ENTRY       ath00030                    Pathway
NAME        Pentose phosphate pathway - Arabidopsis thaliana (thale cress)
DESCRIPTION The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
CLASS       Metabolism; Carbohydrate metabolism
PATHWAY_MAP ath00030  Pentose phosphate pathway
MODULE      ath_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:ath00030]
            ath_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ath00030]
            ath_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:ath00030]
            ath_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:ath00030]
DBLINKS     GO: 0006098
ORGANISM    Arabidopsis thaliana (thale cress) [GN:ath]
GENE        AT4G24620  PGI1; phosphoglucose isomerase 1 [KO:K01810] [EC:5.3.1.9]
            AT5G42740  Sugar isomerase (SIS) family protein [KO:K01810] [EC:5.3.1.9]
            AT3G27300  G6PD5; glucose-6-phosphate dehydrogenase 5 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT5G13110  G6PD2; glucose-6-phosphate dehydrogenase 2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT1G09420  G6PD4; glucose-6-phosphate dehydrogenase 4 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT5G35790  G6PD1; glucose-6-phosphate dehydrogenase 1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT1G24280  G6PD3; glucose-6-phosphate dehydrogenase 3 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT5G40760  G6PD6; glucose-6-phosphate dehydrogenase 6 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            AT5G24410  PGL4; 6-phosphogluconolactonase 4 [KO:K01057] [EC:3.1.1.31]
            AT5G24420  PGL5; 6-phosphogluconolactonase 5 [KO:K01057] [EC:3.1.1.31]
            AT3G49360  PGL2; 6-phosphogluconolactonase 2 [KO:K01057] [EC:3.1.1.31]
            AT1G13700  PGL1; 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
            AT5G24400  EMB2024; NagB/RpiA/CoA transferase-like superfamily protein [KO:K01057] [EC:3.1.1.31]
            AT1G64190  6-phosphogluconate dehydrogenase family protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            AT5G41670  6-phosphogluconate dehydrogenase family protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            AT3G02360  6-phosphogluconate dehydrogenase family protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            AT1G63290  Aldolase-type TIM barrel family protein [KO:K01783] [EC:5.1.3.1]
            AT5G61410  RPE; D-ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]
            AT3G01850  Aldolase-type TIM barrel family protein [KO:K01783] [EC:5.1.3.1]
            AT3G60750  Transketolase [KO:K00615] [EC:2.2.1.1]
            AT2G45290  Transketolase [KO:K00615] [EC:2.2.1.1]
            AT5G13420  TRA2; Aldolase-type TIM barrel family protein [KO:K00616] [EC:2.2.1.2]
            AT1G12230  Aldolase superfamily protein [KO:K00616] [EC:2.2.1.2]
            AT1G71100  RSW10; Ribose 5-phosphate isomerase, type A protein [KO:K01807] [EC:5.3.1.6]
            AT2G01290  RPI2; ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
            AT3G04790  EMB3119; Ribose 5-phosphate isomerase, type A protein [KO:K01807] [EC:5.3.1.6]
            AT5G44520  NagB/RpiA/CoA transferase-like superfamily protein [KO:K01807] [EC:5.3.1.6]
            AT1G17160  pfkB-like carbohydrate kinase family protein [KO:K00852] [EC:2.7.1.15]
            AT5G51820  PGM; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
            AT1G23190  PGM3; Phosphoglucomutase/phosphomannomutase family protein [KO:K01835] [EC:5.4.2.2]
            AT1G70730  PGM2; Phosphoglucomutase/phosphomannomutase family protein [KO:K01835] [EC:5.4.2.2]
            AT2G44530  Phosphoribosyltransferase family protein [KO:K00948] [EC:2.7.6.1]
            AT1G32380  PRS2; phosphoribosyl pyrophosphate (PRPP) synthase 2 [KO:K00948] [EC:2.7.6.1]
            AT2G35390  Phosphoribosyltransferase family protein [KO:K00948] [EC:2.7.6.1]
            AT2G24270  ALDH11A3; aldehyde dehydrogenase 11A3 [KO:K00131] [EC:1.2.1.9]
            AT2G16790  P-loop containing nucleoside triphosphate hydrolases superfamily protein [KO:K00851] [EC:2.7.1.12]
            AT4G26520  FBA7; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT2G36460  FBA6; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT3G52930  FBA8; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT2G01140  PDE345; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT4G38970  FBA2; fructose-bisphosphate aldolase 2 [KO:K01623] [EC:4.1.2.13]
            AT4G26530  FBA5; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT5G03690  FBA4; Aldolase superfamily protein [KO:K01623] [EC:4.1.2.13]
            AT2G21330  FBA1; fructose-bisphosphate aldolase 1 [KO:K01623] [EC:4.1.2.13]
            AT1G43670  FBP; Inositol monophosphatase family protein [KO:K03841] [EC:3.1.3.11]
            AT3G54050  HCEF1; high cyclic electron flow 1 [KO:K03841] [EC:3.1.3.11]
            AT5G64380  Inositol monophosphatase family protein [KO:K03841] [EC:3.1.3.11]
            AT4G32840  PFK6; phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
            AT5G56630  PFK7; phosphofructokinase 7 [KO:K00850] [EC:2.7.1.11]
            AT5G61580  PFK4; phosphofructokinase 4 [KO:K00850] [EC:2.7.1.11]
            AT4G29220  PFK1; phosphofructokinase 1 [KO:K00850] [EC:2.7.1.11]
            AT2G22480  PFK5; phosphofructokinase 5 [KO:K00850] [EC:2.7.1.11]
            AT4G26270  PFK3; phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
            AT5G47810  PFK2; phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
            AT1G76550  Phosphofructokinase family protein [KO:K00895] [EC:2.7.1.90]
            AT4G04040  MEE51; Phosphofructokinase family protein [KO:K00895] [EC:2.7.1.90]
            AT1G12000  Phosphofructokinase family protein [KO:K00895] [EC:2.7.1.90]
            AT1G20950  Phosphofructokinase family protein [KO:K00895] [EC:2.7.1.90]
COMPOUND    C00022  Pyruvate
            C00031  D-Glucose
            C00117  D-Ribose 5-phosphate
            C00118  D-Glyceraldehyde 3-phosphate
            C00119  5-Phospho-alpha-D-ribose 1-diphosphate
            C00121  D-Ribose
            C00197  3-Phospho-D-glycerate
            C00198  D-Glucono-1,5-lactone
            C00199  D-Ribulose 5-phosphate
            C00204  2-Dehydro-3-deoxy-D-gluconate
            C00221  beta-D-Glucose
            C00231  D-Xylulose 5-phosphate
            C00257  D-Gluconic acid
            C00258  D-Glycerate
            C00279  D-Erythrose 4-phosphate
            C00345  6-Phospho-D-gluconate
            C00577  D-Glyceraldehyde
            C00620  alpha-D-Ribose 1-phosphate
            C00631  2-Phospho-D-glycerate
            C00668  alpha-D-Glucose 6-phosphate
            C00672  2-Deoxy-D-ribose 1-phosphate
            C00673  2-Deoxy-D-ribose 5-phosphate
            C01151  D-Ribose 1,5-bisphosphate
            C01172  beta-D-Glucose 6-phosphate
            C01182  D-Ribulose 1,5-bisphosphate
            C01218  6-Phospho-2-dehydro-D-gluconate
            C01236  D-Glucono-1,5-lactone 6-phosphate
            C01801  Deoxyribose
            C03752  2-Amino-2-deoxy-D-gluconate
            C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
            C05345  beta-D-Fructose 6-phosphate
            C05378  beta-D-Fructose 1,6-bisphosphate
            C05382  Sedoheptulose 7-phosphate
            C06019  D-arabino-Hex-3-ulose 6-phosphate
            C06473  2-Keto-D-gluconic acid
            C20589  D-Glucosaminate-6-phosphate
REFERENCE   
  AUTHORS   Nishizuka Y (ed).
  TITLE     [Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1980)
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   
  AUTHORS   Michal G.
  TITLE     Biochemical Pathways
  JOURNAL   Wiley (1999)
REFERENCE   PMID:12700258
  AUTHORS   Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  TITLE     Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  JOURNAL   J Bacteriol 185:2793-801 (2003)
            DOI:10.1128/JB.185.9.2793-2801.2003
REFERENCE   PMID:16788179
  AUTHORS   Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  TITLE     The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  JOURNAL   J Bacteriol 188:4698-704 (2006)
            DOI:10.1128/JB.00492-06
REFERENCE   PMID:16428816
  AUTHORS   Kato N, Yurimoto H, Thauer RK
  TITLE     The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  JOURNAL   Biosci Biotechnol Biochem 70:10-21 (2006)
            DOI:10.1271/bbb.70.10
REFERENCE   PMID:23279921
  AUTHORS   Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  TITLE     Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  JOURNAL   FEBS J 280:1126-38 (2013)
            DOI:10.1111/febs.12106
REFERENCE   PMID:16458304
  AUTHORS   Reher M, Schonheit P
  TITLE     Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  JOURNAL   FEBS Lett 580:1198-204 (2006)
            DOI:10.1016/j.febslet.2006.01.029
REFERENCE   PMID:20023024
  AUTHORS   Reher M, Fuhrer T, Bott M, Schonheit P
  TITLE     The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  JOURNAL   J Bacteriol 192:964-74 (2010)
            DOI:10.1128/JB.01281-09
REL_PATHWAY ath00010  Glycolysis / Gluconeogenesis
            ath00040  Pentose and glucuronate interconversions
            ath00052  Galactose metabolism
            ath00230  Purine metabolism
            ath00240  Pyrimidine metabolism
            ath00340  Histidine metabolism
            ath00630  Glyoxylate and dicarboxylate metabolism
            ath00750  Vitamin B6 metabolism
KO_PATHWAY  ko00030
///
