100037470  protein disufide isomerase-like protein precursor [KO:K09584] [EC:5.3.4.1]
            100037471  thioredoxin-like superfamily protein precursor [KO:K09584] [EC:5.3.4.1]
            100037472  PDIS-2; protein disulfide isomerase-like protein precursor [KO:K09584] [EC:5.3.4.1]
            100137076  PDIM-1; protein disulfide isomerse like protein precursor [KO:K09584] [EC:5.3.4.1]
            100811253  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
            100796355  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
            100783550  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
            100783071  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
            100798225  endoplasmic oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
            100792441  protein OS-9-like precursor [KO:K10088]
            100803528  protein OS-9 homolog [KO:K10088]
            100820543  uncharacterized protein LOC100820543 precursor [KO:K13249]
            100777232  translocon-associated protein subunit alpha [KO:K13249]
            100306406  uncharacterized protein LOC100306406 precursor [KO:K13250]
            100500066  translocon-associated protein subunit beta-like precursor [KO:K13250]
            100798727  uncharacterized protein LOC100798727 [KO:K14009]
            100790767  B-cell receptor-associated protein 31 [KO:K14009]
            100812220  B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
            100820199  B-cell receptor-associated protein 31-like protein [KO:K14009]
            100526943  uncharacterized protein LOC100526943 [KO:K14009]
            100500010  B-cell receptor-associated protein 31 [KO:K14009]
            100793884  uncharacterized protein LOC100793884 [KO:K14009]
            100780491  derlin-1.1 [KO:K13989]
            100783754  derlin-1 [KO:K13989]
            100801156  derlin-1.1 isoform X2 [KO:K13989]
            100785303  derlin-1 isoform X1 [KO:K13989]
            100802618  uncharacterized protein LOC100802618 [KO:K13989]
            100791885  derlin-2.2 [KO:K13989]
            100779218  UBX domain-containing protein 1 [KO:K24348]
            100794687  UBX domain-containing protein 1 isoform X2 [KO:K24348]
            100779271  plant UBX domain-containing protein 2 [KO:K14011]
            100807576  plant UBX domain-containing protein 2 [KO:K14011]
            100820141  plant UBX domain-containing protein 4 [KO:K14012]
            100792095  plant UBX domain-containing protein 4 [KO:K14012]
            100806361  plant UBX domain-containing protein 4 [KO:K14012]
            100789588  plant UBX domain-containing protein 4 [KO:K14012]
            100798680  cell division cycle protein 48 homolog [KO:K13525]
            100814141  cell division cycle protein 48 homolog [KO:K13525]
            100783508  cell division cycle protein 48 homolog [KO:K13525]
            547850  CDC48; cell division cycle protein 48 homolog [KO:K13525]
            100805946  cell division cycle protein 48 homolog [KO:K13525]
            100806067  cell division cycle protein 48 homolog [KO:K13525]
            100776762  cell division cycle protein 48 homolog [KO:K13525]
            100791603  cell division cycle protein 48 homolog [KO:K13525]
            100799580  cell division cycle protein 48 homolog [KO:K13525]
            100811623  NPL4-like protein 1 [KO:K14015]
            100779549  NPL4-like protein 1 [KO:K14015]
            100781066  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            100799569  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            100807536  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
            100812915  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
            100795133  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
            100803896  ubiquitin recognition factor in ER-associated degradation protein 1 isoform X2 [KO:K14016]
            100790356  heat shock 70 kDa protein-like [KO:K03283]
            100800698  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
            100798307  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100816111  heat shock 70 [KO:K03283]
            100812707  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100777767  heat shock cognate 70 kDa protein 2 [KO:K03283]
            102667578  heat shock 70 kDa protein 4-like [KO:K03283]
            100789474  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100783822  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100787543  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100789485  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100782173  HSP70; heat shock 70 kDa protein [KO:K03283]
            100798636  heat shock cognate 70 kDa protein 2 isoform X1 [KO:K03283]
            100807713  stromal 70 kDa heat shock-related protein, chloroplastic isoform X1 [KO:K03283]
            100795699  heat shock 70 kDa protein-like [KO:K03283]
            102667572  heat shock 70 kDa protein 4 [KO:K03283]
            100788531  heat shock 70 kDa protein-like [KO:K03283]
            100800590  dnaJ protein homolog 1 [KO:K09503]
            100812236  dnaJ protein homolog 1 [KO:K09503]
            100778677  dnaJ protein homolog [KO:K09503]
            100808604  chaperone protein dnaJ isoform 2 [KO:K09503]
            100818805  chaperone protein dnaJ [KO:K09503]
            547558  PM37; seed maturation protein PM37 [KO:K09503]
            100788812  chaperone protein dnaJ 49 [KO:K09518]
            100789271  chaperone protein dnaJ 49 [KO:K09518]
            100820432  chaperone protein dnaJ 49 [KO:K09518]
            100793797  chaperone protein dnaJ 49 [KO:K09518]
            100194423  HSP90-1; heat shock protein 90-1 [KO:K04079]
            100194422  heat shock protein 90-2 [KO:K04079]
            100811234  HSP90A1; heat shock protein 90-A1 [KO:K04079]
            100819568  HSP90-2; uncharacterized protein LOC100819568 [KO:K04079]
            100807416  heat shock cognate protein 80 [KO:K04079]
            100784477  HSP90A2; heat shock protein 83 [KO:K04079]
            100803376  hsp70 nucleotide exchange factor fes1 [KO:K09562]
            100779530  hsp70 nucleotide exchange factor fes1 [KO:K09562]
            100780990  nucleotide exchange factor SIL1 [KO:K09562]
            100526870  HSP17.3-B; 17.3 kDa class I heat shock protein [KO:K13993]
            100527912  HSP20-like chaperone protein [KO:K13993]
            100305750  HSP17.5-E; 17.5 kDa class I heat shock protein [KO:K13993]
            100500319  alpha crystallin domain-containing protein precursor [KO:K13993]
            547971  HSP22.5; heat shock protein Hsp22.5 precursor [KO:K13993]
            547537  PM31; seed maturation protein PM31 [KO:K13993]
            102663230  uncharacterized protein LOC102663230 [KO:K13993]
            548078  small heat shock protein, chloroplastic [KO:K13993]
            100797426  18.5 kDa class I heat shock protein [KO:K13993]
            100500307  18.2 kDa class I heat shock protein [KO:K13993]
            100817744  18.1 kDa class I heat shock protein [KO:K13993]
            100789931  17.5 kDa class I heat shock protein [KO:K13993]
            100788881  18.1 kDa class I heat shock protein [KO:K13993]
            100526965  HSP22.0; 22.0 kDa class IV heat shock protein precursor [KO:K13993]
            100812935  17.5 kDa class I heat shock protein-like protein [KO:K13993]
            100500475  HSP20-like chaperones superfamily protein [KO:K13993]
            100499727  HSP18.5-C; 18.5 kDa class I heat shock protein [KO:K13993]
            547853  HSP22.3; low molecular weight heat shock protein Hsp22.3 precursor [KO:K13993]
            100787482  uncharacterized protein LOC100787482 [KO:K13993]
            100799280  17.4 kDa class III heat shock protein [KO:K13993]
            100803161  HSP20-like chaperone protein [KO:K13993]
            100793628  15.4 kDa class V heat shock protein [KO:K13993]
            100798019  uncharacterized protein LOC100798019 [KO:K13993]
            547852  HSP23.9; heat shock 22 kDa protein, mitochondrial isoform 2 [KO:K13993]
            100811966  putative heat shock protein [KO:K13993]
            100791734  uncharacterized protein LOC100791734 [KO:K13993]
            100788249  small heat shock protein, chloroplastic [KO:K13993]
            100791705  17.5 kDa class I heat shock protein [KO:K13993]
            100527855  HSP6834-A; class I heat shock protein [KO:K13993]
            100816496  HSP17.6-L; 17.6 kDa class I heat shock protein [KO:K13993]
            100526893  putative class I heat shock protein [KO:K13993]
            100791172  HSP17.5-M; 17.5 kDa class I heat shock protein [KO:K13993]
            100780308  18.5 kDa class I heat shock protein [KO:K13993]
            100813974  17.5 kDa class I heat shock protein [KO:K13993]
            100500220  putative class II heat shock protein [KO:K13993]
            100499658  class II heat shock protein [KO:K13993]
            100813195  HSP17.9-D; 17.9 kDa class II heat shock protein [KO:K13993]
            100500503  alpha-crystallin-Hsps_p23-like superfamily protein [KO:K13993]
            100500666  alpha-crystallin domain-containing protein [KO:K13993]
            100802108  uncharacterized protein LOC100802108 [KO:K13993]
            100170732  peroxisomal small heat shock protein [KO:K13993]
            100813153  16.9 kDa class I heat shock protein 1 [KO:K13993]
            100779969  17.3 kDa class I heat shock protein [KO:K13993]
            100813727  17.9 kDa class II heat shock protein [KO:K13993]
            100798298  small heat shock protein, chloroplastic isoform X1 [KO:K13993]
            100777269  22.7 kDa class IV heat shock protein [KO:K13993]
            106797062  22.7 kDa class IV heat shock protein-like [KO:K13993]
            100817672  18.1 kDa class I heat shock protein [KO:K13993]
            100809008  17.6 kDa class I heat shock protein [KO:K13993]
            100780960  22.7 kDa class IV heat shock protein [KO:K13993]
            100795633  18.1 kDa class I heat shock protein [KO:K13993]
            100810287  22.7 kDa class IV heat shock protein [KO:K13993]
            113001242  heat shock 22 kDa protein, mitochondrial [KO:K13993]
            111240470  putative 18.5 kDa class I heat shock protein [KO:K13993]
            111255647  heat shock protein [KO:K13993]
            111605749  Hsp20/alpha crystallin family protein [KO:K13993]
            100305751  putative heat shock protein [KO:K13993]
            100499809  uncharacterized protein LOC100499809 [KO:K13719] [EC:3.1.2.-]
            100793701  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 isoform X1 [KO:K13719] [EC:3.1.2.-]
            100805404  phospholipase A-2-activating protein [KO:K14018]
            100816481  phospholipase A-2-activating protein [KO:K14018]
            100819019  uncharacterized protein LOC100819019 [KO:K10839]
            100818012  ubiquitin receptor RAD23c [KO:K10839]
            100778187  ubiquitin receptor RAD23b isoform X1 [KO:K10839]
            100809066  uncharacterized protein LOC100809066 [KO:K10839]
            100813881  ubiquitin receptor RAD23c-like isoform 1 [KO:K10839]
            100804038  ubiquitin receptor RAD23b [KO:K10839]
            100814162  ubiquitin receptor RAD23c [KO:K10839]
            100817821  ubiquitin receptor RAD23d [KO:K10839]
            100797539  ubiquitin domain-containing protein DSK2b isoform X1 [KO:K04523]
            100806776  ubiquitin domain-containing protein DSK2a [KO:K04523]
            100776447  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
            100780421  ubiquitin domain-containing protein DSK2a [KO:K04523]
            100792131  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
            100794435  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X4 [KO:K01456] [EC:3.5.1.52]
            100808056  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
            100776098  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
            100806175  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            100811444  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            100797996  eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
            100815696  eukaryotic translation initiation factor 2 subunit alpha-like [KO:K03237]
            100805950  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
            100819188  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
            100797547  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
            100809949  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
            100788389  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            102661527  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            100785363  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            100785904  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
            100813205  probable E3 ubiquitin ligase SUD1 isoform X2 [KO:K10661] [EC:2.3.2.27]
            100811171  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
            100811370  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            100804054  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
            100804291  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
            100798396  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            100778181  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            100789952  uncharacterized protein LOC100789952 [KO:K04554] [EC:2.3.2.23]
            100499900  ubiquitin-conjugating enzyme E2 [KO:K10575] [EC:2.3.2.23]
            100500474  uncharacterized protein LOC100500474 [KO:K10575] [EC:2.3.2.23]
            100305813  uncharacterized protein LOC100305813 [KO:K10575] [EC:2.3.2.23]
            100782328  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            100816441  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X2 [KO:K10601] [EC:2.3.2.27]
            100782356  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X3 [KO:K10601] [EC:2.3.2.27]
            100782225  uncharacterized protein LOC100782225 [KO:K10666] [EC:2.3.2.27]
            100527488  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            100780540  E3 ubiquitin-protein ligase RMA1 [KO:K10666] [EC:2.3.2.27]
            100794086  E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
            100811099  uncharacterized protein LOC100811099 [KO:K10666] [EC:2.3.2.27]
            100807061  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            100816864  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            100782827  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            100779793  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            100780643  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
            100785491  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
            100786373  uncharacterized protein LOC100786373 [KO:K10666] [EC:2.3.2.27]
            100817526  uncharacterized protein LOC100817526 [KO:K10666] [EC:2.3.2.27]
            100807729  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
            100794016  RING finger and U-box domain-containing protein isoform 2 [KO:K10666] [EC:2.3.2.27]
            100793230  uncharacterized protein LOC100793230 [KO:K10666] [EC:2.3.2.27]
            100778919  E3 ubiquitin-protein ligase RMA3 [KO:K10666] [EC:2.3.2.27]
            100811423  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
            100814783  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
            732556  SEL-1 precursor [KO:K14026]
            100787823  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
            100819656  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
            100820578  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
            100796519  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            100798587  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            100527105  putative ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
            100499741  uncharacterized protein LOC100499741 [KO:K06689] [EC:2.3.2.23]
            100777678  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100500665  uncharacterized protein LOC100500665 [KO:K06689] [EC:2.3.2.23]
            100818920  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100788548  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100789422  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100790317  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100817810  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100500045  uncharacterized protein LOC100500045 [KO:K03868] [EC:2.3.2.32]
            100789570  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            100526919  uncharacterized protein LOC100526919 [KO:K03868] [EC:2.3.2.32]
            100798515  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            100778287  cullin-1 isoform X2 [KO:K03347]
            100819650  cullin-1 [KO:K03347]
            100793682  cullin-1 [KO:K03347]
            100786561  cullin-1 [KO:K03347]
            100306458  uncharacterized protein LOC100306458 [KO:K03094]
            100527683  SKP1-like protein [KO:K03094]
            100809769  SKP1-like protein 1A isoform X2 [KO:K03094]
            100811974  SKP1-like protein 14 [KO:K03094]
            100798104  uncharacterized protein LOC100798104 [KO:K03094]
            100803525  SKP1-like protein 14 [KO:K03094]
            100790479  SKP1-like protein 1A [KO:K03094]
            100791526  SKP1-like protein 1A [KO:K03094]
COMPOUND    C00076  Calcium cation
            G00009
            G00010
            G00011
            G00012
            G10694
REFERENCE   PMID:19491040
  AUTHORS   Naidoo N
  TITLE     ER and aging-Protein folding and the ER stress response.
  JOURNAL   Ageing Res Rev 8:150-9 (2009)
            DOI:10.1016/j.arr.2009.03.001
REFERENCE   PMID:18023214
  AUTHORS   Malhotra JD, Kaufman RJ
  TITLE     The endoplasmic reticulum and the unfolded protein response.
  JOURNAL   Semin Cell Dev Biol 18:716-31 (2007)
            DOI:10.1016/j.semcdb.2007.09.003
REFERENCE   PMID:20347046
  AUTHORS   Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  TITLE     Protein quality control in the ER: the recognition of misfolded proteins.
  JOURNAL   Semin Cell Dev Biol 21:500-11 (2010)
            DOI:10.1016/j.semcdb.2010.03.006
REFERENCE   PMID:20219571
  AUTHORS   Stolz A, Wolf DH
  TITLE     Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  JOURNAL   Biochim Biophys Acta 1803:694-705 (2010)
            DOI:10.1016/j.bbamcr.2010.02.005
REFERENCE   PMID:20112977
  AUTHORS   Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  TITLE     Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  JOURNAL   J Proteome Res 9:1763-71 (2010)
            DOI:10.1021/pr900900x
REL_PATHWAY gmx00510  N-Glycan biosynthesis
            gmx03050  Proteasome
            gmx03060  Protein export
KO_PATHWAY  ko04141
///
