Motif ID: ZFHX3

Z-value: 0.310


Transcription factors associated with ZFHX3:

Gene SymbolEntrez IDGene Name
ZFHX3 ENSG00000140836.10 ZFHX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274-0.844.7e-03Click!


Activity profile for motif ZFHX3.

activity profile for motif ZFHX3


Sorted Z-values histogram for motif ZFHX3

Sorted Z-values for motif ZFHX3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFHX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_68052694 0.419 ENST00000457448.1
 AC010987.6
AC010987.6
chrX_-_32173579 0.361 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD




dystrophin




chr20_-_7921090 0.359 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr12_+_54410664 0.310 ENST00000303406.4
 HOXC4
homeobox C4
chr1_+_76540386 0.304 ENST00000328299.3
 ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chrX_+_16668278 0.288 ENST00000380200.3
 S100G
S100 calcium binding protein G
chr8_+_104831472 0.278 ENST00000262231.10
ENST00000507740.1
 RIMS2

regulating synaptic membrane exocytosis 2

chr14_+_95027772 0.188 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
 SERPINA4

SERPINA5

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

chr6_-_32374900 0.132 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
 BTNL2







butyrophilin-like 2 (MHC class II associated)







chr3_+_46919235 0.124 ENST00000449590.1
 PTH1R
parathyroid hormone 1 receptor
chr7_+_130126165 0.117 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
 MEST


mesoderm specific transcript


chrM_+_10053 0.114 ENST00000361227.2
 MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr7_+_130126012 0.110 ENST00000341441.5
 MEST
mesoderm specific transcript
chr16_+_87636474 0.107 ENST00000284262.2
 JPH3
junctophilin 3
chr19_+_926000 0.106 ENST00000263620.3
 ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr11_+_8040739 0.106 ENST00000534099.1
 TUB
tubby bipartite transcription factor
chr3_+_101659682 0.102 ENST00000465215.1
 RP11-221J22.1
RP11-221J22.1
chr19_+_54466179 0.100 ENST00000270458.2
 CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr22_-_30970560 0.089 ENST00000402369.1
ENST00000406361.1
 GAL3ST1

galactose-3-O-sulfotransferase 1

chr3_-_114477787 0.088 ENST00000464560.1
 ZBTB20
zinc finger and BTB domain containing 20
chr2_+_88047606 0.080 ENST00000359481.4
 PLGLB2
plasminogen-like B2
chr17_+_17685422 0.078 ENST00000395774.1
 RAI1
retinoic acid induced 1
chr6_-_152793728 0.072 ENST00000495090.2
 SYNE1
spectrin repeat containing, nuclear envelope 1
chr8_+_92114060 0.068 ENST00000518304.1
 LRRC69
leucine rich repeat containing 69
chr15_+_58724184 0.065 ENST00000433326.2
 LIPC
lipase, hepatic
chr6_-_161085291 0.060 ENST00000316300.5
 LPA
lipoprotein, Lp(a)
chr11_-_111649074 0.059 ENST00000534218.1
 RP11-108O10.2
RP11-108O10.2
chr1_+_162601774 0.058 ENST00000415555.1
 DDR2
discoidin domain receptor tyrosine kinase 2
chr7_-_100026280 0.057 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1



zinc finger, CW type with PWWP domain 1



chrX_-_15288154 0.055 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
 ASB9


ankyrin repeat and SOCS box containing 9


chr2_-_60780607 0.054 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
 BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr11_+_71934962 0.051 ENST00000543234.1
 INPPL1
inositol polyphosphate phosphatase-like 1
chr4_+_74347400 0.048 ENST00000226355.3
 AFM
afamin
chr8_-_87242589 0.046 ENST00000419776.2
ENST00000297524.3
 SLC7A13

solute carrier family 7 (anionic amino acid transporter), member 13

chr9_-_123812542 0.045 ENST00000223642.1
 C5
complement component 5
chr15_-_76352069 0.044 ENST00000305435.10
ENST00000563910.1
 NRG4

neuregulin 4

chr3_-_108248169 0.043 ENST00000273353.3
 MYH15
myosin, heavy chain 15
chr22_-_30970498 0.042 ENST00000431313.1
 GAL3ST1
galactose-3-O-sulfotransferase 1
chr2_-_60780536 0.041 ENST00000538214.1
 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr22_-_30642728 0.037 ENST00000403987.3
 LIF
leukemia inhibitory factor
chr2_+_234621551 0.036 ENST00000373414.3
ENST00000608381.1
 UGT1A5
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A5
UDP glucuronosyltransferase 1 family, polypeptide A8
chr2_-_60780546 0.036 ENST00000358510.4
 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr1_-_247921982 0.035 ENST00000408896.2
 OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr3_-_49066811 0.035 ENST00000442157.1
ENST00000326739.4
 IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

chr14_-_83262540 0.034 ENST00000554451.1
 RP11-11K13.1
RP11-11K13.1
chr9_-_95298254 0.033 ENST00000444490.2
 ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chrY_+_20708557 0.033 ENST00000307393.2
ENST00000309834.4
ENST00000382856.2
 HSFY1


heat shock transcription factor, Y-linked 1


chr16_-_69385681 0.033 ENST00000288025.3
 TMED6
transmembrane emp24 protein transport domain containing 6
chrX_-_18690210 0.033 ENST00000379984.3
 RS1
retinoschisin 1
chr8_-_9762871 0.033 ENST00000521242.1
 LINC00599
long intergenic non-protein coding RNA 599
chr11_-_559377 0.031 ENST00000486629.1
 C11orf35
chromosome 11 open reading frame 35
chr22_+_31488433 0.031 ENST00000455608.1
 SMTN
smoothelin
chr2_-_60780702 0.030 ENST00000359629.5
 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chrY_-_20935572 0.030 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
 HSFY2


heat shock transcription factor, Y linked 2


chr8_+_104831440 0.029 ENST00000515551.1
 RIMS2
regulating synaptic membrane exocytosis 2
chr1_-_153585539 0.027 ENST00000368706.4
 S100A16
S100 calcium binding protein A16
chr8_-_101733794 0.025 ENST00000523555.1
 PABPC1
poly(A) binding protein, cytoplasmic 1
chr13_-_30880979 0.025 ENST00000414289.1
 KATNAL1
katanin p60 subunit A-like 1
chr12_-_101801505 0.024 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1



ADP-ribosylation factor-like 1



chr1_+_212475148 0.023 ENST00000537030.3
 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr15_+_76352178 0.023 ENST00000388942.3
 C15orf27
chromosome 15 open reading frame 27
chr6_-_128239749 0.021 ENST00000537166.1
 THEMIS
thymocyte selection associated
chrM_+_8527 0.019 ENST00000361899.2
 MT-ATP6
mitochondrially encoded ATP synthase 6
chr2_+_234637754 0.018 ENST00000609767.1
ENST00000482026.1
 UGT1A1
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A3
chr11_-_74800799 0.018 ENST00000305159.3
 OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr3_+_35722487 0.017 ENST00000441454.1
 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_-_128239685 0.016 ENST00000368250.1
 THEMIS
thymocyte selection associated
chr4_-_69111401 0.016 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr2_+_234627424 0.015 ENST00000373409.3
 UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr17_+_41052808 0.015 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC


glucose-6-phosphatase, catalytic subunit


chr8_-_141774467 0.015 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
 PTK2


protein tyrosine kinase 2


chr7_-_142181009 0.015 ENST00000390368.2
 TRBV6-5
T cell receptor beta variable 6-5
chr13_-_30881134 0.014 ENST00000380617.3
ENST00000441394.1
 KATNAL1

katanin p60 subunit A-like 1

chr13_-_103719196 0.014 ENST00000245312.3
 SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chrM_-_14670 0.013 ENST00000361681.2
 MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr22_+_39101728 0.012 ENST00000216044.5
ENST00000484657.1
 GTPBP1

GTP binding protein 1

chr7_+_150725510 0.011 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
 ABCB8







ATP-binding cassette, sub-family B (MDR/TAP), member 8







chr7_+_100026406 0.011 ENST00000414441.1
 MEPCE
methylphosphate capping enzyme
chrM_+_9207 0.010 ENST00000362079.2
 MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr10_-_74283694 0.010 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
 MICU1


mitochondrial calcium uptake 1


chr19_+_50016610 0.010 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_91546926 0.010 ENST00000550758.1
 DCN
decorin
chr11_+_6220376 0.009 ENST00000311352.2
 OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr6_-_116447283 0.009 ENST00000452729.1
ENST00000243222.4
 COL10A1

collagen, type X, alpha 1

chr3_+_35722424 0.009 ENST00000396481.2
 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr16_-_28192360 0.008 ENST00000570033.1
 XPO6
exportin 6
chr7_+_133615169 0.008 ENST00000541309.1
 EXOC4
exocyst complex component 4
chr7_-_86595190 0.006 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
 KIAA1324L


KIAA1324-like


chr12_+_80750134 0.006 ENST00000546620.1
 OTOGL
otogelin-like
chr16_-_15474904 0.006 ENST00000534094.1
 NPIPA5
nuclear pore complex interacting protein family, member A5
chr22_-_22337204 0.006 ENST00000430142.1
ENST00000357179.5
 TOP3B

topoisomerase (DNA) III beta

chr9_+_44868935 0.005 ENST00000448436.2
 RP11-160N1.10
RP11-160N1.10
chr7_+_48211048 0.005 ENST00000435803.1
 ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chrX_+_9431324 0.004 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr10_-_75226166 0.004 ENST00000544628.1
 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr9_-_95298314 0.004 ENST00000344604.5
ENST00000375540.1
 ECM2

extracellular matrix protein 2, female organ and adipocyte specific

chrM_+_14741 0.003 ENST00000361789.2
 MT-CYB
mitochondrially encoded cytochrome b
chr4_-_152149033 0.002 ENST00000514152.1
 SH3D19
SH3 domain containing 19
chr12_-_10321754 0.002 ENST00000539518.1
 OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr11_+_57559005 0.002 ENST00000534647.1
 CTNND1
catenin (cadherin-associated protein), delta 1
chr11_+_74459876 0.001 ENST00000299563.4
 RNF169
ring finger protein 169
chrM_+_10464 0.001 ENST00000361335.1
 MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr11_-_107729504 0.001 ENST00000265836.7
 SLC35F2
solute carrier family 35, member F2
chr12_-_2944184 0.001 ENST00000337508.4
 NRIP2
nuclear receptor interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.2 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0 0.2 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0007498 mesoderm development(GO:0007498)
0.0 0.4 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.4 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.0 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)