## New Classes

 * [MONDO:0030801](http://purl.obolibrary.org/obo/MONDO_0030801) monosomy 7 myelodysplasia and leukemia syndrome 2
 * [MONDO:0030840](http://purl.obolibrary.org/obo/MONDO_0030840) mismatch repair cancer syndrome 2
 * [MONDO:0030841](http://purl.obolibrary.org/obo/MONDO_0030841) mismatch repair cancer syndrome 3
 * [MONDO:0030843](http://purl.obolibrary.org/obo/MONDO_0030843) mismatch repair cancer syndrome 4
 * [MONDO:0030844](http://purl.obolibrary.org/obo/MONDO_0030844) spermatogenic failure 47
 * [MONDO:0030846](http://purl.obolibrary.org/obo/MONDO_0030846) spermatogenic failure 48
 * [MONDO:0030847](http://purl.obolibrary.org/obo/MONDO_0030847) arthrogryposis, distal, type 1C
 * [MONDO:0030854](http://purl.obolibrary.org/obo/MONDO_0030854) combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1
 * [MONDO:0030855](http://purl.obolibrary.org/obo/MONDO_0030855) combined osteogenesis imperfecta and Ehlers-Danlos syndrome 2
 * [MONDO:0030856](http://purl.obolibrary.org/obo/MONDO_0030856) developmental and epileptic encephalopathy 89
 * [MONDO:0030858](http://purl.obolibrary.org/obo/MONDO_0030858) immunodeficiency 75
 * [MONDO:0030861](http://purl.obolibrary.org/obo/MONDO_0030861) osteogenesis imperfecta, type 21
 * [MONDO:0030864](http://purl.obolibrary.org/obo/MONDO_0030864) Ritscher-Schinzel syndrome 3
 * [MONDO:0030867](http://purl.obolibrary.org/obo/MONDO_0030867) thrombocytopenia 7
 * [MONDO:0030868](http://purl.obolibrary.org/obo/MONDO_0030868) spermatogenic failure 49
 * [MONDO:0030869](http://purl.obolibrary.org/obo/MONDO_0030869) spermatogenic failures 50
 * [MONDO:0030870](http://purl.obolibrary.org/obo/MONDO_0030870) premature ovarian failure 17
 * [MONDO:0030872](http://purl.obolibrary.org/obo/MONDO_0030872) frontotemporal dementia and/or amyotrophic lateral sclerosis 8
 * [MONDO:0030875](http://purl.obolibrary.org/obo/MONDO_0030875) frontotemporal dementia and/or amyotrophic lateral sclerosis 5
 * [MONDO:0030876](http://purl.obolibrary.org/obo/MONDO_0030876) cardioacrofacial dysplasia 1
 * [MONDO:0030877](http://purl.obolibrary.org/obo/MONDO_0030877) cardioacrofacial dysplasia 2
 * [MONDO:0030883](http://purl.obolibrary.org/obo/MONDO_0030883) carpal tunnel syndrome 2
 * [MONDO:0031178](http://purl.obolibrary.org/obo/MONDO_0031178) monosomy 7 myelodysplasia and leukemia syndrome
 * [MONDO:0031219](http://purl.obolibrary.org/obo/MONDO_0031219) mismatch repair cancer syndrome
 * [MONDO:0031386](http://purl.obolibrary.org/obo/MONDO_0031386) cardioacrofacial dysplasia
 * [MONDO:0035117](http://purl.obolibrary.org/obo/MONDO_0035117) PUM1-associated developmental disability-ataxia-seizure syndrome
 * [MONDO:0035121](http://purl.obolibrary.org/obo/MONDO_0035121) myeloid/lymphoid neoplasm associated with JAK2 rearrangement
 * [MONDO:0035122](http://purl.obolibrary.org/obo/MONDO_0035122) GRIN2B-related developmental delay, intellectual disability and autism spectrum disorder
 * [MONDO:0035124](http://purl.obolibrary.org/obo/MONDO_0035124) linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies
 * [MONDO:0035133](http://purl.obolibrary.org/obo/MONDO_0035133) PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
 * [MONDO:0035136](http://purl.obolibrary.org/obo/MONDO_0035136) isolated melanotic schwannoma
 * [MONDO:0100230](http://purl.obolibrary.org/obo/MONDO_0100230) fatty acyl-CoA reductase 1 dysregulation
 * [MONDO:0100231](http://purl.obolibrary.org/obo/MONDO_0100231) psoriatic arthritis, susceptibility to, 1
 * [MONDO:0100232](http://purl.obolibrary.org/obo/MONDO_0100232) 'psoriatic arthritis, susceptibility to
 * [MONDO:0100233](http://purl.obolibrary.org/obo/MONDO_0100233) long COVID-19
 * [MONDO:0100234](http://purl.obolibrary.org/obo/MONDO_0100234) paroxysmal familial ventricular fibrillation

## Obsoletions

 * [MONDO:0015502](http://purl.obolibrary.org/obo/MONDO_0015502) pinnae and external auditory canal anomaly --> obsolete pinnae and external auditory canal anomaly
 * [MONDO:0015891](http://purl.obolibrary.org/obo/MONDO_0015891) hypogonadotropic hypogonadism associated with other endocrinopathies --> obsolete hypogonadotropic hypogonadism associated with other endocrinopathies
 * [MONDO:0016131](http://purl.obolibrary.org/obo/MONDO_0016131) spinal muscular atrophy associated with central nervous system anomaly --> obsolete spinal muscular atrophy associated with central nervous system anomaly
 * [MONDO:0016138](http://purl.obolibrary.org/obo/MONDO_0016138) malignant lymphoma with peripheral neuropathy --> obsolete malignant lymphoma with peripheral neuropathy
 * [MONDO:0016404](http://purl.obolibrary.org/obo/MONDO_0016404) metabolic neurotransmission anomaly with epilepsy --> obsolete metabolic neurotransmission anomaly with epilepsy
 * [MONDO:0016804](http://purl.obolibrary.org/obo/MONDO_0016804) exercise intolerance with lactic acidosis --> obsolete exercise intolerance with lactic acidosis
 * [MONDO:0017000](http://purl.obolibrary.org/obo/MONDO_0017000) X chromosome number anomaly with female phenotype --> obsolete X chromosome number anomaly with female phenotype
 * [MONDO:0017001](http://purl.obolibrary.org/obo/MONDO_0017001) X chromosome number anomaly with male phenotype --> obsolete X chromosome number anomaly with male phenotype
 * [MONDO:0017083](http://purl.obolibrary.org/obo/MONDO_0017083) lipoma associated with neurospinal dysraphism --> obsolete lipoma associated with neurospinal dysraphism
 * [MONDO:0017085](http://purl.obolibrary.org/obo/MONDO_0017085) malformation of the neurenteric canal, spinal cord and column --> obsolete malformation of the neurenteric canal, spinal cord and column
 * [MONDO:0017433](http://purl.obolibrary.org/obo/MONDO_0017433) dysostosis with combined reduction defects of upper and lower limbs --> obsolete dysostosis with combined reduction defects of upper and lower limbs
 * [MONDO:0017653](http://purl.obolibrary.org/obo/MONDO_0017653) epilepsy and/or ataxia with myoclonus as major feature --> obsolete epilepsy and/or ataxia with myoclonus as major feature
 * [MONDO:0017654](http://purl.obolibrary.org/obo/MONDO_0017654) non progressive epilepsy and/or ataxia with myoclonus as a major feature --> obsolete non progressive epilepsy and/or ataxia with myoclonus as a major feature
 * [MONDO:0017655](http://purl.obolibrary.org/obo/MONDO_0017655) progressive epilepsy and/or ataxia with myoclonus as a major feature --> obsolete progressive epilepsy and/or ataxia with myoclonus as a major feature
 * [MONDO:0018032](http://purl.obolibrary.org/obo/MONDO_0018032) constitutional neutropenia with extra-hematopoietic manifestations --> obsolete constitutional neutropenia with extra-hematopoietic manifestations
 * [MONDO:0018038](http://purl.obolibrary.org/obo/MONDO_0018038) immunodeficiency with isotype or light chain deficiencies with normal number of B-cells --> obsolete immunodeficiency with isotype or light chain deficiencies with normal number of B-cells
 * [MONDO:0018200](http://purl.obolibrary.org/obo/MONDO_0018200) acute encephalopathy with inflammation-mediated status epilepticus --> obsolete acute encephalopathy with inflammation-mediated status epilepticus
 * [MONDO:0018299](http://purl.obolibrary.org/obo/MONDO_0018299) sphingolipidosis with epilepsy --> obsolete sphingolipidosis with epilepsy
 * [MONDO:0018545](http://purl.obolibrary.org/obo/MONDO_0018545) primary immunodeficiency with predisposition to severe viral infection --> obsolete primary immunodeficiency with predisposition to severe viral infection
 * [MONDO:0018699](http://purl.obolibrary.org/obo/MONDO_0018699) pseudohypoparathyroidism with Albright hereditary osteodystrophy --> obsolete pseudohypoparathyroidism with Albright hereditary osteodystrophy
 * [MONDO:0018700](http://purl.obolibrary.org/obo/MONDO_0018700) pseudohypoparathyroidism without Albright hereditary osteodystrophy --> obsolete pseudohypoparathyroidism without Albright hereditary osteodystrophy
 * [MONDO:0018722](http://purl.obolibrary.org/obo/MONDO_0018722) primary lymphedema with associated anomalies --> obsolete primary lymphedema with associated anomalies
 * [MONDO:0019709](http://purl.obolibrary.org/obo/MONDO_0019709) cleidocranial dysplasia and isolated cranial ossification defect --> obsolete cleidocranial dysplasia and isolated cranial ossification defect
 * [MONDO:0019710](http://purl.obolibrary.org/obo/MONDO_0019710) dysostosis with predominant craniofacial involvement --> obsolete dysostosis with predominant craniofacial involvement
 * [MONDO:0019711](http://purl.obolibrary.org/obo/MONDO_0019711) dysostosis with predominant vertebral and costal involvement --> obsolete dysostosis with predominant vertebral and costal involvement
 * [MONDO:0019987](http://purl.obolibrary.org/obo/MONDO_0019987) congenital and infantile nephrotic syndrome --> obsolete congenital and infantile nephrotic syndrome
 * [MONDO:0020139](http://purl.obolibrary.org/obo/MONDO_0020139) early-onset ataxia with dementia --> obsolete early-onset ataxia with dementia
 * [MONDO:0020140](http://purl.obolibrary.org/obo/MONDO_0020140) late-onset ataxia with dementia --> obsolete late-onset ataxia with dementia
 * [MONDO:0020221](http://purl.obolibrary.org/obo/MONDO_0020221) secondary glaucoma due to a proliferation and differentiation anomaly --> obsolete secondary glaucoma due to a proliferation and differentiation anomaly
 * [MONDO:0020234](http://purl.obolibrary.org/obo/MONDO_0020234) craniofacial anomaly with cataract --> obsolete craniofacial anomaly with cataract
 * [MONDO:0020243](http://purl.obolibrary.org/obo/MONDO_0020243) colobomatous and areolar dystrophy --> obsolete colobomatous and areolar dystrophy
 * [MONDO:0020254](http://purl.obolibrary.org/obo/MONDO_0020254) craniostenosis associated with a strabismus --> obsolete craniostenosis associated with a strabismus
 * [MONDO:0020262](http://purl.obolibrary.org/obo/MONDO_0020262) nervous system anomaly with eye involvement --> obsolete nervous system anomaly with eye involvement
 * [MONDO:0020263](http://purl.obolibrary.org/obo/MONDO_0020263) spinocerebellar ataxia with oculomotor anomaly --> obsolete spinocerebellar ataxia with oculomotor anomaly
 * [MONDO:0020264](http://purl.obolibrary.org/obo/MONDO_0020264) spinocerebellar degenerescence and spastic paraparesis with an oculomotor anomaly --> obsolete spinocerebellar degenerescence and spastic paraparesis with an oculomotor anomaly
 * [MONDO:0020268](http://purl.obolibrary.org/obo/MONDO_0020268) ichthyosis associated with ocular features --> obsolete ichthyosis associated with ocular features
 * [MONDO:0020269](http://purl.obolibrary.org/obo/MONDO_0020269) syndromic ichthyosis associated with ocular features --> obsolete syndromic ichthyosis associated with ocular features
 * [MONDO:0020271](http://purl.obolibrary.org/obo/MONDO_0020271) phakomatosis with eye involvement --> obsolete phakomatosis with eye involvement
 * [MONDO:0028741](http://purl.obolibrary.org/obo/MONDO_0028741) overgrowth or tall stature syndrome with skeletal involvement --> obsolete overgrowth or tall stature syndrome with skeletal involvement
 * [MONDO:0028742](http://purl.obolibrary.org/obo/MONDO_0028742) dysostosis with brachydactyly without extraskeletal manifestations --> obsolete dysostosis with brachydactyly without extraskeletal manifestations
 * [MONDO:0028743](http://purl.obolibrary.org/obo/MONDO_0028743) dysostosis with brachydactyly with extraskeletal manifestations --> obsolete dysostosis with brachydactyly with extraskeletal manifestations

## Renaming

 * [MONDO:0000914](http://purl.obolibrary.org/obo/MONDO_0000914) CADASIL 1 --> cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
 * [MONDO:0007432](http://purl.obolibrary.org/obo/MONDO_0007432) CADASIL --> cerebral arteriopathy with subcortical infarcts and leukoencephalopathy
 * [MONDO:0009646](http://purl.obolibrary.org/obo/MONDO_0009646) monosomy 7 of bone marrow --> Monosomy 7 myelodysplasia and leukemia syndrome 1
 * [MONDO:0010120](http://purl.obolibrary.org/obo/MONDO_0010120) THC3 --> thrombocytopenia 3
 * [MONDO:0010159](http://purl.obolibrary.org/obo/MONDO_0010159) constitutional mismatch repair deficiency syndrome --> mismatch repair cancer syndrome 1
 * [MONDO:0010743](http://purl.obolibrary.org/obo/MONDO_0010743) X-linked thrombocytopenia with normal platelets --> thrombocytopenia 1
 * [MONDO:0010829](http://purl.obolibrary.org/obo/MONDO_0010829) CARASIL --> CARASIL syndrome
 * [MONDO:0010958](http://purl.obolibrary.org/obo/MONDO_0010958) cardiac arrhythmia, ankyrin-b-related --> cardiac arrhythmia, ankyrin-B-related
 * [MONDO:0011376](http://purl.obolibrary.org/obo/MONDO_0011376) idiopathic ventricular fibrillation, non Brugada type --> ventricular fibrillation, paroxysmal familial, type 1
 * [MONDO:0014837](http://purl.obolibrary.org/obo/MONDO_0014837) hereditary thrombocytopenia with early-onset myelofibrosis --> thrombocytopenia 6
 * [MONDO:0015502](http://purl.obolibrary.org/obo/MONDO_0015502) pinnae and external auditory canal anomaly --> obsolete pinnae and external auditory canal anomaly
 * [MONDO:0015688](http://purl.obolibrary.org/obo/MONDO_0015688) myeloid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB or FGFR1 --> myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2
 * [MONDO:0015891](http://purl.obolibrary.org/obo/MONDO_0015891) hypogonadotropic hypogonadism associated with other endocrinopathies --> obsolete hypogonadotropic hypogonadism associated with other endocrinopathies
 * [MONDO:0016131](http://purl.obolibrary.org/obo/MONDO_0016131) spinal muscular atrophy associated with central nervous system anomaly --> obsolete spinal muscular atrophy associated with central nervous system anomaly
 * [MONDO:0016138](http://purl.obolibrary.org/obo/MONDO_0016138) malignant lymphoma with peripheral neuropathy --> obsolete malignant lymphoma with peripheral neuropathy
 * [MONDO:0016404](http://purl.obolibrary.org/obo/MONDO_0016404) metabolic neurotransmission anomaly with epilepsy --> obsolete metabolic neurotransmission anomaly with epilepsy
 * [MONDO:0016804](http://purl.obolibrary.org/obo/MONDO_0016804) exercise intolerance with lactic acidosis --> obsolete exercise intolerance with lactic acidosis
 * [MONDO:0017000](http://purl.obolibrary.org/obo/MONDO_0017000) X chromosome number anomaly with female phenotype --> obsolete X chromosome number anomaly with female phenotype
 * [MONDO:0017001](http://purl.obolibrary.org/obo/MONDO_0017001) X chromosome number anomaly with male phenotype --> obsolete X chromosome number anomaly with male phenotype
 * [MONDO:0017083](http://purl.obolibrary.org/obo/MONDO_0017083) lipoma associated with neurospinal dysraphism --> obsolete lipoma associated with neurospinal dysraphism
 * [MONDO:0017085](http://purl.obolibrary.org/obo/MONDO_0017085) malformation of the neurenteric canal, spinal cord and column --> obsolete malformation of the neurenteric canal, spinal cord and column
 * [MONDO:0017433](http://purl.obolibrary.org/obo/MONDO_0017433) dysostosis with combined reduction defects of upper and lower limbs --> obsolete dysostosis with combined reduction defects of upper and lower limbs
 * [MONDO:0017653](http://purl.obolibrary.org/obo/MONDO_0017653) epilepsy and/or ataxia with myoclonus as major feature --> obsolete epilepsy and/or ataxia with myoclonus as major feature
 * [MONDO:0017654](http://purl.obolibrary.org/obo/MONDO_0017654) non progressive epilepsy and/or ataxia with myoclonus as a major feature --> obsolete non progressive epilepsy and/or ataxia with myoclonus as a major feature
 * [MONDO:0017655](http://purl.obolibrary.org/obo/MONDO_0017655) progressive epilepsy and/or ataxia with myoclonus as a major feature --> obsolete progressive epilepsy and/or ataxia with myoclonus as a major feature
 * [MONDO:0018032](http://purl.obolibrary.org/obo/MONDO_0018032) constitutional neutropenia with extra-hematopoietic manifestations --> obsolete constitutional neutropenia with extra-hematopoietic manifestations
 * [MONDO:0018038](http://purl.obolibrary.org/obo/MONDO_0018038) immunodeficiency with isotype or light chain deficiencies with normal number of B-cells --> obsolete immunodeficiency with isotype or light chain deficiencies with normal number of B-cells
 * [MONDO:0018200](http://purl.obolibrary.org/obo/MONDO_0018200) acute encephalopathy with inflammation-mediated status epilepticus --> obsolete acute encephalopathy with inflammation-mediated status epilepticus
 * [MONDO:0018299](http://purl.obolibrary.org/obo/MONDO_0018299) sphingolipidosis with epilepsy --> obsolete sphingolipidosis with epilepsy
 * [MONDO:0018545](http://purl.obolibrary.org/obo/MONDO_0018545) primary immunodeficiency with predisposition to severe viral infection --> obsolete primary immunodeficiency with predisposition to severe viral infection
 * [MONDO:0018699](http://purl.obolibrary.org/obo/MONDO_0018699) pseudohypoparathyroidism with Albright hereditary osteodystrophy --> obsolete pseudohypoparathyroidism with Albright hereditary osteodystrophy
 * [MONDO:0018700](http://purl.obolibrary.org/obo/MONDO_0018700) pseudohypoparathyroidism without Albright hereditary osteodystrophy --> obsolete pseudohypoparathyroidism without Albright hereditary osteodystrophy
 * [MONDO:0018722](http://purl.obolibrary.org/obo/MONDO_0018722) primary lymphedema with associated anomalies --> obsolete primary lymphedema with associated anomalies
 * [MONDO:0019709](http://purl.obolibrary.org/obo/MONDO_0019709) cleidocranial dysplasia and isolated cranial ossification defect --> obsolete cleidocranial dysplasia and isolated cranial ossification defect
 * [MONDO:0019710](http://purl.obolibrary.org/obo/MONDO_0019710) dysostosis with predominant craniofacial involvement --> obsolete dysostosis with predominant craniofacial involvement
 * [MONDO:0019711](http://purl.obolibrary.org/obo/MONDO_0019711) dysostosis with predominant vertebral and costal involvement --> obsolete dysostosis with predominant vertebral and costal involvement
 * [MONDO:0019987](http://purl.obolibrary.org/obo/MONDO_0019987) congenital and infantile nephrotic syndrome --> obsolete congenital and infantile nephrotic syndrome
 * [MONDO:0020139](http://purl.obolibrary.org/obo/MONDO_0020139) early-onset ataxia with dementia --> obsolete early-onset ataxia with dementia
 * [MONDO:0020140](http://purl.obolibrary.org/obo/MONDO_0020140) late-onset ataxia with dementia --> obsolete late-onset ataxia with dementia
 * [MONDO:0020221](http://purl.obolibrary.org/obo/MONDO_0020221) secondary glaucoma due to a proliferation and differentiation anomaly --> obsolete secondary glaucoma due to a proliferation and differentiation anomaly
 * [MONDO:0020234](http://purl.obolibrary.org/obo/MONDO_0020234) craniofacial anomaly with cataract --> obsolete craniofacial anomaly with cataract
 * [MONDO:0020243](http://purl.obolibrary.org/obo/MONDO_0020243) colobomatous and areolar dystrophy --> obsolete colobomatous and areolar dystrophy
 * [MONDO:0020254](http://purl.obolibrary.org/obo/MONDO_0020254) craniostenosis associated with a strabismus --> obsolete craniostenosis associated with a strabismus
 * [MONDO:0020262](http://purl.obolibrary.org/obo/MONDO_0020262) nervous system anomaly with eye involvement --> obsolete nervous system anomaly with eye involvement
 * [MONDO:0020263](http://purl.obolibrary.org/obo/MONDO_0020263) spinocerebellar ataxia with oculomotor anomaly --> obsolete spinocerebellar ataxia with oculomotor anomaly
 * [MONDO:0020264](http://purl.obolibrary.org/obo/MONDO_0020264) spinocerebellar degenerescence and spastic paraparesis with an oculomotor anomaly --> obsolete spinocerebellar degenerescence and spastic paraparesis with an oculomotor anomaly
 * [MONDO:0020268](http://purl.obolibrary.org/obo/MONDO_0020268) ichthyosis associated with ocular features --> obsolete ichthyosis associated with ocular features
 * [MONDO:0020269](http://purl.obolibrary.org/obo/MONDO_0020269) syndromic ichthyosis associated with ocular features --> obsolete syndromic ichthyosis associated with ocular features
 * [MONDO:0020271](http://purl.obolibrary.org/obo/MONDO_0020271) phakomatosis with eye involvement --> obsolete phakomatosis with eye involvement
 * [MONDO:0020686](http://purl.obolibrary.org/obo/MONDO_0020686) acute adenoiditis --> acute tonsillitis
 * [MONDO:0028741](http://purl.obolibrary.org/obo/MONDO_0028741) overgrowth or tall stature syndrome with skeletal involvement --> obsolete overgrowth or tall stature syndrome with skeletal involvement
 * [MONDO:0028742](http://purl.obolibrary.org/obo/MONDO_0028742) dysostosis with brachydactyly without extraskeletal manifestations --> obsolete dysostosis with brachydactyly without extraskeletal manifestations
 * [MONDO:0028743](http://purl.obolibrary.org/obo/MONDO_0028743) dysostosis with brachydactyly with extraskeletal manifestations --> obsolete dysostosis with brachydactyly with extraskeletal manifestations

