Motif ID: TP73

Z-value: 0.223


Transcription factors associated with TP73:

Gene SymbolEntrez IDGene Name
TP73 ENSG00000078900.10 TP73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3598871_35989300.627.5e-02Click!


Activity profile for motif TP73.

activity profile for motif TP73


Sorted Z-values histogram for motif TP73

Sorted Z-values for motif TP73



Network of associatons between targets according to the STRING database.



First level regulatory network of TP73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_17035943 0.372 ENST00000355661.3
ENST00000532079.1
ENST00000448080.2
ENST00000531066.1
 PLEKHA7



pleckstrin homology domain containing, family A member 7



chr17_+_73750699 0.200 ENST00000584939.1
 ITGB4
integrin, beta 4
chr17_+_72427477 0.198 ENST00000342648.5
ENST00000481232.1
 GPRC5C

G protein-coupled receptor, family C, group 5, member C

chrX_+_9880412 0.169 ENST00000418909.2
 SHROOM2
shroom family member 2
chrX_+_9880590 0.142 ENST00000452575.1
 SHROOM2
shroom family member 2
chr10_-_105212059 0.136 ENST00000260743.5
 CALHM2
calcium homeostasis modulator 2
chr10_-_105212141 0.132 ENST00000369788.3
 CALHM2
calcium homeostasis modulator 2
chr7_-_100493482 0.109 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
 ACHE



acetylcholinesterase (Yt blood group)



chr14_+_52780998 0.098 ENST00000557436.1
 PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr4_-_87770416 0.098 ENST00000273905.6
 SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr10_-_105238997 0.096 ENST00000369783.4
 CALHM3
calcium homeostasis modulator 3
chr3_-_185538849 0.095 ENST00000421047.2
 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_95940220 0.084 ENST00000542147.1
 PROM2
prominin 2
chr10_-_47173994 0.083 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
 ANXA8L1



LINC00842
annexin A8-like 1



long intergenic non-protein coding RNA 842
chr9_+_116343192 0.082 ENST00000471324.2
 RGS3
regulator of G-protein signaling 3
chr2_-_230135937 0.077 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
 PID1


phosphotyrosine interaction domain containing 1


chr16_+_222846 0.069 ENST00000251595.6
ENST00000397806.1
 HBA2

hemoglobin, alpha 2

chr19_-_19626838 0.065 ENST00000360913.3
 TSSK6
testis-specific serine kinase 6
chr17_-_80059726 0.063 ENST00000583053.1
 CCDC57
coiled-coil domain containing 57
chr2_-_98972468 0.059 ENST00000454230.1
 AC092675.3
Uncharacterized protein
chr1_-_241799232 0.059 ENST00000366553.1
 CHML
choroideremia-like (Rab escort protein 2)
chr20_-_52790512 0.055 ENST00000216862.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr1_+_26485511 0.053 ENST00000374268.3
 FAM110D
family with sequence similarity 110, member D
chr19_+_41620335 0.052 ENST00000331105.2
 CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr8_-_145016692 0.052 ENST00000357649.2
 PLEC
plectin
chr8_-_70745575 0.052 ENST00000524945.1
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr7_-_100493744 0.052 ENST00000428317.1
ENST00000441605.1
 ACHE

acetylcholinesterase (Yt blood group)

chr6_+_31515337 0.051 ENST00000376148.4
ENST00000376145.4
 NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr20_-_52790055 0.049 ENST00000395955.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr2_+_95940186 0.043 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
 PROM2


prominin 2


chr5_+_125758865 0.042 ENST00000542322.1
ENST00000544396.1
 GRAMD3

GRAM domain containing 3

chr19_+_10654854 0.042 ENST00000586477.1
ENST00000586863.1
 ATG4D

autophagy related 4D, cysteine peptidase

chr14_-_105531759 0.040 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
 GPR132


G protein-coupled receptor 132


chr5_+_125758813 0.040 ENST00000285689.3
ENST00000515200.1
 GRAMD3

GRAM domain containing 3

chr13_-_48877795 0.039 ENST00000436963.1
ENST00000433480.2
 LINC00441

long intergenic non-protein coding RNA 441

chr18_-_28681950 0.039 ENST00000251081.6
 DSC2
desmocollin 2
chr5_+_125759140 0.038 ENST00000543198.1
 GRAMD3
GRAM domain containing 3
chr18_+_77623668 0.037 ENST00000316249.3
 KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr5_+_139027877 0.036 ENST00000302517.3
 CXXC5
CXXC finger protein 5
chr15_+_41136369 0.035 ENST00000563656.1
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr11_-_65686496 0.033 ENST00000449692.3
 C11orf68
chromosome 11 open reading frame 68
chrX_+_77166172 0.033 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
 ATP7A


ATPase, Cu++ transporting, alpha polypeptide


chr8_+_120885949 0.033 ENST00000523492.1
ENST00000286234.5
 DEPTOR

DEP domain containing MTOR-interacting protein

chr5_+_138940742 0.032 ENST00000398733.3
ENST00000253815.2
ENST00000505007.1
 UBE2D2


ubiquitin-conjugating enzyme E2D 2


chr10_-_91295304 0.031 ENST00000341233.4
ENST00000371790.4
 SLC16A12

solute carrier family 16, member 12

chr12_+_96196875 0.029 ENST00000553095.1
 RP11-536G4.1
Uncharacterized protein
chr15_+_41136216 0.029 ENST00000562057.1
ENST00000344051.4
 SPINT1

serine peptidase inhibitor, Kunitz type 1

chr3_-_48936272 0.028 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
 SLC25A20


solute carrier family 25 (carnitine/acylcarnitine translocase), member 20


chr20_+_48807351 0.027 ENST00000303004.3
 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr19_-_35981358 0.027 ENST00000484218.2
ENST00000338897.3
 KRTDAP

keratinocyte differentiation-associated protein

chr14_+_72399833 0.026 ENST00000553530.1
ENST00000556437.1
 RGS6

regulator of G-protein signaling 6

chr7_-_2883650 0.025 ENST00000544127.1
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr15_+_41136586 0.024 ENST00000431806.1
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr6_-_72130472 0.024 ENST00000426635.2
 LINC00472
long intergenic non-protein coding RNA 472
chr9_-_128003606 0.023 ENST00000324460.6
 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr8_+_37654424 0.023 ENST00000315215.7
 GPR124
G protein-coupled receptor 124
chr17_+_21191341 0.022 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
 MAP2K3


mitogen-activated protein kinase kinase 3


chr7_-_2883928 0.022 ENST00000275364.3
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr5_+_119799927 0.021 ENST00000407149.2
ENST00000379551.2
 PRR16

proline rich 16

chr16_-_8891481 0.021 ENST00000333050.6
 TMEM186
transmembrane protein 186
chr12_-_56881874 0.020 ENST00000539272.1
 GLS2
glutaminase 2 (liver, mitochondrial)
chr4_+_6717842 0.020 ENST00000320776.3
 BLOC1S4
biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
chr11_+_31833939 0.020 ENST00000530348.1
 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chrX_+_153770421 0.018 ENST00000369609.5
ENST00000369607.1
 IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

chr20_-_62203808 0.017 ENST00000467148.1
 HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr4_-_76598544 0.017 ENST00000515457.1
ENST00000357854.3
 G3BP2

GTPase activating protein (SH3 domain) binding protein 2

chr15_+_75498739 0.017 ENST00000565074.1
 C15orf39
chromosome 15 open reading frame 39
chr17_-_42452063 0.017 ENST00000588098.1
 ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr17_-_79818354 0.017 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
 P4HB








prolyl 4-hydroxylase, beta polypeptide








chr20_+_35504522 0.015 ENST00000602922.1
ENST00000217320.3
 TLDC2

TBC/LysM-associated domain containing 2

chr11_+_65686952 0.014 ENST00000527119.1
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr2_-_98950434 0.014 ENST00000409490.1
 AC092675.3
Uncharacterized protein
chr6_-_33256664 0.014 ENST00000444176.1
 WDR46
WD repeat domain 46
chr9_-_20382446 0.013 ENST00000380321.1
 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr7_-_27213893 0.013 ENST00000283921.4
 HOXA10
homeobox A10
chr17_+_43318434 0.012 ENST00000587489.1
 FMNL1
formin-like 1
chr15_+_75498355 0.012 ENST00000567617.1
 C15orf39
chromosome 15 open reading frame 39
chr11_+_63448955 0.012 ENST00000377819.5
ENST00000339997.4
ENST00000540798.1
ENST00000545432.1
ENST00000543552.1
ENST00000537981.1
 RTN3





reticulon 3





chr2_-_27357479 0.011 ENST00000406567.3
ENST00000260643.2
 PREB

prolactin regulatory element binding

chr14_+_95982451 0.011 ENST00000554161.1
 RP11-1070N10.3
Uncharacterized protein
chr16_+_75032901 0.011 ENST00000335325.4
ENST00000320619.6
 ZNRF1

zinc and ring finger 1, E3 ubiquitin protein ligase

chr15_+_41136263 0.011 ENST00000568823.1
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_76030311 0.011 ENST00000543887.1
 AC019294.1
AC019294.1
chr1_-_220220000 0.010 ENST00000366923.3
 EPRS
glutamyl-prolyl-tRNA synthetase
chr1_-_235324530 0.009 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
 RBM34


RNA binding motif protein 34


chr17_+_4835580 0.009 ENST00000329125.5
 GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr11_+_63448918 0.009 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
 RTN3


reticulon 3


chr2_+_114163945 0.009 ENST00000453673.3
 IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr1_-_26197744 0.008 ENST00000374296.3
 PAQR7
progestin and adipoQ receptor family member VII
chr12_-_56881909 0.008 ENST00000461077.1
 GLS2
glutaminase 2 (liver, mitochondrial)
chr16_+_21312170 0.008 ENST00000338573.5
ENST00000561968.1
 CRYM-AS1

CRYM antisense RNA 1

chr1_-_220219775 0.007 ENST00000609181.1
 EPRS
glutamyl-prolyl-tRNA synthetase
chr1_-_160832670 0.007 ENST00000368032.2
 CD244
CD244 molecule, natural killer cell receptor 2B4
chr6_-_112194484 0.006 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
 FYN






FYN oncogene related to SRC, FGR, YES






chr8_+_145065705 0.006 ENST00000533044.1
 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr11_+_63449045 0.006 ENST00000354497.4
 RTN3
reticulon 3
chr17_-_39023462 0.006 ENST00000251643.4
 KRT12
keratin 12
chr22_-_39150947 0.005 ENST00000411587.2
ENST00000420859.1
ENST00000452294.1
ENST00000456894.1
 SUN2



Sad1 and UNC84 domain containing 2



chr6_-_122792919 0.005 ENST00000339697.4
 SERINC1
serine incorporator 1
chr16_-_2581409 0.005 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
 CEMP1


cementum protein 1


chr1_-_78444738 0.005 ENST00000436586.2
ENST00000370768.2
 FUBP1

far upstream element (FUSE) binding protein 1

chr6_+_35995552 0.004 ENST00000468133.1
 MAPK14
mitogen-activated protein kinase 14
chr6_+_35995531 0.004 ENST00000229794.4
 MAPK14
mitogen-activated protein kinase 14
chr11_+_65687158 0.004 ENST00000532933.1
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr14_+_75746340 0.004 ENST00000555686.1
ENST00000555672.1
 FOS

FBJ murine osteosarcoma viral oncogene homolog

chr14_+_103566481 0.004 ENST00000380069.3
 EXOC3L4
exocyst complex component 3-like 4
chr1_+_162467595 0.004 ENST00000538489.1
ENST00000489294.1
 UHMK1

U2AF homology motif (UHM) kinase 1

chr12_-_57505121 0.003 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
 STAT6





signal transducer and activator of transcription 6, interleukin-4 induced





chr12_+_44152740 0.003 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
 IRAK4




interleukin-1 receptor-associated kinase 4




chr2_-_158485387 0.003 ENST00000243349.8
 ACVR1C
activin A receptor, type IC
chr10_-_79686284 0.002 ENST00000372391.2
ENST00000372388.2
 DLG5

discs, large homolog 5 (Drosophila)

chr17_+_37356586 0.002 ENST00000579260.1
ENST00000582193.1
 RPL19

ribosomal protein L19

chr11_+_63057412 0.002 ENST00000544661.1
 SLC22A10
solute carrier family 22, member 10
chr1_+_47137445 0.002 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
 TEX38


testis expressed 38


chr8_+_145065521 0.002 ENST00000534791.1
 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr1_-_78444776 0.001 ENST00000370767.1
ENST00000421641.1
 FUBP1

far upstream element (FUSE) binding protein 1

chr9_-_132383055 0.001 ENST00000372478.4
 C9orf50
chromosome 9 open reading frame 50
chr11_-_75062829 0.001 ENST00000393505.4
 ARRB1
arrestin, beta 1
chr2_-_232328867 0.001 ENST00000453992.1
ENST00000417652.1
ENST00000454824.1
 NCL


nucleolin


chr11_+_75479850 0.001 ENST00000376262.3
ENST00000604733.1
 DGAT2

diacylglycerol O-acyltransferase 2

chr8_+_54764346 0.001 ENST00000297313.3
ENST00000344277.6
 RGS20

regulator of G-protein signaling 20

chr19_+_45281118 0.000 ENST00000270279.3
ENST00000341505.4
 CBLC

Cbl proto-oncogene C, E3 ubiquitin protein ligase

chr17_+_37356555 0.000 ENST00000579374.1
 RPL19
ribosomal protein L19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008057 eye pigment granule organization(GO:0008057)
0.1 0.2 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0042369 vitamin D catabolic process(GO:0042369)
0.0 0.1 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.0 GO:0015881 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0005308 creatine transmembrane transporter activity(GO:0005308)