Motif ID: ZIC3_ZIC4

Z-value: 0.740

Transcription factors associated with ZIC3_ZIC4:

Gene SymbolEntrez IDGene Name
ZIC3 ENSG00000156925.7 ZIC3
ZIC4 ENSG00000174963.13 ZIC4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v2_chrX_+_136648643_1366487110.363.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_1711918 3.378 ENST00000331222.4
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr19_-_58609570 1.567 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18





zinc finger and SCAN domain containing 18





chr14_+_31343747 1.299 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
COCH


cochlin


chrX_+_51927919 1.088 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr2_+_37571717 0.969 ENST00000338415.3
ENST00000404976.1
QPCT

glutaminyl-peptide cyclotransferase

chr2_+_37571845 0.889 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr11_+_66790816 0.834 ENST00000527043.1
SYT12
synaptotagmin XII
chrX_-_102319092 0.828 ENST00000372728.3
BEX1
brain expressed, X-linked 1
chr1_-_32801825 0.658 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr14_+_71108460 0.658 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr4_-_40631859 0.630 ENST00000295971.7
ENST00000319592.4
RBM47

RNA binding motif protein 47

chr9_-_130742792 0.620 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr16_+_30996502 0.619 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7




hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7




chrX_+_105066524 0.606 ENST00000243300.9
ENST00000428173.2
NRK

Nik related kinase

chr2_+_8822113 0.543 ENST00000396290.1
ENST00000331129.3
ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr7_+_155250824 0.509 ENST00000297375.4
EN2
engrailed homeobox 2
chr10_-_61122220 0.486 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C






family with sequence similarity 13, member C






chrX_+_105066554 0.457 ENST00000536164.1
NRK
Nik related kinase
chr17_+_38599693 0.451 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr2_+_65216462 0.434 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr2_-_99552620 0.429 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211L


KIAA1211-like


chr9_+_19408999 0.410 ENST00000340967.2
ACER2
alkaline ceramidase 2
chr3_+_143690640 0.408 ENST00000315691.3
C3orf58
chromosome 3 open reading frame 58
chr7_-_4923259 0.407 ENST00000536091.1
RADIL
Ras association and DIL domains
chr9_+_19408919 0.406 ENST00000380376.1
ACER2
alkaline ceramidase 2
chr21_+_46825032 0.400 ENST00000400337.2
COL18A1
collagen, type XVIII, alpha 1
chr6_+_33168597 0.379 ENST00000374675.3
SLC39A7
solute carrier family 39 (zinc transporter), member 7
chr4_-_168155577 0.378 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3





sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3





chr2_+_238768187 0.370 ENST00000254661.4
ENST00000409726.1
RAMP1

receptor (G protein-coupled) activity modifying protein 1

chr11_+_121322832 0.356 ENST00000260197.7
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_-_168155730 0.351 ENST00000502330.1
ENST00000357154.3
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr6_+_33168637 0.345 ENST00000374677.3
SLC39A7
solute carrier family 39 (zinc transporter), member 7
chr8_-_41522779 0.339 ENST00000522231.1
ENST00000314214.8
ENST00000348036.4
ENST00000457297.1
ENST00000522543.1
ANK1




ankyrin 1, erythrocytic




chr4_-_168155700 0.339 ENST00000357545.4
ENST00000512648.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr5_+_150406527 0.332 ENST00000520059.1
GPX3
glutathione peroxidase 3 (plasma)
chr1_+_9242221 0.331 ENST00000412639.2
RP3-510D11.2
RP3-510D11.2
chr8_-_18942240 0.320 ENST00000521475.1
PSD3
pleckstrin and Sec7 domain containing 3
chr7_-_4877677 0.311 ENST00000538469.1
RADIL
Ras association and DIL domains
chr14_-_21994337 0.310 ENST00000537235.1
ENST00000450879.2
SALL2

spalt-like transcription factor 2

chrX_+_153686614 0.310 ENST00000369682.3
PLXNA3
plexin A3
chr2_-_192016316 0.303 ENST00000358470.4
ENST00000432798.1
ENST00000450994.1
STAT4


signal transducer and activator of transcription 4


chr4_-_168155417 0.301 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr1_+_180875711 0.301 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr4_+_52917451 0.300 ENST00000295213.4
ENST00000419395.2
SPATA18

spermatogenesis associated 18

chr4_+_53728457 0.288 ENST00000248706.3
RASL11B
RAS-like, family 11, member B
chr20_-_18038521 0.276 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr5_+_169064245 0.272 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr14_+_94405901 0.270 ENST00000557646.1
RP11-131H24.4
Uncharacterized protein
chr16_+_28996572 0.269 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT


linker for activation of T cells


chr6_-_10419871 0.267 ENST00000319516.4
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_-_62129163 0.266 ENST00000298049.7
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_6673745 0.265 ENST00000377648.4
PHF13
PHD finger protein 13
chr2_-_42721110 0.263 ENST00000394973.4
ENST00000306078.1
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr5_-_126366500 0.262 ENST00000308660.5
MARCH3
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
chr8_+_22250334 0.261 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr2_-_233792837 0.260 ENST00000373552.4
ENST00000409079.1
NGEF

neuronal guanine nucleotide exchange factor

chr10_+_6779326 0.260 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr11_-_32457075 0.254 ENST00000448076.3
WT1
Wilms tumor 1
chr6_+_97372734 0.254 ENST00000539200.1
KLHL32
kelch-like family member 32
chr14_-_105635090 0.252 ENST00000331782.3
ENST00000347004.2
JAG2

jagged 2

chr19_+_30156400 0.251 ENST00000588833.1
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr17_-_5026397 0.247 ENST00000250076.3
ZNF232
zinc finger protein 232
chr4_+_38869298 0.240 ENST00000510213.1
ENST00000515037.1
FAM114A1

family with sequence similarity 114, member A1

chr7_-_4923315 0.237 ENST00000399583.3
RADIL
Ras association and DIL domains
chr4_-_168155169 0.237 ENST00000534949.1
ENST00000535728.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr3_+_50712672 0.235 ENST00000266037.9
DOCK3
dedicator of cytokinesis 3
chr10_-_105212059 0.233 ENST00000260743.5
CALHM2
calcium homeostasis modulator 2
chr2_-_98612379 0.231 ENST00000425805.2
TMEM131
transmembrane protein 131
chr10_-_61122625 0.229 ENST00000468840.2
FAM13C
family with sequence similarity 13, member C
chr16_+_28996364 0.228 ENST00000564277.1
LAT
linker for activation of T cells
chr7_-_105925367 0.223 ENST00000354289.4
NAMPT
nicotinamide phosphoribosyltransferase
chr10_-_105212141 0.223 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr2_-_219925189 0.221 ENST00000295731.6
IHH
indian hedgehog
chr19_-_40724246 0.216 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr8_-_27462822 0.213 ENST00000522098.1
CLU
clusterin
chr17_-_38721711 0.209 ENST00000578085.1
ENST00000246657.2
CCR7

chemokine (C-C motif) receptor 7

chr19_-_12992244 0.208 ENST00000538460.1
DNASE2
deoxyribonuclease II, lysosomal
chr4_+_38869410 0.206 ENST00000358869.2
FAM114A1
family with sequence similarity 114, member A1
chr6_+_97372645 0.205 ENST00000536676.1
ENST00000544166.1
KLHL32

kelch-like family member 32

chr4_-_149363376 0.205 ENST00000512865.1
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr10_+_28966271 0.201 ENST00000375533.3
BAMBI
BMP and activin membrane-bound inhibitor
chr3_+_186288454 0.200 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr1_-_6240183 0.197 ENST00000262450.3
ENST00000378021.1
CHD5

chromodomain helicase DNA binding protein 5

chr4_-_149363662 0.196 ENST00000355292.3
ENST00000358102.3
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr7_+_128577972 0.195 ENST00000357234.5
ENST00000477535.1
ENST00000479582.1
ENST00000464557.1
ENST00000402030.2
IRF5




interferon regulatory factor 5




chr4_-_168155300 0.194 ENST00000541637.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_+_33352036 0.193 ENST00000373467.3
HPCA
hippocalcin
chr7_+_302918 0.191 ENST00000599994.1
AC187652.1
Protein LOC100996433
chr2_-_98612350 0.190 ENST00000186436.5
TMEM131
transmembrane protein 131
chr19_-_12992274 0.189 ENST00000592506.1
ENST00000222219.3
DNASE2

deoxyribonuclease II, lysosomal

chr3_-_176914998 0.187 ENST00000431421.1
ENST00000422066.1
ENST00000413084.1
TBL1XR1


transducin (beta)-like 1 X-linked receptor 1


chr5_+_421030 0.186 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr8_-_70745575 0.185 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr19_+_5823813 0.184 ENST00000303212.2
NRTN
neurturin
chr1_+_3607228 0.184 ENST00000378285.1
ENST00000378280.1
ENST00000378288.4
TP73


tumor protein p73


chr10_-_116164239 0.184 ENST00000419268.1
ENST00000304129.4
ENST00000545353.1
AFAP1L2


actin filament associated protein 1-like 2


chr7_-_105925558 0.179 ENST00000222553.3
NAMPT
nicotinamide phosphoribosyltransferase
chr17_+_78194205 0.179 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
SLC26A11





solute carrier family 26 (anion exchanger), member 11





chr11_+_124932955 0.177 ENST00000403796.2
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr5_+_140753444 0.177 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr7_+_120969045 0.175 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr4_-_121993673 0.174 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr16_+_56691911 0.168 ENST00000568475.1
MT1F
metallothionein 1F
chr17_+_78194261 0.165 ENST00000572725.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr1_+_3569129 0.165 ENST00000354437.4
ENST00000357733.3
ENST00000346387.4
TP73


tumor protein p73


chr1_+_15480197 0.165 ENST00000400796.3
ENST00000434578.2
ENST00000376008.2
TMEM51


transmembrane protein 51


chr14_+_75894714 0.165 ENST00000559060.1
JDP2
Jun dimerization protein 2
chr3_-_176915036 0.162 ENST00000427349.1
ENST00000352800.5
TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr7_+_150758642 0.161 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr3_+_183948161 0.161 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr17_+_74734052 0.160 ENST00000590514.1
MFSD11
major facilitator superfamily domain containing 11
chr11_-_60719213 0.159 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chrX_-_19533379 0.159 ENST00000338883.4
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr20_+_49411523 0.158 ENST00000371608.2
BCAS4
breast carcinoma amplified sequence 4
chr7_-_44924939 0.155 ENST00000395699.2
PURB
purine-rich element binding protein B
chr17_-_78194124 0.155 ENST00000570427.1
ENST00000570923.1
SGSH

N-sulfoglucosamine sulfohydrolase

chrX_+_13707235 0.153 ENST00000464506.1
RAB9A
RAB9A, member RAS oncogene family
chr8_+_38758737 0.153 ENST00000521746.1
ENST00000420274.1
PLEKHA2

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2

chr19_+_47523058 0.153 ENST00000602212.1
ENST00000602189.1
NPAS1

neuronal PAS domain protein 1

chr7_+_150758304 0.152 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2


solute carrier family 4 (anion exchanger), member 2


chr4_-_15656923 0.148 ENST00000382358.4
ENST00000412094.2
ENST00000341285.3
FBXL5


F-box and leucine-rich repeat protein 5


chr17_-_78194147 0.147 ENST00000534910.1
ENST00000326317.6
SGSH

N-sulfoglucosamine sulfohydrolase

chrX_-_54070607 0.146 ENST00000338154.6
ENST00000338946.6
PHF8

PHD finger protein 8

chr4_-_20985632 0.146 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr17_+_74733744 0.145 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
MFSD11




major facilitator superfamily domain containing 11




chr2_-_202645612 0.145 ENST00000409632.2
ENST00000410052.1
ENST00000467448.1
ALS2


amyotrophic lateral sclerosis 2 (juvenile)


chr17_-_27893990 0.143 ENST00000307201.4
ABHD15
abhydrolase domain containing 15
chr19_+_1908013 0.143 ENST00000454697.1
ADAT3
adenosine deaminase, tRNA-specific 3
chr3_-_176915215 0.143 ENST00000457928.2
ENST00000422442.1
TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr9_+_4490394 0.142 ENST00000262352.3
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr2_+_103236004 0.139 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_-_106015527 0.139 ENST00000344213.4
ENST00000358129.4
FHL2

four and a half LIM domains 2

chr17_+_45771420 0.137 ENST00000578982.1
TBKBP1
TBK1 binding protein 1
chr1_-_11866034 0.136 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_64692143 0.133 ENST00000164133.2
ENST00000532850.1
PPP2R5B

protein phosphatase 2, regulatory subunit B', beta

chr19_+_37096194 0.133 ENST00000460670.1
ENST00000292928.2
ENST00000439428.1
ZNF382


zinc finger protein 382


chr14_-_21994525 0.133 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr5_+_133707252 0.131 ENST00000506787.1
ENST00000507277.1
UBE2B

ubiquitin-conjugating enzyme E2B

chr5_+_145316120 0.130 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr12_-_7244469 0.130 ENST00000538050.1
ENST00000536053.2
C1R

complement component 1, r subcomponent

chr6_+_97372596 0.130 ENST00000369261.4
KLHL32
kelch-like family member 32
chr5_+_139055055 0.130 ENST00000511457.1
CXXC5
CXXC finger protein 5
chr16_+_56691838 0.129 ENST00000394501.2
MT1F
metallothionein 1F
chr16_+_56691606 0.129 ENST00000334350.6
MT1F
metallothionein 1F
chr1_+_6845578 0.128 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1

chr19_+_30156351 0.127 ENST00000592810.1
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr5_-_131563501 0.125 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2




prolyl 4-hydroxylase, alpha polypeptide II




chr1_-_21503337 0.125 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3



eukaryotic translation initiation factor 4 gamma, 3



chr2_-_201374781 0.125 ENST00000359878.3
ENST00000409157.1
KCTD18

potassium channel tetramerization domain containing 18

chrX_-_153881842 0.124 ENST00000369585.3
ENST00000247306.4
CTAG2

cancer/testis antigen 2

chr4_-_169239921 0.123 ENST00000514995.1
ENST00000393743.3
DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr17_-_9862772 0.123 ENST00000580865.1
ENST00000583882.1
GAS7

growth arrest-specific 7

chr14_+_57857262 0.123 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30


N(alpha)-acetyltransferase 30, NatC catalytic subunit


chr5_-_38556728 0.123 ENST00000506990.1
ENST00000453190.2
LIFR

leukemia inhibitory factor receptor alpha

chr1_-_154928562 0.121 ENST00000368463.3
ENST00000539880.1
ENST00000542459.1
ENST00000368460.3
ENST00000368465.1
PBXIP1




pre-B-cell leukemia homeobox interacting protein 1




chr22_-_41636892 0.119 ENST00000455425.1
CHADL
chondroadherin-like
chr9_+_132565454 0.118 ENST00000427860.1
TOR1B
torsin family 1, member B (torsin B)
chr22_+_29702572 0.118 ENST00000407647.2
ENST00000416823.1
ENST00000428622.1
GAS2L1


growth arrest-specific 2 like 1


chr3_+_187420101 0.118 ENST00000449623.1
ENST00000437407.1
RP11-211G3.3

Uncharacterized protein

chr9_+_1051481 0.117 ENST00000358146.2
ENST00000259622.6
DMRT2

doublesex and mab-3 related transcription factor 2

chr5_-_131563474 0.116 ENST00000417528.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr17_-_80291818 0.115 ENST00000269389.3
ENST00000581691.1
SECTM1

secreted and transmembrane 1

chr16_+_9185450 0.115 ENST00000327827.7
C16orf72
chromosome 16 open reading frame 72
chr17_+_27894180 0.115 ENST00000583940.1
TP53I13
tumor protein p53 inducible protein 13
chr1_-_43232649 0.115 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1



leucine proline-enriched proteoglycan (leprecan) 1



chr17_-_74137374 0.114 ENST00000322957.6
FOXJ1
forkhead box J1
chr3_+_195413160 0.114 ENST00000599448.1
LINC00969
long intergenic non-protein coding RNA 969
chr2_+_48757278 0.113 ENST00000404752.1
ENST00000406226.1
STON1

stonin 1

chr4_+_119810134 0.113 ENST00000434046.2
SYNPO2
synaptopodin 2
chr5_-_110074603 0.112 ENST00000515278.2
TMEM232
transmembrane protein 232
chr2_+_134877740 0.111 ENST00000409645.1
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr6_-_38607673 0.111 ENST00000481247.1
BTBD9
BTB (POZ) domain containing 9
chr4_-_110624564 0.110 ENST00000352981.3
ENST00000265164.2
ENST00000505486.1
CASP6


caspase 6, apoptosis-related cysteine peptidase


chr3_+_50192457 0.109 ENST00000414301.1
ENST00000450338.1
SEMA3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

chr7_+_79763271 0.107 ENST00000442586.1
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr8_-_135708787 0.107 ENST00000520356.1
ENST00000520727.1
ENST00000520214.1
ENST00000518191.1
ENST00000429442.2
ZFAT




zinc finger and AT hook domain containing




chr2_-_202645835 0.107 ENST00000264276.6
ALS2
amyotrophic lateral sclerosis 2 (juvenile)
chr19_+_17186577 0.105 ENST00000595618.1
ENST00000594824.1
MYO9B

myosin IXB

chr1_+_3569072 0.104 ENST00000378295.4
ENST00000604074.1
TP73

tumor protein p73

chr9_+_132565418 0.104 ENST00000259339.2
TOR1B
torsin family 1, member B (torsin B)
chr2_+_219264762 0.103 ENST00000452977.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr9_+_19230433 0.103 ENST00000434457.2
ENST00000602925.1
DENND4C

DENN/MADD domain containing 4C

chr3_+_184097836 0.103 ENST00000204604.1
ENST00000310236.3
CHRD

chordin

chr1_-_11751529 0.102 ENST00000376672.1
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr5_+_137688285 0.101 ENST00000314358.5
KDM3B
lysine (K)-specific demethylase 3B
chr10_-_14920599 0.100 ENST00000609399.1
RP11-398C13.6
RP11-398C13.6
chr2_-_197791441 0.100 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
PGAP1


post-GPI attachment to proteins 1


chr9_-_124989804 0.100 ENST00000373755.2
ENST00000373754.2
LHX6

LIM homeobox 6

chr17_-_42988004 0.098 ENST00000586125.1
ENST00000591880.1
GFAP

glial fibrillary acidic protein

chr11_-_34379546 0.098 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr5_+_75699149 0.098 ENST00000379730.3
IQGAP2
IQ motif containing GTPase activating protein 2
chr4_+_492985 0.097 ENST00000296306.7
ENST00000536264.1
ENST00000310340.5
ENST00000453061.2
ENST00000504346.1
ENST00000503111.1
ENST00000383028.4
ENST00000509768.1
PIGG







phosphatidylinositol glycan anchor biosynthesis, class G







chr22_-_36635598 0.097 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr3_+_125985620 0.097 ENST00000511512.1
ENST00000512435.1
RP11-71E19.1

RP11-71E19.1

chr1_+_150954493 0.095 ENST00000368947.4
ANXA9
annexin A9
chr7_+_73498118 0.095 ENST00000336180.2
LIMK1
LIM domain kinase 1
chr1_-_6052463 0.094 ENST00000378156.4
NPHP4
nephronophthisis 4
chr20_+_3870024 0.092 ENST00000610179.1
PANK2
pantothenate kinase 2
chr9_+_115913222 0.092 ENST00000259392.3
SLC31A2
solute carrier family 31 (copper transporter), member 2
chr3_+_50192499 0.092 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.3 1.1 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.2 0.8 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.1 0.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.4 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 0.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.2 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 0.3 GO:0072299 visceral serous pericardium development(GO:0061032) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.4 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.6 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.4 GO:0015811 L-cystine transport(GO:0015811)
0.1 0.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.3 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.2 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101)
0.0 0.3 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 3.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.5 GO:0060613 fat pad development(GO:0060613)
0.0 0.5 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.5 GO:0021636 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.2 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.5 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.5 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.0 0.3 GO:0031580 membrane raft polarization(GO:0001766) establishment of T cell polarity(GO:0001768) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.0 0.1 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 1.0 GO:0006882 cellular zinc ion homeostasis(GO:0006882)
0.0 0.3 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:2000646 lipid transport involved in lipid storage(GO:0010877) regulation of Cdc42 protein signal transduction(GO:0032489) positive regulation of receptor catabolic process(GO:2000646)
0.0 0.0 GO:0003274 endocardial cushion fusion(GO:0003274)
0.0 0.4 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.0 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.3 GO:0001842 neural fold formation(GO:0001842)
0.0 0.1 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050) negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.4 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.4 GO:0032011 ARF protein signal transduction(GO:0032011)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.0 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555) progesterone secretion(GO:0042701)
0.0 0.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0021539 subthalamus development(GO:0021539)
0.0 0.1 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.0 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.1 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.2 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.0 3.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.4 GO:0030663 COPI vesicle coat(GO:0030126) COPI-coated vesicle membrane(GO:0030663)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 2.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363) discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.0 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3 0.8 GO:0071633 dihydroceramidase activity(GO:0071633)
0.1 0.4 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.1 0.4 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.4 GO:0016826 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.1 0.4 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0015186 L-cystine transmembrane transporter activity(GO:0015184) L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 1.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.2 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.2 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.1 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.2 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.0 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.0 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism