ENTRY       gmx00260                    Pathway
NAME        Glycine, serine and threonine metabolism - Glycine max (soybean)
DESCRIPTION Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
CLASS       Metabolism; Amino acid metabolism
PATHWAY_MAP gmx00260  Glycine, serine and threonine metabolism
MODULE      gmx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:gmx00260]
            gmx_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:gmx00260]
            gmx_M00555  Betaine biosynthesis, choline => betaine [PATH:gmx00260]
DBLINKS     GO: 0006544 0006563 0070178 0006566
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        547546  precursor monofunctional aspartokinase [KO:K00928] [EC:2.7.2.4]
            100792482  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
            100805860  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
            100803204  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
            548017  AK-HSDH; aspartokinase-homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            100812202  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
            100793061  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
            100814757  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
            100789754  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
            100805303  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
            100813292  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
            100788585  threonine synthase 1, chloroplastic [KO:K01733] [EC:4.2.3.1]
            100790890  L-allo-threonine aldolase-like [KO:K01620] [EC:4.1.2.48]
            100806463  probable low-specificity L-threonine aldolase 1 isoform X2 [KO:K01620] [EC:4.1.2.48]
            100800811  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
            100305381  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
            100305380  SHMT; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
            100816213  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
            100499635  serine hydroxymethyltransferase 5 [KO:K00600] [EC:2.1.2.1]
            100776419  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
            100793208  LOW QUALITY PROTEIN: serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
            100799472  serine hydroxymethyltransferase 7 isoform X1 [KO:K00600] [EC:2.1.2.1]
            100815417  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
            100499634  serine hydroxymethyltransferase 3 [KO:K00600] [EC:2.1.2.1]
            100779843  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
            100810926  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
            100812952  serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
            732565  serine glyoxylate aminotransferase 3 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            100786630  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
            547640  putative NADH-dependent hydroxypyruvate reductase [KO:K15893] [EC:1.1.1.29]
            548099  P42-1; conversion of hydroxypyruvate to glycerate [KO:K15893] [EC:1.1.1.29]
            100776772  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
            100777582  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 isoform X2 [KO:K01834] [EC:5.4.2.11]
            100784422  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
            100802621  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
            100804183  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
            100790852  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
            100804369  uncharacterized protein LOC100804369 [KO:K15634] [EC:5.4.2.11]
            100802260  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
            100794734  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            100820155  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
            100806896  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
            100820573  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
            100817949  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            100793819  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            100819264  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            100806526  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            100808771  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
            100798600  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
            100795286  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
            100779355  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
            100789869  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
            100814193  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
            547524  PAO1; peroxisomal copper-containing amine oxidase [KO:K00276] [EC:1.4.3.21]
            100819571  putative copper amine oxidase precursor [KO:K00276] [EC:1.4.3.21]
            100778802  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
            100798722  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
            100804651  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            100781472  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
            548000  DAO; copper amino oxidase precursor [KO:K00276] [EC:1.4.3.21]
            100802062  primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
            100800090  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            100802589  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
            100798399  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            100799555  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            100817454  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
            100817473  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
            100783091  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
            100795673  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            100814366  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
            100819714  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            100777528  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
            100778188  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
            100800509  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
            100809241  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
            547523  ferric leghemoglobin reductase-2 precursor [KO:K00382] [EC:1.8.1.4]
            100782004  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            100803176  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            100788043  leghemoglobin reductase-like [KO:K00382] [EC:1.8.1.4]
            100809578  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            100776304  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
            100306654  uncharacterized protein LOC100306654 [KO:K02437]
            100305815  glycine cleavage system H protein 2-like [KO:K02437]
            100785811  glycine cleavage system H protein, mitochondrial [KO:K02437]
            100792708  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
            100796561  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
            100170733  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100780526  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100819821  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100170738  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100804017  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100797583  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
            100127414  ALAAT2; alanine aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
            100787173  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
            100785909  choline monooxygenase, chloroplastic isoform X3 [KO:K00499] [EC:1.14.15.7]
            100170755  ALDH10A2; betaine aldehyde dehydrogenase 1 [KO:K00130] [EC:1.2.1.8]
            100170731  ALDH10A1; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
            547717  ALDH7B1; aldehyde dehydrogenase family 7 member B1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            100811186  ALDH7B2; aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            100789864  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
            100777200  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            100802802  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
            100799758  serine racemase [KO:K12235] [EC:5.1.1.18]
            100808400  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
            732610  TSA; tryptophan synthase alpha chain isoform X2 [KO:K01695] [EC:4.2.1.20]
            100170686  TSB; tryptophan synthase beta subunit [KO:K01696] [EC:4.2.1.20]
            100792812  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
            100801288  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
            100802258  tryptophan synthase beta chain 2 [KO:K06001] [EC:4.2.1.20]
COMPOUND    C00011  CO2
            C00014  Ammonia
            C00022  Pyruvate
            C00037  Glycine
            C00048  Glyoxylate
            C00049  L-Aspartate
            C00065  L-Serine
            C00078  L-Tryptophan
            C00097  L-Cysteine
            C00101  Tetrahydrofolate
            C00109  2-Oxobutanoate
            C00114  Choline
            C00143  5,10-Methylenetetrahydrofolate
            C00168  Hydroxypyruvate
            C00188  L-Threonine
            C00197  3-Phospho-D-glycerate
            C00213  Sarcosine
            C00258  D-Glycerate
            C00263  L-Homoserine
            C00300  Creatine
            C00430  5-Aminolevulinate
            C00441  L-Aspartate 4-semialdehyde
            C00546  Methylglyoxal
            C00576  Betaine aldehyde
            C00581  Guanidinoacetate
            C00631  2-Phospho-D-glycerate
            C00719  Betaine
            C00740  D-Serine
            C00986  1,3-Diaminopropane
            C01005  O-Phospho-L-serine
            C01026  N,N-Dimethylglycine
            C01102  O-Phospho-L-homoserine
            C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
            C01888  Aminoacetone
            C02051  Lipoylprotein
            C02291  L-Cystathionine
            C02737  Phosphatidylserine
            C02972  Dihydrolipoylprotein
            C03082  4-Phospho-L-aspartate
            C03194  (R)-1-Aminopropan-2-ol
            C03232  3-Phosphonooxypyruvate
            C03283  L-2,4-Diaminobutanoate
            C03508  L-2-Amino-3-oxobutanoic acid
            C05519  L-Allothreonine
            C06231  Ectoine
            C06442  N(gamma)-Acetyldiaminobutyrate
            C16432  5-Hydroxyectoine
            C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:11823218
  AUTHORS   Kuhlmann AU, Bremer E.
  TITLE     Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  JOURNAL   Appl Environ Microbiol 68:772-83 (2002)
            DOI:10.1128/AEM.68.2.772-783.2002
REFERENCE   PMID:10473374
  AUTHORS   Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  TITLE     Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  JOURNAL   Appl Environ Microbiol 65:3774-9 (1999)
            DOI:10.1128/AEM.65.9.3774-3779.1999
REFERENCE   PMID:17636255
  AUTHORS   Bursy J, Pierik AJ, Pica N, Bremer E.
  TITLE     Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  JOURNAL   J Biol Chem 282:31147-55 (2007)
            DOI:10.1074/jbc.M704023200
REFERENCE   PMID:16707670
  AUTHORS   Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  TITLE     The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  JOURNAL   J Bacteriol 188:3774-84 (2006)
            DOI:10.1128/JB.00136-06
REFERENCE   PMID:15470257
  AUTHORS   Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  TITLE     FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  JOURNAL   Eukaryot Cell 3:1287-96 (2004)
            DOI:10.1128/EC.3.5.1287-1296.2004
REFERENCE   PMID:7639721
  AUTHORS   Rees WD, Hay SM
  TITLE     The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  JOURNAL   Biochem J 309 ( Pt 3):999-1007 (1995)
            DOI:10.1042/bj3090999
REFERENCE   PMID:11341914
  AUTHORS   Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  TITLE     Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  JOURNAL   Biochim Biophys Acta 1544:28-41 (2001)
            DOI:10.1016/S0167-4838(00)00203-X
REFERENCE   PMID:15520012
  AUTHORS   Chen X, Jhee KH, Kruger WD
  TITLE     Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  JOURNAL   J Biol Chem 279:52082-6 (2004)
            DOI:10.1074/jbc.C400481200
REL_PATHWAY gmx00010  Glycolysis / Gluconeogenesis
            gmx00020  Citrate cycle (TCA cycle)
            gmx00230  Purine metabolism
            gmx00250  Alanine, aspartate and glutamate metabolism
            gmx00270  Cysteine and methionine metabolism
            gmx00290  Valine, leucine and isoleucine biosynthesis
            gmx00300  Lysine biosynthesis
            gmx00330  Arginine and proline metabolism
            gmx00460  Cyanoamino acid metabolism
            gmx00470  D-Amino acid metabolism
            gmx00564  Glycerophospholipid metabolism
            gmx00600  Sphingolipid metabolism
            gmx00620  Pyruvate metabolism
            gmx00630  Glyoxylate and dicarboxylate metabolism
            gmx00640  Propanoate metabolism
            gmx00860  Porphyrin metabolism
            gmx00920  Sulfur metabolism
KO_PATHWAY  ko00260
///
