Motif ID: UCACAGU

Z-value: 0.527


Mature miRNA associated with seed UCACAGU:

NamemiRBase Accession
hsa-miR-27a-3p MIMAT0000084
hsa-miR-27b-3p MIMAT0000419



Activity profile for motif UCACAGU.

activity profile for motif UCACAGU


Sorted Z-values histogram for motif UCACAGU

Sorted Z-values for motif UCACAGU



Network of associatons between targets according to the STRING database.



First level regulatory network of UCACAGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_34642656 1.101 ENST00000257831.3
ENST00000450654.2
EHF

ets homologous factor

chr8_+_120220561 0.830 ENST00000276681.6
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_-_38303218 0.817 ENST00000407341.1
ENST00000260630.3
CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

chr7_+_155250824 0.723 ENST00000297375.4
EN2
engrailed homeobox 2
chr16_-_65155833 0.718 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
CDH11


cadherin 11, type 2, OB-cadherin (osteoblast)


chr1_-_23886285 0.641 ENST00000374561.5
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr1_+_110453203 0.597 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1


colony stimulating factor 1 (macrophage)


chr20_+_10199468 0.592 ENST00000254976.2
ENST00000304886.2
SNAP25

synaptosomal-associated protein, 25kDa

chr15_+_81071684 0.589 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199


KIAA1199


chr11_+_121322832 0.574 ENST00000260197.7
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr9_+_118916082 0.562 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chrX_+_105066524 0.536 ENST00000243300.9
ENST00000428173.2
NRK

Nik related kinase

chr4_-_139163491 0.511 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr7_-_103629963 0.418 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
RELN


reelin


chr6_+_19837592 0.378 ENST00000378700.3
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr22_-_37823468 0.375 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr2_-_166651191 0.374 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chrX_-_74145273 0.370 ENST00000055682.6
KIAA2022
KIAA2022
chr11_-_1771797 0.369 ENST00000340134.4
IFITM10
interferon induced transmembrane protein 10
chr1_-_57045228 0.363 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_60272814 0.330 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr7_-_95225768 0.324 ENST00000005178.5
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr1_-_47655686 0.303 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr18_+_19749386 0.294 ENST00000269216.3
GATA6
GATA binding protein 6
chr9_-_130742792 0.294 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr2_+_46524537 0.288 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr5_-_121413974 0.282 ENST00000231004.4
LOX
lysyl oxidase
chr5_+_52285144 0.270 ENST00000296585.5
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr2_-_27718052 0.268 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr10_-_21786179 0.268 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr5_-_115910630 0.263 ENST00000343348.6
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr11_-_94964354 0.257 ENST00000536441.1
SESN3
sestrin 3
chr8_-_41166953 0.248 ENST00000220772.3
SFRP1
secreted frizzled-related protein 1
chr1_-_92351769 0.247 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr11_+_72929319 0.245 ENST00000393597.2
ENST00000311131.2
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr2_+_113403434 0.238 ENST00000272542.3
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr8_-_72268889 0.235 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr10_+_52751010 0.234 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chr2_+_158114051 0.226 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_-_60031762 0.225 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr5_-_38595498 0.222 ENST00000263409.4
LIFR
leukemia inhibitory factor receptor alpha
chr12_-_47219733 0.220 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4


solute carrier family 38, member 4


chr11_-_88796803 0.218 ENST00000418177.2
ENST00000455756.2
GRM5

glutamate receptor, metabotropic 5

chr18_-_30050395 0.206 ENST00000269209.6
ENST00000399218.4
GAREM

GRB2 associated, regulator of MAPK1

chr5_-_124080203 0.200 ENST00000504926.1
ZNF608
zinc finger protein 608
chr12_-_88974236 0.199 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KITLG


KIT ligand


chr4_-_177713788 0.198 ENST00000280193.2
VEGFC
vascular endothelial growth factor C
chr1_+_70876891 0.196 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr6_+_41514078 0.194 ENST00000373063.3
ENST00000373060.1
FOXP4

forkhead box P4

chr4_+_20255123 0.189 ENST00000504154.1
ENST00000273739.5
SLIT2

slit homolog 2 (Drosophila)

chr1_+_82266053 0.189 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2






latrophilin 2






chr2_+_203879568 0.188 ENST00000449802.1
NBEAL1
neurobeachin-like 1
chr3_-_178790057 0.188 ENST00000311417.2
ZMAT3
zinc finger, matrin-type 3
chr7_+_116312411 0.183 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET


met proto-oncogene


chr3_+_69812877 0.182 ENST00000457080.1
ENST00000328528.6
MITF

microphthalmia-associated transcription factor

chr10_+_11206925 0.182 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2


CUGBP, Elav-like family member 2


chr3_-_24536253 0.181 ENST00000428492.1
ENST00000396671.2
ENST00000431815.1
ENST00000418247.1
ENST00000416420.1
ENST00000356447.4
THRB





thyroid hormone receptor, beta





chr2_-_235405679 0.181 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr3_+_178866199 0.180 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr6_+_136172820 0.179 ENST00000308191.6
PDE7B
phosphodiesterase 7B
chrX_+_16964794 0.176 ENST00000357277.3
REPS2
RALBP1 associated Eps domain containing 2
chr7_-_79082867 0.174 ENST00000419488.1
ENST00000354212.4
MAGI2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr7_+_114055052 0.174 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2







forkhead box P2







chr12_-_26278030 0.174 ENST00000242728.4
BHLHE41
basic helix-loop-helix family, member e41
chr2_+_30454390 0.174 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chrX_-_55515635 0.173 ENST00000500968.3
USP51
ubiquitin specific peptidase 51
chr8_-_37756972 0.173 ENST00000330843.4
ENST00000522727.1
ENST00000287263.4
RAB11FIP1


RAB11 family interacting protein 1 (class I)


chr6_+_126112001 0.166 ENST00000392477.2
NCOA7
nuclear receptor coactivator 7
chr21_-_44846999 0.165 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr4_+_85504075 0.162 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr3_-_179169330 0.160 ENST00000232564.3
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chrX_+_49687216 0.159 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr5_+_109025067 0.159 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr2_-_227664474 0.159 ENST00000305123.5
IRS1
insulin receptor substrate 1
chr1_+_64239657 0.158 ENST00000371080.1
ENST00000371079.1
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr21_+_35445827 0.156 ENST00000381151.3
ENST00000608209.1
SLC5A3
SLC5A3
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
sodium/myo-inositol cotransporter
chr2_+_232260254 0.155 ENST00000287590.5
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr6_+_117586713 0.151 ENST00000352536.3
ENST00000326274.5
VGLL2

vestigial like 2 (Drosophila)

chr5_+_143584814 0.151 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr12_-_65146636 0.146 ENST00000418919.2
GNS
glucosamine (N-acetyl)-6-sulfatase
chr8_-_91997427 0.143 ENST00000517562.2
RP11-122A3.2
chromosome 8 open reading frame 88
chr6_-_53530474 0.139 ENST00000370905.3
KLHL31
kelch-like family member 31
chr3_-_124774802 0.139 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr17_+_15848231 0.139 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr8_-_28243934 0.137 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395


zinc finger protein 395


chr2_+_192542850 0.135 ENST00000410026.2
NABP1
nucleic acid binding protein 1
chr8_-_81787006 0.135 ENST00000327835.3
ZNF704
zinc finger protein 704
chr10_-_90712520 0.134 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chrX_-_54384425 0.133 ENST00000375169.3
ENST00000354646.2
WNK3

WNK lysine deficient protein kinase 3

chr1_-_204329013 0.133 ENST00000272203.3
ENST00000414478.1
PLEKHA6

pleckstrin homology domain containing, family A member 6

chr8_+_1922024 0.132 ENST00000320248.3
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr18_+_32073253 0.130 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA


dystrobrevin, alpha


chr11_+_118401706 0.130 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25


transmembrane protein 25


chr8_-_41655107 0.128 ENST00000347528.4
ENST00000289734.7
ENST00000379758.2
ENST00000396945.1
ENST00000396942.1
ENST00000352337.4
ANK1





ankyrin 1, erythrocytic





chr9_-_91793675 0.125 ENST00000375835.4
ENST00000375830.1
SHC3

SHC (Src homology 2 domain containing) transforming protein 3

chr1_-_93426998 0.125 ENST00000370310.4
FAM69A
family with sequence similarity 69, member A
chr17_+_45608430 0.124 ENST00000322157.4
NPEPPS
aminopeptidase puromycin sensitive
chr14_+_71108460 0.124 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr12_+_70760056 0.122 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr4_-_42154895 0.122 ENST00000502486.1
ENST00000504360.1
BEND4

BEN domain containing 4

chr4_+_26862400 0.119 ENST00000467011.1
ENST00000412829.2
STIM2

stromal interaction molecule 2

chr17_+_25799008 0.119 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
KSR1


kinase suppressor of ras 1


chr11_+_48002076 0.117 ENST00000418331.2
ENST00000440289.2
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr9_-_14314066 0.117 ENST00000397575.3
NFIB
nuclear factor I/B
chr15_-_73661605 0.116 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr17_+_38375574 0.116 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2



WAS/WASL interacting protein family, member 2



chr6_-_37665751 0.115 ENST00000297153.7
ENST00000434837.3
MDGA1

MAM domain containing glycosylphosphatidylinositol anchor 1

chr9_+_137533615 0.113 ENST00000371817.3
COL5A1
collagen, type V, alpha 1
chr3_-_171178157 0.113 ENST00000465393.1
ENST00000436636.2
ENST00000369326.5
ENST00000538048.1
ENST00000341852.6
TNIK




TRAF2 and NCK interacting kinase




chr12_+_133066137 0.113 ENST00000434748.2
FBRSL1
fibrosin-like 1
chr6_-_33547975 0.111 ENST00000442998.2
ENST00000360661.5
BAK1

BCL2-antagonist/killer 1

chr2_-_206950781 0.111 ENST00000403263.1
INO80D
INO80 complex subunit D
chr1_+_180199393 0.111 ENST00000263726.2
LHX4
LIM homeobox 4
chr8_-_75233563 0.110 ENST00000342232.4
JPH1
junctophilin 1
chr3_+_98451275 0.109 ENST00000265261.6
ENST00000497008.1
ST3GAL6

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

chr14_+_85996471 0.108 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_+_1286097 0.108 ENST00000215368.2
EFNA2
ephrin-A2
chr4_-_39640700 0.107 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr3_-_56502375 0.107 ENST00000288221.6
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr12_-_106641728 0.106 ENST00000378026.4
CKAP4
cytoskeleton-associated protein 4
chr3_+_58223228 0.105 ENST00000478253.1
ENST00000295962.4
ABHD6

abhydrolase domain containing 6

chr4_-_24914508 0.104 ENST00000504487.1
CCDC149
coiled-coil domain containing 149
chr1_-_36022979 0.102 ENST00000469892.1
ENST00000325722.3
KIAA0319L

KIAA0319-like

chr17_+_28705921 0.102 ENST00000225719.4
CPD
carboxypeptidase D
chr5_-_132299313 0.102 ENST00000265343.5
AFF4
AF4/FMR2 family, member 4
chr1_-_155881156 0.101 ENST00000539040.1
ENST00000368323.3
RIT1

Ras-like without CAAX 1

chr5_-_57756087 0.100 ENST00000274289.3
PLK2
polo-like kinase 2
chr1_+_6673745 0.100 ENST00000377648.4
PHF13
PHD finger protein 13
chr2_-_201936302 0.099 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B



family with sequence similarity 126, member B



chr16_-_70719925 0.099 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr13_-_107187462 0.099 ENST00000245323.4
EFNB2
ephrin-B2
chr1_+_16693578 0.099 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1




SUZ RNA binding domain containing 1




chr1_-_184723942 0.097 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr2_-_178128528 0.097 ENST00000397063.4
ENST00000421929.1
NFE2L2

nuclear factor, erythroid 2-like 2

chr1_+_27561007 0.096 ENST00000319394.3
WDTC1
WD and tetratricopeptide repeats 1
chr5_+_110559784 0.095 ENST00000282356.4
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr12_+_20522179 0.095 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr8_+_38758737 0.094 ENST00000521746.1
ENST00000420274.1
PLEKHA2

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2

chr5_+_172068232 0.094 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B


neuralized E3 ubiquitin protein ligase 1B


chr8_+_26240414 0.094 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr17_-_35969409 0.094 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG







synergin, gamma







chr2_-_190927447 0.093 ENST00000260950.4
MSTN
myostatin
chr4_-_74124502 0.092 ENST00000358602.4
ENST00000330838.6
ENST00000561029.1
ANKRD17


ankyrin repeat domain 17


chr1_+_6266228 0.092 ENST00000377939.4
RNF207
ring finger protein 207
chr20_-_20693131 0.092 ENST00000202677.7
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr5_-_111754948 0.091 ENST00000261486.5
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr17_+_38474489 0.091 ENST00000394089.2
ENST00000425707.3
RARA

retinoic acid receptor, alpha

chr4_-_7873981 0.090 ENST00000360265.4
AFAP1
actin filament associated protein 1
chr2_+_43864387 0.089 ENST00000282406.4
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr2_+_206547215 0.089 ENST00000360409.3
ENST00000540178.1
ENST00000540841.1
ENST00000355117.4
ENST00000450507.1
ENST00000417189.1
NRP2





neuropilin 2





chr5_+_112312416 0.089 ENST00000389063.2
DCP2
decapping mRNA 2
chr8_-_10697281 0.088 ENST00000553390.1
ENST00000524114.1
ENST00000554914.1
SOX7
PINX1
SOX7
SRY (sex determining region Y)-box 7
PIN2/TERF1 interacting, telomerase inhibitor 1
Transcription factor SOX-7; Uncharacterized protein; cDNA FLJ58508, highly similar to Transcription factor SOX-7
chr14_-_59932044 0.087 ENST00000395116.1
GPR135
G protein-coupled receptor 135
chr8_+_40010989 0.087 ENST00000315792.3
C8orf4
chromosome 8 open reading frame 4
chr7_-_108096822 0.086 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM


neuronal cell adhesion molecule


chr5_+_173315283 0.086 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr4_-_114682936 0.086 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D




calcium/calmodulin-dependent protein kinase II delta




chr2_-_43453734 0.084 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr17_+_47572647 0.084 ENST00000172229.3
NGFR
nerve growth factor receptor
chr18_-_31803435 0.083 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4


nucleolar protein 4


chr1_-_21671968 0.083 ENST00000415912.2
ECE1
endothelin converting enzyme 1
chr1_+_206680879 0.083 ENST00000355294.4
ENST00000367117.3
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr6_+_36164487 0.082 ENST00000357641.6
BRPF3
bromodomain and PHD finger containing, 3
chr12_+_40787194 0.081 ENST00000425730.2
ENST00000454784.4
MUC19

mucin 19, oligomeric

chr4_-_80994210 0.080 ENST00000403729.2
ANTXR2
anthrax toxin receptor 2
chr4_+_160188889 0.080 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr4_+_174089904 0.080 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr12_-_90049828 0.079 ENST00000261173.2
ENST00000348959.3
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_+_52709229 0.079 ENST00000334635.5
ENST00000381441.3
ENST00000381437.4
DCUN1D4


DCN1, defective in cullin neddylation 1, domain containing 4


chr1_+_32573636 0.079 ENST00000373625.3
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr1_-_95007193 0.077 ENST00000370207.4
ENST00000334047.7
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_-_8751068 0.075 ENST00000276282.6
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr8_+_19796381 0.075 ENST00000524029.1
ENST00000522701.1
ENST00000311322.8
LPL


lipoprotein lipase


chr6_-_42419649 0.075 ENST00000372922.4
ENST00000541110.1
ENST00000372917.4
TRERF1


transcriptional regulating factor 1


chr9_+_101867359 0.074 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr5_+_156887027 0.074 ENST00000435489.2
ENST00000311946.7
NIPAL4

NIPA-like domain containing 4

chr13_-_67804445 0.073 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
PCDH9


protocadherin 9


chr2_+_228336849 0.073 ENST00000409979.2
ENST00000310078.8
AGFG1

ArfGAP with FG repeats 1

chr11_+_130029457 0.073 ENST00000278742.5
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr12_-_15942309 0.073 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8


epidermal growth factor receptor pathway substrate 8


chr2_-_100939195 0.072 ENST00000393437.3
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr20_-_62610982 0.070 ENST00000369886.3
ENST00000450107.1
SAMD10

sterile alpha motif domain containing 10

chr5_-_81046922 0.070 ENST00000514493.1
ENST00000320672.4
SSBP2

single-stranded DNA binding protein 2

chr2_+_148602058 0.070 ENST00000241416.7
ENST00000535787.1
ENST00000404590.1
ACVR2A


activin A receptor, type IIA


chr6_-_30712313 0.070 ENST00000376377.2
ENST00000259874.5
IER3

immediate early response 3

chr3_+_169684553 0.069 ENST00000337002.4
ENST00000480708.1
SEC62

SEC62 homolog (S. cerevisiae)

chr9_-_26947453 0.069 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr16_+_66878814 0.069 ENST00000394069.3
CA7
carbonic anhydrase VII
chr7_+_45039783 0.066 ENST00000258781.6
ENST00000541586.1
ENST00000544363.1
CCM2


cerebral cavernous malformation 2


chr17_+_38278530 0.065 ENST00000398532.4
MSL1
male-specific lethal 1 homolog (Drosophila)
chr14_-_39901618 0.065 ENST00000554932.1
ENST00000298097.7
FBXO33

F-box protein 33

chr6_+_34759837 0.065 ENST00000192788.5
ENST00000452449.2
UHRF1BP1

UHRF1 binding protein 1

chr5_+_167718604 0.064 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr20_+_5107420 0.064 ENST00000460006.1
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr1_-_31712401 0.064 ENST00000373736.2
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr1_-_85156216 0.064 ENST00000342203.3
ENST00000370612.4
SSX2IP

synovial sarcoma, X breakpoint 2 interacting protein

chr5_+_133861790 0.063 ENST00000395003.1
PHF15
jade family PHD finger 2
chr4_-_22517620 0.063 ENST00000502482.1
ENST00000334304.5
GPR125

G protein-coupled receptor 125

chr20_+_23342783 0.063 ENST00000544236.1
ENST00000338121.5
ENST00000542987.1
ENST00000424216.1
GZF1



GDNF-inducible zinc finger protein 1



chr5_+_71403061 0.062 ENST00000512974.1
ENST00000296755.7
MAP1B

microtubule-associated protein 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 0.6 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.4 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.5 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.1 0.6 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.1 0.3 GO:0033341 regulation of collagen binding(GO:0033341)
0.1 0.4 GO:0071504 cellular response to heparin(GO:0071504)
0.1 0.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.8 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.2 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.3 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.1 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.7 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.7 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.1 GO:0002545 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.0 0.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.2 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.0 0.2 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.0 0.1 GO:1903762 regulation of heart looping(GO:1901207) positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)
0.0 0.1 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.2 GO:2000035 positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.6 GO:0030903 notochord development(GO:0030903)
0.0 0.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.3 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0021764 amygdala development(GO:0021764)
0.0 0.1 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.1 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.0 0.1 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.0 0.1 GO:0042713 sperm ejaculation(GO:0042713) Sertoli cell proliferation(GO:0060011)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.0 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.1 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.0 0.0 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.4 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.0 GO:0044335 external genitalia morphogenesis(GO:0035261) canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.0 0.0 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.1 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.0 0.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.0 GO:1990535 neuron projection maintenance(GO:1990535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.0 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.1 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.0 GO:0075341 host cell PML body(GO:0075341)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.2 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.1 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.2 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.2 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.8 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0017129 triglyceride binding(GO:0017129)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.0 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.0 0.0 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors