ENTRY       gmx04120                    Pathway
NAME        Ubiquitin mediated proteolysis - Glycine max (soybean)
DESCRIPTION Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP gmx04120  Ubiquitin mediated proteolysis
DBLINKS     GO: 0016567
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100815545  polyubiquitin 3 [KO:K08770]
            100791065  SUBI-1; polyubiquitin [KO:K08770]
            100799042  SUBI-1; polyubiquitin [KO:K08770]
            100817214  polyubiquitin [KO:K08770]
            114515510  SUBI-2; polyubiquitin [KO:K08770]
            121173310  polyubiquitin-like [KO:K08770]
            121173311  polyubiquitin [KO:K08770]
            100819694  polyubiquitin [KO:K08770]
            100782546  polyubiquitin [KO:K08770]
            100792206  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            100794617  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            100306626  uncharacterized protein LOC100306626 [KO:K02927]
            100800784  ubiquitin-60S ribosomal protein L40 [KO:K02927]
            100527579  putative ubiquitin-40S ribosomal protein S27a [KO:K02977]
            100784307  ubiquitin-40S ribosomal protein S27a [KO:K02977]
            100785758  ubiquitin-40S ribosomal protein S27a [KO:K02977]
            100527854  ubiquitin-40S ribosomal protein S27a [KO:K02977]
            100811391  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
            100817492  ubiquitin-activating enzyme E1 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
            100799433  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
            100780392  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
            100807922  SUMO-activating enzyme subunit 1B-like isoform 2 [KO:K10684] [EC:6.2.1.45]
            100809607  SUMO-activating enzyme subunit 1B-1 isoform X2 [KO:K10684] [EC:6.2.1.45]
            100794304  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
            100779926  SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
            100808837  NEDD8-activating enzyme E1 catalytic subunit isoform X2 [KO:K10686] [EC:6.2.1.64]
            100803924  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
            100305873  ubiquiting-conjugating enzyme E2 [KO:K10573] [EC:2.3.2.23]
            100499698  uncharacterized protein LOC100499698 [KO:K10573] [EC:2.3.2.23]
            100802605  ubiquitin-conjugating enzyme E2 2 isoform X1 [KO:K10573] [EC:2.3.2.23]
            100499775  uncharacterized protein LOC100499775 [KO:K10573] [EC:2.3.2.23]
            100500581  uncharacterized protein LOC100500581 [KO:K10573] [EC:2.3.2.23]
            100306222  ubiquitin-conjugating enzyme E2 [KO:K10573] [EC:2.3.2.23]
            100784962  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
            100803594  ubiquitin-conjugating enzyme E2 2 isoform X1 [KO:K10573] [EC:2.3.2.23]
            100305664  ubiquitin-conjugating enzyme E2 [KO:K06688] [EC:2.3.2.23]
            100820153  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
            100527864  ubiquitin-conjugating enzyme [KO:K06688] [EC:2.3.2.23]
            100813446  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
            100527105  putative ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
            100499741  uncharacterized protein LOC100499741 [KO:K06689] [EC:2.3.2.23]
            100777678  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100500665  uncharacterized protein LOC100500665 [KO:K06689] [EC:2.3.2.23]
            100818920  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100788548  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100789422  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100790317  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
            100817810  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100527196  COP10; constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
            100499900  ubiquitin-conjugating enzyme E2 [KO:K10575] [EC:2.3.2.23]
            100500474  uncharacterized protein LOC100500474 [KO:K10575] [EC:2.3.2.23]
            100305813  uncharacterized protein LOC100305813 [KO:K10575] [EC:2.3.2.23]
            100782328  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            100527526  putative ubiquitin-conjugating enzyme [KO:K10576] [EC:2.3.2.23]
            548025  UBC4; ubiquitin carrier protein 4 [KO:K10576] [EC:2.3.2.23]
            100791133  ubiquitin-conjugating enzyme E2 5 isoform X1 [KO:K10576] [EC:2.3.2.23]
            100805356  ubiquitin-conjugating enzyme E2 5-like isoform 1 [KO:K10576] [EC:2.3.2.23]
            100527756  uncharacterized protein LOC100527756 [KO:K10576] [EC:2.3.2.23]
            100790685  ubiquitin-conjugating enzyme E2-23 kDa isoform X1 [KO:K10576] [EC:2.3.2.23]
            100804969  ubiquitin-conjugating enzyme E2 5 isoform X1 [KO:K10576] [EC:2.3.2.23]
            100812138  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
            100305922  uncharacterized protein LOC100305922 [KO:K10577]
            100803022  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100500268  uncharacterized protein LOC100500268 [KO:K10577]
            100793579  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100811370  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            100804054  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
            100804291  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
            100798396  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
            100778181  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            100789952  uncharacterized protein LOC100789952 [KO:K04554] [EC:2.3.2.23]
            100813186  uncharacterized protein LOC100813186 [KO:K10579] [EC:2.3.2.34]
            100783122  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
            100805631  uncharacterized protein LOC100805631 [KO:K10580] [EC:2.3.2.23]
            100500231  uncharacterized protein LOC100500231 [KO:K10580] [EC:2.3.2.23]
            100306707  uncharacterized protein LOC100306707 [KO:K10580] [EC:2.3.2.23]
            100804355  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
            100809853  probable ubiquitin-conjugating enzyme E2 25 isoform X1 [KO:K10581] [EC:2.3.2.24]
            100810772  uncharacterized protein LOC100810772 isoform X1 [KO:K10581] [EC:2.3.2.24]
            100800819  uncharacterized protein LOC100800819 [KO:K10581] [EC:2.3.2.24]
            100791144  uncharacterized protein LOC100791144 isoform X2 [KO:K10581] [EC:2.3.2.24]
            100809740  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
            100784814  probable ubiquitin-conjugating enzyme E2 24 isoform X1 [KO:K10581] [EC:2.3.2.24]
            100810844  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
            100791343  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
            100810318  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
            100811389  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
            100812552  putative ubiquitin-conjugating enzyme E2 38 isoform X1 [KO:K10581] [EC:2.3.2.24]
            100797350  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
            100306246  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
            100805463  probable ubiquitin-conjugating enzyme E2 24 isoform X2 [KO:K10581] [EC:2.3.2.24]
            100799332  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
            100809513  probable ubiquitin-conjugating enzyme E2 23 isoform X1 [KO:K10581] [EC:2.3.2.24]
            100811067  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
            100794952  ubiquitin-conjugating enzyme E2 22 isoform X1 [KO:K10583] [EC:2.3.2.23]
            100801681  ubiquitin-conjugating enzyme E2 22 isoform X2 [KO:K10583] [EC:2.3.2.23]
            100305572  uncharacterized protein LOC100305572 [KO:K10688] [EC:2.3.2.25]
            100785024  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.25]
            100527458  putative ubiquitin-conjugating enzyme E2 [KO:K04649] [EC:2.3.2.23]
            100808816  ubiquitin-conjugating enzyme E2 27-like [KO:K04649] [EC:2.3.2.23]
            100805744  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
            100527169  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
            100787467  E3 ubiquitin-protein ligase UPL6 isoform X1 [KO:K10589] [EC:2.3.2.26]
            100776303  E3 ubiquitin-protein ligase UPL6 isoform X1 [KO:K10589] [EC:2.3.2.26]
            100804501  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            100791450  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            100818972  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            100798530  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
            100793534  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
            100783336  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
            100777899  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
            100806175  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            100811444  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            100796519  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            100798587  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
            100819923  CYP19; peptidyl-prolyl cis-trans isomerase CYP65 isoform X1 [KO:K10598] [EC:5.2.1.8]
            100785814  CYP18; peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
            100800213  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
            100527039  pre-mRNA-processing factor 19 homolog 2 [KO:K10599] [EC:2.3.2.27]
            100797881  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
            100810573  uncharacterized protein LOC100810573 [KO:K04506] [EC:2.3.2.27]
            100782764  E3 ubiquitin-protein ligase SINAT3 isoform X2 [KO:K04506] [EC:2.3.2.27]
            100778869  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
            100813966  uncharacterized protein LOC100813966 [KO:K04506] [EC:2.3.2.27]
            100793457  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
            100781022  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
            100792687  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
            100500061  E3 ubiquitin-protein ligase SINAT2 isoform X2 [KO:K04506] [EC:2.3.2.27]
            102662420  E3 ubiquitin-protein ligase SINA-like 1 [KO:K04506] [EC:2.3.2.27]
            100813745  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
            100788171  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
            100818374  E3 ubiquitin-protein ligase MIEL1 isoform X3 [KO:K10144] [EC:2.3.2.27]
            100812023  C2H2-Zn transcription factor isoform 1 [KO:K10144] [EC:2.3.2.27]
            100792038  uncharacterized protein LOC100792038 [KO:K10144] [EC:2.3.2.27]
            100812709  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            100781566  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
            100812839  uncharacterized protein LOC100812839 [KO:K10144] [EC:2.3.2.27]
            100783915  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            100777215  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            100812246  E3 ubiquitin-protein ligase MIEL1 isoform X2 [KO:K10144] [EC:2.3.2.27]
            100794082  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            100803569  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
            100784204  E4 SUMO-protein ligase PIAL2 [KO:K04706] [EC:2.3.2.-]
            100780539  E4 SUMO-protein ligase PIAL2 isoform X2 [KO:K04706] [EC:2.3.2.-]
            100816441  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X2 [KO:K10601] [EC:2.3.2.27]
            100782356  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X3 [KO:K10601] [EC:2.3.2.27]
            100500045  uncharacterized protein LOC100500045 [KO:K03868] [EC:2.3.2.32]
            100789570  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            100526919  uncharacterized protein LOC100526919 [KO:K03868] [EC:2.3.2.32]
            100798515  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            100778287  cullin-1 isoform X2 [KO:K03347]
            100819650  cullin-1 [KO:K03347]
            100793682  cullin-1 [KO:K03347]
            100786561  cullin-1 [KO:K03347]
            100306458  uncharacterized protein LOC100306458 [KO:K03094]
            100527683  SKP1-like protein [KO:K03094]
            100809769  SKP1-like protein 1A isoform X2 [KO:K03094]
            100811974  SKP1-like protein 14 [KO:K03094]
            100798104  uncharacterized protein LOC100798104 [KO:K03094]
            100803525  SKP1-like protein 14 [KO:K03094]
            100790479  SKP1-like protein 1A [KO:K03094]
            100791526  SKP1-like protein 1A [KO:K03094]
            100793275  F-box protein SKP2B-like [KO:K03875]
            100797840  F-box protein SKP2A [KO:K03875]
            100788845  F-box protein SKP2B [KO:K03875]
            100818928  F-box protein SKP2B [KO:K03875]
            100500097  uncharacterized protein LOC100500097 [KO:K03872]
            100305702  uncharacterized protein LOC100305702 [KO:K03872]
            100306583  uncharacterized protein LOC100306583 [KO:K03873]
            100499885  uncharacterized protein LOC100499885 [KO:K03873]
            100794520  cullin-3A [KO:K03869]
            100798198  cullin-3A [KO:K03869]
            100782923  cullin-3A [KO:K03869]
            100795098  cullin-3A isoform X1 [KO:K03869]
            100782239  cullin-3A [KO:K03869]
            100797895  cullin-4 isoform X1 [KO:K10609]
            100779748  cullin-4 [KO:K10609]
            100805491  cullin-4 [KO:K10609]
            100777459  DNA damage-binding protein 1 [KO:K10610]
            100793506  protein DAMAGED DNA-BINDING 2 isoform X1 [KO:K10140]
            100527914  protein DAMAGED DNA-BINDING 2 [KO:K10140]
            100815581  WD repeat-containing protein ATCSA-1 [KO:K10570]
            100790433  WD repeat-containing protein ATCSA-1 [KO:K10570]
            100790158  light-mediated development protein DET1 isoform X4 [KO:K10571]
            100785677  light-mediated development protein DET1 [KO:K10571]
            100801685  light-mediated development protein DET1 isoform X1 [KO:K10571]
            100776546  anaphase-promoting complex subunit 11 [KO:K03358]
            100775777  anaphase-promoting complex subunit 11 [KO:K03358]
            100805741  anaphase-promoting complex subunit 2 isoform X4 [KO:K03349]
            100785428  anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
            100784841  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
            100801495  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
            100783578  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
            100787876  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
            100811967  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
            100800467  protein FIZZY-RELATED 2 [KO:K03364]
            100785726  protein FIZZY-RELATED 2 [KO:K03364]
            100797791  protein FIZZY-RELATED 2 [KO:K03364]
            100808928  protein FIZZY-RELATED 3 [KO:K03364]
            547741  CCS52; WD-repeat cell cycle regulatory protein [KO:K03364]
            100780928  protein FIZZY-RELATED 2 isoform X2 [KO:K03364]
            100778607  anaphase-promoting complex subunit 1 isoform X3 [KO:K03348]
            100818647  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
            100802544  cell division cycle protein 27 homolog B [KO:K03350]
            100804373  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
            100813971  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
            100527617  anaphase-promoting complex subunit 4 [KO:K03351]
            100775410  anaphase-promoting complex subunit 5 [KO:K03352]
            100808661  anaphase-promoting complex subunit 5 [KO:K03352]
            100818974  anaphase-promoting complex subunit 6 [KO:K03353]
            100817356  anaphase-promoting complex subunit 6 [KO:K03353]
            100785127  anaphase-promoting complex subunit 7 [KO:K03354]
            100808673  anaphase-promoting complex subunit 7 [KO:K03354]
            100789971  anaphase-promoting complex subunit 8 isoform X1 [KO:K03355]
            100811816  ILPA1; anaphase-promoting complex subunit 8 [KO:K03355]
            100783872  anaphase-promoting complex subunit 8 [KO:K03355]
            100526925  anaphase-promoting complex subunit 10-like [KO:K03357]
            100806981  uncharacterized protein LOC100806981 [KO:K03357]
            100527611  anaphase-promoting complex subunit 13 [KO:K12456]
            100779178  anaphase-promoting complex subunit 13 [KO:K12456]
REFERENCE   PMID:16922370
  AUTHORS   Kamura T.
  TITLE     [Cullin-based E3 family]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
REFERENCE   PMID:16922408
  AUTHORS   Matsuda N.
  TITLE     [Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
REFERENCE   PMID:16922367
  AUTHORS   Tokunaga F.
  TITLE     [E2 ubiquitin-conjugating enzymes: structures and functions]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
REFERENCE   PMID:16816840
  AUTHORS   Nalepa G, Rolfe M, Harper JW.
  TITLE     Drug discovery in the ubiquitin-proteasome system.
  JOURNAL   Nat Rev Drug Discov 5:596-613 (2006)
            DOI:10.1038/nrd2056
REFERENCE   PMID:16405856
  AUTHORS   Hsu YJ, Goodman SR.
  TITLE     Spectrin and ubiquitination: a review.
  JOURNAL   Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
REFERENCE   PMID:12944364
  AUTHORS   Hatakeyama S, Nakayama KI.
  TITLE     Ubiquitylation as a quality control system for intracellular proteins.
  JOURNAL   J Biochem 134:1-8 (2003)
            DOI:10.1093/jb/mvg106
REFERENCE   PMID:17588513
  AUTHORS   Lee J, Zhou P.
  TITLE     DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  JOURNAL   Mol Cell 26:775-80 (2007)
            DOI:10.1016/j.molcel.2007.06.001
REL_PATHWAY gmx03050  Proteasome
KO_PATHWAY  ko04120
///
