ENTRY       ath04145                    Pathway
NAME        Phagosome - Arabidopsis thaliana (thale cress)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP ath04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Arabidopsis thaliana (thale cress) [GN:ath]
GENE        AT1G51740  SYP81; syntaxin of plants 81 [KO:K08492]
            AT1G11890  SEC22; Synaptobrevin family protein [KO:K08517]
            AT5G52270  SNARE-like superfamily protein [KO:K08517]
            AT1G60490  VPS34; vacuolar protein sorting 34 [KO:K00914] [EC:2.7.1.137]
            AT1G78900  VHA-A; vacuolar ATP synthase subunit A [KO:K02145] [EC:7.1.2.2]
            AT1G76030  VAB1; ATPase, V1 complex, subunit B protein [KO:K02147]
            AT1G20260  VAB3; ATPase, V1 complex, subunit B protein [KO:K02147]
            AT4G38510  VAB2; ATPase, V1 complex, subunit B protein [KO:K02147]
            AT1G12840  DET3; vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [KO:K02148]
            AT3G58730  vacuolar ATP synthase subunit D (VATD) / V-ATPase D subunit / vacuolar proton pump D subunit (VATPD) [KO:K02149]
            AT1G64200  VHA-E3; vacuolar H+-ATPase subunit E isoform 3 [KO:K02150]
            AT3G08560  VHA-E2; vacuolar H+-ATPase subunit E isoform 2 [KO:K02150]
            AT4G11150  TUF; vacuolar ATP synthase subunit E1 [KO:K02150]
            AT4G02620  vacuolar ATPase subunit F family protein [KO:K02151]
            AT4G23710  VAG2; vacuolar ATP synthase subunit G2 [KO:K02152]
            AT4G25950  VATG3; vacuolar ATP synthase G3 [KO:K02152]
            AT3G01390  VMA10; vacuolar membrane ATPase 10 [KO:K02152]
            AT5G55290  ATPase, V0 complex, subunit E [KO:K02153]
            AT4G26710  ATPase, V0 complex, subunit E [KO:K02153]
            AT2G21410  VHA-A2; vacuolar proton ATPase A2 [KO:K02154]
            AT2G28520  VHA-A1; vacuolar proton ATPase A1 [KO:K02154]
            AT4G39080  VHA-A3; vacuolar proton ATPase A3 [KO:K02154]
            AT3G28710  ATPase, V0/A0 complex, subunit C/D [KO:K02146]
            AT3G28715  ATPase, V0/A0 complex, subunit C/D [KO:K02146]
            AT3G42050  vacuolar ATP synthase subunit H family protein [KO:K02144]
            AT1G19910  AVA-P2; ATPase, F0/V0 complex, subunit C protein [KO:K02155]
            AT1G75630  AVA-P4; vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4 [KO:K02155]
            AT2G16510  ATPase, F0/V0 complex, subunit C protein [KO:K02155]
            AT4G34720  AVA-P1; ATPase, F0/V0 complex, subunit C protein [KO:K02155]
            AT4G38920  VHA-C3; vacuolar-type H[+]-ATPase C3 [KO:K02155]
            AT2G25610  ATPase, F0/V0 complex, subunit C protein [KO:K03661]
            AT4G32530  ATPase, F0/V0 complex, subunit C protein [KO:K03661]
            AT3G18820  RAB7B; RAB GTPase homolog G3F [KO:K07897]
            AT1G52280  RABG3d; RAB GTPase homolog G3D [KO:K07897]
            AT3G16100  RABG3c; RAB GTPase homolog G3C [KO:K07897]
            AT1G22740  RABG3B; RAB GTPase homolog G3B [KO:K07897]
            AT4G09720  RABG3A; RAB GTPase homolog G3A [KO:K07897]
            AT2G21880  RAB7A; RAB GTPase homolog 7A [KO:K07897]
            AT4G14960  TUA6; Tubulin/FtsZ family protein [KO:K07374]
            AT5G19770  TUA3; tubulin alpha-3 [KO:K07374]
            AT1G04820  TUA4; tubulin alpha-4 chain [KO:K07374]
            AT1G50010  TUA2; tubulin alpha-2 chain [KO:K07374]
            AT5G19780  TUA5; tubulin alpha-5 [KO:K07374]
            AT1G64740  TUA1; alpha-1 tubulin [KO:K07374]
            AT2G29550  TUB7; tubulin beta-7 chain [KO:K07375]
            AT5G12250  TUB6; beta-6 tubulin [KO:K07375]
            AT1G20010  TUB5; tubulin beta-5 chain [KO:K07375]
            AT1G75780  TUB1; tubulin beta-1 chain [KO:K07375]
            AT4G20890  TUB9; tubulin beta-9 chain [KO:K07375]
            AT5G23860  TUB8; tubulin beta 8 [KO:K07375]
            AT5G44340  TUB4; tubulin beta chain 4 [KO:K07375]
            AT5G62690  TUB2; tubulin beta chain 2 [KO:K07375]
            AT5G62700  TUB3; tubulin beta chain 3 [KO:K07375]
            AT4G33240  FAB1A; 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A [KO:K00921] [EC:2.7.1.150]
            AT3G14270  FAB1B; phosphatidylinositol-4-phosphate 5-kinase family protein [KO:K00921] [EC:2.7.1.150]
            AT1G34260  FAB1D; FORMS APLOID AND BINUCLEATE CELLS 1A [KO:K00921] [EC:2.7.1.150]
            AT1G71010  FAB1C; FORMS APLOID AND BINUCLEATE CELLS 1C [KO:K00921] [EC:2.7.1.150]
            AT1G78720  SecY protein transport family protein [KO:K10956]
            AT1G29310  SecY protein transport family protein [KO:K10956]
            AT2G18710  SCY1; SECY homolog 1 [KO:K10956]
            AT2G34250  SecY protein transport family protein [KO:K10956]
            AT5G60460  Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
            AT2G45070  SEC61_BETA; Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
            AT3G60540  Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
            AT4G24920  secE/sec61-gamma protein transport protein [KO:K07342]
            AT3G48570  secE/sec61-gamma protein transport protein [KO:K07342]
            AT5G50460  secE/sec61-gamma protein transport protein [KO:K07342]
            AT1G09210  CRT1b; calreticulin 1b [KO:K08057]
            AT1G56340  CRT1a; calreticulin 1a [KO:K08057]
            AT1G08450  CRT3; calreticulin 3 [KO:K08057]
            AT5G61790  CNX1; calnexin 1 [KO:K08054]
            AT5G07340  Calreticulin family protein [KO:K08054]
            AT4G35020  RAC3; RAC-like 3 [KO:K04392]
            AT4G35950  RAC6; RAC-like 6 [KO:K04392]
            AT5G45970  RAC2; RAC-like 2 [KO:K04392]
            AT1G75840  ARAC5; RAC-like GTP binding protein 5 [KO:K04392]
            AT2G44690  ARAC9; RAC-like 9 [KO:K04392]
            AT3G48040  ROP10; RHO-related protein from plants 10 [KO:K04392]
            AT3G51300  ROP1; RHO-related protein from plants 1 [KO:K04392]
            AT4G28950  ROP9; RHO-related protein from plants 9 [KO:K04392]
            AT5G62880  RAC10; RAC-like 10 [KO:K04392]
            AT1G20090  ROP2; RHO-related protein from plants 2 [KO:K04392]
            AT2G17800  ARAC1; RAC-like 1 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY ath04144  Endocytosis
KO_PATHWAY  ko04145
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