Motif ID: THRB

Z-value: 0.358


Transcription factors associated with THRB:

Gene SymbolEntrez IDGene Name
THRB ENSG00000151090.13 THRB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536253_24536328-0.809.2e-03Click!


Activity profile for motif THRB.

activity profile for motif THRB


Sorted Z-values histogram for motif THRB

Sorted Z-values for motif THRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_54378923 0.380 ENST00000303460.4
 HOXC10
homeobox C10
chr12_+_54378849 0.318 ENST00000515593.1
 HOXC10
homeobox C10
chr11_-_47400062 0.138 ENST00000533030.1
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47399942 0.132 ENST00000227163.4
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr15_+_35838446 0.126 ENST00000559210.1
 DPH6-AS1
DPH6 antisense RNA 1 (head to head)
chr15_+_35838396 0.116 ENST00000501169.2
 DPH6-AS1
DPH6 antisense RNA 1 (head to head)
chr10_+_60145155 0.108 ENST00000373895.3
 TFAM
transcription factor A, mitochondrial
chr11_+_73498973 0.102 ENST00000537007.1
 MRPL48
mitochondrial ribosomal protein L48
chr13_-_24007815 0.099 ENST00000382298.3
 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr20_+_3024266 0.095 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
 GNRH2


gonadotropin-releasing hormone 2


chr11_+_73498898 0.084 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr16_+_72088376 0.081 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
 HP








HPR
haptoglobin








haptoglobin-related protein
chr11_-_47400078 0.080 ENST00000378538.3
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr22_+_19938419 0.078 ENST00000412786.1
 COMT
catechol-O-methyltransferase
chr10_+_62538248 0.078 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr2_-_74692473 0.074 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
 MOGS





mannosyl-oligosaccharide glucosidase





chr10_+_62538089 0.070 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1


cyclin-dependent kinase 1


chr11_+_46366918 0.067 ENST00000528615.1
ENST00000395574.3
 DGKZ

diacylglycerol kinase, zeta

chr11_+_46366799 0.066 ENST00000532868.2
 DGKZ
diacylglycerol kinase, zeta
chr11_-_45307817 0.066 ENST00000020926.3
 SYT13
synaptotagmin XIII
chr16_+_8736232 0.066 ENST00000562973.1
 METTL22
methyltransferase like 22
chr15_-_101084547 0.061 ENST00000394113.1
 CERS3
ceramide synthase 3
chr6_-_99842041 0.060 ENST00000254759.3
ENST00000369242.1
 COQ3

coenzyme Q3 methyltransferase

chr3_+_50606901 0.059 ENST00000455834.1
 HEMK1
HemK methyltransferase family member 1
chr11_-_47400032 0.059 ENST00000533968.1
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr15_-_101084446 0.058 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
 CERS3


ceramide synthase 3


chr3_+_50606577 0.054 ENST00000434410.1
ENST00000232854.4
 HEMK1

HemK methyltransferase family member 1

chr15_-_35838348 0.052 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
 DPH6


diphthamine biosynthesis 6


chr8_-_124037890 0.049 ENST00000519018.1
ENST00000523036.1
 DERL1

derlin 1

chr1_+_77997785 0.048 ENST00000478255.1
 AK5
adenylate kinase 5
chr8_-_100905850 0.047 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
 COX6C




cytochrome c oxidase subunit VIc




chr9_-_139268068 0.046 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
 CARD9


caspase recruitment domain family, member 9


chr10_+_35456444 0.045 ENST00000361599.4
 CREM
cAMP responsive element modulator
chr4_+_189321881 0.044 ENST00000512839.1
ENST00000513313.1
 LINC01060

long intergenic non-protein coding RNA 1060

chr8_-_100905363 0.043 ENST00000524245.1
 COX6C
cytochrome c oxidase subunit VIc
chr8_-_100905925 0.036 ENST00000518171.1
 COX6C
cytochrome c oxidase subunit VIc
chr1_-_154164534 0.035 ENST00000271850.7
ENST00000368530.2
 TPM3

tropomyosin 3

chr2_+_200472779 0.033 ENST00000427045.1
ENST00000419243.1
 AC093590.1

AC093590.1

chr20_+_61640711 0.032 ENST00000606208.1
ENST00000607802.1
 RP11-305P22.9

RP11-305P22.9

chr11_-_64014379 0.031 ENST00000309318.3
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_21810765 0.030 ENST00000450584.1
ENST00000350669.1
 LDHB

lactate dehydrogenase B

chr7_+_102937869 0.030 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
 PMPCB


peptidase (mitochondrial processing) beta


chr11_+_71934962 0.029 ENST00000543234.1
 INPPL1
inositol polyphosphate phosphatase-like 1
chrX_+_101854096 0.029 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
 ARMCX5


armadillo repeat containing, X-linked 5


chr8_-_131028782 0.026 ENST00000519020.1
 FAM49B
family with sequence similarity 49, member B
chr12_-_21810726 0.026 ENST00000396076.1
 LDHB
lactate dehydrogenase B
chr8_+_28174649 0.020 ENST00000301908.3
 PNOC
prepronociceptin
chr15_-_101084881 0.017 ENST00000284382.4
 CERS3
ceramide synthase 3
chr19_-_9003586 0.014 ENST00000380951.5
 MUC16
mucin 16, cell surface associated
chr1_-_207224307 0.012 ENST00000315927.4
 YOD1
YOD1 deubiquitinase
chr19_+_55085248 0.008 ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
 LILRB1


LILRA2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2


chr17_-_73840774 0.008 ENST00000207549.4
 UNC13D
unc-13 homolog D (C. elegans)
chr11_-_18747727 0.007 ENST00000513874.1
 IGSF22
immunoglobulin superfamily, member 22
chr20_+_37434329 0.005 ENST00000299824.1
ENST00000373331.2
 PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr7_-_38394118 0.005 ENST00000390345.2
 TRGV4
T cell receptor gamma variable 4
chr1_+_32712815 0.005 ENST00000373582.3
 FAM167B
family with sequence similarity 167, member B
chr11_-_117170403 0.005 ENST00000504995.1
 BACE1
beta-site APP-cleaving enzyme 1
chr16_-_69368774 0.003 ENST00000562949.1
 RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr6_+_151042224 0.002 ENST00000358517.2
 PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr18_-_47807829 0.001 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
 MBD1




methyl-CpG binding domain protein 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.0 GO:0006173 dADP biosynthetic process(GO:0006173)
0.0 0.1 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)