ENTRY       ath00600                    Pathway
NAME        Sphingolipid metabolism - Arabidopsis thaliana (thale cress)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP ath00600  Sphingolipid metabolism
MODULE      ath_M00100  Sphingosine degradation [PATH:ath00600]
DBLINKS     GO: 0006665
ORGANISM    Arabidopsis thaliana (thale cress) [GN:ath]
GENE        AT5G23670  LCB2; long chain base2 [KO:K00654] [EC:2.3.1.50]
            AT3G48780  SPT1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
            AT3G48790  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [KO:K00654] [EC:2.3.1.50]
            AT4G36480  LCB1; long-chain base1 [KO:K00654] [EC:2.3.1.50]
            AT3G06060  TSC10A; NAD(P)-binding Rossmann-fold superfamily protein [KO:K04708] [EC:1.1.1.102]
            AT5G19200  TSC10B; NAD(P)-binding Rossmann-fold superfamily protein [KO:K04708] [EC:1.1.1.102]
            AT1G07380  Neutral/alkaline non-lysosomal ceramidase [KO:K12349] [EC:3.5.1.23]
            AT2G38010  Neutral/alkaline non-lysosomal ceramidase [KO:K12349] [EC:3.5.1.23]
            AT5G58980  Neutral/alkaline non-lysosomal ceramidase [KO:K12349] [EC:3.5.1.23]
            AT4G22330  ATCES1; Alkaline phytoceramidase (aPHC) [KO:K04711] [EC:3.5.1.-]
            AT4G04930  DES-1-LIKE; fatty acid desaturase family protein [KO:K04712] [EC:1.14.19.17 1.14.18.5]
            AT1G14290  SBH2; sphingoid base hydroxylase 2 [KO:K04713] [EC:1.14.18.5]
            AT1G69640  SBH1; sphingoid base hydroxylase 1 [KO:K04713] [EC:1.14.18.5]
            AT5G51290  ACD5; Diacylglycerol kinase family protein [KO:K04715] [EC:2.7.1.138]
            AT4G21540  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
            AT4G21534  SPHK2; Diacylglycerol kinase family protein [KO:K04718] [EC:2.7.1.91]
            AT1G27980  DPL1; dihydrosphingosine phosphate lyase [KO:K01634] [EC:4.1.2.27]
            AT3G24180  Beta-glucosidase, GBA2 type family protein [KO:K17108] [EC:3.2.1.45]
            AT5G49900  Beta-glucosidase, GBA2 type family protein [KO:K17108] [EC:3.2.1.45]
            AT4G10060  Beta-glucosidase, GBA2 type family protein [KO:K17108] [EC:3.2.1.45]
            AT1G33700  Beta-glucosidase, GBA2 type family protein [KO:K17108] [EC:3.2.1.45]
            AT3G54440  glycoside hydrolase family 2 protein [KO:K01190] [EC:3.2.1.23]
            AT1G72990  BGAL17; beta-galactosidase 17 [KO:K12309] [EC:3.2.1.23]
            AT3G52840  BGAL2; beta-galactosidase 2 [KO:K12309] [EC:3.2.1.23]
            AT3G56310  Melibiase family protein [KO:K07407] [EC:3.2.1.22]
            AT5G08370  AGAL2; alpha-galactosidase 2 [KO:K07407] [EC:3.2.1.22]
            AT5G08380  AGAL1; alpha-galactosidase 1 [KO:K07407] [EC:3.2.1.22]
            AT3G55260  HEXO1; beta-hexosaminidase 1 [KO:K12373] [EC:3.2.1.52]
            AT1G65590  HEXO3; beta-hexosaminidase 3 [KO:K12373] [EC:3.2.1.52]
            AT1G05590  HEXO2; beta-hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
            AT3G51730  saposin B domain-containing protein [KO:K12382]
            AT5G01800  saposin B domain-containing protein [KO:K12382]
COMPOUND    C00065  L-Serine
            C00154  Palmitoyl-CoA
            C00195  N-Acylsphingosine
            C00319  Sphingosine
            C00346  Ethanolamine phosphate
            C00550  Sphingomyelin
            C00836  Sphinganine
            C01120  Sphinganine 1-phosphate
            C01190  Glucosylceramide
            C01290  Lactosylceramide
            C01747  Psychosine
            C02686  Galactosylceramide
            C02934  3-Dehydrosphinganine
            C02960  Ceramide 1-phosphate
            C03405  Lactosylceramide sulfate
            C03640  Sphingosyl-phosphocholine
            C05681  Ceramide 2-aminoethylphosphonate
            C06062  Ceramide phosphoethanolamine
            C06124  Sphingosine 1-phosphate
            C06125  Sulfatide
            C06126  Digalactosylceramide
            C06127  Digalactosylceramide sulfate
            C06128  GM4
            C12126  Dihydroceramide
            C12144  Phytosphingosine
            C12145  Phytoceramide
            C22467  Gangliotriaosylceramide-II3 sulfate
REFERENCE   PMID:12011104
  AUTHORS   Merrill AH Jr.
  TITLE     De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  JOURNAL   J Biol Chem 277:25843-6 (2002)
            DOI:10.1074/jbc.R200009200
REFERENCE   PMID:10652340
  AUTHORS   Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  TITLE     Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  JOURNAL   J Biol Chem 275:3462-8 (2000)
            DOI:10.1074/jbc.275.5.3462
REFERENCE   PMID:11305904
  AUTHORS   Hannun YA, Luberto C, Argraves KM.
  TITLE     Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  JOURNAL   Biochemistry 40:4893-903 (2001)
            DOI:10.1021/bi002836k
REFERENCE   PMID:1495423
  AUTHORS   Merrill AH Jr, Wang E.
  TITLE     Enzymes of ceramide biosynthesis.
  JOURNAL   Methods Enzymol 209:427-37 (1992)
            DOI:10.1016/0076-6879(92)09053-6
REFERENCE   PMID:8457204
  AUTHORS   Hirschberg K, Rodger J, Futerman AH.
  TITLE     The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  JOURNAL   Biochem J 290 ( Pt 3):751-7 (1993)
            DOI:10.1042/bj2900751
REFERENCE   PMID:10366774
  AUTHORS   Dickson RC, Lester RL.
  TITLE     Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  JOURNAL   Biochim Biophys Acta 1438:305-21 (1999)
            DOI:10.1016/S1388-1981(99)00068-2
REL_PATHWAY ath00260  Glycine, serine and threonine metabolism
            ath00601  Glycosphingolipid biosynthesis - lacto and neolacto series
            ath00603  Glycosphingolipid biosynthesis - globo and isoglobo series
            ath00604  Glycosphingolipid biosynthesis - ganglio series
KO_PATHWAY  ko00600
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