ENTRY       ath00999                    Pathway
NAME        Biosynthesis of various plant secondary metabolites - Arabidopsis thaliana (thale cress)
  INCLUDING Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
CLASS       Metabolism; Biosynthesis of other secondary metabolites
PATHWAY_MAP ath00999  Biosynthesis of various plant secondary metabolites
ORGANISM    Arabidopsis thaliana (thale cress) [GN:ath]
GENE        AT2G36880  MAT3; methionine adenosyltransferase 3 [KO:K00789] [EC:2.5.1.6]
            AT3G17390  MTO3; S-adenosylmethionine synthetase family protein [KO:K00789] [EC:2.5.1.6]
            AT4G01850  SAM-2; S-adenosylmethionine synthetase 2 [KO:K00789] [EC:2.5.1.6]
            AT1G02500  SAM1; S-adenosylmethionine synthetase 1 [KO:K00789] [EC:2.5.1.6]
            AT5G04950  NAS1; nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
            AT5G56080  NAS2; nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
            AT1G09240  NAS3; nicotianamine synthase 3 [KO:K05953] [EC:2.5.1.43]
            AT1G56430  NAS4; nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
            AT1G59960  NAD(P)-linked oxidoreductase superfamily protein [KO:K22374] [EC:1.1.1.285]
            AT1G59950  NAD(P)-linked oxidoreductase superfamily protein [KO:K22374] [EC:1.1.1.285]
            AT3G06350  MEE32; dehydroquinate dehydratase, putative / shikimate dehydrogenase [KO:K13832] [EC:4.2.1.10 1.1.1.25]
            AT5G42260  BGLU12; beta glucosidase 12 [KO:K01188] [EC:3.2.1.21]
            AT5G44640  BGLU13; beta glucosidase 13 [KO:K01188] [EC:3.2.1.21]
            AT2G44450  BGLU15; beta glucosidase 15 [KO:K01188] [EC:3.2.1.21]
            AT1G26560  BGLU40; beta glucosidase 40 [KO:K01188] [EC:3.2.1.21]
            AT2G44480  BGLU17; beta glucosidase 17 [KO:K01188] [EC:3.2.1.21]
            AT3G47050  Glycosyl hydrolase family protein [KO:K01188] [EC:3.2.1.21]
            AT1G75940  ATA27; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT1G66280  BGLU22; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT1G66270  BGLU21; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT3G09260  PYK10; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT5G28510  BGLU24; beta glucosidase 24 [KO:K01188] [EC:3.2.1.21]
            AT5G36890  BGLU42; beta glucosidase 42 [KO:K01188] [EC:3.2.1.21]
            AT5G54570  BGLU41; beta glucosidase 41 [KO:K01188] [EC:3.2.1.21]
            AT2G32860  BGLU33; beta glucosidase 33 [KO:K01188] [EC:3.2.1.21]
            AT3G03640  BGLU25; beta glucosidase 25 [KO:K01188] [EC:3.2.1.21]
            AT3G21370  BGLU19; beta glucosidase 19 [KO:K01188] [EC:3.2.1.21]
            AT3G60130  BGLU16; beta glucosidase 16 [KO:K01188] [EC:3.2.1.21]
            AT2G25630  BGLU14; beta glucosidase 14 [KO:K01188] [EC:3.2.1.21]
            AT3G60140  DIN2; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT2G44470  BGLU29; beta glucosidase 29 [KO:K01188] [EC:3.2.1.21]
            AT2G44460  BGLU28; beta glucosidase 28 [KO:K01188] [EC:3.2.1.21]
            AT2G44490  PEN2; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT5G24550  BGLU32; beta glucosidase 32 [KO:K01188] [EC:3.2.1.21]
            AT5G24540  BGLU31; beta glucosidase 31 [KO:K01188] [EC:3.2.1.21]
            AT3G60120  BGLU27; beta glucosidase 27 [KO:K01188] [EC:3.2.1.21]
            AT1G02850  BGLU11; beta glucosidase 11 [KO:K01188] [EC:3.2.1.21]
            AT1G45191  BGLU1; Glycosyl hydrolase superfamily protein [KO:K01188] [EC:3.2.1.21]
            AT4G22100  BGLU3; beta glucosidase 2 [KO:K01188] [EC:3.2.1.21]
            AT4G27830  BGLU10; beta glucosidase 10 [KO:K01188] [EC:3.2.1.21]
            AT3G62750  BGLU8; beta glucosidase 8 [KO:K01188] [EC:3.2.1.21]
            AT5G16580  BGLU2; beta glucosidase 2 [KO:K01188] [EC:3.2.1.21]
            AT1G60270  BGLU6; beta glucosidase 6 [KO:K01188] [EC:3.2.1.21]
            AT3G62740  BGLU7; beta glucosidase 7 [KO:K01188] [EC:3.2.1.21]
            AT4G27820  BGLU9; beta glucosidase 9 [KO:K01188] [EC:3.2.1.21]
            AT1G60260  BGLU5; beta glucosidase 5 [KO:K01188] [EC:3.2.1.21]
            AT1G60090  BGLU4; beta glucosidase 4 [KO:K01188] [EC:3.2.1.21]
            AT3G47000  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT5G20950  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT5G20940  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT3G47040  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT5G04885  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT3G47010  Glycosyl hydrolase family protein [KO:K05349] [EC:3.2.1.21]
            AT3G18080  BGLU44; B-S glucosidase 44 [KO:K05350] [EC:3.2.1.21]
            AT1G61820  BGLU46; beta glucosidase 46 [KO:K05350] [EC:3.2.1.21]
            AT4G21760  BGLU47; beta-glucosidase 47 [KO:K05350] [EC:3.2.1.21]
            AT1G61810  BGLU45; beta-glucosidase 45 [KO:K05350] [EC:3.2.1.21]
            AT3G18070  BGLU43; beta glucosidase 43 [KO:K05350] [EC:3.2.1.21]
            AT3G13610  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K06892] [EC:1.14.11.61]
            AT1G55290  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K06892] [EC:1.14.11.61]
            AT3G12900  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [KO:K23145] [EC:1.14.11.60]
            AT4G31940  CYP82C4; cytochrome P450, family 82, subfamily C, polypeptide 4 [KO:K23136] [EC:1.14.14.164]
            AT4G31970  CYP82C2; cytochrome P450, family 82, subfamily C, polypeptide 2 [KO:K23137] [EC:1.14.14.165]
            AT1G32100  PRR1; pinoresinol reductase 1 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
            AT4G13660  PRR2; pinoresinol reductase 2 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
            AT5G61160  AACT1; anthocyanin 5-aromatic acyltransferase 1 [KO:K14329] [EC:2.3.1.64 2.3.1.-]
COMPOUND    C00019  S-Adenosyl-L-methionine
            C00024  Acetyl-CoA
            C00036  Oxaloacetate
            C00049  L-Aspartate
            C00073  L-Methionine
            C00074  Phosphoenolpyruvate
            C00078  L-Tryptophan
            C00079  L-Phenylalanine
            C00082  L-Tyrosine
            C00083  Malonyl-CoA
            C00108  Anthranilate
            C00179  Agmatine
            C00223  p-Coumaroyl-CoA
            C00251  Chorismate
            C00254  Prephenate
            C00323  Caffeoyl-CoA
            C00353  Geranylgeranyl diphosphate
            C00406  Feruloyl-CoA
            C00423  trans-Cinnamate
            C00448  trans,trans-Farnesyl diphosphate
            C00463  Indole
            C00493  Shikimate
            C00590  Coniferyl alcohol
            C00751  Squalene
            C00758  Bergaptol
            C00841  Xanthotoxol
            C01054  (S)-2,3-Epoxysqualene
            C01158  1-O-Galloyl-beta-D-glucose
            C01198  3-(2-Hydroxyphenyl)propanoate
            C01424  Gallate
            C01527  Scopolin
            C01557  Bergapten
            C01752  Scopoletin
            C01772  trans-2-Hydroxycinnamate
            C01864  Xanthotoxin
            C02162  Isopimpinellin
            C02274  Dihydrocoumarin
            C02637  3-Dehydroshikimate
            C02951  5-Hydroxyxanthotoxin
            C03506  Indoleglycerol phosphate
            C04498  p-Coumaroylagmatine
            C04576  Pentagalloylglucose
            C04831  DIMBOA-glucoside
            C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
            C05324  Nicotianamine
            C05366  (+)-Pinoresinol
            C05838  cis-2-Hydroxycinnamate
            C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
            C05851  Coumarin
            C06098  Zeaxanthin
            C06972  Dronabinol
            C07578  Cannabidiol
            C08304  Gramine
            C08307  Hordatine A
            C08308  Hordatine B
            C08588  Crocetin
            C08589  Crocin
            C08946  Ginsenoside Rg1
            C09060  Angelicin
            C09263  Esculetin
            C09265  Fraxetin
            C09276  Marmesin
            C09305  Psoralen
            C09311  Scoparone
            C09315  Umbelliferone
            C10556  Deoxypodophyllotoxin
            C10557  Dihydroanhydropodorhizol
            C10646  Lariciresinol
            C10682  Matairesinol
            C10784  Cannabidiolic acid
            C10874  Podophyllotoxin
            C11130  3-Hydroxyindolin-2-one
            C12312  Indolin-2-one
            C15485  2'-Deoxymugineic acid
            C15486  3''-Deamino-3''-oxonicotianamine
            C15500  Mugineic acid
            C15501  3-Epihydroxymugineic acid
            C15502  3-Epihydroxy-2'-deoxymugineic acid
            C15769  HBOA
            C15770  DIBOA
            C15772  DIBOA-glucoside
            C17055  Picrocrocin
            C17062  Safranal
            C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
            C18062  TRIBOA-glucoside
            C18079  Isoscopoletin
            C18080  Osthenol
            C18083  Demethylsuberosin
            C18167  Secoisolariciresinol
            C18325  Feruloylagmatine
            C19707  (+)-Columbianetin
            C19730  Crocetin dialdehyde
            C19731  (3S)-3-Hydroxycyclocitral
            C19829  Dammarenediol-II
            C19867  beta-D-Glucosyl crocetin
            C19868  Bis(beta-D-glucosyl) crocetin
            C19869  beta-D-Gentiobiosyl crocetin
            C20406  Cannabigerolate
            C20413  3,5,7-Trioxododecanoyl-CoA
            C20417  2,4-Dihydroxy-6-pentylbenzoate
            C20454  (-)-Lariciresinol
            C20455  (-)-Pinoresinol
            C20456  (+)-Secoisolariciresinol
            C20713  Ginsenoside Rb1
            C20715  Protopanaxadiol
            C20716  Protopanaxatriol
            C20725  Ginsenoside Rd
            C20778  Ginsenoside Rg3
            C20779  Ginsenoside F2
            C20780  Ginsenoside F1
            C20894  beta-Citraurin
            C21183  Bursehernin
            C21184  (-)-5'-Demethylyatein
            C21191  Pluviatolide
            C21459  6-Hydroxyferuloyl-CoA
            C21601  3-(Aminomethyl)indole
            C21602  (1H-Indol-3-yl)-N-methylmethanamine
            C21903  Delta9-Tetrahydrocannabinolate
            C22007  Sideretin
            C22070  2,4-Dihydroxycinnamoyl-CoA
            C22127  Ginsenoside C-K
            C22128  (20S)-Ginsenoside Rh2
            C22129  Ginsenoside Rh1
            C22152  Bergamottin
            C22153  Epoxybergamottin
            C22156  6',7'-Dihydroxybergamottin
            C22438  3,5-Dehydroshikimate
            C22444  5,8-Dihydroxypsoralen
            C22445  8-Hydroxybergapten
            C22452  6,7,8-Trihydroxycoumarin
REFERENCE   PMID:22569263
  AUTHORS   Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  TITLE     UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  JOURNAL   FEBS Lett 586:1055-61 (2012)
            DOI:10.1016/j.febslet.2012.03.003
REFERENCE   PMID:17544411
  AUTHORS   Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  TITLE     Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  JOURNAL   FEBS Lett 581:2929-34 (2007)
            DOI:10.1016/j.febslet.2007.05.043
REFERENCE   PMID:9952442
  AUTHORS   Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  TITLE     Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  JOURNAL   Plant Physiol 119:471-80 (1999)
            DOI:10.1104/pp.119.2.471
REFERENCE   PMID:7622460
  AUTHORS   Ma JF, Shinada T, Matsuda C, Nomoto K
  TITLE     Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  JOURNAL   J Biol Chem 270:16549-54 (1995)
            DOI:10.1074/jbc.270.28.16549
REFERENCE   PMID:33346890
  AUTHORS   Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  TITLE     Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  JOURNAL   Planta 253:3 (2020)
            DOI:10.1007/s00425-020-03516-w
REFERENCE   PMID:26558757
  AUTHORS   Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  TITLE     The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  JOURNAL   PLoS One 10:e0142757 (2015)
            DOI:10.1371/journal.pone.0142757
REFERENCE   PMID:15009205
  AUTHORS   Hehmann M, Lukacin R, Ekiert H, Matern U
  TITLE     Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  JOURNAL   Eur J Biochem 271:932-40 (2004)
            DOI:10.1111/j.1432-1033.2004.03995.x
REFERENCE   PMID:26359402
  AUTHORS   Lau W, Sattely ES
  TITLE     Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  JOURNAL   Science 349:1224-8 (2015)
            DOI:10.1126/science.aac7202
REL_PATHWAY ath00010  Glycolysis / Gluconeogenesis
            ath00020  Citrate cycle (TCA cycle)
            ath00270  Cysteine and methionine metabolism
            ath00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            ath00900  Terpenoid backbone biosynthesis
            ath00940  Phenylpropanoid biosynthesis
KO_PATHWAY  ko00999
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