Motif ID: TEAD3_TEAD1
Z-value: 1.194
Transcription factors associated with TEAD3_TEAD1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TEAD1 | ENSG00000187079.10 | TEAD1 |
| TEAD3 | ENSG00000007866.14 | TEAD3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD1 | hg19_v2_chr11_+_12695944_12695989 | 0.94 | 1.9e-04 | Click! |
| TEAD3 | hg19_v2_chr6_-_35464727_35464738 | 0.86 | 3.1e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.4 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.4 | 3.6 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) |
| 0.4 | 2.6 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
| 0.3 | 4.6 | GO:0035878 | nail development(GO:0035878) |
| 0.3 | 3.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.2 | 3.4 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.2 | 0.6 | GO:0048320 | axial mesoderm formation(GO:0048320) |
| 0.2 | 1.2 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.2 | 0.9 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.1 | 0.4 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.1 | 1.2 | GO:0097396 | response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398) |
| 0.1 | 0.9 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.1 | 0.1 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 0.3 | GO:0044335 | external genitalia morphogenesis(GO:0035261) canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335) |
| 0.1 | 0.6 | GO:0030879 | mammary gland development(GO:0030879) |
| 0.1 | 0.3 | GO:1905246 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.1 | 0.3 | GO:0008057 | eye pigment granule organization(GO:0008057) |
| 0.1 | 0.3 | GO:2000646 | lipid transport involved in lipid storage(GO:0010877) regulation of Cdc42 protein signal transduction(GO:0032489) positive regulation of receptor catabolic process(GO:2000646) |
| 0.1 | 0.5 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.1 | 0.3 | GO:0002605 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605) negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 0.1 | 0.5 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.1 | 0.6 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.3 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 0.2 | GO:0043385 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
| 0.1 | 1.6 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.1 | 0.2 | GO:0032765 | positive regulation of mast cell cytokine production(GO:0032765) |
| 0.1 | 0.3 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.1 | 0.3 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.1 | 0.2 | GO:0006481 | C-terminal protein methylation(GO:0006481) |
| 0.1 | 0.3 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.1 | 0.6 | GO:1900127 | positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 0.1 | 0.2 | GO:0090076 | fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 0.2 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.1 | 0.2 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 1.4 | GO:0060856 | establishment of blood-brain barrier(GO:0060856) |
| 0.1 | 0.4 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 1.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 1.7 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.1 | 0.2 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
| 0.1 | 0.2 | GO:0014839 | myoblast migration involved in skeletal muscle regeneration(GO:0014839) |
| 0.1 | 0.5 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.0 | 0.5 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.0 | 0.1 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 0.0 | 0.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.2 | GO:0030070 | insulin processing(GO:0030070) |
| 0.0 | 0.2 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.0 | 0.3 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.0 | 0.3 | GO:0097070 | ductus arteriosus closure(GO:0097070) |
| 0.0 | 0.2 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.0 | 0.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 0.2 | GO:1905045 | Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045) |
| 0.0 | 0.6 | GO:0035562 | protein desumoylation(GO:0016926) negative regulation of chromatin binding(GO:0035562) |
| 0.0 | 1.1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.1 | GO:0060981 | cell migration involved in coronary angiogenesis(GO:0060981) |
| 0.0 | 0.2 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.0 | 0.4 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.4 | GO:0070779 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.2 | GO:0045229 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.0 | 0.2 | GO:0072092 | ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093) |
| 0.0 | 0.2 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.0 | 0.2 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 0.0 | 0.1 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.0 | 0.3 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.1 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.0 | 0.1 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 0.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.0 | 0.2 | GO:0070997 | neuron death(GO:0070997) |
| 0.0 | 0.1 | GO:0008052 | sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193) |
| 0.0 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 0.7 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.0 | 0.2 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.0 | 0.1 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.0 | 0.5 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.0 | 0.1 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.0 | 0.4 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.0 | 0.2 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.1 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.0 | 0.2 | GO:0040031 | snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031) |
| 0.0 | 1.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.1 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
| 0.0 | 0.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.1 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) sensory neuron axon guidance(GO:0097374) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.0 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.1 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.0 | 0.1 | GO:1903615 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.0 | 1.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.1 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.0 | 0.3 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.1 | GO:0072752 | cellular response to rapamycin(GO:0072752) |
| 0.0 | 0.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.0 | 1.4 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 0.1 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.0 | 0.2 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.6 | GO:0032011 | ARF protein signal transduction(GO:0032011) |
| 0.0 | 1.0 | GO:0006363 | transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.1 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.4 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.3 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.1 | GO:0042335 | cuticle development(GO:0042335) |
| 0.0 | 0.1 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.0 | 0.1 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.0 | 0.1 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 0.1 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.0 | 0.1 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.0 | 0.1 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.0 | 0.9 | GO:0044380 | protein localization to cytoskeleton(GO:0044380) |
| 0.0 | 0.1 | GO:1901804 | beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457) |
| 0.0 | 0.2 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 0.1 | GO:0039506 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.0 | 0.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 0.6 | GO:1901798 | positive regulation of signal transduction by p53 class mediator(GO:1901798) |
| 0.0 | 0.3 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 0.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.0 | 0.1 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 0.3 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.0 | 0.2 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.0 | 0.1 | GO:1990569 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.0 | 0.1 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.0 | 0.2 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 0.1 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.0 | 0.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.2 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.1 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 0.0 | 0.1 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.0 | 0.3 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.0 | 0.1 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 0.1 | GO:0042713 | brain renin-angiotensin system(GO:0002035) angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106) sperm ejaculation(GO:0042713) |
| 0.0 | 0.0 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.0 | 0.1 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 0.2 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.0 | 0.2 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.0 | 0.1 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.0 | 0.2 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.1 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.5 | GO:0010107 | potassium ion import(GO:0010107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.3 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.2 | 0.6 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 4.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.4 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.1 | 0.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 0.3 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.1 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.4 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 1.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.8 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 4.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 2.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 0.2 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 0.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.2 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 3.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.1 | GO:0005923 | bicellular tight junction(GO:0005923) apical junction complex(GO:0043296) occluding junction(GO:0070160) |
| 0.0 | 2.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.2 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.0 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.4 | 5.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 1.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.2 | 0.8 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.1 | 1.0 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 1.2 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.1 | 3.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.4 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.1 | 0.5 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.1 | 0.3 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 0.1 | 0.3 | GO:0050333 | thiamin-triphosphatase activity(GO:0050333) |
| 0.1 | 0.3 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 0.2 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 0.6 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.5 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.1 | 0.3 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 0.4 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.1 | 0.3 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.1 | 1.5 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 0.3 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 0.2 | GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) |
| 0.1 | 0.2 | GO:0031859 | platelet activating factor receptor binding(GO:0031859) |
| 0.1 | 0.5 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 0.1 | GO:0005030 | neurotrophin receptor activity(GO:0005030) nerve growth factor receptor activity(GO:0010465) |
| 0.1 | 0.1 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 0.3 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 0.2 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.1 | 0.3 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.1 | 0.3 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 0.4 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 1.1 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 1.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055) |
| 0.0 | 2.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.5 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 0.2 | GO:0052591 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.0 | 0.3 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 0.1 | GO:0005135 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 0.0 | 0.7 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 4.3 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.4 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 0.5 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.2 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.0 | 0.2 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.2 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.2 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.1 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.1 | GO:0050429 | calcium-dependent phospholipase C activity(GO:0050429) |
| 0.0 | 0.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 0.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.1 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.0 | 0.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 0.1 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 0.1 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.0 | 0.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.1 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 0.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.1 | GO:0043813 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) |
| 0.0 | 0.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.1 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.0 | 0.1 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.0 | 0.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.2 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.0 | 0.4 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 0.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.0 | 0.1 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.1 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.0 | 0.1 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.0 | 0.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.3 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.2 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 0.1 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 5.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.2 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.2 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.8 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.4 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.7 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 1.5 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.5 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.3 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 0.4 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.2 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 0.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.4 | PID_IL27_PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.3 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.3 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.7 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 4.6 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.5 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.2 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.6 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 0.4 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.7 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
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