ENTRY       gmx03013                    Pathway
NAME        Nucleocytoplasmic transport - Glycine max (soybean)
DESCRIPTION The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP gmx03013  Nucleocytoplasmic transport
DBLINKS     GO: 0050658
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100781306  aladin isoform X1 [KO:K14320]
            100808599  aladin [KO:K14320]
            100782777  zinc finger CCCH domain-containing protein 16 [KO:K14321]
            100814339  zinc finger CCCH domain-containing protein 16 [KO:K14321]
            100802744  protein GLE1 isoform X1 [KO:K18723]
            100784739  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            100778091  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:3.6.4.13]
            100527204  protein RAE1 [KO:K14298]
            100819240  putative mRNA export factor [KO:K14298]
            100780721  uncharacterized protein LOC100780721 [KO:K14298]
            100803005  protein RAE1 isoform X1 [KO:K14298]
            100790967  nuclear pore complex protein NUP96 [KO:K14297]
            100789177  nuclear pore complex protein NUP98A [KO:K14297]
            100786534  nuclear pore complex protein NUP98A [KO:K14297]
            100806517  nuclear pore complex protein NUP214 [KO:K14317]
            100794048  nuclear pore complex protein NUP214 [KO:K14317]
            100801853  nuclear pore complex protein NUP88 [KO:K14318]
            100796487  RAN GTPase-activating protein 1 [KO:K14319]
            100819800  RAN GTPase-activating protein 1 [KO:K14319]
            100785942  RAN GTPase-activating protein 2 [KO:K14319]
            100795339  RAN GTPase-activating protein 2 [KO:K14319]
            100305922  uncharacterized protein LOC100305922 [KO:K10577]
            100803022  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100500268  uncharacterized protein LOC100500268 [KO:K10577]
            100793579  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100785741  nuclear pore complex protein NUP85 [KO:K14304]
            100787533  protein transport protein SEC13 homolog B-like [KO:K14004]
            100798414  protein transport protein SEC13 homolog B-like [KO:K14004]
            100794696  protein transport protein SEC13 homolog B [KO:K14004]
            100783637  protein transport protein SEC13 homolog B [KO:K14004]
            100786552  nuclear pore complex protein NUP107 [KO:K14301]
            100793167  nuclear pore complex protein NUP133 [KO:K14300]
            100780148  nuclear pore complex protein NUP133 [KO:K14300]
            100812825  protein SEH1 isoform X1 [KO:K14299]
            100780788  protein SEH1 [KO:K14299]
            100795073  nuclear pore complex protein NUP43 [KO:K14305]
            100778776  nuclear pore complex protein NUP43 [KO:K14305]
            100781711  nuclear pore complex protein NUP62 [KO:K14306]
            100803385  nuclear pore complex protein NUP62 [KO:K14306]
            100776992  nuclear pore complex protein NUP58 [KO:K14307]
            100805204  nuclear pore complex protein NUP58 isoform X1 [KO:K14307]
            100797030  nuclear pore complex protein NUP54 [KO:K14308]
            100791608  nuclear pore complex protein NUP54 [KO:K14308]
            100777616  nuclear pore complex protein NUP205 [KO:K14310]
            100796560  nucleoporin NUP188 [KO:K14311]
            100794352  nuclear pore complex protein NUP155 [KO:K14312]
            100798527  nuclear pore complex protein NUP155 [KO:K14312]
            100777660  nuclear pore complex protein NUP93A [KO:K14309]
            100782831  nuclear pore complex protein NUP93A [KO:K14309]
            100783752  uncharacterized protein LOC100783752 [KO:K14313]
            100803145  nuclear pore complex protein NUP35 [KO:K14313]
            100796588  uncharacterized protein LOC100796588 [KO:K14315]
            100800150  uncharacterized protein LOC100800150 [KO:K14315]
            100778001  nuclear pore complex protein GP210 [KO:K14314]
            100789872  uncharacterized protein LOC100789872 [KO:K20724]
            100794639  uncharacterized protein LOC100794639 isoform X2 [KO:K20724]
            100788022  nuclear-pore anchor isoform X1 [KO:K09291]
            100811882  nuclear-pore anchor [KO:K09291]
            100816975  uncharacterized protein LOC100816975 [KO:K14295]
            100788565  pleckstrin homology-like domain-containing protein [KO:K14295]
            100813229  importin subunit alpha-4 [KO:K15042]
            100798125  importin subunit alpha-2 [KO:K15042]
            100806288  importin subunit alpha-2 [KO:K15042]
            100793734  importin subunit alpha-4 [KO:K15042]
            100780020  importin subunit alpha-2 [KO:K15042]
            100789135  importin subunit alpha-2 [KO:K15042]
            100808498  importin subunit alpha-2 [KO:K15042]
            100792804  importin subunit alpha-2 [KO:K15042]
            100782992  importin subunit alpha-9 [KO:K15042]
            100797267  importin subunit alpha-2 [KO:K15042]
            100813320  importin subunit alpha-1 [KO:K15042]
            106796830  importin subunit alpha-4 [KO:K15042]
            102668055  importin subunit alpha-4 [KO:K15042]
            100775604  importin subunit alpha-1a [KO:K15042]
            100785398  importin subunit alpha-4 [KO:K15042]
            100786446  importin subunit alpha-4 [KO:K15042]
            100793195  importin subunit alpha-4 isoform X1 [KO:K15042]
            100785130  importin subunit beta-1 [KO:K14293]
            100805445  importin subunit beta-1 [KO:K14293]
            100818831  importin subunit beta-1 [KO:K14293]
            100792702  transportin-1 [KO:K18752]
            100792837  transportin-1 [KO:K18752]
            100808691  transportin MOS14 isoform X1 [KO:K15436]
            100813996  transportin MOS14 [KO:K15436]
            100798786  transportin MOS14 [KO:K15436]
            100780430  transportin MOS14 isoform X1 [KO:K15436]
            100795772  importin-4 isoform X1 [KO:K20221]
            100815107  importin-4 isoform X2 [KO:K20221]
            100787600  importin-5 isoform X1 [KO:K20222]
            100805849  importin-5 [KO:K20222]
            100780183  importin-5 [KO:K20222]
            100797431  importin-5 [KO:K20222]
            102669706  uncharacterized protein LOC102669706 [KO:K20222]
            100809471  importin beta-like SAD2 [KO:K20223]
            100807264  importin beta-like SAD2 [KO:K20223]
            100795105  importin beta-like SAD2 [KO:K20223]
            100790154  importin-9 [KO:K20224]
            100792825  importin-9 [KO:K20224]
            100785151  importin-11 isoform X1 [KO:K25201]
            100780767  importin-11 isoform X2 [KO:K25201]
            100801927  snurportin-1 [KO:K13151]
            100786485  snurportin-1 [KO:K13151]
            100802384  protein EXPORTIN 1A [KO:K14290]
            100813443  protein EXPORTIN 1A [KO:K14290]
            100783433  protein EXPORTIN 1A isoform X1 [KO:K14290]
            100787912  protein EXPORTIN 1A [KO:K14290]
            100806017  exportin-2 [KO:K18423]
            100801426  exportin-2 [KO:K18423]
            100800596  exportin-T [KO:K14288]
            100812358  exportin-T [KO:K14288]
            100804486  exportin-4 isoform X1 [KO:K25203]
            100786647  exportin-4 [KO:K25203]
            100790207  protein HASTY 1 [KO:K14289]
            100789688  protein HASTY 1 [KO:K14289]
            100804346  exportin-7-B isoform X3 [KO:K18460]
            100803866  exportin-7-B isoform X5 [KO:K18460]
            100791060  exportin-7-A isoform X1 [KO:K18460]
            100500437  RAN GTPase 3 [KO:K07936]
            100813067  GTP-binding nuclear protein Ran-3 [KO:K07936]
            100813605  GTP-binding nuclear protein Ran-3 [KO:K07936]
            100814146  GTP-binding nuclear protein Ran-3 [KO:K07936]
            100801379  GTP-binding nuclear protein Ran-3 [KO:K07936]
            100775298  uncharacterized protein LOC100775298 [KO:K07936]
            100305680  uncharacterized protein LOC100305680 [KO:K07936]
            100499630  TEFS1; elongation factor 1-alpha [KO:K03231]
            100776330  elongation factor 1-alpha-like [KO:K03231]
            100801611  elongation factor 1-alpha [KO:K03231]
            100785429  elongation factor 1-alpha [KO:K03231]
            110008577  EF4; elongation factor 1-alpha [KO:K03231]
            100807572  elongation factor 1-alpha-like [KO:K03231]
            100805103  uncharacterized protein LOC100805103 [KO:K14291]
            100793038  uncharacterized protein LOC100793038 [KO:K14291]
            100775515  uncharacterized protein LOC100775515 [KO:K14291]
            100791079  nuclear cap-binding protein subunit 1 [KO:K12882]
            100811738  nuclear cap-binding protein subunit 1 [KO:K12882]
            100789535  nuclear cap-binding protein subunit 2-like protein [KO:K12883]
            100776217  nuclear cap-binding protein subunit 2 [KO:K12883]
            100799026  60S ribosomal export protein NMD3 [KO:K07562]
            100527187  uncharacterized protein LOC100527187 [KO:K12876]
            100778595  RNA-binding protein Y14 [KO:K12876]
            100804377  RNA-binding protein Y14 [KO:K12876]
            100499908  protein mago nashi homolog isoform 1 [KO:K12877]
            100305742  protein mago nashi-like [KO:K12877]
            100813864  protein mago nashi homolog 2 [KO:K12877]
            100800020  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:3.6.4.13]
            100795032  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:3.6.4.13]
            100816245  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
            100786288  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
            100526922  uncharacterized protein LOC100526922 [KO:K14324]
            100784572  histone deacetylase complex subunit SAP18-like [KO:K14324]
            100804778  serine/arginine-rich splicing factor SR45 [KO:K14325]
            100783566  serine/arginine-rich splicing factor SR45 [KO:K14325]
            100801229  pinin isoform X1 [KO:K13114]
            100801958  pinin isoform X1 [KO:K13114]
            100785926  THO complex subunit 4B isoform X2 [KO:K12881]
            100820344  THO complex subunit 4D isoform X1 [KO:K12881]
            100817317  THO complex subunit 4A [KO:K12881]
            100801491  THO complex subunit 4D [KO:K12881]
            100783362  THO complex subunit 4A [KO:K12881]
            100775827  THO complex subunit 4A [KO:K12881]
            100786092  regulator of nonsense transcripts UPF2 [KO:K14327]
            100795746  LOW QUALITY PROTEIN: regulator of nonsense transcripts UPF2 [KO:K14327]
            100795376  regulator of nonsense transcripts UPF3 isoform X8 [KO:K14328]
            100799816  regulator of nonsense transcripts UPF3 [KO:K14328]
            100801152  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
            100798866  regulator of nonsense transcripts UPF3 [KO:K14328]
            100785358  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:3.6.4.13]
            100799082  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:3.6.4.13]
            100808957  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:3.6.4.13]
            100796232  DEAD-box ATP-dependent RNA helicase 15 isoform X2 [KO:K12812] [EC:3.6.4.13]
            100790051  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
            100810238  serine/arginine repetitive matrix protein 1 [KO:K13171]
            100791525  partner of Y14 and mago [KO:K14294]
            100820219  partner of Y14 and mago [KO:K14294]
            100781333  THO complex subunit 1 [KO:K12878]
            100790946  THO complex subunit 2 isoform X1 [KO:K12879]
            100817413  THO complex subunit 2 isoform X1 [KO:K12879]
            100775509  THO complex subunit 5A [KO:K13174]
            100816115  THO complex subunit 5A [KO:K13174]
            100813001  THO complex subunit 5B isoform X1 [KO:K13174]
            100781588  THO complex subunit 5B isoform X2 [KO:K13174]
            100820024  WD40 domain-containing protin [KO:K13175]
            100305782  uncharacterized protein LOC100305782 [KO:K13176]
            100783192  THO complex subunit 7A [KO:K13176]
            100782507  THO complex subunit 3 [KO:K12880]
            100812126  THO complex subunit 3 [KO:K12880]
REFERENCE   PMID:16777596
  AUTHORS   Tran EJ, Wente SR
  TITLE     Dynamic nuclear pore complexes: life on the edge.
  JOURNAL   Cell 125:1041-53 (2006)
            DOI:10.1016/j.cell.2006.05.027
REFERENCE   PMID:15519698
  AUTHORS   Rodriguez MS, Dargemont C, Stutz F
  TITLE     Nuclear export of RNA.
  JOURNAL   Biol Cell 96:639-55 (2004)
            DOI:10.1016/j.biolcel.2004.04.014
REFERENCE   PMID:18313922
  AUTHORS   Palancade B, Doye V
  TITLE     Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  JOURNAL   Trends Cell Biol 18:174-83 (2008)
            DOI:10.1016/j.tcb.2008.02.001
REFERENCE   PMID:15901496
  AUTHORS   Reed R, Cheng H
  TITLE     TREX, SR proteins and export of mRNA.
  JOURNAL   Curr Opin Cell Biol 17:269-73 (2005)
            DOI:10.1016/j.ceb.2005.04.011
REFERENCE   PMID:16314458
  AUTHORS   Tange TO, Shibuya T, Jurica MS, Moore MJ
  TITLE     Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  JOURNAL   RNA 11:1869-83 (2005)
            DOI:10.1261/rna.2155905
REFERENCE   PMID:28673770
  AUTHORS   Beck M, Schirmacher P, Singer S
  TITLE     Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  JOURNAL   J Hepatol 67:1051-1061 (2017)
            DOI:10.1016/j.jhep.2017.06.021
REL_PATHWAY gmx03015  mRNA surveillance pathway
KO_PATHWAY  ko03013
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