DFS								DSS
				HR (95% CI)	HR	2.5% CI	97.5% CI	Per-term P-value	Per-model P-value	C-index	N	HR (95% CI)	HR	2.5% CI	97.5% CI	Per-term P-value	Per-model P-value	C-index	N
Model type	Term	Ref level	Level
univariate	stage							<0.0001	<0.0001	0.64	218					<0.0001	<0.0001	0.63	219
		2	3		3.13	2.00	4.91						3.05	1.91	4.88
	treatment							0.28	0.28	0.54	218					0.21	0.21	0.54	219
		observation	chemotherapy		0.78	0.50	1.23						0.74	0.46	1.19
	age				1.00	0.98	1.03	0.82	0.82	0.52	218		1.00	0.98	1.03	0.77	0.77	0.51	219
	sex							0.65	0.65	0.51	218					0.73	0.73	0.52	219
		male	female		0.90	0.57	1.42						1.09	0.68	1.74
	cancer type							0.27	0.27	0.53	215					0.34	0.34	0.52	216
		colon	rectum		1.32	0.81	2.16						1.29	0.77	2.14
	type of surgery							0.72	0.72	0.52	218					0.86	0.86	0.51	219
		resection	colectomy		0.79	0.36	1.72						0.93	0.42	2.06
			hemicolectomy		0.84	0.52	1.35						0.87	0.52	1.43
	CIC in tumour tissue							0.72	0.72	0.52	209					0.38	0.38	0.54	210
		T-CIC=0	T-CIC>0		1.09	0.67	1.78						1.26	0.75	2.12
	CIC in invasive front tissue							0.051	0.051	0.56	196					0.02	0.02	0.58	197
		S-CIC=0	S-CIC>0		1.64	0.98	2.74						1.88	1.08	3.27
	CIC in normal tissue							0.56	0.56	0.51	195					0.81	0.81	0.51	196
		N-CIC=0	N-CIC>0		0.82	0.42	1.61						0.92	0.47	1.81
multivariate									<0.0001	0.71	193						<0.0001	0.71	194
	stage							<0.0001								<0.0001
		2	3		3.98	2.43	6.50						3.77	2.26	6.29
	treatment							0.01								0.02
		observation	chemotherapy		0.54	0.33	0.88						0.55	0.33	0.92
	age				1.00	0.98	1.03	0.79					1.00	0.97	1.02	0.87
	sex							0.48								0.77
		male	female		0.84	0.51	1.38						1.08	0.65	1.81
	cancer type							0.13								0.29
		colon	rectum		1.53	0.90	2.61						1.36	0.78	2.37
	CIC in invasive front tissue							0.007								0.006
		S-CIC=0	S-CIC>0		2.01	1.19	3.39						2.13	1.21	3.74