ENTRY       gmx00053                    Pathway
NAME        Ascorbate and aldarate metabolism - Glycine max (soybean)
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP gmx00053  Ascorbate and aldarate metabolism
MODULE      gmx_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:gmx00053]
DBLINKS     GO: 0019852 0019577 0019572
ORGANISM    Glycine max (soybean) [GN:gmx]
GENE        100820448  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
            100799142  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
            548074  UGD1; UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100781197  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100802280  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100803962  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100810907  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100794368  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
            100793599  UDP-sugar pyrophosphorylase 1 [KO:K12447] [EC:2.7.7.64]
            778158  USP1; UDP-sugar pyrophosphorylase 1 [KO:K12447] [EC:2.7.7.64]
            100793412  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
            100788665  putative inositol oxygenase [KO:K00469] [EC:1.13.99.1]
            100777649  inositol oxygenase 2 isoform X1 [KO:K00469] [EC:1.13.99.1]
            100794523  uncharacterized protein LOC100794523 [KO:K00469] [EC:1.13.99.1]
            100791726  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
            100816064  aldose reductase [KO:K00002] [EC:1.1.1.2]
            100781137  uncharacterized protein LOC100781137 [KO:K00002] [EC:1.1.1.2]
            100788951  putative NADPH-dependent aldo-keto reductase [KO:K00002] [EC:1.1.1.2]
            100802323  NADPH-dependent aldo-keto reductase, chloroplastic isoform X1 [KO:K00002] [EC:1.1.1.2]
            100781684  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            100809492  aldo-keto reductase family protein isoform 1 [KO:K00002] [EC:1.1.1.2]
            100784139  aldose reductase [KO:K00002] [EC:1.1.1.2]
            100789478  NADPH-dependent aldo-keto reductase, chloroplastic isoform X2 [KO:K00002] [EC:1.1.1.2]
            100801791  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            100792657  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
            100778616  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
            100787286  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
            100801515  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100790483  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100791439  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100806810  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
            100789425  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100799814  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
            100780764  uncharacterized protein LOC100780764 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100806498  GDP-mannose 3,5-epimerase 2 isoform X2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100527798  GME1; GDP-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100794772  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100797618  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
            100800738  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
            100806541  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
            100785588  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
            100817591  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            100799849  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            100790820  inositol monophosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
            100527811  bifunctional phosphatase IMPL2, chloroplastic isoform X1 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
            100809400  uncharacterized protein LOC100809400 [KO:K17744] [EC:1.1.1.316]
            100793515  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
            100526948  putative L-galactono-1,4-lactone dehydrogenase [KO:K00225] [EC:1.3.2.3]
            100795967  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
            100818861  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
            100788739  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
            100786653  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
            100790218  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
            100788035  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
            100819586  UDP-glucuronate 4-epimerase 4 isoform X4 [KO:K08679] [EC:5.1.3.6]
            100778050  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
            100818071  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
            100819919  monodehydroascorbate reductase, chloroplastic-like [KO:K08232] [EC:1.6.5.4]
            100301881  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
            100816879  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
            100787700  pyridine nucleotide-disulphide oxidoreductase [KO:K08232] [EC:1.6.5.4]
            100500084  monodehydroascorbate reductase isoform X2 [KO:K08232] [EC:1.6.5.4]
            100813526  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            100806101  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
            100170727  peroxisomal ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
            100170737  ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
            606508  APX2; L-ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
            100792735  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
            100795192  peroxidase-like protein [KO:K00434] [EC:1.11.1.11]
            100802238  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X2 [KO:K00434] [EC:1.11.1.11]
            553156  APX1; ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            100799504  thylakoid lumenal 29 kDa protein, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
            100784258  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X2 [KO:K00434] [EC:1.11.1.11]
            112998405  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
            100306061  DHAR4; DHAR class glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100805216  DHAR2; glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100819803  DHAR1; DHAR class glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            732557  DHAR3; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100810107  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            102666289  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
            100776011  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
            100808812  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
            547647  AO; L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
            100810636  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            100782413  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            100812197  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
            100778722  ALDH3H4; aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
            100782019  ALDH2B2; aldehyde dehydrogenase family 2 member B2 [KO:K00128] [EC:1.2.1.3]
            100783726  ALDH3H2; aldehyde dehydrogenase family 3 member H2 [KO:K00128] [EC:1.2.1.3]
            100786773  ALDH2B1; aldehyde dehydrogenase family 2 member B1 [KO:K00128] [EC:1.2.1.3]
            100800699  ALDH3I1; aldehyde dehydrogenase family 3 member I1 [KO:K00128] [EC:1.2.1.3]
            100808513  ALDH3F2; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            100811501  ALDH2B4; aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
            100811891  ALDH2B5; aldehyde dehydrogenase family 2 member B5, mitochondrial [KO:K00128] [EC:1.2.1.3]
            100816594  ALDH3H3; aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            100817701  ALDH3J2; aldehyde dehydrogenase family 3 member J2 [KO:K00128] [EC:1.2.1.3]
            100798020  ALDH3J3; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            100784210  ALDH3J1; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            100809812  ALDH3F1; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
            100777399  ALDH2B8; aldehyde dehydrogenase family 2 member B8 [KO:K00128] [EC:1.2.1.3]
            100819197  ALDH3J4; aldehyde dehydrogenase family 3 member J4 [KO:K00128] [EC:1.2.1.3]
            100803104  ALDH3H1; aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
            100798892  ALDH2B6; aldehyde dehydrogenase family 2 member B6 [KO:K00128] [EC:1.2.1.3]
            547717  ALDH7B1; aldehyde dehydrogenase family 7 member B1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
            100811186  ALDH7B2; aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
COMPOUND    C00022  Pyruvate
            C00026  2-Oxoglutarate
            C00029  UDP-glucose
            C00072  Ascorbate
            C00096  GDP-mannose
            C00137  myo-Inositol
            C00167  UDP-glucuronate
            C00191  D-Glucuronate
            C00216  D-Arabinose
            C00231  D-Xylulose 5-phosphate
            C00259  L-Arabinose
            C00333  D-Galacturonate
            C00433  2,5-Dioxopentanoate
            C00545  L-Arabinonate
            C00558  D-Tagaturonate
            C00617  UDP-D-galacturonate
            C00618  3-Dehydro-L-gulonate
            C00652  D-Arabinono-1,4-lactone
            C00679  5-Dehydro-4-deoxy-D-glucarate
            C00684  2-Dehydro-3-deoxy-L-arabinonate
            C00800  L-Gulonate
            C00818  D-Glucarate
            C00878  D-Arabinonate
            C00879  D-Galactarate
            C01040  L-Gulono-1,4-lactone
            C01041  Monodehydroascorbate
            C01101  L-Ribulose 5-phosphate
            C01114  L-Arabinono-1,4-lactone
            C01115  L-Galactono-1,4-lactone
            C01146  2-Hydroxy-3-oxopropanoate
            C01620  Threonate
            C01825  L-Galactose
            C02280  GDP-L-galactose
            C02670  D-Glucuronolactone
            C03033  beta-D-Glucuronoside
            C03064  3-Dehydro-L-threonate
            C03289  L-xylo-Hexulonolactone
            C03291  L-Xylulose 5-phosphate
            C03826  2-Dehydro-3-deoxy-D-xylonate
            C03921  2-Dehydro-3-deoxy-D-glucarate
            C04037  1-Phospho-alpha-D-galacturonate
            C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
            C05385  D-Glucuronate 1-phosphate
            C05411  L-Xylonate
            C05412  L-Lyxonate
            C05422  Dehydroascorbate
            C06316  Dehydro-D-arabinono-1,4-lactone
            C14899  3-Dehydro-L-gulonate 6-phosphate
            C15923  L-Gulose
            C15924  L-Gulose 1-phosphate
            C15925  GDP-L-gulose
            C15926  beta-L-Galactose 1-phosphate
            C15930  L-Galactonate
            C16186  L-Ascorbate 6-phosphate
            C20889  D-Galactaro-1,5-lactone
            C20896  D-Galactaro-1,4-lactone
            C21955  L-Galactono-1,5-lactone
REFERENCE   PMID:17222174
  AUTHORS   Linster CL, Van Schaftingen E
  TITLE     Vitamin C. Biosynthesis, recycling and degradation in mammals.
  JOURNAL   FEBS J 274:1-22 (2007)
            DOI:10.1111/j.1742-4658.2006.05607.x
REFERENCE   PMID:15564123
  AUTHORS   Valpuesta V, Botella MA.
  TITLE     Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  JOURNAL   Trends Plant Sci 9:573-7 (2004)
            DOI:10.1016/j.tplants.2004.10.002
REFERENCE   PMID:10517845
  AUTHORS   Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  TITLE     Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  JOURNAL   Plant Physiol 121:535-43 (1999)
            DOI:10.1104/pp.121.2.535
REFERENCE   PMID:16595667
  AUTHORS   Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  TITLE     Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  JOURNAL   J Biol Chem 281:15662-70 (2006)
            DOI:10.1074/jbc.M601409200
REFERENCE   PMID:17462988
  AUTHORS   Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  TITLE     Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  JOURNAL   J Biol Chem 282:18879-85 (2007)
            DOI:10.1074/jbc.M702094200
REFERENCE   PMID:14996803
  AUTHORS   Campos E, Baldoma L, Aguilar J, Badia J.
  TITLE     Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  JOURNAL   J Bacteriol 186:1720-8 (2004)
            DOI:10.1128/JB.186.6.1720-1728.2004
REFERENCE   PMID:12644495
  AUTHORS   Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  TITLE     The ascorbate transporter of Escherichia coli.
  JOURNAL   J Bacteriol 185:2243-50 (2003)
            DOI:10.1128/JB.185.7.2243-2250.2003
REL_PATHWAY gmx00020  Citrate cycle (TCA cycle)
            gmx00040  Pentose and glucuronate interconversions
            gmx00051  Fructose and mannose metabolism
            gmx00520  Amino sugar and nucleotide sugar metabolism
            gmx00630  Glyoxylate and dicarboxylate metabolism
KO_PATHWAY  ko00053
///
