ENTRY       gmx03050                    Pathway
NAME        Proteasome - Glycine max (soybean)
DESCRIPTION The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP gmx03050  Proteasome
DBLINKS     GO: 0000502
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100814379  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            100787034  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            100819526  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            100779667  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            100801569  probable 26S proteasome regulatory subunit p27 isoform X2 [KO:K06693]
            100803329  probable 26S proteasome regulatory subunit p27 isoform X1 [KO:K06693]
            100801382  26S proteasome non-ATPase regulatory subunit 12 homolog A isoform X2 [KO:K03035]
            100791893  26S proteasome non-ATPase regulatory subunit 12 homolog A isoform X2 [KO:K03035]
            100793755  26S proteasome non-ATPase regulatory subunit 12 homolog A isoform X3 [KO:K03035]
            100817016  26S proteasome non-ATPase regulatory subunit 12 homolog A [KO:K03035]
            100777365  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            100780845  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            100796188  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            100789022  26S proteasome non-ATPase regulatory subunit 6 homolog [KO:K03037]
            100802610  26S proteasome non-ATPase regulatory subunit 6 homolog [KO:K03037]
            100810692  uncharacterized protein LOC100810692 [KO:K03037]
            100790393  26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
            100815353  uncharacterized protein LOC100815353 [KO:K03038]
            100816479  26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
            100804455  26S proteasome non-ATPase regulatory subunit 13-like [KO:K03039]
            100793480  uncharacterized protein LOC100793480 [KO:K03039]
            100787992  26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
            100813116  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            100778174  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            100817264  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            100803720  26S proteasome non-ATPase regulatory subunit 8 homolog A [KO:K03031]
            100785835  uncharacterized protein LOC100785835 [KO:K03031]
            100790035  uncharacterized protein LOC100790035 [KO:K03031]
            100500106  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100306674  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100793857  protein DSS1 HOMOLOG ON CHROMOSOME V [KO:K10881]
            100499672  uncharacterized protein LOC100499672 [KO:K10881]
            100814594  26S proteasome non-ATPase regulatory subunit 4 homolog isoform X1 [KO:K03029]
            100780583  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
            100803975  uncharacterized protein LOC100803975 [KO:K03029]
            100791370  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
            100799779  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            100777078  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            100817941  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            100790425  26S proteasome non-ATPase regulatory subunit 1 homolog A isoform X1 [KO:K03032]
            100799938  26S proteasome regulatory subunit RPN13 isoform X2 [KO:K06691]
            100815281  26S proteasome regulatory subunit RPN13 isoform X1 [KO:K06691]
            100808239  26S proteasome regulatory subunit 7 [KO:K03061]
            100796358  26S protease regulatory subunit 7-like [KO:K03061]
            100779787  26S proteasome regulatory subunit 7 [KO:K03061]
            100820271  26S proteasome regulatory subunit 7 [KO:K03061]
            100816363  26S proteasome regulatory subunit 7 [KO:K03061]
            100798835  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
            100783293  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
            100802442  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
            100776168  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
            100812783  uncharacterized protein LOC100812783 [KO:K03066]
            100776268  uncharacterized protein LOC100776268 [KO:K03066]
            100794489  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100788475  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100785863  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100802514  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100817206  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100798637  26S protease regulatory subunit 6A homolog A-like [KO:K03065]
            100807867  26S proteasome regulatory subunit 6A homolog [KO:K03065]
            100788486  26S proteasome regulatory subunit 6A homolog [KO:K03065]
            100819819  26S proteasome regulatory subunit 6B homolog [KO:K03063]
            100820353  26S proteasome regulatory subunit 6B homolog [KO:K03063]
            100783650  26S proteasome regulatory subunit 6B homolog [KO:K03063]
            100781622  proteasome activator subunit 4 [KO:K06699]
            100814812  proteasome activator subunit 4 isoform X1 [KO:K06699]
            732640  PAA1; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
            100803124  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
            100527630  N-terminal nucleophile-hydrolase superfamily protein [KO:K02726] [EC:3.4.25.1]
            100799108  uncharacterized protein LOC100799108 [KO:K02726] [EC:3.4.25.1]
            100807110  proteasome subunit alpha type-2-A [KO:K02726] [EC:3.4.25.1]
            100795748  proteasome subunit alpha type-2-A [KO:K02726] [EC:3.4.25.1]
            100802854  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
            100793282  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
            102662733  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
            100786457  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
            100808731  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
            100790481  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
            547598  PAE1; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
            100499756  uncharacterized protein LOC100499756 [KO:K02729] [EC:3.4.25.1]
            100799919  uncharacterized protein LOC100799919 [KO:K02729] [EC:3.4.25.1]
            100796147  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
            100819051  proteasome subunit alpha type-1-B [KO:K02725] [EC:3.4.25.1]
            100792921  proteasome subunit alpha type-1-B [KO:K02725] [EC:3.4.25.1]
            100797380  proteasome subunit alpha type-1-A [KO:K02725] [EC:3.4.25.1]
            100527499  putative proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
            100820387  uncharacterized protein LOC100820387 [KO:K02727] [EC:3.4.25.1]
            100793551  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
            100305513  uncharacterized protein LOC100305513 [KO:K02738] [EC:3.4.25.1]
            100808133  proteasome subunit beta type-7-B [KO:K02739] [EC:3.4.25.1]
            100819784  proteasome subunit beta type-7-B [KO:K02739] [EC:3.4.25.1]
            100306084  putative proteasome beta subunit C1 [KO:K02735] [EC:3.4.25.1]
            100499664  proteasome beta subunit C1 [KO:K02735] [EC:3.4.25.1]
            100527027  20S proteasome beta subunit C1 [KO:K02735] [EC:3.4.25.1]
            100499738  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
            100306158  uncharacterized protein LOC100306158 [KO:K02734] [EC:3.4.25.1]
            100779240  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
            100778498  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
            100306148  putative proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
            100810291  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
            100499795  20S proteasome beta subunit [KO:K02736] [EC:3.4.25.1]
            100527174  thr-endopeptidase [KO:K02736] [EC:3.4.25.1]
            100814792  uncharacterized protein LOC100814792 [KO:K06700]
            100811536  probable proteasome inhibitor [KO:K06700]
            100500555  proteasome maturation factor UMP1 family protein [KO:K11599]
            100789182  cyclin-B1-2 [KO:K11599]
REFERENCE   PMID:16338359
  AUTHORS   Hirano Y, Murata S, Tanaka K
  TITLE     Large- and small-scale purification of mammalian 26S proteasomes.
  JOURNAL   Methods Enzymol 399:227-40 (2005)
            DOI:10.1016/S0076-6879(05)99015-0
REFERENCE   PMID:18497808
  AUTHORS   Saeki Y, Tanaka K
  TITLE     Cell biology: two hands for degradation.
  JOURNAL   Nature 453:460-1 (2008)
            DOI:10.1038/453460a
REFERENCE   PMID:16919475
  AUTHORS   Smith DM, Benaroudj N, Goldberg A
  TITLE     Proteasomes and their associated ATPases: a destructive combination.
  JOURNAL   J Struct Biol 156:72-83 (2006)
            DOI:10.1016/j.jsb.2006.04.012
REFERENCE   PMID:16181324
  AUTHORS   Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  TITLE     Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  JOURNAL   Immunol Rev 207:19-30 (2005)
            DOI:10.1111/j.0105-2896.2005.00308.x
REFERENCE   PMID:19483713
  AUTHORS   Darwin KH
  TITLE     Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
  JOURNAL   Nat Rev Microbiol 7:485-91 (2009)
            DOI:10.1038/nrmicro2148
REFERENCE   PMID:23495936
  AUTHORS   Tomko RJ Jr, Hochstrasser M
  TITLE     Molecular architecture and assembly of the eukaryotic proteasome.
  JOURNAL   Annu Rev Biochem 82:415-45 (2013)
            DOI:10.1146/annurev-biochem-060410-150257
REFERENCE   PMID:28583440
  AUTHORS   Budenholzer L, Cheng CL, Li Y, Hochstrasser M
  TITLE     Proteasome Structure and Assembly.
  JOURNAL   J Mol Biol 429:3500-3524 (2017)
            DOI:10.1016/j.jmb.2017.05.027
REFERENCE   PMID:29071527
  AUTHORS   Cloos J, Roeten MS, Franke NE, van Meerloo J, Zweegman S, Kaspers GJ, Jansen G
  TITLE     (Immuno)proteasomes as therapeutic target in acute leukemia.
  JOURNAL   Cancer Metastasis Rev 36:599-615 (2017)
            DOI:10.1007/s10555-017-9699-4
REFERENCE   PMID:22215586
  AUTHORS   Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  TITLE     Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
  JOURNAL   Proc Natl Acad Sci U S A 109:1479-84 (2012)
            DOI:10.1073/pnas.1119394109
REL_PATHWAY gmx04120  Ubiquitin mediated proteolysis
KO_PATHWAY  ko03050
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