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[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c(N([H])C(=O)c3c([H])c([H])c([H])c(C([H])([H])[H])c3[H])c([H])c2[H])c([H])c1C([H])([H])C([H])([H])N2C([H])([H])C2([H])[H]
[H]c1nc(C([H])([H])[H])c([H])c2nc(N3C([H])([H])C([H])([H])N([H])C3([H])[H])c([H])c2c1[H]
[H]c1c([H])c([H])c([H])c([H])c1Cl
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[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H])c([H])c1[H]
[H]c1nc(N([H])c2c([H])c([H])c(N([H])c3c([H])c([H])c(N([H])c4c([H])c([H])c([H])c([H])c4[H])c([H])c3[H])c([H])c2[H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]Oc1c([H])c([H])c([H])c([H])c1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c([H])c([H])c2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c1c([H])c([H])c([H])c([H])c1[H]
[H]c1nc(N([H])[H])c([H])c(N([H])[H])c1[H]
[H]c1nc(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N/C([H])([H])C([H])([H])N2C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])nc([H])c1C([H])([H])N([H])[H]
[H]OC(=O)C([H])([H])C([H])=C([H])c1c([H])n([H])c([H])c1[H]
[H]Oc1c([H])c([H])c(C([H])([H])Oc2c([H])c([H])c(C([H])([H])C([H])([H])[H])c([H])c(N([H])c3c([H])c([H])c(C(F)(F)F)c([H])c3[H])c([H])c2[H])c([H])c1[H]
[H]c1nc(N([H])C(=O)N([H])c2c([H])c([H])c([H])c([H])c2[H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3C2([H])[H])C([H])([H])C1([H])[H]
[H]c1nc(C([H])([H])[H])c(N([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])c2c([H])c([H])c([H])c([H])c2[H])c(C([H])([H])[H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c([H])c([H])c2[H])c([H])c1[H]
[H]c1nc(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])Sc2c([H])c1[H]
[H]c1nc(N([H])[H])c([H])nc1-c1c([H])c([H])c([H])c(O[C@]([H])(N([H])[H])N([H])[H])c1
[H]c1nc(C([H])([H])[H])c([H])c(N2C([H])([H])c3c([H])c([H])c([H])c(OC([H])([H])[H])c3[H])c([H])c(C([H])([H])[H])c2nc1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]c1nc(N([H])C(=O)N([H])c2c([H])c([H])c(Cl)c([H])c2[H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])[H])c([H])c1[H]
[H]c1nc(N([H])[H])c([H])c([H])c1N([H])C(=O)c1c([H])c([H])c([H])c([H])c1[H]
[H]c1nc([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C2([H])[H])nc2c1[H]
[H]/N=C
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[H]c1c([H])c([H])c(OC([H])([H])[H])c([H])c1[H]
[H]c1nc(-c2c([H])c(OC(=O)C([H])([H])[H])c([H])c(C([H])([H])[H])c2[H])n(C([H])([H])C([H])([H])N2C([H])([H])C2([H])[H])c1[H]
[H]c1nc(C([H])([H])[H])c([H])c([H])c1N([H])C(=O)c1c([H])c([H])c([H])c([H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])OC([H])([H])N([H])C(=O)c3c([H])c([H])c([H])c([H])c3OC([H])([H])C2([H])[H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]c1c([H])c([H])c(N2C([H])([H])C(=O)c3c([H])c([H])c(N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C3([H])[H])c([H])c3C([H])([H])C([H])([H])C3([H])[H])c([H])c3[H])c([H])c2[H])c([H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)c3c([H])c([H])c([H])c([H])c3[H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])c([H])c1[H]
[H]c1nc(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])c1[H]
N
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[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c(C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H])c([H])c2[H])c([H])c1[H]
[H]c1nc(N([H])C(=O)c2c([H])c([H])c(C([H])([H])[H])c([H])c2[H])c(C([H])([H])[H])nc1[H]
[H]c1c([H])c([H])c(OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c([H])c([H])c2[H])c([H])c1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)c1c([H])c([H])c([H])c(C([H])([H])[H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]c1c([H])c([H])c(OC([H])([H])Oc2c([H])c([H])c([H])c([H])c2[H])c([H])c1[H]
[H]Oc1c([H])c([H])c(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])N([H])C(=O)c2c([H])c([H])c(Cl)c([H])c2[H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])[H])c([H])c1OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c([H])c([H])c2[H])c([H])c1[H]
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[H]c1nc(N([H])C(=O)N([H])c2c([H])c([H])c(OC([H])([H])c3c([H])c([H])c([H])c([H])c3[H])c([H])c2[H])c1[H]
[H]c1nc2c([H])c([H])c([H])c(N([H])C(=O)c1c([H])c([H])c([H])c([H])c1[H])c([H])c2c1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c1c([H])c([H])c(Br)c([H])c1[H]
[H]Oc1c([H])c([H])c(N([H])C(=O)c2c([H])c(C([H])([H])c3c([H])c([H])c(OC([H])([H])[H])c(OC([H])([H])[H])c3[H])c([H])c(Br)c2[H])c([H])c1[H]
[H]c1c([H])c([H])c([H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])[H])c([H])c1-c1c([H])c([H])c(C([H])([H])[H])c([H])c1[H]
[H]c1nc(N([H])C(=O)c2c([H])c([H])c(N([H])c3c([H])c([H])c([H])c(C(=O)N([H])C([H])([H])[H])c3[H])c([H])c2C([H])([H])[H])c1[H]
[H]c1c([H])c(C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C(=O)N([H])[H])c1[H]
[H]Oc1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]C
[H]c1nc2c([H])c([H])c([H])c2c1[H]
[H]Oc1c([H])c(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])c2c([H])c([H])c([H])c([H])c2[H])c1[H]
[H]c1nc(N([H])C(=O)N([H])C([H])([H])c2c([H])c([H])c([H])c([H])c2[H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]c1nc(N([H])c2nc(N([H])c3c([H])c([H])c(OC([H])([H])[H])c([H])c3[H])c2[H])nc(N([H])c3c([H])c([H])c([H])c([H])c3[H])c1[H]
[H]/C
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[H]c1c([H])c([C@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[H])c([H])c2c1C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]c1c([H])c([H])c([H])c([H])c1-c1c([H])c(C([H])([H])[H])c([H])c(C([H])([H])[H])c1[H]
[H]c1nc(C([H])([H])c2nc(N([H])c3c([H])c([H])c([H])c([H])c3[H])nn(C([H])([H])[H])c2c([H])c([H])c([H])c([H])c([H])c2[H])c2c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N([H])C(=O)c3c([H])c([H])c([H])c([H])c3C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1nc(C([H])([H])Oc2c([H])c([H])c(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])N([H])C(=O)c3c([H])c([H])c([H])c([H])c3[H])c([H])c2[H])c1[H]
[H]c1c([H])c([C@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])c([H])c2c1[H]
[H]Oc1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c([H])c(C([H])([H])[H])c3[H])N([H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]OC
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[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c(Cl)c([H])c2[H])c([H])c1[H]
[H]c1c([H])c([H])c(N([H])c2nc3c([H])c([H])c([H])c([H])c3C([H])([H])C([H])([H])N([H])c3c([H])c([H])c([H])c([H])c3C(=O)N([H])c3c([H])c([H])c([H])c([H])c3C2([H])[H])c([H])c1[H]
[H]c1nc(N([H])[H])c2c([H])c([H])c(N([H])[H])c([H])c2c1[H]
[H]c1nc(C(=O)N([H])c2nc(C(=O)N([H])c3c([H])c([H])c([H])c([H])c3[H])c2[H])n([H])c1N([H])C([H])([H])C([H])([H])N([H])[H]
[H]c1c([H])c([H])c(C([H])([H])c2nc3c([H])c([H])c(OC([H])([H])[H])c([H])c3o=c2[H])c([H])c1[H]
[H]c1c([H])c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C2([H])[H])c1[H]
[H]c1nc(N([H])[H])c([H])c([H])c1[H]
[H]c1c([H])c([H])c(OC([H])([H])Oc2c([H])c([H])c([H])c([H])c(-c3oc([H])c([H])c([H])c([H])c3[H])c([H])c2[H])c([H])c1C([H])([H])N([H])[H]
[H]c1nc(N([H])C(=O)c2c([H])c([H])c([H])c(C([H])([H])[H])c2[H])nc(N([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])n1
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[H]c1c([H])c([H])c([H])c(C([H])([H])C([H])([H])N([H])[H])c1[H]
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[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N([H])C([H])([H])[H])c([H])c1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C(=O)c1c([H])c([H])c([H])c(C([H])([H])[H])c([H])c([H])c1[H]
[H]c1c([H])c([H])c([C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C2([H])[H])c([H])c1C([H])([H])C([H])([H])C2([H])[H]
[H]c1nc(N([H])C(=O)N([H])c2c([H])c([H])c(Oc3c([H])c([H])c(Br)c([H])c3[H])c([H])c2[H])nc([H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])c3c([H])c([H])c(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])c([H])c3[H])c([H])c1C([H])([H])C2([H])[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]c1nc(N([H])[H])c([H])c([H])c1C([H])([H])N(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]c1nc2c([H])c(N([H])C(=O)c3c([H])c([H])c([H])c([H])c3[H])c([H])c2c1[H]
[H]c1nc(N([H])[H])c([H])c([H])c(N([H])C(=O)c2nc3c(C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])c([H])c2[H])c([H])c1[H]
[H]c1nc2c([H])c([H])c(N([H])C(=O)N([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3C([H])([H])c3c([H])c([H])c([H])c([H])c3Cl)c([H])c2nc1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c([H])c(F)c3[H])OC([H])([H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c1-c1c([H])c([H])c([H])c([H])c1-c1c([H])c([H])c1-c1c([H])c([H])c([H])c([H])c1-c1c([H])c([H])c1[H]
[H]c1c([H])c([H])c([H])c(C([H])([H])[H])c1[H]
[H]c1nc(N([H])C(=O)N([H])c2c([H])c([H])c(N([H])C(=O)c3c([H])c([H])c([H])c([H])c3[H])c([H])c2[H])c1[H]
[H]OC(=O)c1c([H])c([H])c([H])c([H])c1[H]
[H]c1nc(Oc2c([H])c([H])c(N([H])C(=O)N([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])c([H])c2[H])nc([H])c1[H]
[H]c1c([H])c([H])c([H])c(OC(F)(F)F)c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]c1c([H])c([H])c(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])N([H])c2c([H])c([H])c([H])c([H])c2[H])c(C([H])([H])C([H])([H])[H])c1[H]
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])c3c([H])c([H])c([H])c([H])c3[H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c(OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C(\[H])[H])c([H])c1[H]
[H]Oc1c([H])c([H])c([H])c(N2C([H])([H])C([H])([H])N([H])C(=O)c3c([H])c(F)c([H])c(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])c3[H])c([H])c3c1C([H])([H])C([H])([H])C2([H])[H])[C]
[H]c1nc(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)c2c([H])c([H])c([H])c([H])c2[H])nc(C([H])([H])[H])c1[H]
[H]c1nc(N([H])[H])c([H])c([H])c(N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]c1c([H])c([H])c(C([H])([H])Oc2c([H])c([H])c(F)c([H])c2[H])c([H])c1F
[H]c1c([H])c([H])c(N2C([H])([H])C([H])([H])N(C([H])([H])c3c([H])c([H])c(OC([H])([H])[H])c([H])c3[H])C([H])([H])C2([H])[H])c([H])c1[H]
[H]OC(=O)C([H])([H])C([H])([H])c1nc2c([H])c(N([H])C(=O)c3c([H])c([H])c(C([H])([H])C([H])=C([H])[H])c([H])c3[H])c([H])c2c1N([H])C(=O)N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
