ENTRY       ath00590                    Pathway
NAME        Arachidonic acid metabolism - Arabidopsis thaliana (thale cress)
CLASS       Metabolism; Lipid metabolism
PATHWAY_MAP ath00590  Arachidonic acid metabolism
DBLINKS     GO: 0019369
ORGANISM    Arabidopsis thaliana (thale cress) [GN:ath]
GENE        AT2G06925  PLA2-ALPHA; Phospholipase A2 family protein [KO:K01047] [EC:3.1.1.4]
            AT3G57140  SDP1-LIKE; sugar-dependent 1-like protein [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
            AT5G04040  SDP1; Patatin-like phospholipase family protein [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
            AT5G42150  Glutathione S-transferase family protein [KO:K05309] [EC:5.3.99.3]
            AT3G59710  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            AT5G61830  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            AT5G51030  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
            AT5G13520  peptidase M1 family protein [KO:K01254] [EC:3.3.2.6]
            AT4G39640  GGT1; gamma-glutamyl transpeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            AT4G39650  GGT2; gamma-glutamyl transpeptidase 2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            AT1G69820  GGT3; gamma-glutamyl transpeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            AT4G29210  GGT4; gamma-glutamyl transpeptidase 4 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
COMPOUND    C00157  Phosphatidylcholine
            C00219  Arachidonate
            C00427  Prostaglandin H2
            C00584  Prostaglandin E2
            C00639  Prostaglandin F2alpha
            C00696  Prostaglandin D2
            C00909  Leukotriene A4
            C01312  Prostaglandin I2
            C02165  Leukotriene B4
            C02166  Leukotriene C4
            C02198  Thromboxane A2
            C03577  20-Hydroxyleukotriene E4
            C04577  15-OxoETE
            C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
            C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
            C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
            C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
            C04805  5(S)-HETE
            C04822  8(R)-HPETE
            C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
            C04853  20-OH-Leukotriene B4
            C05356  5(S)-HPETE
            C05949  12-Keto-leukotriene B4
            C05950  20-COOH-Leukotriene B4
            C05951  Leukotriene D4
            C05952  Leukotriene E4
            C05953  Prostaglandin A2
            C05954  Prostaglandin B2
            C05955  Prostaglandin C2
            C05956  Prostaglandin G2
            C05957  Prostaglandin J2
            C05958  Delta-12-Prostaglandin J2
            C05959  11-epi-Prostaglandin F2alpha
            C05960  15-Keto-prostaglandin F2alpha
            C05961  6-Keto-prostaglandin F1alpha
            C05962  6-Keto-prostaglandin E1
            C05963  Thromboxane B2
            C05964  11-Dehydro-thromboxane B2
            C05965  12(S)-HPETE
            C05966  15(S)-HPETE
            C06314  Lipoxin A4
            C06315  Lipoxin B4
            C06462  Leukotriene F4
            C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
            C14717  15-Deoxy-Delta12,14-PGJ2
            C14732  5-OxoETE
            C14748  20-HETE
            C14749  19(S)-HETE
            C14768  5,6-EET
            C14769  8,9-EET
            C14770  11,12-EET
            C14771  14,15-EET
            C14772  5,6-DHET
            C14773  8,9-DHET
            C14774  11,12-DHET
            C14775  14,15-DHET
            C14776  8(S)-HETE
            C14777  12(S)-HETE
            C14778  16(R)-HETE
            C14779  9(S)-HETE
            C14780  11(R)-HETE
            C14781  15H-11,12-EETA
            C14782  11,12,15-THETA
            C14794  2,3-Dinor-8-iso prostaglandin F2alpha
            C14795  2,3-Dinor-8-iso prostaglandin F1alpha
            C14807  12-OxoETE
            C14808  Hepoxilin A3
            C14809  Trioxilin A3
            C14810  Hepoxilin B3
            C14811  Trioxilin B3
            C14812  12(R)-HPETE
            C14813  11H-14,15-EETA
            C14814  11,14,15-THETA
            C14815  5,6-Epoxytetraene
            C14820  11(R)-HPETE
            C14821  9(S)-HPETE
            C14822  12(R)-HETE
            C14823  8(S)-HPETE
            C14824  8(R)-HETE
REFERENCE   PMID:14636671
  AUTHORS   Spector AA, Fang X, Snyder GD, Weintraub NL.
  TITLE     Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  JOURNAL   Prog Lipid Res 43:55-90 (2004)
            DOI:10.1016/S0163-7827(03)00049-3
REFERENCE   PMID:15292194
  AUTHORS   Harman CA, Rieke CJ, Garavito RM, Smith WL.
  TITLE     Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  JOURNAL   J Biol Chem 279:42929-35 (2004)
            DOI:10.1074/jbc.M403013200
REFERENCE   PMID:15205388
  AUTHORS   Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  TITLE     The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  JOURNAL   Drug Metab Dispos 32:727-33 (2004)
            DOI:10.1124/dmd.32.7.727
REFERENCE   PMID:14660610
  AUTHORS   Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  TITLE     CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  JOURNAL   J Biol Chem 279:6305-14 (2004)
            DOI:10.1074/jbc.M311830200
REFERENCE   PMID:14626496
  AUTHORS   Sacerdoti D, Gatta A, McGiff JC.
  TITLE     Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  JOURNAL   Prostaglandins Other Lipid Mediat 72:51-71 (2003)
            DOI:10.1016/S1098-8823(03)00077-7
REFERENCE   PMID:14622984
  AUTHORS   Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  TITLE     Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  JOURNAL   Arch Biochem Biophys 420:142-52 (2003)
            DOI:10.1016/j.abb.2003.09.026
REFERENCE   PMID:11679404
  AUTHORS   Fleming I.
  TITLE     Cytochrome p450 and vascular homeostasis.
  JOURNAL   Circ Res 89:753-62 (2001)
            DOI:10.1161/hh2101.099268
REFERENCE   PMID:11328810
  AUTHORS   Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  TITLE     Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  JOURNAL   J Biol Chem 276:25467-79 (2001)
            DOI:10.1074/jbc.M100545200
REFERENCE   PMID:10908295
  AUTHORS   Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  TITLE     CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  JOURNAL   Mol Pharmacol 58:279-87 (2000)
            DOI:10.1124/mol.58.2.279
REFERENCE   PMID:9812980
  AUTHORS   Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  TITLE     Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  JOURNAL   J Biol Chem 273:30879-87 (1998)
            DOI:10.1074/jbc.273.47.30879
REL_PATHWAY ath00591  Linoleic acid metabolism
KO_PATHWAY  ko00590
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