Motif ID: TFAP2E

Z-value: 0.486


Transcription factors associated with TFAP2E:

Gene SymbolEntrez IDGene Name
TFAP2E ENSG00000116819.6 TFAP2E

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.402.9e-01Click!


Activity profile for motif TFAP2E.

activity profile for motif TFAP2E


Sorted Z-values histogram for motif TFAP2E

Sorted Z-values for motif TFAP2E



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2E

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_25519095 0.662 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
 STXBP6



syntaxin binding protein 6 (amisyn)



chrX_-_124097620 0.586 ENST00000371130.3
ENST00000422452.2
 TENM1

teneurin transmembrane protein 1

chr14_+_24837226 0.515 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
 NFATC4




nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4




chr14_-_25519317 0.514 ENST00000323944.5
 STXBP6
syntaxin binding protein 6 (amisyn)
chr6_+_13272904 0.467 ENST00000379335.3
ENST00000379329.1
 PHACTR1

phosphatase and actin regulator 1

chr15_+_23810903 0.458 ENST00000564592.1
 MKRN3
makorin ring finger protein 3
chr1_+_76540386 0.378 ENST00000328299.3
 ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr12_+_72666407 0.289 ENST00000261180.4
 TRHDE
thyrotropin-releasing hormone degrading enzyme
chr17_+_37824700 0.239 ENST00000581428.1
 PNMT
phenylethanolamine N-methyltransferase
chr5_+_176237478 0.230 ENST00000329542.4
 UNC5A
unc-5 homolog A (C. elegans)
chr17_+_37824411 0.226 ENST00000269582.2
 PNMT
phenylethanolamine N-methyltransferase
chr17_+_40932610 0.225 ENST00000246914.5
 WNK4
WNK lysine deficient protein kinase 4
chr12_+_72667203 0.223 ENST00000547300.1
 TRHDE
thyrotropin-releasing hormone degrading enzyme
chr17_+_37824217 0.207 ENST00000394246.1
 PNMT
phenylethanolamine N-methyltransferase
chr11_+_63974135 0.193 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
 FERMT3


fermitin family member 3


chr10_-_98480243 0.155 ENST00000339364.5
 PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr3_+_155860751 0.132 ENST00000471742.1
 KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_-_75784669 0.127 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
 CAPS2



calcyphosine 2



chr1_+_233749739 0.127 ENST00000366621.3
 KCNK1
potassium channel, subfamily K, member 1
chr1_-_231175964 0.125 ENST00000366654.4
 FAM89A
family with sequence similarity 89, member A
chr3_+_49591881 0.115 ENST00000296452.4
 BSN
bassoon presynaptic cytomatrix protein
chr2_+_75061108 0.111 ENST00000290573.2
 HK2
hexokinase 2
chr20_+_55205825 0.110 ENST00000544508.1
 TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr3_-_48632593 0.102 ENST00000454817.1
ENST00000328333.8
 COL7A1

collagen, type VII, alpha 1

chrX_-_118826784 0.097 ENST00000394616.4
 SEPT6
septin 6
chr17_-_42188598 0.095 ENST00000591714.1
 HDAC5
histone deacetylase 5
chr7_+_100464760 0.092 ENST00000200457.4
 TRIP6
thyroid hormone receptor interactor 6
chr19_-_43969796 0.088 ENST00000244333.3
 LYPD3
LY6/PLAUR domain containing 3
chr19_-_35981358 0.074 ENST00000484218.2
ENST00000338897.3
 KRTDAP

keratinocyte differentiation-associated protein

chr2_-_133429091 0.069 ENST00000345008.6
 LYPD1
LY6/PLAUR domain containing 1
chr19_+_45504688 0.067 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
 RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr1_+_150122034 0.064 ENST00000025469.6
ENST00000369124.4
 PLEKHO1

pleckstrin homology domain containing, family O member 1

chr7_-_140624499 0.060 ENST00000288602.6
 BRAF
v-raf murine sarcoma viral oncogene homolog B
chr8_+_146277764 0.059 ENST00000331434.6
 C8orf33
chromosome 8 open reading frame 33
chr4_-_101439148 0.058 ENST00000511970.1
ENST00000502569.1
ENST00000305864.3
 EMCN


endomucin


chr6_+_150070857 0.056 ENST00000544496.1
 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr2_-_24149918 0.055 ENST00000439915.1
 ATAD2B
ATPase family, AAA domain containing 2B
chr22_+_31608219 0.055 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
 LIMK2


LIM domain kinase 2


chr2_-_241831424 0.055 ENST00000402775.2
ENST00000307486.8
 C2orf54

chromosome 2 open reading frame 54

chr1_+_228194693 0.052 ENST00000284523.1
ENST00000366753.2
 WNT3A

wingless-type MMTV integration site family, member 3A

chr2_-_45236540 0.051 ENST00000303077.6
 SIX2
SIX homeobox 2
chr6_+_150070831 0.051 ENST00000367380.5
 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr19_-_39264072 0.050 ENST00000599035.1
ENST00000378626.4
 LGALS7

lectin, galactoside-binding, soluble, 7

chr3_-_136471204 0.046 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
 STAG1



stromal antigen 1



chrX_+_131157290 0.041 ENST00000394334.2
 MST4
Serine/threonine-protein kinase MST4
chr12_-_68797580 0.040 ENST00000539404.1
 RP11-81H14.2
RP11-81H14.2
chr10_+_99894399 0.040 ENST00000298999.3
ENST00000314594.5
 R3HCC1L

R3H domain and coiled-coil containing 1-like

chr1_+_35225339 0.040 ENST00000339480.1
 GJB4
gap junction protein, beta 4, 30.3kDa
chrX_+_131157322 0.039 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
 MST4


Serine/threonine-protein kinase MST4


chr12_-_48213568 0.039 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
 HDAC7




histone deacetylase 7




chr22_+_31644388 0.038 ENST00000333611.4
ENST00000340552.4
 LIMK2

LIM domain kinase 2

chr12_+_53443963 0.038 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr10_+_99894380 0.037 ENST00000370584.3
 R3HCC1L
R3H domain and coiled-coil containing 1-like
chr10_-_98273668 0.035 ENST00000357947.3
 TLL2
tolloid-like 2
chr4_+_154387480 0.035 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
 KIAA0922


KIAA0922


chr11_-_71752571 0.034 ENST00000544238.1
 NUMA1
nuclear mitotic apparatus protein 1
chr13_-_76056250 0.033 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
 TBC1D4



TBC1 domain family, member 4



chr11_-_65625014 0.032 ENST00000534784.1
 CFL1
cofilin 1 (non-muscle)
chr6_+_292051 0.032 ENST00000344450.5
 DUSP22
dual specificity phosphatase 22
chr11_-_66056596 0.031 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
 YIF1A


Yip1 interacting factor homolog A (S. cerevisiae)


chr19_+_13229126 0.031 ENST00000292431.4
 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr11_-_71753188 0.030 ENST00000543009.1
 NUMA1
nuclear mitotic apparatus protein 1
chr11_-_66056478 0.030 ENST00000431556.2
ENST00000528575.1
 YIF1A

Yip1 interacting factor homolog A (S. cerevisiae)

chr3_+_110790590 0.029 ENST00000485303.1
 PVRL3
poliovirus receptor-related 3
chr11_+_66045634 0.029 ENST00000528852.1
ENST00000311445.6
 CNIH2

cornichon family AMPA receptor auxiliary protein 2

chr11_-_71752838 0.028 ENST00000537930.1
 NUMA1
nuclear mitotic apparatus protein 1
chr6_+_99282570 0.028 ENST00000328345.5
 POU3F2
POU class 3 homeobox 2
chr2_-_37551846 0.028 ENST00000443187.1
 PRKD3
protein kinase D3
chr6_+_292253 0.028 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
 DUSP22


dual specificity phosphatase 22


chr19_+_13228917 0.027 ENST00000586171.1
 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_+_43148625 0.025 ENST00000436427.1
 YBX1
Y box binding protein 1
chr9_+_128024067 0.024 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
 GAPVD1









GTPase activating protein and VPS9 domains 1









chrX_+_115567767 0.024 ENST00000371900.4
 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_+_152990302 0.023 ENST00000218104.3
 ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr22_+_35653445 0.023 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
 HMGXB4



HMG box domain containing 4



chr5_-_179499086 0.023 ENST00000261947.4
 RNF130
ring finger protein 130
chr20_-_13619550 0.021 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
 TASP1



taspase, threonine aspartase, 1



chr11_-_65624415 0.021 ENST00000524553.1
ENST00000527344.1
 CFL1

cofilin 1 (non-muscle)

chr2_+_232572361 0.020 ENST00000409321.1
 PTMA
prothymosin, alpha
chr22_+_29601840 0.019 ENST00000334018.6
ENST00000429226.1
ENST00000404755.3
ENST00000404820.3
ENST00000430127.1
 EMID1




EMI domain containing 1




chr1_+_214163033 0.018 ENST00000607425.1
 PROX1
prospero homeobox 1
chr6_-_88411911 0.018 ENST00000257787.5
 AKIRIN2
akirin 2
chr2_+_74741569 0.016 ENST00000233638.7
 TLX2
T-cell leukemia homeobox 2
chr17_+_3627185 0.016 ENST00000325418.4
 GSG2
germ cell associated 2 (haspin)
chr11_-_47869865 0.015 ENST00000530326.1
ENST00000532747.1
 NUP160

nucleoporin 160kDa

chr15_+_27112058 0.015 ENST00000355395.5
 GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr2_-_24149977 0.015 ENST00000238789.5
 ATAD2B
ATPase family, AAA domain containing 2B
chr1_+_182584314 0.014 ENST00000566297.1
 RP11-317P15.4
RP11-317P15.4
chr10_-_50603497 0.014 ENST00000374139.2
 DRGX
dorsal root ganglia homeobox
chr5_-_179499108 0.013 ENST00000521389.1
 RNF130
ring finger protein 130
chr5_-_179498703 0.013 ENST00000522208.2
 RNF130
ring finger protein 130
chr15_+_27112251 0.012 ENST00000400081.3
 GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr3_-_48130314 0.010 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
 MAP4


microtubule-associated protein 4


chr17_-_47755436 0.010 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
 SPOP






speckle-type POZ protein






chr4_-_82393009 0.010 ENST00000436139.2
 RASGEF1B
RasGEF domain family, member 1B
chr1_-_63782888 0.010 ENST00000436475.2
 LINC00466
long intergenic non-protein coding RNA 466
chr11_+_118478313 0.009 ENST00000356063.5
 PHLDB1
pleckstrin homology-like domain, family B, member 1
chr12_-_48213735 0.008 ENST00000417902.1
ENST00000417107.1
 HDAC7

histone deacetylase 7

chr11_-_47870019 0.007 ENST00000378460.2
 NUP160
nucleoporin 160kDa
chr11_-_35441524 0.007 ENST00000395750.1
ENST00000449068.1
 SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr20_+_58508817 0.006 ENST00000358293.3
 FAM217B
family with sequence similarity 217, member B
chr5_-_151304337 0.006 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
 GLRA1


glycine receptor, alpha 1


chr17_+_74070853 0.005 ENST00000329003.3
 GALR2
galanin receptor 2
chr11_-_6633799 0.005 ENST00000299424.4
 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr3_-_170459154 0.005 ENST00000473110.1
 RP11-373E16.4
RP11-373E16.4
chr20_+_36888551 0.004 ENST00000418004.1
ENST00000451435.1
 BPI

bactericidal/permeability-increasing protein

chr22_+_38146987 0.004 ENST00000418339.1
 TRIOBP
TRIO and F-actin binding protein
chr2_+_232573222 0.004 ENST00000341369.7
ENST00000409683.1
 PTMA

prothymosin, alpha

chr11_-_35440796 0.002 ENST00000278379.3
 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_128207349 0.002 ENST00000487848.1
 GATA2
GATA binding protein 2
chr1_-_114355083 0.002 ENST00000261441.5
 RSBN1
round spermatid basic protein 1
chr19_-_54676846 0.002 ENST00000301187.4
 TMC4
transmembrane channel-like 4
chr2_+_232573208 0.001 ENST00000409115.3
 PTMA
prothymosin, alpha
chr10_-_112678976 0.001 ENST00000448814.1
 BBIP1
BBSome interacting protein 1
chr11_-_113345995 0.001 ENST00000355319.2
ENST00000542616.1
 DRD2

dopamine receptor D2

chr3_+_51428704 0.001 ENST00000323686.4
 RBM15B
RNA binding motif protein 15B
chr14_-_64010046 0.000 ENST00000337537.3
 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr17_-_47755338 0.000 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
 SPOP



speckle-type POZ protein



chr13_-_27334879 0.000 ENST00000405846.3
 GPR12
G protein-coupled receptor 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 1.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.5 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.2 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0061184 positive regulation of cell fate specification(GO:0042660) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) positive regulation of dermatome development(GO:0061184) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.0 0.1 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)
0.0 1.2 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 1.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones