ENTRY       gmx00300                    Pathway
NAME        Lysine biosynthesis - Glycine max (soybean)
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP gmx00300  Lysine biosynthesis
MODULE      gmx_M00527  Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:gmx00300]
DBLINKS     GO: 0009085
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        547546  precursor monofunctional aspartokinase [KO:K00928] [EC:2.7.2.4]
            100792482  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
            100805860  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
            100803204  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
            548017  AK-HSDH; aspartokinase-homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            100812202  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            100793061  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
            100814757  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
            548067  DHPS1; 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic [KO:K01714] [EC:4.3.3.7]
            100788930  4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic [KO:K01714] [EC:4.3.3.7]
            100806626  4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic [KO:K01714] [EC:4.3.3.7]
            100807997  uncharacterized protein LOC100807997 [KO:K00215] [EC:1.17.1.8]
            100819889  4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic [KO:K00215] [EC:1.17.1.8]
            100807528  diaminopimelate epimerase, chloroplastic-like [KO:K01778] [EC:5.1.1.7]
            100784731  diaminopimelate epimerase, chloroplastic [KO:K01778] [EC:5.1.1.7]
            100807796  LL-diaminopimelate aminotransferase, chloroplastic [KO:K10206] [EC:2.6.1.83]
            100791895  aminotransferase ALD1, chloroplastic isoform X1 [KO:K10206] [EC:2.6.1.83]
            100801405  LL-diaminopimelate aminotransferase, chloroplastic [KO:K10206] [EC:2.6.1.83]
            100786832  uncharacterized protein LOC100786832 [KO:K01586] [EC:4.1.1.20]
            100809499  uncharacterized protein LOC100809499 [KO:K01586] [EC:4.1.1.20]
            100791677  diaminopimelate decarboxylase 1, chloroplastic isoform X2 [KO:K01586] [EC:4.1.1.20]
COMPOUND    C00024  Acetyl-CoA
            C00026  2-Oxoglutarate
            C00047  L-Lysine
            C00049  L-Aspartate
            C00263  L-Homoserine
            C00322  2-Oxoadipate
            C00441  L-Aspartate 4-semialdehyde
            C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
            C00666  LL-2,6-Diaminoheptanedioate
            C00680  meso-2,6-Diaminoheptanedioate
            C00956  L-2-Aminoadipate
            C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
            C03082  4-Phospho-L-aspartate
            C03871  L-2-Amino-6-oxoheptanedioate
            C03972  2,3,4,5-Tetrahydrodipicolinate
            C04002  (Z)-But-1-ene-1,2,4-tricarboxylate
            C04076  L-2-Aminoadipate 6-semialdehyde
            C04390  N6-Acetyl-LL-2,6-diaminoheptanedioate
            C04421  N-Succinyl-LL-2,6-diaminoheptanedioate
            C04462  N-Succinyl-2-L-amino-6-oxoheptanedioate
            C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
            C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
            C05535  alpha-Aminoadipoyl-S-acyl enzyme
            C05539  N-Acetyl-L-2-amino-6-oxopimelate
            C05560  L-2-Aminoadipate adenylate
            C05662  Homoisocitrate
            C16138  L-Pyrrolysine
            C19886  LysW-gamma-L-alpha-aminoadipate
            C19887  LysW-gamma-L-alpha-aminoadipyl 6-phosphate
            C19888  LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
            C19889  LysW-gamma-L-lysine
            C20258  (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
            C20277  (2R,3R)-3-Methylornithine
            C20278  (2R,3R)-3-Methylornithinyl-N6-lysine
            C20279  (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
REFERENCE   PMID:10074354
  AUTHORS   Ledwidge R, Blanchard JS.
  TITLE     The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
  JOURNAL   Biochemistry 38:3019-3024 (1999)
            DOI:10.1021/bi982574a
REFERENCE   PMID:10850974
  AUTHORS   Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
  TITLE     Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
  JOURNAL   J Bacteriol 182:3626-3631 (2000)
            DOI:10.1128/JB.182.13.3626-3631.2000
REFERENCE   PMID:10714900
  AUTHORS   Zabriskie TM, Jackson MD.
  TITLE     Lysine biosynthesis and metabolism in fungi.
  JOURNAL   Nat Prod Rep 17:85-97 (2000)
            DOI:10.1039/A801345D
REFERENCE   PMID:14627808
  AUTHORS   Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
  TITLE     Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
  JOURNAL   Nucleic Acids Res 31:6748-57 (2003)
            DOI:10.1093/nar/gkg900
REFERENCE   PMID:12355264
  AUTHORS   Velasco AM, Leguina JI, Lazcano A.
  TITLE     Molecular evolution of the lysine biosynthetic pathways.
  JOURNAL   J Mol Evol 55:445-59 (2002)
            DOI:10.1007/s00239-002-2340-2
REFERENCE   PMID:15256574
  AUTHORS   Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
  TITLE     alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
  JOURNAL   Microbiology 150:2327-34 (2004)
            DOI:10.1099/mic.0.27037-0
REFERENCE   PMID:12126930
  AUTHORS   Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
  TITLE     Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
  JOURNAL   Mol Genet Metab 76:172-80 (2002)
            DOI:10.1016/S1096-7192(02)00037-9
REFERENCE   PMID:15160885
  AUTHORS   Nishiyama M.
  TITLE     [Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
  JOURNAL   Tanpakushitsu Kakusan Koso 49:758-63 (2004)
REFERENCE   PMID:10613839
  AUTHORS   Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  TITLE     A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  JOURNAL   Genome Res 9:1175-83 (1999)
            DOI:10.1101/gr.9.12.1175
REFERENCE   PMID:12963379
  AUTHORS   Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
  TITLE     Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
  JOURNAL   J Mol Biol 332:729-40 (2003)
            DOI:10.1016/S0022-2836(03)00946-X
REFERENCE   PMID:16361515
  AUTHORS   Hudson AO, Singh BK, Leustek T, Gilvarg C.
  TITLE     An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
  JOURNAL   Plant Physiol 140:292-301 (2006)
            DOI:10.1104/pp.105.072629
REFERENCE   PMID:19620981
  AUTHORS   Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  TITLE     Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  JOURNAL   Nat Chem Biol 5:673-9 (2009)
            DOI:10.1038/nchembio.198
REFERENCE   PMID:21547300
  AUTHORS   Dairi T, Kuzuyama T, Nishiyama M, Fujii I
  TITLE     Convergent strategies in biosynthesis.
  JOURNAL   Nat Prod Rep 28:1054-86 (2011)
            DOI:10.1039/c0np00047g
REFERENCE   PMID:21550296
  AUTHORS   Gaston MA, Jiang R, Krzycki JA
  TITLE     Functional context, biosynthesis, and genetic encoding of pyrrolysine.
  JOURNAL   Curr Opin Microbiol 14:342-9 (2011)
            DOI:10.1016/j.mib.2011.04.001
REL_PATHWAY gmx00010  Glycolysis / Gluconeogenesis
            gmx00020  Citrate cycle (TCA cycle)
            gmx00250  Alanine, aspartate and glutamate metabolism
            gmx00260  Glycine, serine and threonine metabolism
            gmx00310  Lysine degradation
            gmx00620  Pyruvate metabolism
            gmx00960  Tropane, piperidine and pyridine alkaloid biosynthesis
KO_PATHWAY  ko00300
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