ENTRY       gmx03430                    Pathway
NAME        Mismatch repair - Glycine max (soybean)
DESCRIPTION DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
            The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP gmx03430  Mismatch repair
DBLINKS     GO: 0006298
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100778373  endonuclease MutS2 [KO:K07456]
            100809336  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
            100793891  DNA mismatch repair protein PMS1 isoform X1 [KO:K10858]
            100802535  DNA mismatch repair protein PMS1 [KO:K10858]
            100794788  DNA mismatch repair protein MLH1 [KO:K08734]
            100776965  DNA mismatch repair protein MSH7 [KO:K08737]
            100811104  DNA mismatch repair protein MSH6 [KO:K08737]
            100818859  DNA mismatch repair protein MSH7 isoform X1 [KO:K08737]
            100792272  DNA mismatch repair protein MSH2 [KO:K08735]
            100789883  DNA mismatch repair protein MSH3 isoform X1 [KO:K08736]
            100788019  DNA mismatch repair protein MLH3 isoform X1 [KO:K08739]
            100780255  LOW QUALITY PROTEIN: DNA mismatch repair protein MLH3 [KO:K08739]
            100802809  replication factor C subunit 1 [KO:K10754]
            100790070  replication factor C subunit 1 isoform X1 [KO:K10754]
            100788329  replication factor C subunit 2 isoform X1 [KO:K10755]
            100781364  replication factor C subunit 2 [KO:K10755]
            100798331  replication factor C subunit 2 [KO:K10755]
            100775926  replication factor C subunit 2 [KO:K10755]
            100818329  uncharacterized protein LOC100818329 [KO:K10756]
            100782652  replication factor C subunit 3 [KO:K10756]
            100807039  replication factor C subunit 3 isoform X1 [KO:K10756]
            100805231  replication factor C subunit 3 [KO:K10756]
            100817775  uncharacterized protein LOC100817775 isoform X2 [KO:K10756]
            102664389  uncharacterized protein LOC102664389 [KO:K10756]
            100795321  uncharacterized protein LOC100795321 [KO:K10756]
            548079  proliferating cell nuclear antigen [KO:K04802]
            100817651  proliferating cell nuclear antigen [KO:K04802]
            100780038  proliferating cell nuclear antigen [KO:K04802]
            100801178  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
            100817932  exonuclease 1 [KO:K10746] [EC:3.1.-.-]
            100798062  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
            100778597  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            100792409  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
            100777091  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
            100789756  replication protein A 32 kDa subunit A [KO:K10739]
            100782819  replication protein A 32 kDa subunit B [KO:K10739]
            100802512  replication protein A 32 kDa subunit A [KO:K10739]
            100306197  uncharacterized protein LOC100306197 [KO:K10740]
            100306641  uncharacterized protein LOC100306641 [KO:K10740]
            100781484  replication protein A 14 kDa subunit B [KO:K10740]
            548092  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100817379  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100780072  DNA polymerase delta small subunit [KO:K02328]
            100805951  DNA polymerase delta small subunit isoform X1 [KO:K02328]
            100812372  DNA polymerase delta subunit 3 [KO:K03504]
            100793247  uncharacterized protein LOC100793247 isoform X1 [KO:K03504]
            100778329  DNA polymerase delta subunit 4 [KO:K03505]
            100799459  DNA polymerase delta subunit 4 [KO:K03505]
            100783155  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
REFERENCE   PMID:16612326
  AUTHORS   Jiricny J.
  TITLE     The multifaceted mismatch-repair system.
  JOURNAL   Nat Rev Mol Cell Biol 7:335-46 (2006)
            DOI:10.1038/nrm1907
REFERENCE   PMID:18157157
  AUTHORS   Li GM.
  TITLE     Mechanisms and functions of DNA mismatch repair.
  JOURNAL   Cell Res 18:85-98 (2008)
            DOI:10.1038/cr.2007.115
REFERENCE   PMID:11920679
  AUTHORS   Marti TM, Kunz C, Fleck O.
  TITLE     DNA mismatch repair and mutation avoidance pathways.
  JOURNAL   J Cell Physiol 191:28-41 (2002)
            DOI:10.1002/jcp.10077
REFERENCE   PMID:11436301
  AUTHORS   Ikejima M, Shimada T.
  TITLE     [Molecular mechanism of mismatch repair]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO_PATHWAY  ko03430
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