Category	Use For	Protein	Accession	Entry name	Protein names	Type	Notes	assignment
3	All EVs as purity control	RPL37AP8 RPL37L	A6NKH3	RL37L_HUMAN	Putative 60S ribosomal protein L37a-like protein (Ribosomal protein L37a pseudogene 8)	protein and protein/nucleic acid aggregates		
2	All EVs	ANXA2P2 ANX2L2 ANX2P2 LPC2B	A6NMY6	AXA2L_HUMAN	Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene)	with lipid or membrane protein-binding ability	Annexins	
5	Functional component of EVs: need to determine the mode of association with EVs	COL6A6	A6NMZ7	CO6A6_HUMAN	Collagen alpha-6(VI) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL6A5 COL29A1 VWA4	A8TX70	CO6A5_HUMAN	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4)			
2	All EVs	SDCBP	O00560	SDCB1_HUMAN	Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)	with lipid or membrane protein-binding ability	syntenin	LYSOSOME
1	All EVs	ADAM10	O14672	ADA10_HUMAN	Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)	non-tissue specific		unknown
1	All EVs	ITGB1BP1 ICAP1	O14713	ITBP1_HUMAN	Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1)	non-tissue specific	Integrins	unknown
3	All EVs as purity control	MRPS12 RPMS12 RPSM12	O15235	RT12_HUMAN	"28S ribosomal protein S12, mitochondrial (MRP-S12) (S12mt) (MT-RPS12) (Mitochondrial small ribosomal subunit protein uS12m)"	protein and protein/nucleic acid aggregates		unknown
2	All EVs	CHMP2a	O43633	CHM2A_HUMAN	Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)	with lipid or membrane protein-binding ability		unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	ACTN4	O43707	ACTN4_HUMAN	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	others		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	CD5L	O43866	CD5L_HUMAN	CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha)	adhesion and extracellular matrix proteins		
3	All EVs as purity control	MRPS14	O60783	RT14_HUMAN	"28S ribosomal protein S14, mitochondrial (MRP-S14) (S14mt) (Mitochondrial small ribosomal subunit protein uS14m)"	protein and protein/nucleic acid aggregates		unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC12 H2BFT HIRIP1 HIST1H2BK	O60814	H2B1K_HUMAN	Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)	nucleus	Histones	NUCLEUS-CHROMATIN
2	All EVs	VSPS4B	O75351	VPS4B_HUMAN	Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)	with lipid or membrane protein-binding ability		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	ENTPD6 CD39L2 IL6ST2	O75354	ENTP6_HUMAN	Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)	Cytokines and growth factors		unknown
3	All EVs as purity control	MRPL33 C2orf1	O75394	RM33_HUMAN	"39S ribosomal protein L33, mitochondrial (L33mt) (MRP-L33) (Mitochondrial large ribosomal subunit protein bL33m)"	protein and protein/nucleic acid aggregates		unknown
1	All EVs	H2AP CXorf27 HYPM	O75409	HYPM_HUMAN	Huntingtin-interacting protein M (Histone H2A.P) (Huntingtin yeast partner M)	cell/tissue specific	MHC class II	
1	All EVs	ITGA10 UNQ468/PRO827	O75578	ITA10_HUMAN	Integrin alpha-10	non-tissue specific	Integrins	
2	All EVs	FLOT1	O75955	FLOT1_HUMAN	Flotillin-1	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	RSL1D1 CATX11 CSIG PBK1 L12	O76021	RL1D1_HUMAN	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	protein and protein/nucleic acid aggregates		NUCLEUS
2	All EVs	ANXA9 ANX31	O76027	ANXA9_HUMAN	Annexin A9 (Annexin XXXI) (Annexin-31) (Annexin-9) (Pemphaxin)	with lipid or membrane protein-binding ability	Annexins	
5	Functional component of EVs: need to determine the mode of association with EVs	IL18RAP IL1R7	O95256	I18RA_HUMAN	Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)	Cytokines and growth factors		
3	All EVs as purity control	NSA2 TINP1 HUSSY-29	O95478	NSA2_HUMAN	Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)	protein and protein/nucleic acid aggregates		NUCLEUS
5	Functional component of EVs: need to determine the mode of association with EVs	IL33 C9orf26 IL1F11 NFHEV	O95760	IL33_HUMAN	Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]	Cytokines and growth factors		
1	All EVs	GNA14	O95837	GNA14_HUMAN	Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14)	non-tissue specific		
5	Functional component of EVs: need to determine the mode of association with EVs	IL18BP	O95998	I18BP_HUMAN	Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	PDGFB PDGF2 SIS	P01127	PDGFB_HUMAN	Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	EGF	P01133	EGF_HUMAN	Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	TGFB1	P01137	TGFB1_HUMAN	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]	Cytokines and growth factors		ER
5	Functional component of EVs: need to determine the mode of association with EVs	IFNG	P01579	IFNG_HUMAN	Interferon gamma (IFN-gamma) (Immune interferon)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1A IL1F1	P01583	IL1A_HUMAN	Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1B IL1F2	P01584	IL1B_HUMAN	Interleukin-1 beta (IL-1 beta) (Catabolin)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL2RA	P01589	IL2RA_HUMAN	Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)	Cytokines and growth factors		
1	All EVs	HLA-B	P01889	HLAB_HUMAN	"HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)"	non-tissue specific	MHC class I	
1	All EVs	HLA-DRA HLA-DRA1	P01903	DRA_HUMAN	"HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)"	cell/tissue specific	MHC class II	
1	All EVs	HLA-DQA2 HLA-DXA	P01906	DQA2_HUMAN	"HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)"	cell/tissue specific	MHC class II	
1	All EVs	HLA-DQA1	P01909	DQA1_HUMAN	"HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)"	cell/tissue specific	MHC class II	
1	All EVs	HLA-DRB1	P01911	DRB_HUMAN	"HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)"	cell/tissue specific	MHC class II	
1	All EVs	HLA-DQB1 HLA-DQB	P01920	DQB1_HUMAN	"HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1)"	cell/tissue specific	MHC class II	unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL1A1	P02452	CO1A1_HUMAN	Collagen alpha-1(I) chain (Alpha-1 type I collagen)			unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL2A1	P02458	CO2A1_HUMAN	Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]			
5	Functional component of EVs: need to determine the mode of association with EVs	COL3A1	P02461	CO3A1_HUMAN	Collagen alpha-1(III) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A1	P02462	CO4A1_HUMAN	Collagen alpha-1(IV) chain [Cleaved into: Arresten]			unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	LMNA	P02545	LMNA_HUMAN	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	nucleus	Lamin A/C	unknown
3	All EVs as purity control	APOA1	P02647	APOA1_HUMAN	Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]	lipoproteins	"produced by liver, abundant in plasma, serum"	
3	All EVs as purity control	APOA2	P02652	APOA2_HUMAN	Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]	lipoproteins	"produced by liver, abundant in plasma, serum"	
3	All EVs as purity control	APOA2	P02652	APOA2_HUMAN	Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]	lipoproteins	"produced by liver, abundant in plasma, serum"	
1	All EVs	GYPA	P02724	GLPA_HUMAN	Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)	cell/tissue specific	Glycophorin A (RBC)	
5	Functional component of EVs: need to determine the mode of association with EVs	FN!	P02751	FINC_HUMAN	Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]	adhesion and extracellular matrix proteins		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	AHSG	P02765	FETUA_HUMAN	Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B]	adhesion and extracellular matrix proteins		unknown
3	All EVs as purity control	ALB	P02768	ALBU_HUMAN	Albumin	lipoproteins	"produced by liver, abundant in plasma, serum"	
2	All EVs	ANXA1 ANX1 LPC1	P04083	ANXA1_HUMAN	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)	with lipid or membrane protein-binding ability	Annexins	unknown
5	Functional component of EVs: need to determine the mode of association with EVs	PDGFA PDGF1	P04085	PDGFA_HUMAN	Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide)	Cytokines and growth factors		
3	All EVs as purity control	APOB	P04114	APOB_HUMAN	Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]	lipoproteins	"produced by liver, abundant in plasma, serum"	
1	All EVs	CD90	P04216	THY1_HUMAN	Thy-1 membrane glycoprotein OS=Homo sapiens OX=9606 GN=THY1 PE=1 SV=2	cell/tissue specific	immune cells	PM
1	All EVs	CD3D	P04234	CD3D_HUMAN	T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)	cell/tissue specific	T cells	
2	All EVs	GAPDH	P04406	G3P_HUMAN	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)	promiscuous incorporation in EVs (and possibly exomeres)	enzyme	unknown
1	All EVs	HLA-A	P04439	HLAA_HUMAN	"HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)"	non-tissue specific	MHC class I	
1	All EVs	HLA-DPB1 HLA-DP1B	P04440	DPB1_HUMAN	"HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)"	cell/tissue specific	MHC class II	
1	All EVs	ERBB2	P04626	ERBB2_HUMAN	Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)	cell/tissue specific	breast cancer	PM
1	All EVs	GNAI2 GNAI2B	P04899	GNAI2_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	non-tissue specific		PM
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC4 H2AFM HIST1H2AB; H2AC8 H2AFA HIST1H2AE	P04908	H2A1B_HUMAN	Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)	nucleus	Histones	
1	All EVs	"A4, APP"	P05067	A4_HUMAN	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	cell/tissue specific	neurons	unknown
1	All EVs	ITGB3 GP3A	P05106	ITB3_HUMAN	Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)	non-tissue specific	Integrins	PM
1	All EVs	ITGB2 CD18 MFI7	P05107	ITB2_HUMAN	"Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)"	non-tissue specific	Integrins	
5	Functional component of EVs: need to determine the mode of association with EVs	IL4	P05112	IL4_HUMAN	Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL5	P05113	IL5_HUMAN	Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	FGF1	P05230	FGF1_HUMAN	Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL6 IFNB2	P05231	IL6_HUMAN	Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)	Cytokines and growth factors		
3	All EVs as purity control	RPLP1 RRP1	P05386	RLA1_HUMAN	60S acidic ribosomal protein P1 (Large ribosomal subunit protein P1)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPLP2 D11S2243E RPP2	P05387	RLA2_HUMAN	60S acidic ribosomal protein P2 (Large ribosomal subunit protein P2) (Renal carcinoma antigen NY-REN-44)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPLP0	P05388	RLA0_HUMAN	60S acidic ribosomal protein P0 (60S ribosomal protein L10E) (Large ribosomal subunit protein uL10)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	HLA-DQB2 HLA-DXB	P05538	DQB2_HUMAN	"HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)"	cell/tissue specific	MHC class II	PM
1	All EVs	ITGB1 FNRB MDF2 MSK12	P05556	ITB1_HUMAN	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)	non-tissue specific	Integrins	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	KRT18	P05783	K1C18_HUMAN	"Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)"	others		
5	Functional component of EVs: need to determine the mode of association with EVs	COL5A2	P05997	CO5A2_HUMAN	Collagen alpha-2(V) chain			unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC11 H2BFR HIST1H2BJ	P06899	H2B1J_HUMAN	Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)	nucleus	Histones	
2	All EVs	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	P07355	ANXA2_HUMAN	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	with lipid or membrane protein-binding ability	Annexins	unknown
1	All EVs	CD42a	P07359	GP1BA_HUMAN	Platelet glycoprotein Ib alpha chain OS=Homo sapiens OX=9606 GN=GP1BA PE=1 SV=2	cell/tissue specific	platelets	
1	All EVs	CD3E	P07766	CD3E_HUMAN	T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)	cell/tissue specific	T cells	
3	All EVs as purity control	UMOD	P07911	UROM_HUMAN	"Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]"	protein and protein/nucleic acid aggregates	urine	
5	Functional component of EVs: need to determine the mode of association with EVs	COL1A2	P08123	CO1A2_HUMAN	Collagen alpha-2(I) chain (Alpha-2 type I collagen)			Abundant in exomeres
2	All EVs	ANXA6 ANX6	P08133	ANXA6_HUMAN	Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)	with lipid or membrane protein-binding ability	Annexins	unknown
1	All EVs	CD55	P08174	DAF_HUMAN	Complement decay-accelerating factor (CD antigen CD55)	non-tissue specific	complement-binding proteins	PM
2	All EVs	HSP90AB1	P08238	HS90B_HUMAN	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)	with lipid or membrane protein-binding ability	Heat shock proteins	CYTOSOL
1	All EVs	CD41	P08514	ITA2B_HUMAN	Integrin alpha-IIb OS=Homo sapiens OX=9606 GN=ITGA2B PE=1 SV=3	cell/tissue specific	platelets	
1	All EVs	CD14	P08571	CD14_HUMAN	"Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]"	cell/tissue specific	monocytes	
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A2	P08572	CO4A2_HUMAN	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]			unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	CYC1	P08574	CY1_HUMAN	"Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)"	mitochondrial		MITOCHONDRIA
1	All EVs	"CD45,PTPRC"	P08575	PTPRC_HUMAN	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)	cell/tissue specific	immune cells	
1	All EVs	ITGA5 FNRA	P08648	ITA5_HUMAN	Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]	non-tissue specific	Integrins	PM
5	Functional component of EVs: need to determine the mode of association with EVs	IL3	P08700	IL3_HUMAN	Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)	Cytokines and growth factors		
3	All EVs as purity control	RPS17 RPS17L	P08708	RS17_HUMAN	40S ribosomal protein S17 (Small ribosomal subunit protein eS17)	protein and protein/nucleic acid aggregates		
1	All EVs	GNAI3	P08754	GNAI3_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3)	non-tissue specific		PM
2	All EVs	ANXA5 ANX5 ENX2 PP4	P08758	ANXA5_HUMAN	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)	with lipid or membrane protein-binding ability	Annexins	unknown
3	All EVs as purity control	RPSA LAMBR LAMR1	P08865	RSSA_HUMAN	40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) (Small ribosomal subunit protein uS2)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
5	Functional component of EVs: need to determine the mode of association with EVs	IL6R	P08887	IL6RA_HUMAN	Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)	Cytokines and growth factors		
1	All EVs	CD63	P08962	CD63_HUMAN	CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)	non-tissue specific	Tetraspanins	unknown
3	All EVs as purity control	MRPL3 MRL3 RPML3	P09001	RM03_HUMAN	"39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3) (Mitochondrial large ribosomal subunit protein uL3m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	FGF2	P09038	FGF2_HUMAN	Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)	Cytokines and growth factors		unknown
2	All EVs	ANXA4 ANX4	P09525	ANXA4_HUMAN	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	with lipid or membrane protein-binding ability	Annexins	unknown
1	All EVs	CD3G	P09693	CD3G_HUMAN	T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)	cell/tissue specific	T cells	
1	All EVs	H2AZ1 H2AFZ H2AZ	P0C0S5	H2AZ_HUMAN	Histone H2A.Z (H2A/z)	cell/tissue specific	MHC class II	NUCLEUS-CHROMATIN
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM	P0C0S8	H2A1_HUMAN	Histone H2A type 1 (H2A.1) (Histone H2A/ptl)	nucleus	Histones	
1	All EVs	H2AB1 H2AFB1	P0C5Y9	H2AB1_HUMAN	Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd)	cell/tissue specific	MHC class II	
1	All EVs	H2AB2 H2AFB2; H2AB3 H2ABBD H2AFB H2AFB3	P0C5Z0	H2AB2_HUMAN	Histone H2A-Bbd type 2/3 (H2A Barr body-deficient) (H2A.Bbd)	cell/tissue specific	MHC class II	
2	All EVs	HSPA1A	P0DMV8	HS71A_HUMAN	Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)	promiscuous incorporation in EVs (and possibly exomeres)	Heat shock proteins	
5	Functional component of EVs: need to determine the mode of association with EVs	CXCL8 IL8	P10145	IL8_HUMAN	Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]	Cytokines and growth factors		
1	All EVs	HLA-C	P10321	HLAC_HUMAN	"HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)"	non-tissue specific	MHC class I	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-4 H1F4 HIST1H1E	P10412	H14_HUMAN	Histone H1.4 (Histone H1b) (Histone H1s-4)	nucleus	Histones	NUCLEUS-CHROMATIN
2	All EVs	MAPT	P10636	TAU_HUMAN	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	with lipid or membrane protein-binding ability	neurons	Abundant in exomeres
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	BIP	P11021	BIP_HUMAN	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	secretory pathway		ER
1	All EVs	CD37	P11049	CD37_HUMAN	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)	cell/tissue specific	leukocytes	
2	All EVs	"HSC70,HSPA8"	P11142	HSP7C_HUMAN	Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	with lipid or membrane protein-binding ability	Heat shock proteins	unknown
1	All EVs	LAMP1	P11279	LAMP1_HUMAN	Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)	non-tissue specific		LYSOSOME
5	Functional component of EVs: need to determine the mode of association with EVs	COL11A1 COLL6	P12107	COBA1_HUMAN	Collagen alpha-1(XI) chain			unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL6A1	P12109	CO6A1_HUMAN	Collagen alpha-1(VI) chain			ER
5	Functional component of EVs: need to determine the mode of association with EVs	COL6A2	P12110	CO6A2_HUMAN	Collagen alpha-2(VI) chain			ER
5	Functional component of EVs: need to determine the mode of association with EVs	COL6A3	P12111	CO6A3_HUMAN	Collagen alpha-3(VI) chain			unknown
2	All EVs	ANXA3 ANX3	P12429	ANXA3_HUMAN	"Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)"	with lipid or membrane protein-binding ability	Annexins	unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	ACTN1	P12814	ACTN1_HUMAN	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	others		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL7	P13232	IL7_HUMAN	Interleukin-7 (IL-7)	Cytokines and growth factors		
1	All EVs	LAMP2	P13473	LAMP2_HUMAN	Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)	non-tissue specific		unknown
1	All EVs	ITGA4 CD49D	P13612	ITA4_HUMAN	Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)	non-tissue specific	Integrins	
1	All EVs	HLA-DRB4	P13762	DRB4_HUMAN	"HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)"	cell/tissue specific	MHC class II	
2	All EVs	ANXA8 ANX8	P13928	ANXA8_HUMAN	Annexin A8 (Annexin VIII) (Annexin-8) (Vascular anticoagulant-beta) (VAC-beta)	with lipid or membrane protein-binding ability	Annexins	
5	Functional component of EVs: need to determine the mode of association with EVs	COL11A2	P13942	COBA2_HUMAN	Collagen alpha-2(XI) chain			
1	All EVs	CD59	P13987	CD59_HUMAN	CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)	non-tissue specific	complement-binding proteins	unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	"GRP94,HSP90B1"	P14625	ENPL_HUMAN	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	secretory pathway		ER
1	All EVs	GP9	P14770	GPIX_HUMAN	Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a)	cell/tissue specific	platelets	
5	Functional component of EVs: need to determine the mode of association with EVs	IL1R1 IL1R IL1RA IL1RT1	P14778	IL1R1_HUMAN	"Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]"	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL2RB IL15RB	P14784	IL2RB_HUMAN	Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL9	P15248	IL9_HUMAN	Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	VEGFA	P15692	VEGFA_HUMAN	Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)	Cytokines and growth factors		
3	All EVs as purity control	RPS2 RPS4	P15880	RS2_HUMAN	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
1	All EVs	H2AX H2AFX	P16104	H2AX_HUMAN	Histone H2AX (H2a/x) (Histone H2A.X)	cell/tissue specific	MHC class II	NUCLEUS-CHROMATIN
1	All EVs	ITGB4	P16144	ITB4_HUMAN	Integrin beta-4 (GP150) (CD antigen CD104)	non-tissue specific	Integrins	PM
1	All EVs	PECAM1	P16284	PECA1_HUMAN	Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)	cell/tissue specific	endothelial cells	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-5 H1F5 HIST1H1B	P16401	H15_HUMAN	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	nucleus	Histones	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-3 H1F3 HIST1H1D	P16402	H13_HUMAN	Histone H1.3 (Histone H1c) (Histone H1s-2)	nucleus	Histones	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-2 H1F2 HIST1H1C	P16403	H12_HUMAN	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	nucleus	Histones	NUCLEUS-CHROMATIN
1	All EVs	EPCAM	P16422	EPCAM_HUMAN	Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)	cell/tissue specific	epithelial	
5	Functional component of EVs: need to determine the mode of association with EVs	IL7R	P16871	IL7RA_HUMAN	Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)	Cytokines and growth factors		
2	All EVs	HSPA6 HSP70B'	P17066	HSP76_HUMAN	Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B')	promiscuous incorporation in EVs (and possibly exomeres)	Heat shock proteins	
1	All EVs	ITGA2 CD49B	P17301	ITA2_HUMAN	Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)	non-tissue specific	Integrins	PM
3	All EVs as purity control	RPL35A GIG33	P18077	RL35A_HUMAN	60S ribosomal protein L35a (Cell growth-inhibiting gene 33 protein) (Large ribosomal subunit protein eL33)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	ITGB5	P18084	ITB5_HUMAN	Integrin beta-5	non-tissue specific	Integrins	PM
3	All EVs as purity control	RPL7	P18124	RL7_HUMAN	60S ribosomal protein L7 (Large ribosomal subunit protein uL30)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RN IL1F3 IL1RA	P18510	IL1RA_HUMAN	Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)	Cytokines and growth factors		
1	All EVs	ITGB6	P18564	ITB6_HUMAN	Integrin beta-6	non-tissue specific	Integrins	
3	All EVs as purity control	RPL17	P18621	RL17_HUMAN	60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	SDC*	P18827	SDC1_HUMAN	Syndecan-1 (SYND1) (CD antigen CD138)	non-tissue specific	heparan sulfate proteoglycans including syndecans	
1	All EVs	TSPAN8	P19075	TSN8_HUMAN	Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)	cell/tissue specific	epithelial cell	
1	All EVs	CD53	P19397	CD53_HUMAN	Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)	cell/tissue specific	leukocytes	
1	All EVs	HLA-DPA1 HLA-DP1A HLASB	P20036	DPA1_HUMAN	"HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)"	cell/tissue specific	MHC class II	
2	All EVs	ANXA7 ANX7 SNX OK/SW-cl.95	P20073	ANXA7_HUMAN	Annexin A7 (Annexin VII) (Annexin-7) (Synexin)	with lipid or membrane protein-binding ability	Annexins	unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC7 H2AFG HIST1H2AD	P20671	H2A1D_HUMAN	Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL11	P20809	IL11_HUMAN	Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL9A1	P20849	CO9A1_HUMAN	Collagen alpha-1(IX) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL5A1	P20908	CO5A1_HUMAN	Collagen alpha-1(V) chain			unknown
1	All EVs	NT5E	P21589	5NTD_HUMAN	5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73)	non-tissue specific	GPI-anchored 5' nucleotidase	
1	All EVs	CD72	P21854	CD72_HUMAN	B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)	non-tissue specific	GPI-anchored 5' nucleotidase	
1	All EVs	CD9	P21926	CD9_HUMAN	CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)	cell/tissue specific	"absent from NK, B and some MSC"	
3	All EVs as purity control	RPS4Y1 RPS4Y PRO2646	P22090	RS4Y1_HUMAN	"40S ribosomal protein S4, Y isoform 1 (Small ribosomal subunit protein eS4)"	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	IL10	P22301	IL10_HUMAN	Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)	Cytokines and growth factors		
1	All EVs	AChE-S	P22303	ACES_HUMAN	Acetylcholinesterase (AChE) (EC 3.1.1.7)	cell/tissue specific	neurons	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-6 H1FT H1T HIST1H1T	P22492	H1T_HUMAN	Histone H1t (Testicular H1 histone)	nucleus	Histones	
1	All EVs	ITGA6	P23229	ITA6_HUMAN	Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]	non-tissue specific	Integrins	unknown
3	All EVs as purity control	RPS3 OK/SW-cl.26	P23396	RS3_HUMAN	40S ribosomal protein S3 (EC 4.2.99.18) (Small ribosomal subunit protein uS3)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC17 H2BFH H2BFN HIST1H2BO	P23527	H2B1O_HUMAN	Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL32 NK4 TAIF	P24001	IL32_HUMAN	Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL4R IL4RA 582J2.1	P24394	IL4RA_HUMAN	Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	CXCR1 CMKAR1 IL8RA	P25024	CXCR1_HUMAN	C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	CXCR2 IL8RB	P25025	CXCR2_HUMAN	C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL8A2	P25067	CO8A2_HUMAN	Collagen alpha-2(VIII) chain (Endothelial collagen)			
3	All EVs as purity control	RPS12	P25398	RS12_HUMAN	40S ribosomal protein S12 (Small ribosomal subunit protein eS12)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
5	Functional component of EVs: need to determine the mode of association with EVs	COL5A3	P25940	CO5A3_HUMAN	Collagen alpha-3(V) chain			
1	All EVs	ITGA3 MSK18	P26006	ITA3_HUMAN	Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]	non-tissue specific	Integrins	PM
1	All EVs	ITGB7	P26010	ITB7_HUMAN	Integrin beta-7 (Gut homing receptor beta subunit)	non-tissue specific	Integrins	
1	All EVs	ITGB8	P26012	ITB8_HUMAN	Integrin beta-8	non-tissue specific	Integrins	PM
3	All EVs as purity control	RPL13 BBC1 OK/SW-cl.46	P26373	RL13_HUMAN	60S ribosomal protein L13 (Breast basic conserved protein 1) (Large ribosomal subunit protein eL13)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	IL3RA IL3R	P26951	IL3RA_HUMAN	Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)	Cytokines and growth factors		
2	All EVs	ANXA13 ANX13	P27216	ANX13_HUMAN	Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)	with lipid or membrane protein-binding ability	Annexins	
3	All EVs as purity control	RPL10 DXS648E QM	P27635	RL10_HUMAN	60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	COL8A1 C3orf7	P27658	CO8A1_HUMAN	Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]			
1	All EVs	CD82	P27701	CD82_HUMAN	CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)	non-tissue specific	Tetraspanins	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	CANX	P27824	CALX_HUMAN	Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)	secretory pathway	Calnexin	ER
5	Functional component of EVs: need to determine the mode of association with EVs	IL1R2 IL1RB	P27930	IL1R2_HUMAN	"Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]"	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A5	P29400	CO4A5_HUMAN	Collagen alpha-5(IV) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IL12A NKSF1	P29459	IL12A_HUMAN	Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL12B NKSF2	P29460	IL12B_HUMAN	Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)	Cytokines and growth factors		
1	All EVs	GNA11 GA11	P29992	GNA11_HUMAN	Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)	non-tissue specific	heterotrimeric G proteins	PM
3	All EVs as purity control	RPL12	P30050	RL12_HUMAN	60S ribosomal protein L12 (Large ribosomal subunit protein uL11)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	GNA15 GNA16	P30679	GNA15_HUMAN	Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16)	non-tissue specific		
5	Functional component of EVs: need to determine the mode of association with EVs	IL2RG	P31785	IL2RG_HUMAN	Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	CSF2RB IL3RB IL5RB	P32927	IL3RB_HUMAN	Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)	Cytokines and growth factors		
3	All EVs as purity control	RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9	P32969	RL9_HUMAN	60S ribosomal protein L9 (Large ribosomal subunit protein uL6)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	ABCC1	P33527	MRP1_HUMAN	Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)	cell/tissue specific	multidrug resistance-associated protein	PM
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC3 H2BFF HIST1H2BB	P33778	H2B1B_HUMAN	Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL13 NC30	P35225	IL13_HUMAN	Interleukin-13 (IL-13)	Cytokines and growth factors		
3	All EVs as purity control	RPL22	P35268	RL22_HUMAN	60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) (Large ribosomal subunit protein eL22)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	BSG	P35613	BASI_HUMAN	Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)	non-tissue specific	EMMPRIN	PM
3	All EVs as purity control	RPL4 RPL1	P36578	RL4_HUMAN	60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS19	P39019	RS19_HUMAN	40S ribosomal protein S19 (Small ribosomal subunit protein eS19)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPL3 OK/SW-cl.32	P39023	RL3_HUMAN	60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	COL15A1	P39059	COFA1_HUMAN	Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)]			
5	Functional component of EVs: need to determine the mode of association with EVs	COL18A1	P39060	COIA1_HUMAN	Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]			
5	Functional component of EVs: need to determine the mode of association with EVs	IL6ST	P40189	IL6RB_HUMAN	Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)	Cytokines and growth factors		unknown
3	All EVs as purity control	RPL13A	P40429	RL13A_HUMAN	60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	IL15	P40933	IL15_HUMAN	Interleukin-15 (IL-15)	Cytokines and growth factors		
2	All EVs	FLOT1	P41440	S19A1_HUMAN	Reduced folate transporter (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)	with lipid or membrane protein-binding ability		PM
3	All EVs as purity control	RPS27 MPS1	P42677	RS27_HUMAN	40S ribosomal protein S27 (Metallopan-stimulin 1) (MPS-1) (Small ribosomal subunit protein eS27)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
5	Functional component of EVs: need to determine the mode of association with EVs	IL12RB1 IL12R IL12RB	P42701	I12R1_HUMAN	Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)	Cytokines and growth factors		
3	All EVs as purity control	RPL35	P42766	RL35_HUMAN	60S ribosomal protein L35 (Large ribosomal subunit protein uL29)	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	RPL27A	P46776	RL27A_HUMAN	60S ribosomal protein L27a (Large ribosomal subunit protein uL15)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL5 MSTP030	P46777	RL5_HUMAN	60S ribosomal protein L5 (Large ribosomal subunit protein uL18)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL21	P46778	RL21_HUMAN	60S ribosomal protein L21 (Large ribosomal subunit protein eL21)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL28	P46779	RL28_HUMAN	60S ribosomal protein L28 (Large ribosomal subunit protein eL28)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS9	P46781	RS9_HUMAN	40S ribosomal protein S9 (Small ribosomal subunit protein uS4)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS5	P46782	RS5_HUMAN	"40S ribosomal protein S5 (Small ribosomal subunit protein uS7) [Cleaved into: 40S ribosomal protein S5, N-terminally processed]"	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS10	P46783	RS10_HUMAN	40S ribosomal protein S10 (Small ribosomal subunit protein eS10)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPL29	P47914	RL29_HUMAN	60S ribosomal protein L29 (Cell surface heparin-binding protein HIP) (Large ribosomal subunit protein eL29)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
2	All EVs	HSPA7 HSP70B	P48741	HSP77_HUMAN	Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B)	promiscuous incorporation in EVs (and possibly exomeres)	Heat shock proteins	
3	All EVs as purity control	RPL34	P49207	RL34_HUMAN	60S ribosomal protein L34 (Large ribosomal subunit protein eL34)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	MRPL19 KIAA0104 MRPL15	P49406	RM19_HUMAN	"39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19) (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein bL19m)"	protein and protein/nucleic acid aggregates		unknown
1	All EVs	GNAQ GAQ	P50148	GNAQ_HUMAN	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	non-tissue specific		
2	All EVs	TUB*	P50607	TUB_HUMAN	Tubby protein homolog	promiscuous incorporation in EVs (and possibly exomeres)	cytoskeleton	
3	All EVs as purity control	RPL14	P50914	RL14_HUMAN	60S ribosomal protein L14 (CAG-ISL 7) (Large ribosomal subunit protein eL14)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
2	All EVs	ANXA11 ANX11	P50995	ANX11_HUMAN	Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)	with lipid or membrane protein-binding ability	Annexins	unknown
3	All EVs as purity control	DAP3 MRPS29	P51398	RT29_HUMAN	"28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) (Mitochondrial small ribosomal subunit protein mS29)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL12 MRPL7 RPML12	P52815	RM12_HUMAN	"39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12) (5c5-2) (Mitochondrial large ribosomal subunit protein bL12m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A4	P53420	CO4A4_HUMAN	Collagen alpha-4(IV) chain			
1	All EVs	ITGA8	P53708	ITA8_HUMAN	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	non-tissue specific	Integrins	
3	All EVs as purity control	SNU13 NHP2L1	P55769	NH2L1_HUMAN	"NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]"	protein and protein/nucleic acid aggregates		NUCLEUS
1	All EVs	ITGA1	P56199	ITA1_HUMAN	Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)	non-tissue specific	Integrins	PM
1	All EVs	EIF6 EIF3A ITGB4BP OK/SW-cl.27	P56537	IF6_HUMAN	Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))	non-tissue specific	Integrins	unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC5 H2BFB HIRIP2 HIST1H2BD	P58876	H2B1D_HUMAN	Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)	nucleus	Histones	
1	All EVs	CD81	P60033	CD81_HUMAN	CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)	non-tissue specific	Tetraspanins	PM
5	Functional component of EVs: need to determine the mode of association with EVs	IL2	P60568	IL2_HUMAN	Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)	Cytokines and growth factors		
3	All EVs as purity control	RPS20	P60866	RS20_HUMAN	40S ribosomal protein S20 (Small ribosomal subunit protein uS10)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS3A FTE1 MFTL	P61247	RS3A_HUMAN	40S ribosomal protein S3a (Small ribosomal subunit protein eS1) (v-fos transformation effector protein) (Fte-1)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPL26	P61254	RL26_HUMAN	60S ribosomal protein L26 (Large ribosomal subunit protein uL24)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL15 EC45 TCBAP0781	P61313	RL15_HUMAN	60S ribosomal protein L15 (Large ribosomal subunit protein eL15)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL27	P61353	RL27_HUMAN	60S ribosomal protein L27 (Large ribosomal subunit protein eL27)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL37A	P61513	RL37A_HUMAN	60S ribosomal protein L37a (Large ribosomal subunit protein eL43)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
2	All EVs	RHOA	P61586	RHOA_HUMAN	Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)	with lipid or membrane protein-binding ability		PM
5	Functional component of EVs: need to determine the mode of association with EVs	TGFB2	P61812	TGFB2_HUMAN	Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]	Cytokines and growth factors		unknown
3	All EVs as purity control	RPL37	P61927	RL37_HUMAN	60S ribosomal protein L37 (G1.16) (Large ribosomal subunit protein eL37)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS7	P62081	RS7_HUMAN	40S ribosomal protein S7 (Small ribosomal subunit protein eS7)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS8 OK/SW-cl.83	P62241	RS8_HUMAN	40S ribosomal protein S8 (Small ribosomal subunit protein eS8)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS15A OK/SW-cl.82	P62244	RS15A_HUMAN	40S ribosomal protein S15a (Small ribosomal subunit protein uS8)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS16	P62249	RS16_HUMAN	40S ribosomal protein S16 (Small ribosomal subunit protein uS9)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS14 PRO2640	P62263	RS14_HUMAN	40S ribosomal protein S14 (Small ribosomal subunit protein uS11)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS23	P62266	RS23_HUMAN	40S ribosomal protein S23 (Small ribosomal subunit protein uS12)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS18 D6S218E	P62269	RS18_HUMAN	40S ribosomal protein S18 (Ke-3) (Ke3) (Small ribosomal subunit protein uS13)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS29	P62273	RS29_HUMAN	40S ribosomal protein S29 (Small ribosomal subunit protein uS14)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS13	P62277	RS13_HUMAN	40S ribosomal protein S13 (Small ribosomal subunit protein uS15)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS11	P62280	RS11_HUMAN	40S ribosomal protein S11 (Small ribosomal subunit protein uS17)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
2	All EVs	ARF6	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	RPL7A SURF-3 SURF3	P62424	RL7A_HUMAN	60S ribosomal protein L7a (Large ribosomal subunit protein eL8) (PLA-X polypeptide) (Surfeit locus protein 3)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS4X CCG2 RPS4 SCAR	P62701	RS4X_HUMAN	"40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)"	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPL23A	P62750	RL23A_HUMAN	60S ribosomal protein L23a (Large ribosomal subunit protein uL23)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS6 OK/SW-cl.2	P62753	RS6_HUMAN	40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4-16 HIST4H4	P62805	H4_HUMAN	Histone H4	nucleus	Histones	NUCLEUS-CHROMATIN
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	P62807	H2B1C_HUMAN	Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)	nucleus	Histones	
3	All EVs as purity control	RPL23	P62829	RL23_HUMAN	60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS15 RIG	P62841	RS15_HUMAN	40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS24	P62847	RS24_HUMAN	40S ribosomal protein S24 (Small ribosomal subunit protein eS24)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS25	P62851	RS25_HUMAN	40S ribosomal protein S25 (Small ribosomal subunit protein eS25)	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	RPS26	P62854	RS26_HUMAN	40S ribosomal protein S26 (Small ribosomal subunit protein eS26)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RPS28	P62857	RS28_HUMAN	40S ribosomal protein S28 (Small ribosomal subunit protein eS28)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	FAU	P62861	RS30_HUMAN	40S ribosomal protein S30 (Small ribosomal subunit protein eS30)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
1	All EVs	GNB1	P62873	GBB1_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	non-tissue specific		PM
3	All EVs as purity control	RPL30	P62888	RL30_HUMAN	60S ribosomal protein L30 (Large ribosomal subunit protein eL30)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL39	P62891	RL39_HUMAN	60S ribosomal protein L39 (Large ribosomal subunit protein eL39)	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	RPL31	P62899	RL31_HUMAN	60S ribosomal protein L31 (Large ribosomal subunit protein eL31)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL10A NEDD6	P62906	RL10A_HUMAN	60S ribosomal protein L10a (CSA-19) (Large ribosomal subunit protein uL1) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL32 PP9932	P62910	RL32_HUMAN	60S ribosomal protein L32 (Large ribosomal subunit protein eL32)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL11	P62913	RL11_HUMAN	60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL8	P62917	RL8_HUMAN	60S ribosomal protein L8 (Large ribosomal subunit protein uL2)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL41	P62945	RL41_HUMAN	60S ribosomal protein L41 (HG12) (Large ribosomal subunit protein eL41)	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	RPS27A UBA80 UBCEP1	P62979	RS27A_HUMAN	Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	UBA52 UBCEP2	P62987	RL40_HUMAN	Ubiquitin-60S ribosomal protein L40 (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (Large ribosomal subunit protein eL40)]	protein and protein/nucleic acid aggregates		
1	All EVs	GNAI1	P63096	GNAI1_HUMAN	Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)	non-tissue specific		unknown
3	All EVs as purity control	RPL38	P63173	RL38_HUMAN	60S ribosomal protein L38 (Large ribosomal subunit protein eL38)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS21	P63220	RS21_HUMAN	40S ribosomal protein S21 (Small ribosomal subunit protein eS21)	protein and protein/nucleic acid aggregates		RIBOSOME 40S
3	All EVs as purity control	RACK1 GNB2L1 HLC7 PIG21	P63244	RACK1_HUMAN	"Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]"	protein and protein/nucleic acid aggregates		RIBOSOME 40S
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	P68431	H31_HUMAN	Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)	nucleus	Histones	
3	All EVs as purity control	RPP38	P78345	RPP38_HUMAN	Ribonuclease P protein subunit p38 (RNaseP protein p38) (EC 3.1.26.5)	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	IL13RA1 IL13R IL13RA	P78552	I13R1_HUMAN	Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)	Cytokines and growth factors		unknown
1	All EVs	HLA-DRB3	P79483	DRB3_HUMAN	"HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)"	cell/tissue specific	MHC class II	
3	All EVs as purity control	MRPS22 C3orf5 RPMS22 GK002	P82650	RT22_HUMAN	"28S ribosomal protein S22, mitochondrial (MRP-S22) (S22mt) (Mitochondrial small ribosomal subunit protein mS22)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS25 RPMS25	P82663	RT25_HUMAN	"28S ribosomal protein S25, mitochondrial (MRP-S25) (S25mt) (Mitochondrial small ribosomal subunit protein mS25)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPS10 MSTP040	P82664	RT10_HUMAN	"28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt) (Mitochondrial small ribosomal subunit protein uS10m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213	P82673	RT35_HUMAN	"28S ribosomal protein S35, mitochondrial (MRP-S35) (S35mt) (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (Mitochondrial small ribosomal subunit protein mS35)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS5	P82675	RT05_HUMAN	"28S ribosomal protein S5, mitochondrial (MRP-S5) (S5mt) (Mitochondrial small ribosomal subunit protein uS5m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS11 RPMS11 HCC2	P82912	RT11_HUMAN	"28S ribosomal protein S11, mitochondrial (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) (Mitochondrial small ribosomal subunit protein uS11m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS15 RPMS15 DC37	P82914	RT15_HUMAN	"28S ribosomal protein S15, mitochondrial (MRP-S15) (S15mt) (Mitochondrial small ribosomal subunit protein uS15m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS21 RPMS21 MDS016	P82921	RT21_HUMAN	"28S ribosomal protein S21, mitochondrial (MRP-S21) (S21mt) (Mitochondrial small ribosomal subunit protein bS21m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS34	P82930	RT34_HUMAN	"28S ribosomal protein S34, mitochondrial (MRP-S34) (S34mt) (Mitochondrial small ribosomal subunit protein mS34)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS6 C21orf101 RPMS6	P82932	RT06_HUMAN	"28S ribosomal protein S6, mitochondrial (MRP-S6) (S6mt) (Mitochondrial small ribosomal subunit protein bS6m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPS9 RPMS9	P82933	RT09_HUMAN	"28S ribosomal protein S9, mitochondrial (MRP-S9) (S9mt) (Mitochondrial small ribosomal subunit protein uS9m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	RPL24	P83731	RL24_HUMAN	60S ribosomal protein L24 (60S ribosomal protein L30) (Large ribosomal subunit protein eL24)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL36A RPL44 GIG15 MIG6	P83881	RL36A_HUMAN	60S ribosomal protein L36a (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) (Large ribosomal subunit protein eL42)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL19	P84098	RL19_HUMAN	60S ribosomal protein L19 (Large ribosomal subunit protein eL19)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	IL9R	Q01113	IL9R_HUMAN	Interleukin-9 receptor (IL-9 receptor) (IL-9R) (CD antigen CD129)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL5RA IL5R	Q01344	IL5RA_HUMAN	Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RL1 DER4 ST2 T1	Q01638	ILRL1_HUMAN	Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A3	Q01955	CO4A3_HUMAN	Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin]			
5	Functional component of EVs: need to determine the mode of association with EVs	COL7A1	Q02388	CO7A1_HUMAN	Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen)			
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H1-1 H1F1 HIST1H1A	Q02539	H11_HUMAN	Histone H1.1 (Histone H1a)	nucleus	Histones	NUCLEUS-CHROMATIN
3	All EVs as purity control	RPL18A	Q02543	RL18A_HUMAN	60S ribosomal protein L18a (Large ribosomal subunit protein eL20)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPL6 TXREB1	Q02878	RL6_HUMAN	60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
1	All EVs	GNA12	Q03113	GNA12_HUMAN	Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)	non-tissue specific		unknown
2	All EVs	CAV*	Q03135	CAV1_HUMAN	Caveolin-1	with lipid or membrane protein-binding ability	caveolins	unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL10A1	Q03692	COAA1_HUMAN	Collagen alpha-1(X) chain			
1	All EVs	AChE-E	Q04844	ACHE_HUMAN	Acetylcholine receptor subunit epsilon	cell/tissue specific	erythrocytes	
1	All EVs	A4	Q04941	PLP2_HUMAN	Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein)	cell/tissue specific	neurons	
5	Functional component of EVs: need to determine the mode of association with EVs	COL14A1 UND	Q05707	COEA1_HUMAN	Collagen alpha-1(XIV) chain (Undulin)			
3	All EVs as purity control	RPL18	Q07020	RL18_HUMAN	60S ribosomal protein L18 (Large ribosomal subunit protein eL18)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	COL16A1 FP1572	Q07092	COGA1_HUMAN	Collagen alpha-1(XVI) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IL10RB CRFB4 D21S58 D21S66	Q08334	I10R2_HUMAN	Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)	Cytokines and growth factors		
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	GOLGA2	Q08379	GOGA2_HUMAN	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)	secretory pathway		NUCLEUS
5	Functional component of EVs: need to determine the mode of association with EVs	LGALS3BP	Q08380	LG3BP_HUMAN	Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K)	adhesion and extracellular matrix proteins		PM
5	Functional component of EVs: need to determine the mode of association with EVs	MFGE8	Q08431	MFGM_HUMAN	Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]	adhesion and extracellular matrix proteins		unknown
1	All EVs	CD47	Q08722	CD47_HUMAN	Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)	non-tissue specific	multi-pass membrane proteins	
2	All EVs	HSPA14 HSP60 HSP70L1	Q0VDF9	HSP7E_HUMAN	Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60)	promiscuous incorporation in EVs (and possibly exomeres)	Heat shock proteins	NUCLEUS
5	Functional component of EVs: need to determine the mode of association with EVs	IL24 MDA7 ST16	Q13007	IL24_HUMAN	Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)	Cytokines and growth factors		
3	All EVs as purity control	MRPL28 MAAT1	Q13084	RM28_HUMAN	"39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28) (Melanoma antigen p15) (Melanoma-associated antigen recognized by T-lymphocytes) (Mitochondrial large ribosomal subunit protein bL28m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL15RA	Q13261	I15RA_HUMAN	Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]	Cytokines and growth factors		
1	All EVs	ITGB3BP CENPR NRIF3	Q13352	CENPR_HUMAN	Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)	non-tissue specific	Integrins	
3	All EVs as purity control	MRPL49 C11orf4 NOF1 OK/SW-cl.67	Q13405	RM49_HUMAN	"39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49) (Mitochondrial large ribosomal subunit protein mL49) (Neighbor of FAU) (NOF) (Protein NOF1)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	TMED1 IL1RL1L IL1RL1LG	Q13445	TMED1_HUMAN	Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)	Cytokines and growth factors		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL18R1 IL1RRP	Q13478	IL18R_HUMAN	Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL10RA IL10R	Q13651	I10R1_HUMAN	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)	Cytokines and growth factors		
1	All EVs	ITGA7 UNQ406/PRO768	Q13683	ITA7_HUMAN	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	non-tissue specific	Integrins	PM
1	All EVs	ITGA9	Q13797	ITA9_HUMAN	Integrin alpha-9 (Integrin alpha-RLC)	non-tissue specific	Integrins	
5	Functional component of EVs: need to determine the mode of association with EVs	IL16	Q14005	IL16_HUMAN	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL4A6	Q14031	CO4A6_HUMAN	Collagen alpha-6(IV) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL9A3	Q14050	CO9A3_HUMAN	Collagen alpha-3(IX) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL9A2	Q14055	CO9A2_HUMAN	Collagen alpha-2(IX) chain			unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL18 IGIF IL1F4	Q14116	IL18_HUMAN	Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)	Cytokines and growth factors		CYTOSOL
3	All EVs as purity control	MRPL58 DS1 ICT1	Q14197	ICT1_HUMAN	"Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Mitochondrial large ribosomal subunit protein mL62)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	EBI3 IL27B	Q14213	IL27B_HUMAN	Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)	Cytokines and growth factors		
2	All EVs	FLOT2	Q14254	FLOT2_HUMAN	Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)	with lipid or membrane protein-binding ability		unknown
1	All EVs	GNA13	Q14344	GNA13_HUMAN	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)	non-tissue specific		PM
5	Functional component of EVs: need to determine the mode of association with EVs	IL11RA	Q14626	I11RA_HUMAN	Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL13RA2 IL13R	Q14627	I13R2_HUMAN	Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL19A1	Q14993	COJA1_HUMAN	Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain)			
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	TOMM20	Q15388	TOM20_HUMAN	Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)	mitochondrial		
1	All EVs	SHH	Q15465	SHH_HUMAN	Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]	non-tissue specific	sonic hedgehog	
3	All EVs as purity control	MRPL23 L23MRP RPL23L	Q16540	RM23_HUMAN	"39S ribosomal protein L23, mitochondrial (L23mt) (MRP-L23) (L23 mitochondrial-related protein) (Mitochondrial large ribosomal subunit protein uL23m) (Ribosomal protein L23-like)"	protein and protein/nucleic acid aggregates		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL17A CTLA8 IL17	Q16552	IL17_HUMAN	Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	NFIL3 E4BP4 IL3BP1	Q16649	NFIL3_HUMAN	Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)	Cytokines and growth factors		
1	All EVs	H2AC20 H2AFQ HIST2H2AC	Q16777	H2A2C_HUMAN	Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)	cell/tissue specific	MHC class II	
5	Functional component of EVs: need to determine the mode of association with EVs	COL24A1	Q17RW2	COOA1_HUMAN	Collagen alpha-1(XXIV) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	COL28A1 COL28	Q2UY09	COSA1_HUMAN	Collagen alpha-1(XXVIII) chain			
1	All EVs	HLA-DRB5	Q30154	DRB5_HUMAN	"HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)"	cell/tissue specific	MHC class II	
2	All EVs	ANXA2R AX2R C5orf39	Q3ZCQ2	AX2R_HUMAN	Annexin-2 receptor (Annexin II receptor) (AXIIR)	with lipid or membrane protein-binding ability	Annexins	
3	All EVs as purity control	MRPL51 MRP64 CDA09 HSPC241	Q4U2R6	RM51_HUMAN	"39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51) (Mitochondrial large ribosomal subunit protein mL51) (bMRP-64) (bMRP64)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	RPL39P5	Q59GN2	R39L5_HUMAN	Putative 60S ribosomal protein L39-like 5 (60S ribosomal protein L39 pseudogene 5)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	RPS26P11 RPS26L1	Q5JNZ5	RS26L_HUMAN	Putative 40S ribosomal protein S26-like 1	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	COLEC12 CLP1 NSR2 SCARA4 SRCL	Q5KU26	COL12_HUMAN	Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)	adhesion and extracellular matrix proteins		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL5A1-AS1 C9orf104	Q5SY13	COAS1_HUMAN	Putative uncharacterized protein encoded by COL5A1-AS1 (COL5A1 antisense RNA 1) (COL5A1 antisense gene protein 1)			
3	All EVs as purity control	MRPL2 CGI-22	Q5T653	RM02_HUMAN	"39S ribosomal protein L2, mitochondrial (L2mt) (MRP-L2) (Mitochondrial large ribosomal subunit protein uL2m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	COL13A1	Q5TAT6	CODA1_HUMAN	Collagen alpha-1(XIII) chain (COLXIIIA1)			
2	All EVs	ACT*	Q5TD97	FHL5_HUMAN	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis)	promiscuous incorporation in EVs (and possibly exomeres)	cytoskeleton	
2	All EVs	ANXA8L1 ANXA8L2	Q5VT79	AXA81_HUMAN	Annexin A8-like protein 1	with lipid or membrane protein-binding ability	Annexins	
5	Functional component of EVs: need to determine the mode of association with EVs	IL23R	Q5VWK5	IL23R_HUMAN	Interleukin-23 receptor (IL-23 receptor) (IL-23R)	Cytokines and growth factors		
3	All EVs as purity control	RPL7L1	Q6DKI1	RL7L_HUMAN	60S ribosomal protein L7-like 1 (Large ribosomal subunit protein uL30-like 1)	protein and protein/nucleic acid aggregates		NUCLEUS
5	Functional component of EVs: need to determine the mode of association with EVs	IL31	Q6EBC2	IL31_HUMAN	Interleukin-31 (IL-31)	Cytokines and growth factors		
1	All EVs	H2AC18 H2AFO HIST2H2AA HIST2H2AA3; H2AC19 HIST2H2AA4	Q6FI13	H2A2A_HUMAN	Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)	cell/tissue specific	MHC class II	unknown
3	All EVs as purity control	RPL13AP3	Q6NVV1	R13P3_HUMAN	Putative 60S ribosomal protein L13a protein RPL13AP3 (60S ribosomal protein L13a pseudogene 3)	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPL14 MRPL32 RPML32	Q6P1L8	RM14_HUMAN	"39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) (Mitochondrial large ribosomal subunit protein uL14m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	RPL22L1	Q6P5R6	RL22L_HUMAN	60S ribosomal protein L22-like 1 (Large ribosomal subunit protein eL22-like 1)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
5	Functional component of EVs: need to determine the mode of association with EVs	IL27RA CRL1 TCCR WSX1 UNQ296/PRO336	Q6UWB1	I27RA_HUMAN	Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	C17orf99 IL40 UNQ464/PRO809	Q6UX52	IL40_HUMAN	Protein IL-40 (Interleukin-40) (IL-40)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL20RB DIRS1 UNQ557/PRO1114	Q6UXL0	I20RB_HUMAN	Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL34 C16orf77	Q6ZMJ4	IL34_HUMAN	Interleukin-34 (IL-34)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL25A1-DT ZCCHC23	Q6ZST2	COLDT_HUMAN	Putative uncharacterized protein COL25A1-DT (COL25A1 divergent transcript) (Zinc finger CCHC domain-containing protein 23)			
5	Functional component of EVs: need to determine the mode of association with EVs	IL17REL	Q6ZVW7	I17EL_HUMAN	Putative interleukin-17 receptor E-like (IL-17 receptor E-like) (IL-17RE-like)	Cytokines and growth factors		
1	All EVs	H2AZ2 H2AFV H2AV	Q71UI9	H2AV_HUMAN	Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)	cell/tissue specific	MHC class II	
3	All EVs as purity control	RPS27L	Q71UM5	RS27L_HUMAN	40S ribosomal protein S27-like (Small ribosomal subunit protein eS27-like)	protein and protein/nucleic acid aggregates		
1	All EVs	H2AW HIST3H2A	Q7L7L0	H2A3_HUMAN	Histone H2A type 3	cell/tissue specific	MHC class II	
2	All EVs	CHMP1b	Q7LBR1	CHM1B_HUMAN	Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	MRPL21	Q7Z2W9	RM21_HUMAN	"39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21) (Mitochondrial large ribosomal subunit protein bL21m)"	protein and protein/nucleic acid aggregates		unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	ATG9A	Q7Z3C6	ATG9A_HUMAN	Autophagy-related protein 9A (APG9-like 1) (mATG9)	others		unknown
3	All EVs as purity control	MRPL55 UNQ5835/PRO19675	Q7Z7F7	RM55_HUMAN	"39S ribosomal protein L55, mitochondrial (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m) (Mitochondrial large ribosomal subunit protein mL55)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL10 MRPL8 RPML8	Q7Z7H8	RM10_HUMAN	"39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP-L8) (Mitochondrial large ribosomal subunit protein uL10m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL52	Q86TS9	RM52_HUMAN	"39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52) (Mitochondrial large ribosomal subunit protein mL52)"	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	COL23A1	Q86Y22	CONA1_HUMAN	Collagen alpha-1(XXIII) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IFNL1 IL29 ZCYTO21	Q8IU54	IFNL1_HUMAN	Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IFNLR1 IL28RA LICR2	Q8IU57	INLR1_HUMAN	Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)	Cytokines and growth factors		
1	All EVs	H2AC21 HIST2H2AB	Q8IUE6	H2A2B_HUMAN	Histone H2A type 2-B (H2A-clustered histone 21)	cell/tissue specific	MHC class II	NUCLEUS-CHROMATIN
3	All EVs as purity control	MRPL41 BMRP MRPL27 RPML27 PIG3	Q8IXM3	RM41_HUMAN	"39S ribosomal protein L41, mitochondrial (L41mt) (MRP-L41) (39S ribosomal protein L27 homolog) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog) (Mitochondrial large ribosomal subunit protein mL41)"	protein and protein/nucleic acid aggregates		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL27A1 KIAA1870	Q8IZC6	CORA1_HUMAN	Collagen alpha-1(XXVII) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IFNL2 IL28A ZCYTO20	Q8IZJ0	IFNL2_HUMAN	Interferon lambda-2 (IFN-lambda-2) (Cytokine Zcyto20) (Interleukin-28A) (IL-28A)	Cytokines and growth factors		
3	All EVs as purity control	MRPL50	Q8N5N7	RM50_HUMAN	"39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50) (Mitochondrial large ribosomal subunit protein mL50)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL22RA1 IL22R	Q8N6P7	I22R1_HUMAN	Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)	Cytokines and growth factors		
3	All EVs as purity control	MRPL43	Q8N983	RM43_HUMAN	"39S ribosomal protein L43, mitochondrial (L43mt) (MRP-L43) (Mitochondrial large ribosomal subunit protein mL43) (Mitochondrial ribosomal protein bMRP36a)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL17RC UNQ6118/PRO20040/PRO38901	Q8NAC3	I17RC_HUMAN	Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL27 IL27A IL30	Q8NEV9	IL27A_HUMAN	Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (Interleukin-30) (p28)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL17RD IL17RLM SEF UNQ6115/PRO20026	Q8NFM7	I17RD_HUMAN	Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef)	Cytokines and growth factors		PM
5	Functional component of EVs: need to determine the mode of association with EVs	IL17RE UNQ3056/PRO9877	Q8NFR9	I17RE_HUMAN	Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL22A1	Q8NFW1	COMA1_HUMAN	Collagen alpha-1(XXII) chain			unknown
3	All EVs as purity control	RPLP0P6	Q8NHW5	RLA0L_HUMAN	60S acidic ribosomal protein P0-like (Large ribosomal subunit protein uL10-like)	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384	Q8NI17	IL31R_HUMAN	Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL17D UNQ3096/PRO21175	Q8TAD2	IL17D_HUMAN	Interleukin-17D (IL-17D) (Interleukin-27) (IL-27)	Cytokines and growth factors		
3	All EVs as purity control	GADD45GIP1 MRPL59 PLINP1 PRG6	Q8TAE8	G45IP_HUMAN	"Growth arrest and DNA damage-inducible proteins-interacting protein 1 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Mitochondrial large ribosomal subunit protein mL64) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL30 MRPL28 RPML28 HSPC249	Q8TCC3	RM30_HUMAN	"39S ribosomal protein L30, mitochondrial (L30mt) (MRP-L30) (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Mitochondrial large ribosomal subunit protein uL30m)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	RPS4Y2 RPS4Y2P	Q8TD47	RS4Y2_HUMAN	"40S ribosomal protein S4, Y isoform 2 (Small ribosomal subunit protein eS4)"	protein and protein/nucleic acid aggregates		
2	All EVs	"ALIX,PDCD6IP"	Q8WUM4	PDC6I_HUMAN	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	with lipid or membrane protein-binding ability		unknown
2	All EVs	CHMP7	Q8WUX9	CHMP7_HUMAN	Charged multivesicular body protein 7 (Chromatin-modifying protein 7)	with lipid or membrane protein-binding ability		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1F10 FIL1T IL1HY2 IL38 FKSG75 UNQ6119/PRO20041	Q8WWZ1	IL1FA_HUMAN	Interleukin-1 family member 10 (IL-1F10) (Family of interleukin 1-theta) (FIL1 theta) (Interleukin-1 HY2) (IL-1HY2) (Interleukin-1 theta) (IL-1 theta) (Interleukin-38) (IL-38)	Cytokines and growth factors		
3	All EVs as purity control	MRPS27 KIAA0264	Q92552	RT27_HUMAN	"28S ribosomal protein S27, mitochondrial (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27) (Mitochondrial small ribosomal subunit protein mS27)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPS31 IMOGN38	Q92665	RT31_HUMAN	"28S ribosomal protein S31, mitochondrial (MRP-S31) (S31mt) (Imogen 38) (Mitochondrial small ribosomal subunit protein mS31)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	RPL3L	Q92901	RL3L_HUMAN	60S ribosomal protein L3-like (Large ribosomal subunit protein uL3-like)	protein and protein/nucleic acid aggregates		
1	All EVs	H2AC6 H2AFL HIST1H2AC	Q93077	H2A1C_HUMAN	Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)	cell/tissue specific	MHC class II	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC6 H2AFL HIST1H2AC	Q93077	H2A1C_HUMAN	Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)	nucleus	Histones	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC9 H2BFJ HIST1H2BH	Q93079	H2B1H_HUMAN	Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL22RA2 UNQ5793/PRO19598/PRO19822	Q969J5	I22R2_HUMAN	"Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)"	Cytokines and growth factors		
3	All EVs as purity control	RPL36AL	Q969Q0	RL36L_HUMAN	60S ribosomal protein L36a-like (Large ribosomal subunit protein eL42-like)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC1 HIST1H2BA TSH2B	Q96A08	H2B1A_HUMAN	"Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)"	nucleus	Histones	
3	All EVs as purity control	MRPL24	Q96A35	RM24_HUMAN	"39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24) (Mitochondrial large ribosomal subunit protein uL24m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	COL26A1 EMID2 EMU2	Q96A83	COQA1_HUMAN	Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2)			
3	All EVs as purity control	CHCHD1 C10orf34 MRPS37	Q96BP2	CHCH1_HUMAN	"Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 (28S ribosomal protein S37, mitochondrial) (MRP-S37) (Mitochondrial small ribosomal subunit protein mS37) (Nuclear protein C2360)"	protein and protein/nucleic acid aggregates		
2	All EVs	CHMP4c	Q96CF2	CHM4C_HUMAN	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3)	with lipid or membrane protein-binding ability		
3	All EVs as purity control	MRPL38 HSPC262	Q96DV4	RM38_HUMAN	"39S ribosomal protein L38, mitochondrial (L38mt) (MRP-L38) (Mitochondrial large ribosomal subunit protein mL38)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	RPL39L RPL39L1	Q96EH5	RL39L_HUMAN	60S ribosomal protein L39-like (60S ribosomal protein L39-2) (Large ribosomal subunit protein eL39-like)	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPS24 HSPC335	Q96EL2	RT24_HUMAN	"28S ribosomal protein S24, mitochondrial (MRP-S24) (S24mt) (Mitochondrial small ribosomal subunit protein uS3m) (bMRP-47) (bMRP47)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPL53	Q96EL3	RM53_HUMAN	"39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53) (Mitochondrial large ribosomal subunit protein mL53)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	PTCD3 MRPS39 TRG15	Q96EY7	PTCD3_HUMAN	"Pentatricopeptide repeat domain-containing protein 3, mitochondrial (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Mitochondrial small ribosomal subunit protein mS39) (Transformation-related gene 15 protein) (TRG-15)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL17RA IL17R	Q96F46	I17RA_HUMAN	Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)	Cytokines and growth factors		unknown
2	All EVs	CHMP6	Q96FZ7	CHMP6_HUMAN	Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)	with lipid or membrane protein-binding ability		PM
3	All EVs as purity control	MRPL48 CGI-118 HSPC290	Q96GC5	RM48_HUMAN	"39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48) (Mitochondrial large ribosomal subunit protein mL48)"	protein and protein/nucleic acid aggregates		unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC12 HIST1H2AH HIST1H2AI	Q96KK5	H2A1H_HUMAN	Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)	nucleus	Histones	
3	All EVs as purity control	RPL10L	Q96L21	RL10L_HUMAN	60S ribosomal protein L10-like (Large ribosomal subunit protein uL16-like)	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	COL21A1 COL1AL FP633	Q96P44	COLA1_HUMAN	Collagen alpha-1(XXI) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IL17F	Q96PD4	IL17F_HUMAN	Interleukin-17F (IL-17F) (Cytokine ML-1)	Cytokines and growth factors		
1	All EVs	H2AC1 H2AFR HIST1H2AA	Q96QV6	H2A1A_HUMAN	Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)	cell/tissue specific	MHC class II	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC1 H2AFR HIST1H2AA	Q96QV6	H2A1A_HUMAN	Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL4I1 FIG1 UNQ636/PRO1265	Q96RQ9	OXLA_HUMAN	L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (Protein Fig-1) (hFIG1)	Cytokines and growth factors		
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H4C7 H4/L H4FL HIST1H4G	Q99525	H4G_HUMAN	Histone H4-like protein type G (H4-clustered histone 7)	nucleus	Histones	
5	Functional component of EVs: need to determine the mode of association with EVs	IL12RB2	Q99665	I12R2_HUMAN	Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	COL12A1 COL12A1L	Q99715	COCA1_HUMAN	Collagen alpha-1(XII) chain			unknown
2	All EVs	TSG101	Q99816	TS101_HUMAN	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	with lipid or membrane protein-binding ability		unknown
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC15 H2BFD HIST1H2BN	Q99877	H2B1N_HUMAN	Histone H2B type 1-N (Histone H2B.d) (H2B/d)	nucleus	Histones	
1	All EVs	H2AC14 H2AFE HIST1H2AJ	Q99878	H2A1J_HUMAN	Histone H2A type 1-J (Histone H2A/e)	cell/tissue specific	MHC class II	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2AC14 H2AFE HIST1H2AJ	Q99878	H2A1J_HUMAN	Histone H2A type 1-J (Histone H2A/e)	nucleus	Histones	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC14 H2BFE HIST1H2BM	Q99879	H2B1M_HUMAN	Histone H2B type 1-M (Histone H2B.e) (H2B/e)	nucleus	Histones	
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	H2BC13 H2BFC HIST1H2BL	Q99880	H2B1L_HUMAN	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	nucleus	Histones	
3	All EVs as purity control	MRPL34	Q9BQ48	RM34_HUMAN	"39S ribosomal protein L34, mitochondrial (L34mt) (MRP-L34) (Mitochondrial large ribosomal subunit protein bL34m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL57 MRP63	Q9BQC6	RT63_HUMAN	"Ribosomal protein 63, mitochondrial (hMRP63) (Mitochondrial large ribosomal subunit protein mL63) (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL45	Q9BRJ2	RM45_HUMAN	"39S ribosomal protein L45, mitochondrial (L45mt) (MRP-L45) (Mitochondrial large ribosomal subunit protein mL45)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
1	All EVs	H2AJ H2AFJ	Q9BTM1	H2AJ_HUMAN	Histone H2A.J (H2a/j)	cell/tissue specific	MHC class II	
5	Functional component of EVs: need to determine the mode of association with EVs	COLEC11 UNQ596/PRO1182	Q9BWP8	COL11_HUMAN	Collectin-11 (Collectin kidney protein 1) (CL-K1)			
5	Functional component of EVs: need to determine the mode of association with EVs	COL25A1	Q9BXS0	COPA1_HUMAN	Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)]			
2	All EVs	CHMP4a	Q9BY43	CHM4A_HUMAN	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	MRPL32 HSPC283	Q9BYC8	RM32_HUMAN	"39S ribosomal protein L32, mitochondrial (L32mt) (MRP-L32) (Mitochondrial large ribosomal subunit protein bL32m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL20	Q9BYC9	RM20_HUMAN	"39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20) (Mitochondrial large ribosomal subunit protein bL20m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL13	Q9BYD1	RM13_HUMAN	"39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13) (Mitochondrial large ribosomal subunit protein uL13m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL9	Q9BYD2	RM09_HUMAN	"39S ribosomal protein L9, mitochondrial (L9mt) (MRP-L9) (Mitochondrial large ribosomal subunit protein bL9m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL4 CDABP0091 CGI-28	Q9BYD3	RM04_HUMAN	"39S ribosomal protein L4, mitochondrial (L4mt) (MRP-L4) (Mitochondrial large ribosomal subunit protein uL4m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL1 BM-022	Q9BYD6	RM01_HUMAN	"39S ribosomal protein L1, mitochondrial (L1mt) (MRP-L1) (Mitochondrial large ribosomal subunit protein uL1m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS26 C20orf193 RPMS13	Q9BYN8	RT26_HUMAN	"28S ribosomal protein S26, mitochondrial (MRP-S26) (S26mt) (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (Mitochondrial small ribosomal subunit protein mS26)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL37 MRPL2 RPML2 HSPC235	Q9BZE1	RM37_HUMAN	"39S ribosomal protein L37, mitochondrial (L37mt) (MRP-L37) (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (Mitochondrial large ribosomal subunit protein mL37)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL22 ILTIF ZCYTO18 UNQ3099/PRO10096	Q9GZX6	IL22_HUMAN	Interleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF)	Cytokines and growth factors		
3	All EVs as purity control	MRPL18 HSPC071	Q9H0U6	RM18_HUMAN	"39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18) (Mitochondrial large ribosomal subunit protein uL18m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
2	All EVs	EHD4 HCA10 HCA11 PAST4 FKSG7	Q9H223	EHD4_HUMAN	EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)	with lipid or membrane protein-binding ability		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL25 IL17E UNQ3120/PRO10272	Q9H293	IL25_HUMAN	Interleukin-25 (IL-25) (Interleukin-17E) (IL-17E)	Cytokines and growth factors		
3	All EVs as purity control	MRPL46 C15orf4 LIECG2	Q9H2W6	RM46_HUMAN	"39S ribosomal protein L46, mitochondrial (L46mt) (MRP-L46) (Mitochondrial large ribosomal subunit protein mL46) (P2ECSL)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
2	All EVs	CHMP4b	Q9H444	CHM4B_HUMAN	Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)	with lipid or membrane protein-binding ability		unknown
2	All EVs	EHD1 PAST PAST1 CDABP0131	Q9H4M9	EHD1_HUMAN	EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	MRPL44	Q9H9J2	RM44_HUMAN	"39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-) (Mitochondrial large ribosomal subunit protein mL44)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RL2 IL1RRP2	Q9HB29	ILRL2_HUMAN	Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL21	Q9HBE4	IL21_HUMAN	Interleukin-21 (IL-21) (Za11)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL21R NILR UNQ3121/PRO10273	Q9HBE5	IL21R_HUMAN	Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)	Cytokines and growth factors		
3	All EVs as purity control	MRPL47 NCM1 CGI-204	Q9HD33	RM47_HUMAN	"39S ribosomal protein L47, mitochondrial (L47mt) (MRP-L47) (Mitochondrial large ribosomal subunit protein uL29m) (Nasopharyngeal carcinoma metastasis-related protein 1)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
2	All EVs	CHMP1a	Q9HD42	CHM1A_HUMAN	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	with lipid or membrane protein-binding ability		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RAPL2 IL1R9	Q9NP60	IRPL2_HUMAN	X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1)	Cytokines and growth factors		
3	All EVs as purity control	MRPS30 PDCD9 BM-047	Q9NP92	RT30_HUMAN	"39S ribosomal protein S30, mitochondrial (MRP-S30) (S30mt) (Mitochondrial large ribosomal subunit protein mL65) (Mitochondrial large ribosomal subunit protein mS30) (Programmed cell death protein 9)"	protein and protein/nucleic acid aggregates		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL23A SGRF UNQ2498/PRO5798	Q9NPF7	IL23A_HUMAN	Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RAP C3orf13 IL1R3	Q9NPH3	IL1AP_HUMAN	Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)	Cytokines and growth factors		PM
5	Functional component of EVs: need to determine the mode of association with EVs	IL26 AK155	Q9NPH9	IL26_HUMAN	Interleukin-26 (IL-26) (Protein AK155)	Cytokines and growth factors		
1	All EVs	NMRK2 ITGB1BP3 NRK2	Q9NPI5	NRK2_HUMAN	Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)	non-tissue specific	Integrins	
3	All EVs as purity control	RPS10P5 RPS10L	Q9NQ39	RS10L_HUMAN	Putative 40S ribosomal protein S10-like	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPL40 NLVCF URIM	Q9NQ50	RM40_HUMAN	"39S ribosomal protein L40, mitochondrial (L40mt) (MRP-L40) (Mitochondrial large ribosomal subunit protein mL40) (Nuclear localization signal-containing protein deleted in velocardiofacial syndrome) (Up-regulated in metastasis)"	protein and protein/nucleic acid aggregates		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612	Q9NRM6	I17RB_HUMAN	Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)	Cytokines and growth factors		
3	All EVs as purity control	MRPL17 LIP2	Q9NRX2	RM17_HUMAN	"39S ribosomal protein L17, mitochondrial (L17mt) (MRP-L17) (LYST-interacting protein 2) (Mitochondrial large ribosomal subunit protein bL17m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	IMP3 C15orf12 MRPS4	Q9NV31	IMP3_HUMAN	U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (BRMS2)	protein and protein/nucleic acid aggregates		NUCLEUS
3	All EVs as purity control	MRPS18A	Q9NVS2	RT18A_HUMAN	"39S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (Mitochondrial large ribosomal subunit protein bS18a) (Mitochondrial large ribosomal subunit protein mL66)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	AURKAIP1 AIP AKIP MRPS38	Q9NWT8	AKIP_HUMAN	"Aurora kinase A-interacting protein (AURKA-interacting protein) (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Mitochondrial small ribosomal subunit protein mS38)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPL22 MRPL25 RPML25 HSPC158	Q9NWU5	RM22_HUMAN	"39S ribosomal protein L22, mitochondrial (L22mt) (MRP-L22) (39S ribosomal protein L25, mitochondrial) (L25mt) (MRP-L25) (Mitochondrial large ribosomal subunit protein uL22m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL16 PNAS-111	Q9NX20	RM16_HUMAN	"39S ribosomal protein L16, mitochondrial (L16mt) (MRP-L16) (Mitochondrial large ribosomal subunit protein uL16m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	NHP2 NOLA2 HSPC286	Q9NX24	NHP2_HUMAN	H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)	protein and protein/nucleic acid aggregates		NUCLEUS
3	All EVs as purity control	MRPL39 C21orf92 MRPL5 RPML5 MSTP003 PRED22	Q9NYK5	RM39_HUMAN	"39S ribosomal protein L39, mitochondrial (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5) (Mitochondrial large ribosomal subunit protein mL39)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL20 ZCYTO10 UNQ852/PRO1801	Q9NYY1	IL20_HUMAN	Interleukin-20 (IL-20) (Cytokine Zcyto10)	Cytokines and growth factors		
3	All EVs as purity control	MRPL35 BM-007	Q9NZE8	RM35_HUMAN	"39S ribosomal protein L35, mitochondrial (L35mt) (MRP-L35) (Mitochondrial large ribosomal subunit protein bL35m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
5	Functional component of EVs: need to determine the mode of association with EVs	IL37 FIL1Z IL1F7 IL1H4 IL1RP1	Q9NZH6	IL37_HUMAN	Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL36B IL1F8 IL1H2	Q9NZH7	IL36B_HUMAN	Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL36G IL1E IL1F9 IL1H1 IL1RP2 UNQ2456/PRO5737	Q9NZH8	IL36G_HUMAN	Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL1RAPL1 OPHN4	Q9NZN1	IRPL1_HUMAN	Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)	Cytokines and growth factors		
2	All EVs	EHD3 EHD2 PAST3	Q9NZN3	EHD3_HUMAN	EH domain-containing protein 3 (PAST homolog 3)	with lipid or membrane protein-binding ability		PM
2	All EVs	EHD2 PAST2	Q9NZN4	EHD2_HUMAN	EH domain-containing protein 2 (PAST homolog 2)	with lipid or membrane protein-binding ability		unknown
2	All EVs	CHMP5	Q9NZZ3	CHMP5_HUMAN	Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	MRPL15 HSPC145	Q9P015	RM15_HUMAN	"39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein uL15m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL36 BRIP1	Q9P0J6	RM36_HUMAN	"39S ribosomal protein L36, mitochondrial (L36mt) (MRP-L36) (BRCA1-interacting protein 1) (Mitochondrial large ribosomal subunit protein bL36m)"	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	IL17C UNQ561/PRO1122	Q9P0M4	IL17C_HUMAN	Interleukin-17C (IL-17C) (Cytokine CX2)	Cytokines and growth factors		
3	All EVs as purity control	MRPL27 HSPC250	Q9P0M9	RM27_HUMAN	"39S ribosomal protein L27, mitochondrial (L27mt) (MRP-L27) (Mitochondrial large ribosomal subunit protein bL27m)"	protein and protein/nucleic acid aggregates		unknown
5	Functional component of EVs: need to determine the mode of association with EVs	COL20A1 KIAA1510	Q9P218	COKA1_HUMAN	Collagen alpha-1(XX) chain			
5	Functional component of EVs: need to determine the mode of association with EVs	IL36RN FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 UNQ1896/PRO4342	Q9UBH0	I36RA_HUMAN	Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)	Cytokines and growth factors		
3	All EVs as purity control	RSL24D1 C15orf15 RPL24L My024	Q9UHA3	RLP24_HUMAN	Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like)	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	IL36A FIL1E IL1E IL1F6	Q9UHA7	IL36A_HUMAN	Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL19 ZMDA1	Q9UHD0	IL19_HUMAN	Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL20RA UNQ681/PRO1315	Q9UHF4	I20RA_HUMAN	Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7)	Cytokines and growth factors		
5	Functional component of EVs: need to determine the mode of association with EVs	IL17B IL20 NIRF ZCYTO7 UNQ516/PRO1031	Q9UHF5	IL17B_HUMAN	Interleukin-17B (IL-17B) (Cytokine Zcyto7) (Interleukin-20) (IL-20) (Neuronal interleukin-17-related factor)	Cytokines and growth factors		
2	All EVs	ANXA10 ANX14	Q9UJ72	ANX10_HUMAN	Annexin A10 (Annexin-10) (Annexin-14)	with lipid or membrane protein-binding ability	Annexins	
3	All EVs as purity control	MRTO4 C1orf33 MRT4	Q9UKD2	MRT4_HUMAN	mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4)	protein and protein/nucleic acid aggregates		NUCLEUS
1	All EVs	ITGB1BP2 MSTP015	Q9UKP3	ITBP2_HUMAN	Integrin beta-1-binding protein 2 (Melusin)	non-tissue specific	Integrins	
1	All EVs	ITGA11 MSTP018	Q9UKX5	ITA11_HUMAN	Integrin alpha-11	non-tissue specific	Integrins	
5	Functional component of EVs: need to determine the mode of association with EVs	COL17A1 BP180 BPAG2	Q9UMD9	COHA1_HUMAN	Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]			
2	All EVs	VSPS4A	Q9UN37	VPS4A_HUMAN	Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	RPL26L1 RPL26P1	Q9UNX3	RL26L_HUMAN	60S ribosomal protein L26-like 1 (Large ribosomal subunit protein uL24-like 1)	protein and protein/nucleic acid aggregates		
1	All EVs	TFR2	Q9UP52	TFR2_HUMAN	Transferrin receptor protein 2 (TfR2)	non-tissue specific	transferrin receptor	
2	All EVs	CHMP2b	Q9UQN3	CHM2B_HUMAN	Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)	with lipid or membrane protein-binding ability		unknown
3	All EVs as purity control	MRPS33 CGI-139 PTD003	Q9Y291	RT33_HUMAN	"28S ribosomal protein S33, mitochondrial (MRP-S33) (S33mt) (Mitochondrial small ribosomal subunit protein mS33)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPS28 MRPS35 HSPC007	Q9Y2Q9	RT28_HUMAN	"28S ribosomal protein S28, mitochondrial (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) (Mitochondrial small ribosomal subunit protein bS1m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS17 RPMS17 HSPC011	Q9Y2R5	RT17_HUMAN	"28S ribosomal protein S17, mitochondrial (MRP-S17) (S17mt) (Mitochondrial small ribosomal subunit protein uS17m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS7	Q9Y2R9	RT07_HUMAN	"28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt) (Mitochondrial small ribosomal subunit protein uS7m) (bMRP-27a) (bMRP27a)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPS2 CGI-91	Q9Y399	RT02_HUMAN	"28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt) (Mitochondrial small ribosomal subunit protein uS2m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPL11 CGI-113	Q9Y3B7	RM11_HUMAN	"39S ribosomal protein L11, mitochondrial (L11mt) (MRP-L11) (Mitochondrial large ribosomal subunit protein uL11m)"	protein and protein/nucleic acid aggregates		MITOCHONDRIA
3	All EVs as purity control	MRPS16 RPMS16 CGI-132	Q9Y3D3	RT16_HUMAN	"28S ribosomal protein S16, mitochondrial (MRP-S16) (S16mt) (Mitochondrial small ribosomal subunit protein bS16m)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPS18C CGI-134	Q9Y3D5	RT18C_HUMAN	"28S ribosomal protein S18c, mitochondrial (MRP-S18-c) (Mrps18-c) (S18mt-c) (28S ribosomal protein S18-1, mitochondrial) (MRP-S18-1) (Mitochondrial small ribosomal subunit protein bS18c) (Mitochondrial small ribosomal subunit protein bS18m)"	protein and protein/nucleic acid aggregates		
3	All EVs as purity control	MRPS23 CGI-138 HSPC329	Q9Y3D9	RT23_HUMAN	"28S ribosomal protein S23, mitochondrial (MRP-S23) (S23mt) (Mitochondrial small ribosomal subunit protein mS23)"	protein and protein/nucleic acid aggregates		unknown
2	All EVs	CHMP3	Q9Y3E7	CHMP3_HUMAN	Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)	with lipid or membrane protein-binding ability		
3	All EVs as purity control	RPL36	Q9Y3U8	RL36_HUMAN	60S ribosomal protein L36 (Large ribosomal subunit protein eL36)	protein and protein/nucleic acid aggregates		RIBOSOME 60S
3	All EVs as purity control	MRPS18B C6orf14 HSPC183 PTD017	Q9Y676	RT18B_HUMAN	"28S ribosomal protein S18b, mitochondrial (MRP-S18-b) (Mrps18-b) (S18mt-b) (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (Mitochondrial small ribosomal subunit protein bS18b) (Mitochondrial small ribosomal subunit protein mS40)"	protein and protein/nucleic acid aggregates		unknown
3	All EVs as purity control	MRPL42 MRPL31 MRPS32 RPML31 HSPC204 PTD007	Q9Y6G3	RM42_HUMAN	"39S ribosomal protein L42, mitochondrial (L42mt) (MRP-L42) (39S ribosomal protein L31, mitochondrial) (L31mt) (MRP-L31) (Mitochondrial large ribosomal subunit protein mL42)"	protein and protein/nucleic acid aggregates		
5	Functional component of EVs: need to determine the mode of association with EVs	COLEC10 CLL1 UNQ366/PRO702	Q9Y6Z7	COL10_HUMAN	Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34)			
2	All EVs	ESCRT-I				with lipid or membrane protein-binding ability		
2	All EVs	ESCRT-II				with lipid or membrane protein-binding ability		
2	All EVs	ESCRT-III				with lipid or membrane protein-binding ability		
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	GM130				secretory pathway		
1	All EVs	H2-D				non-tissue specific	MHC class I	
1	All EVs	H2-K				non-tissue specific	MHC class I	
1	All EVs	H2-Q				non-tissue specific	MHC class I	
2	All EVs	HSP84				with lipid or membrane protein-binding ability	Heat shock proteins	Abundant in exomeres
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	HSPAS				secretory pathway		
4	"Subtypes of EVs (e.g. large oncosomes, large EVs) and/or pathologic/atypical state"	MMT				mitochondrial		
1	All EVs	MSCs				cell/tissue specific	immune cells	
3	All EVs as purity control	Tamm-Horsfall protein				protein and protein/nucleic acid aggregates		