ENTRY       gmx03440                    Pathway
NAME        Homologous recombination - Glycine max (soybean)
DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP gmx03440  Homologous recombination
DBLINKS     GO: 0000724
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100809336  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            100798983  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
            100781271  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
            100788534  DNA repair protein recA homolog 1, chloroplastic isoform X1 [KO:K03553]
            100807627  DNA repair protein recA homolog 3, mitochondrial isoform X1 [KO:K03553]
            100797016  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
            100807239  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
            100790704  DNA polymerase I B, chloroplastic/mitochondrial isoform X1 [KO:K02335] [EC:2.7.7.7]
            100806552  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:5.6.2.4]
            100818545  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
            100801335  double-strand break repair protein MRE11 [KO:K10865]
            100783205  nijmegen breakage syndrome 1 protein [KO:K10867]
            100789459  nijmegen breakage syndrome 1 protein [KO:K10867]
            100788458  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
            100784883  BRCA1-associated RING domain protein 1 [KO:K10683]
            100804958  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X2 [KO:K10683]
            100789372  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X2 [KO:K10683]
            100306420  BRCA1 carboxy-terminal domain-containing protein [KO:K10683]
            100779610  regulator of telomere elongation helicase 1 homolog isoform X1 [KO:K15362] [EC:5.6.2.3]
            100783461  BRCT domain-containing protein At4g02110 [KO:K10728]
            100799144  BRCT domain-containing protein At4g02110 [KO:K10728]
            100804966  DNA topoisomerase 2-binding protein 1-A isoform X4 [KO:K10728]
            100527612  uncharacterized protein LOC100527612 [KO:K20776]
            100814793  uncharacterized protein LOC100814793 [KO:K12173]
            100794341  BRISC and BRCA1-A complex member 2 [KO:K12173]
            100784991  uncharacterized protein LOC100784991 [KO:K11864] [EC:3.4.19.-]
            100781761  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
            100797849  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B [KO:K08775]
            100500106  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100306674  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100793857  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100499672  uncharacterized protein LOC100499672 [KO:K10881]
            100778597  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            100792409  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            100777091  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            100789756  replication protein A 32 kDa subunit A [KO:K10739]
            100782819  replication protein A 32 kDa subunit B [KO:K10739]
            100802512  replication protein A 32 kDa subunit A [KO:K10739]
            100306197  uncharacterized protein LOC100306197 [KO:K10740]
            100306641  uncharacterized protein LOC100306641 [KO:K10740]
            100781484  replication protein A 14 kDa subunit B [KO:K10740]
            100812213  DNA repair protein RAD51 homolog 1 [KO:K04482]
            100820307  DNA repair protein RAD51 homolog A [KO:K04482]
            100789073  DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
            100527406  P-loop NTPase domain superfamily protein isoform 1 [KO:K10870]
            100780427  DNA repair protein RAD51 homolog 4-like [KO:K10871]
            100818578  DNA repair protein XRCC2 homolog isoform X2 [KO:K10879]
            100807727  DNA repair protein XRCC2 homolog [KO:K10879]
            100799681  DNA repair protein XRCC3 homolog [KO:K10880]
            100806733  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            100807262  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            100812737  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            100780454  protein CHROMATIN REMODELING 35 isoform X1 [KO:K10875] [EC:5.6.2.-]
            100795356  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
            100785036  SNF2 domain-containing protein CLASSY 2 [KO:K10875] [EC:5.6.2.-]
            100811703  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            100781856  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
            100781631  protein CHROMATIN REMODELING 25 [KO:K10875] [EC:5.6.2.-]
            548092  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100817379  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100780072  DNA polymerase delta small subunit [KO:K02328]
            100805951  DNA polymerase delta small subunit isoform X1 [KO:K02328]
            100812372  DNA polymerase delta subunit 3 [KO:K03504]
            100793247  uncharacterized protein LOC100793247 isoform X1 [KO:K03504]
            100778329  DNA polymerase delta subunit 4 [KO:K03505]
            100799459  DNA polymerase delta subunit 4 [KO:K03505]
            100819601  ATP-dependent DNA helicase Q-like 3 isoform X3 [KO:K10901] [EC:5.6.2.4]
            100800006  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
            100818971  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
            100791807  DNA topoisomerase 3-beta isoform X1 [KO:K03165] [EC:5.6.2.1]
            100798497  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
            100813276  crossover junction endonuclease EME1B isoform X2 [KO:K10882] [EC:3.1.22.-]
            100801969  crossover junction endonuclease EME1B isoform X1 [KO:K10882] [EC:3.1.22.-]
REFERENCE   PMID:18086882
  AUTHORS   Maloisel L, Fabre F, Gangloff S.
  TITLE     DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  JOURNAL   Mol Cell Biol 28:1373-82 (2008)
            DOI:10.1128/MCB.01651-07
REFERENCE   PMID:17571595
  AUTHORS   Haruta-Takahashi N, Iwasaki H.
  TITLE     [Recombination mediators]
  JOURNAL   Seikagaku 79:449-53 (2007)
REFERENCE   PMID:18430459
  AUTHORS   Ouyang KJ, Woo LL, Ellis NA.
  TITLE     Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  JOURNAL   Mech Ageing Dev 129:425-40 (2008)
            DOI:10.1016/j.mad.2008.03.003
REFERENCE   PMID:15902993
  AUTHORS   Kawabata M, Kawabata T, Nishibori M.
  TITLE     Role of recA/RAD51 family proteins in mammals.
  JOURNAL   Acta Med Okayama 59:1-9 (2005)
            DOI:10.18926/AMO/31987
REFERENCE   PMID:12589470
  AUTHORS   Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  TITLE     Mitotic recombination in Saccharomyces cerevisiae.
  JOURNAL   Curr Genet 42:185-98 (2003)
            DOI:10.1007/s00294-002-0346-3
REFERENCE   PMID:16935872
  AUTHORS   Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  TITLE     Rad54: the Swiss Army knife of homologous recombination?
  JOURNAL   Nucleic Acids Res 34:4115-25 (2006)
            DOI:10.1093/nar/gkl481
REFERENCE   PMID:17395553
  AUTHORS   Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  TITLE     Recombination proteins and rescue of arrested replication forks.
  JOURNAL   DNA Repair (Amst) 6:967-80 (2007)
            DOI:10.1016/j.dnarep.2007.02.016
KO_PATHWAY  ko03440
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