Motif ID: VAX2_RHOXF2

Z-value: 0.262

Transcription factors associated with VAX2_RHOXF2:

Gene SymbolEntrez IDGene Name
RHOXF2 ENSG00000131721.4 RHOXF2
VAX2 ENSG00000116035.2 VAX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
VAX2hg19_v2_chr2_+_71127699_71127744-0.472.0e-01Click!
RHOXF2hg19_v2_chrX_+_119292467_1192924670.235.6e-01Click!


Activity profile for motif VAX2_RHOXF2.

activity profile for motif VAX2_RHOXF2


Sorted Z-values histogram for motif VAX2_RHOXF2

Sorted Z-values for motif VAX2_RHOXF2



Network of associatons between targets according to the STRING database.



First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_66536248 0.154 ENST00000514260.1
ENST00000507117.1
 RP11-807H7.1

RP11-807H7.1

chr17_-_40337470 0.136 ENST00000293330.1
 HCRT
hypocretin (orexin) neuropeptide precursor
chr9_+_125133315 0.119 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr12_-_10022735 0.077 ENST00000228438.2
 CLEC2B
C-type lectin domain family 2, member B
chr9_+_125132803 0.072 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_-_121944491 0.068 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr1_-_57045228 0.060 ENST00000371250.3
 PPAP2B
phosphatidic acid phosphatase type 2B
chr9_+_125133467 0.059 ENST00000426608.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_25865159 0.055 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
 SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr16_-_55866997 0.053 ENST00000360526.3
ENST00000361503.4
 CES1

carboxylesterase 1

chr9_-_3469181 0.046 ENST00000366116.2
 AL365202.1
Uncharacterized protein
chr5_+_174151536 0.045 ENST00000239243.6
ENST00000507785.1
 MSX2

msh homeobox 2

chr4_-_66536196 0.043 ENST00000511294.1
 EPHA5
EPH receptor A5
chr2_+_90248739 0.042 ENST00000468879.1
 IGKV1D-43
immunoglobulin kappa variable 1D-43
chr4_-_66536057 0.042 ENST00000273854.3
 EPHA5
EPH receptor A5
chr21_-_35796241 0.041 ENST00000450895.1
 AP000322.53
AP000322.53
chr3_+_185431080 0.040 ENST00000296270.1
 C3orf65
chromosome 3 open reading frame 65
chr6_-_33663474 0.039 ENST00000594414.1
 SBP1
SBP1; Uncharacterized protein
chr9_-_95166976 0.038 ENST00000447356.1
 OGN
osteoglycin
chr10_+_6821545 0.037 ENST00000436383.1
 LINC00707
long intergenic non-protein coding RNA 707
chr12_-_6233828 0.036 ENST00000572068.1
ENST00000261405.5
 VWF

von Willebrand factor

chr10_-_92681033 0.035 ENST00000371697.3
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_191000172 0.035 ENST00000427544.2
 UTS2B
urotensin 2B
chr8_+_92261516 0.035 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr21_+_17443521 0.034 ENST00000456342.1
 LINC00478
long intergenic non-protein coding RNA 478
chr6_+_78400375 0.034 ENST00000602452.2
 MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr20_+_56136136 0.033 ENST00000319441.4
ENST00000543666.1
 PCK1

phosphoenolpyruvate carboxykinase 1 (soluble)

chr2_+_169926047 0.031 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
 DHRS9


dehydrogenase/reductase (SDR family) member 9


chr1_+_225600404 0.031 ENST00000366845.2
 AC092811.1
AC092811.1
chr15_-_88247083 0.030 ENST00000560439.1
 RP11-648K4.2
RP11-648K4.2
chr16_-_30122717 0.029 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr7_-_92777606 0.028 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
 SAMD9L






sterile alpha motif domain containing 9-like






chr5_-_115890554 0.027 ENST00000509665.1
 SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr7_+_73245193 0.027 ENST00000340958.2
 CLDN4
claudin 4
chr11_-_102709441 0.023 ENST00000434103.1
 MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_211307404 0.023 ENST00000367007.4
 KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr2_-_214016314 0.022 ENST00000434687.1
ENST00000374319.4
 IKZF2

IKAROS family zinc finger 2 (Helios)

chr2_+_200472779 0.021 ENST00000427045.1
ENST00000419243.1
 AC093590.1

AC093590.1

chr3_-_141747950 0.021 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71900703 0.019 ENST00000393681.2
 FOLR1
folate receptor 1 (adult)
chrX_+_10126488 0.019 ENST00000380829.1
ENST00000421085.2
ENST00000454850.1
 CLCN4


chloride channel, voltage-sensitive 4


chr11_+_71900572 0.018 ENST00000312293.4
 FOLR1
folate receptor 1 (adult)
chr5_+_96840389 0.018 ENST00000504012.1
 RP11-1E3.1
RP11-1E3.1
chr6_+_26440700 0.017 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3









butyrophilin, subfamily 3, member A3









chr8_-_91095099 0.017 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr7_+_6655225 0.017 ENST00000457543.3
 ZNF853
zinc finger protein 853
chr5_-_20575959 0.017 ENST00000507958.1
 CDH18
cadherin 18, type 2
chr17_-_39203519 0.016 ENST00000542137.1
ENST00000391419.3
 KRTAP2-1

keratin associated protein 2-1

chr12_+_64798826 0.015 ENST00000540203.1
 XPOT
exportin, tRNA
chr4_+_26324474 0.015 ENST00000514675.1
 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_-_74486217 0.015 ENST00000335049.5
ENST00000307439.5
 RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr20_-_50418972 0.014 ENST00000395997.3
 SALL4
spalt-like transcription factor 4
chr1_+_35258592 0.014 ENST00000342280.4
ENST00000450137.1
 GJA4

gap junction protein, alpha 4, 37kDa

chr5_-_87986845 0.014 ENST00000513893.1
 LINC00461
long intergenic non-protein coding RNA 461
chr4_-_138453606 0.014 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18



protocadherin 18



chr16_+_72088376 0.014 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
 HP








HPR
haptoglobin








haptoglobin-related protein
chr4_-_74486109 0.013 ENST00000395777.2
 RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr15_+_58702742 0.012 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic

chr1_-_152386732 0.012 ENST00000271835.3
 CRNN
cornulin
chr2_+_113763031 0.012 ENST00000259211.6
 IL36A
interleukin 36, alpha
chr4_+_151503077 0.012 ENST00000317605.4
 MAB21L2
mab-21-like 2 (C. elegans)
chr8_-_101661887 0.011 ENST00000311812.2
 SNX31
sorting nexin 31
chr3_+_43020773 0.011 ENST00000488863.1
 FAM198A
family with sequence similarity 198, member A
chr5_+_129083772 0.010 ENST00000564719.1
 KIAA1024L
KIAA1024-like
chr11_-_121986923 0.010 ENST00000560104.1
 BLID
BH3-like motif containing, cell death inducer
chr19_+_12175535 0.010 ENST00000550826.1
 ZNF844
zinc finger protein 844
chr10_+_6779326 0.009 ENST00000417112.1
 RP11-554I8.2
RP11-554I8.2
chr2_+_228736321 0.009 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr4_-_159956333 0.009 ENST00000434826.2
 C4orf45
chromosome 4 open reading frame 45
chr10_-_17171785 0.008 ENST00000377823.1
 CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr4_+_80584903 0.008 ENST00000506460.1
 RP11-452C8.1
RP11-452C8.1
chr4_+_169418195 0.008 ENST00000261509.6
ENST00000335742.7
 PALLD

palladin, cytoskeletal associated protein

chrX_-_18690210 0.008 ENST00000379984.3
 RS1
retinoschisin 1
chr14_+_56584414 0.007 ENST00000559044.1
 PELI2
pellino E3 ubiquitin protein ligase family member 2
chr10_+_18549645 0.007 ENST00000396576.2
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_+_34204642 0.007 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1




high mobility group AT-hook 1




chr7_-_99717463 0.007 ENST00000437822.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_+_26402465 0.007 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1





butyrophilin, subfamily 3, member A1





chr4_-_69111401 0.007 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr11_+_101918153 0.007 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr2_-_89340242 0.007 ENST00000480492.1
 IGKV1-12
immunoglobulin kappa variable 1-12
chr14_-_39639523 0.007 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
 TRAPPC6B


trafficking protein particle complex 6B


chr21_+_17442799 0.007 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
 LINC00478


long intergenic non-protein coding RNA 478


chr15_-_98417780 0.007 ENST00000503874.3
 LINC00923
long intergenic non-protein coding RNA 923
chr19_+_12175504 0.006 ENST00000439326.3
 ZNF844
zinc finger protein 844
chr7_+_115862858 0.006 ENST00000393481.2
 TES
testis derived transcript (3 LIM domains)
chrX_+_150565653 0.006 ENST00000330374.6
 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr4_-_74486347 0.006 ENST00000342081.3
 RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr7_+_12726623 0.006 ENST00000439721.1
 ARL4A
ADP-ribosylation factor-like 4A
chr3_+_157154578 0.006 ENST00000295927.3
 PTX3
pentraxin 3, long
chr2_+_149402989 0.006 ENST00000397424.2
 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_103089756 0.006 ENST00000295269.4
 SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr2_-_198540719 0.006 ENST00000295049.4
 RFTN2
raftlin family member 2
chrX_+_7137475 0.005 ENST00000217961.4
 STS
steroid sulfatase (microsomal), isozyme S
chr19_-_36001113 0.005 ENST00000434389.1
 DMKN
dermokine
chr12_+_16500037 0.005 ENST00000536371.1
ENST00000010404.2
 MGST1

microsomal glutathione S-transferase 1

chr6_+_167536230 0.005 ENST00000341935.5
ENST00000349984.4
 CCR6

chemokine (C-C motif) receptor 6

chr4_+_169418255 0.005 ENST00000505667.1
ENST00000511948.1
 PALLD

palladin, cytoskeletal associated protein

chr20_-_50722183 0.005 ENST00000371523.4
 ZFP64
ZFP64 zinc finger protein
chr6_+_3259148 0.005 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
 PSMG4



proteasome (prosome, macropain) assembly chaperone 4



chr17_+_40610862 0.005 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
 ATP6V0A1








ATPase, H+ transporting, lysosomal V0 subunit a1








chr7_+_100860949 0.004 ENST00000305105.2
 ZNHIT1
zinc finger, HIT-type containing 1
chr6_+_53883708 0.004 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
 MLIP


muscular LMNA-interacting protein


chr15_+_49462434 0.004 ENST00000558145.1
ENST00000543495.1
ENST00000544523.1
ENST00000560138.1
 GALK2



galactokinase 2



chr14_+_101359265 0.004 ENST00000599197.1
 AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr16_+_12059050 0.004 ENST00000396495.3
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_-_112127981 0.004 ENST00000486726.2
 RP11-231E6.1
RP11-231E6.1
chr7_+_138145076 0.004 ENST00000343526.4
 TRIM24
tripartite motif containing 24
chr15_+_49462397 0.004 ENST00000396509.2
 GALK2
galactokinase 2
chr14_+_103851712 0.003 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
 MARK3



MAP/microtubule affinity-regulating kinase 3



chr11_-_107729887 0.003 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr1_+_54569968 0.003 ENST00000391366.1
 AL161915.1
Uncharacterized protein
chr9_+_12693336 0.003 ENST00000381137.2
ENST00000388918.5
 TYRP1

tyrosinase-related protein 1

chr11_-_107729287 0.003 ENST00000375682.4
 SLC35F2
solute carrier family 35, member F2
chr12_-_50643664 0.003 ENST00000550592.1
 LIMA1
LIM domain and actin binding 1
chr10_+_90660832 0.003 ENST00000371924.1
 STAMBPL1
STAM binding protein-like 1
chr12_+_6419877 0.003 ENST00000536531.1
 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr7_-_99716952 0.003 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6










TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa










chr9_-_95166884 0.003 ENST00000375561.5
 OGN
osteoglycin
chr7_-_99716940 0.002 ENST00000440225.1
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_186696561 0.002 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
 SORBS2





sorbin and SH3 domain containing 2





chr11_-_62521614 0.002 ENST00000527994.1
ENST00000394807.3
 ZBTB3

zinc finger and BTB domain containing 3

chrX_+_43515467 0.002 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chr17_-_38545799 0.002 ENST00000577541.1
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr11_-_107729504 0.002 ENST00000265836.7
 SLC35F2
solute carrier family 35, member F2
chr14_+_32547434 0.002 ENST00000556191.1
ENST00000554090.1
 ARHGAP5

Rho GTPase activating protein 5

chr5_+_140557371 0.002 ENST00000239444.2
 PCDHB8
protocadherin beta 8
chr17_+_66511540 0.002 ENST00000588188.2
 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr9_-_95166841 0.001 ENST00000262551.4
 OGN
osteoglycin
chr18_-_33709268 0.001 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr1_-_24151903 0.001 ENST00000436439.2
ENST00000374490.3
 HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

chr7_+_148936732 0.001 ENST00000335870.2
 ZNF212
zinc finger protein 212
chrX_+_153533275 0.001 ENST00000426989.1
ENST00000426203.1
ENST00000369912.2
 TKTL1


transketolase-like 1


chr1_-_201140673 0.001 ENST00000367333.2
 TMEM9
transmembrane protein 9
chr20_-_50419055 0.001 ENST00000217086.4
 SALL4
spalt-like transcription factor 4
chr15_-_49912987 0.001 ENST00000560246.1
ENST00000558594.1
 FAM227B

family with sequence similarity 227, member B

chr17_+_43238438 0.001 ENST00000593138.1
ENST00000586681.1
 HEXIM2

hexamethylene bis-acetamide inducible 2

chr7_+_120628731 0.000 ENST00000310396.5
 CPED1
cadherin-like and PC-esterase domain containing 1
chr5_+_89770664 0.000 ENST00000503973.1
ENST00000399107.1
 POLR3G

polymerase (RNA) III (DNA directed) polypeptide G (32kD)

chr7_+_50348268 0.000 ENST00000438033.1
ENST00000439701.1
 IKZF1

IKAROS family zinc finger 1 (Ikaros)

chr20_+_43990576 0.000 ENST00000372727.1
ENST00000414310.1
 SYS1

SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr19_-_46088068 0.000 ENST00000263275.4
ENST00000323060.3
 OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.0 GO:0090427 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.1 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.0 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.0 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.0 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)