ENTRY       gmx00480                    Pathway
NAME        Glutathione metabolism - Glycine max (soybean)
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP gmx00480  Glutathione metabolism
MODULE      gmx_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:gmx00480]
DBLINKS     GO: 0006749
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100810474  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100813586  uncharacterized protein LOC100813586 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100819288  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100777131  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100797040  glutathione hydrolase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100793027  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
            100305985  uncharacterized protein LOC100305985 [KO:K22596] [EC:4.3.2.9]
            100778704  uncharacterized protein LOC100778704 [KO:K22596] [EC:4.3.2.9]
            100817414  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
            100775188  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
            547545  glutamate--cysteine ligase, chloroplastic isoform X2 [KO:K01919] [EC:6.3.2.2]
            100811211  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
            100813419  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
            100784737  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
            547989  HGS; homoglutathione synthetase [KO:K21456] [EC:6.3.2.3]
            100778473  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
            100787686  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
            100797187  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
            100808230  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
            102659388  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
            100775476  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
            100803548  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
            102664541  LOW QUALITY PROTEIN: puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
            547585  GSTU17; glutathione S-transferase GST 17 [KO:K00799] [EC:2.5.1.18]
            547587  GSTU9; glutathione S-transferase GST 19 [KO:K00799] [EC:2.5.1.18]
            547597  GSTL3; Glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
            100500281  GSTU1; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            547950  GSTU37; glutathione S-transferase GST 9 [KO:K00799] [EC:2.5.1.18]
            547951  GST24; glutathione S-transferase 24 [KO:K00799] [EC:2.5.1.18]
            547979  GSTT1; theta class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100808374  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
            100819783  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
            100799868  GSTF2; glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
            547520  GSTa; 2,4-D inducible glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            548031  glutathione S-transferase GST 20 [KO:K00799] [EC:2.5.1.18]
            100499911  GSTF13; phi class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100500680  GSTU58; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            548030  glutathione S-transferase GST 16 [KO:K00799] [EC:2.5.1.18]
            100793025  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
            547583  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100799229  GSTT2; glutathione S-transferase GSTT2 [KO:K00799] [EC:2.5.1.18]
            100816962  GSTL1; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100809406  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
            100793285  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            547588  GSTF7; glutathione S-transferase GST 21 [KO:K00799] [EC:2.5.1.18]
            547584  GSTU42; glutathione S-transferase GST 15 [KO:K00799] [EC:2.5.1.18]
            100796010  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
            547576  glutathione S-transferase GST 5 [KO:K00799] [EC:2.5.1.18]
            100775492  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
            547582  GSTU13; glutathione S-transferase GST 13 [KO:K00799] [EC:2.5.1.18]
            100305870  tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100306119  tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100306196  GSTU28; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100500052  GSTU60; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100500361  tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100527221  GSTU43; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100527381  GSTU4; uncharacterized protein LOC100527381 [KO:K00799] [EC:2.5.1.18]
            100775529  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
            100781460  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
            100782914  tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100788517  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
            100791741  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100795880  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100805827  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100805908  GSTU8; glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
            100806714  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100807613  GSTU24; probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100812340  LOW QUALITY PROTEIN: glutathione S-transferase U18 [KO:K00799] [EC:2.5.1.18]
            100819377  LOW QUALITY PROTEIN: probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
            100819805  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            547577  GSTU27; glutathione S-transferase GST 6 [KO:K00799] [EC:2.5.1.18]
            547936  GSTU47; glutathione transferase [KO:K00799] [EC:2.5.1.18]
            100527851  HSP26-A; probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            547589  GSTF5; phi class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            547578  glutathione S-transferase GST 7 [KO:K00799] [EC:2.5.1.18]
            547579  GSTU30; glutathione S-transferase GST 8 [KO:K00799] [EC:2.5.1.18]
            547586  GSTU62; glutathione S-transferase GST 18 [KO:K00799] [EC:2.5.1.18]
            547581  glutathione S-transferase GST 12 [KO:K00799] [EC:2.5.1.18]
            547580  GSTU41; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100815147  GSTF1; phi class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100500477  GSTU38; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100776076  GSTU50; tau class glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100812502  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
            548029  glutathione S-transferase GST 11 [KO:K00799] [EC:2.5.1.18]
            100808141  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100810671  GSTT3; glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
            100817305  GSTL2; glutathione S-transferase L2 [KO:K00799] [EC:2.5.1.18]
            547925  GST3; glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            100775421  LOW QUALITY PROTEIN: glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
            100813267  LOW QUALITY PROTEIN: glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
            100781859  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
            106796199  LOW QUALITY PROTEIN: glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            100816011  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
            100306061  DHAR4; DHAR class glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100805216  DHAR2; glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100819803  DHAR1; DHAR class glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            732557  DHAR3; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            547793  GR; glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
            100810846  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
            100810005  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
            100783766  glutathione reductase, cytosolic isoform X2 [KO:K00383] [EC:1.8.1.7]
            606295  IDH1; NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
            100791166  IDH; isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            100819151  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
            100786103  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
            100816688  isocitrate dehydrogenase [NADP], chloroplastic [KO:K00031] [EC:1.1.1.42]
            547455  GND; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100796103  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100803740  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100818789  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100799034  6-phosphogluconate dehydrogenase, decarboxylating 2 isoform X2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100793694  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100817852  G6PDH; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100780018  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X3 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100806107  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100811075  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100793462  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100815891  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100796541  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100777353  glucose-6-phosphate 1-dehydrogenase 1, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100801945  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100527421  uncharacterized protein LOC100527421 [KO:K00432] [EC:1.11.1.9]
            100305775  putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
            100306590  uncharacterized protein LOC100306590 [KO:K00432] [EC:1.11.1.9]
            100527034  uncharacterized protein LOC100527034 [KO:K00432] [EC:1.11.1.9]
            100527297  uncharacterized protein LOC100527297 [KO:K00432] [EC:1.11.1.9]
            100527283  uncharacterized protein LOC100527283 [KO:K00432] [EC:1.11.1.9]
            100306136  glutathione peroxidase family protein [KO:K00432] [EC:1.11.1.9]
            100306570  uncharacterized protein LOC100306570 [KO:K00432] [EC:1.11.1.9]
            100306295  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            100808523  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
            100500036  putative glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            102659700  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
            113001172  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
            100820616  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
            547682  ODC2; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            548088  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            100792107  uncharacterized protein LOC100792107 [KO:K00797] [EC:2.5.1.16]
            100792085  uncharacterized protein LOC100792085 [KO:K00797] [EC:2.5.1.16]
            100785862  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
            100790506  uncharacterized protein LOC100790506 [KO:K00797] [EC:2.5.1.16]
            100812978  spermidine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
            100815244  spermine synthase [KO:K00797] [EC:2.5.1.16]
            100816988  spermine synthase [KO:K00797] [EC:2.5.1.16]
            100809346  spermidine synthase [KO:K00797] [EC:2.5.1.16]
            100788406  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
            100802076  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
            100776863  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
            100813526  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            100806101  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            100170727  peroxisomal ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
            100170737  ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
            606508  APX2; L-ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
            100792735  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
            100795192  peroxidase-like protein [KO:K00434] [EC:1.11.1.11]
            100802238  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X2 [KO:K00434] [EC:1.11.1.11]
            553156  APX1; ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            100799504  thylakoid lumenal 29 kDa protein, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
            100784258  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X2 [KO:K00434] [EC:1.11.1.11]
            112998405  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
            547948  ribonucleotide reductase large subunit B [KO:K10807] [EC:1.17.4.1]
            548020  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
            100791639  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
            547521  ribonucleotide reductase small subunit [KO:K10808] [EC:1.17.4.1]
            100779885  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
            100820622  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
            100790224  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
COMPOUND    C00005  NADPH
            C00006  NADP+
            C00024  Acetyl-CoA
            C00025  L-Glutamate
            C00037  Glycine
            C00051  Glutathione
            C00072  Ascorbate
            C00077  L-Ornithine
            C00097  L-Cysteine
            C00127  Glutathione disulfide
            C00134  Putrescine
            C00151  L-Amino acid
            C00315  Spermidine
            C00669  gamma-L-Glutamyl-L-cysteine
            C00750  Spermine
            C01322  RX
            C01419  Cys-Gly
            C01672  Cadaverine
            C01879  5-Oxoproline
            C02090  Trypanothione
            C02320  R-S-Glutathione
            C03170  Trypanothione disulfide
            C03646  Bis-gamma-glutamylcystine
            C03740  (5-L-Glutamyl)-L-amino acid
            C05422  Dehydroascorbate
            C05726  S-Substituted L-cysteine
            C05727  S-Substituted N-acetyl-L-cysteine
            C05729  R-S-Cysteinylglycine
            C05730  Glutathionylspermidine
            C16562  Glutathionylspermine
            C16563  Bis(glutathionyl)spermine
            C16564  Bis(glutathionyl)spermine disulfide
            C16565  Aminopropylcadaverine
            C16566  Glutathionylaminopropylcadaverine
            C16567  Homotrypanothione
            C16568  Homotrypanothione disulfide
            C16663  Tryparedoxin
            C16664  Tryparedoxin disulfide
REFERENCE   PMID:12675513
  AUTHORS   Josch C, Klotz LO, Sies H.
  TITLE     Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  JOURNAL   Biol Chem 384:213-8 (2003)
            DOI:10.1515/BC.2003.023
REFERENCE   PMID:18482986
  AUTHORS   Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  TITLE     A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  JOURNAL   J Biol Chem 283:19351-8 (2008)
            DOI:10.1074/jbc.M801034200
REFERENCE   PMID:14583094
  AUTHORS   Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  TITLE     New role for leucyl aminopeptidase in glutathione turnover.
  JOURNAL   Biochem J 378:35-44 (2004)
            DOI:10.1042/BJ20031336
REFERENCE   PMID:11157967
  AUTHORS   Suzuki H, Kamatani S, Kim ES, Kumagai H.
  TITLE     Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  JOURNAL   J Bacteriol 183:1489-90 (2001)
            DOI:10.1128/JB.183.4.1489-1490.2001
REFERENCE   PMID:15610825
  AUTHORS   Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  TITLE     Trypanothione biosynthesis in Leishmania major.
  JOURNAL   Mol Biochem Parasitol 139:107-16 (2005)
            DOI:10.1016/j.molbiopara.2004.10.004
REFERENCE   PMID:12049631
  AUTHORS   Oza SL, Ariyanayagam MR, Fairlamb AH.
  TITLE     Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  JOURNAL   Biochem J 364:679-86 (2002)
            DOI:10.1042/BJ20011370
REFERENCE   PMID:9677355
  AUTHORS   Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  TITLE     Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  JOURNAL   J Biol Chem 273:19383-90 (1998)
            DOI:10.1074/jbc.273.31.19383
REFERENCE   PMID:12750367
  AUTHORS   Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  TITLE     Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 278:27612-9 (2003)
            DOI:10.1074/jbc.M302750200
REFERENCE   PMID:12967709
  AUTHORS   Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  TITLE     Properties of trypanothione synthetase from Trypanosoma brucei.
  JOURNAL   Mol Biochem Parasitol 131:25-33 (2003)
            DOI:10.1016/S0166-6851(03)00176-2
REFERENCE   PMID:12121990
  AUTHORS   Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  TITLE     A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 277:35853-61 (2002)
            DOI:10.1074/jbc.M204403200
REFERENCE   PMID:15537651
  AUTHORS   Comini M, Menge U, Wissing J, Flohe L.
  TITLE     Trypanothione synthesis in crithidia revisited.
  JOURNAL   J Biol Chem 280:6850-60 (2005)
            DOI:10.1074/jbc.M404486200
REFERENCE   PMID:7813456
  AUTHORS   Hunter KJ, Le Quesne SA, Fairlamb AH.
  TITLE     Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  JOURNAL   Eur J Biochem 226:1019-27 (1994)
            DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
REFERENCE   PMID:12751784
  AUTHORS   Krauth-Siegel RL, Meiering SK, Schmidt H.
  TITLE     The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  JOURNAL   Biol Chem 384:539-49 (2003)
            DOI:10.1515/BC.2003.062
REFERENCE   PMID:18395526
  AUTHORS   Krauth-Siegel RL, Comini MA.
  TITLE     Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  JOURNAL   Biochim Biophys Acta 1780:1236-48 (2008)
            DOI:10.1016/j.bbagen.2008.03.006
REFERENCE   PMID:8892297
  AUTHORS   Krauth-Siegel RL, Ludemann H.
  TITLE     Reduction of dehydroascorbate by trypanothione.
  JOURNAL   Mol Biochem Parasitol 80:203-8 (1996)
            DOI:10.1016/0166-6851(96)02689-8
REFERENCE   PMID:11150302
  AUTHORS   Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  TITLE     Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  JOURNAL   J Biol Chem 276:10602-6 (2001)
            DOI:10.1074/jbc.M010352200
REFERENCE   PMID:12949079
  AUTHORS   Schmidt H, Krauth-Siegel RL.
  TITLE     Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  JOURNAL   J Biol Chem 278:46329-36 (2003)
            DOI:10.1074/jbc.M305338200
REFERENCE   PMID:9851611
  AUTHORS   Tetaud E, Fairlamb AH.
  TITLE     Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  JOURNAL   Mol Biochem Parasitol 96:111-23 (1998)
            DOI:10.1016/S0166-6851(98)00120-0
REFERENCE   PMID:12446213
  AUTHORS   Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  TITLE     Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  JOURNAL   Free Radic Biol Med 33:1552-62 (2002)
            DOI:10.1016/S0891-5849(02)01089-4
REFERENCE   PMID:10713147
  AUTHORS   Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  TITLE     Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 275:8220-5 (2000)
            DOI:10.1074/jbc.275.11.8220
REFERENCE   PMID:17922848
  AUTHORS   Konig J, Fairlamb AH.
  TITLE     A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  JOURNAL   FEBS J 274:5643-58 (2007)
            DOI:10.1111/j.1742-4658.2007.06087.x
REFERENCE   PMID:12466271
  AUTHORS   Hillebrand H, Schmidt A, Krauth-Siegel RL.
  TITLE     A second class of peroxidases linked to the trypanothione metabolism.
  JOURNAL   J Biol Chem 278:6809-15 (2003)
            DOI:10.1074/jbc.M210392200
REFERENCE   PMID:14982633
  AUTHORS   Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  TITLE     Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  JOURNAL   Mol Microbiol 51:1401-12 (2004)
            DOI:10.1046/j.1365-2958.2003.03913.x
REFERENCE   PMID:6798961
  AUTHORS   Pegg AE, Shuttleworth K, Hibasami H.
  TITLE     Specificity of mammalian spermidine synthase and spermine synthase.
  JOURNAL   Biochem J 197:315-20 (1981)
            DOI:10.1042/bj1970315
REL_PATHWAY gmx00220  Arginine biosynthesis
            gmx00250  Alanine, aspartate and glutamate metabolism
            gmx00270  Cysteine and methionine metabolism
            gmx00430  Taurine and hypotaurine metabolism
            gmx00460  Cyanoamino acid metabolism
KO_PATHWAY  ko00480
///
