Motif ID: SREBF2

Z-value: 0.239


Transcription factors associated with SREBF2:

Gene SymbolEntrez IDGene Name
SREBF2 ENSG00000198911.7 SREBF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.752.0e-02Click!


Activity profile for motif SREBF2.

activity profile for motif SREBF2


Sorted Z-values histogram for motif SREBF2

Sorted Z-values for motif SREBF2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_159656437 0.284 ENST00000402432.3
 FABP6
fatty acid binding protein 6, ileal
chr6_+_43968306 0.258 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
 C6orf223


chromosome 6 open reading frame 223


chr6_+_151561085 0.185 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr8_+_104513086 0.158 ENST00000406091.3
 RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_112084043 0.130 ENST00000304758.1
 AMOT
angiomotin
chr19_-_11308190 0.113 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
 KANK2




KN motif and ankyrin repeat domains 2




chr1_+_247582097 0.098 ENST00000391827.2
 NLRP3
NLR family, pyrin domain containing 3
chr22_+_42229100 0.092 ENST00000361204.4
 SREBF2
sterol regulatory element binding transcription factor 2
chr17_-_41738931 0.075 ENST00000329168.3
ENST00000549132.1
 MEOX1

mesenchyme homeobox 1

chr1_+_206643787 0.073 ENST00000367120.3
 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr9_+_126131131 0.071 ENST00000373629.2
 CRB2
crumbs homolog 2 (Drosophila)
chr6_+_41604747 0.067 ENST00000419164.1
ENST00000373051.2
 MDFI

MyoD family inhibitor

chr5_-_43313574 0.067 ENST00000325110.6
ENST00000433297.2
 HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr15_-_66858298 0.066 ENST00000537670.1
 LCTL
lactase-like
chr17_-_17726907 0.064 ENST00000423161.3
 SREBF1
sterol regulatory element binding transcription factor 1
chr1_+_55505184 0.063 ENST00000302118.5
 PCSK9
proprotein convertase subtilisin/kexin type 9
chr6_+_41604620 0.060 ENST00000432027.1
 MDFI
MyoD family inhibitor
chr5_-_43313269 0.059 ENST00000511774.1
 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr3_-_16554403 0.059 ENST00000449415.1
ENST00000441460.1
 RFTN1

raftlin, lipid raft linker 1

chr6_+_79577189 0.057 ENST00000369940.2
 IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr3_+_46742823 0.057 ENST00000326431.3
 TMIE
transmembrane inner ear
chr1_+_206643806 0.055 ENST00000537984.1
 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr3_+_5020801 0.055 ENST00000256495.3
 BHLHE40
basic helix-loop-helix family, member e40
chr16_+_8736232 0.052 ENST00000562973.1
 METTL22
methyltransferase like 22
chrX_-_103087136 0.045 ENST00000243298.2
 RAB9B
RAB9B, member RAS oncogene family
chr20_+_58533471 0.041 ENST00000244047.5
ENST00000348616.4
 CDH26

cadherin 26

chr5_+_137774706 0.040 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
 REEP2


receptor accessory protein 2


chr17_-_40075219 0.035 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
 ACLY



ATP citrate lyase



chr15_-_73076030 0.035 ENST00000311669.8
 ADPGK
ADP-dependent glucokinase
chr17_-_39274606 0.035 ENST00000391413.2
 KRTAP4-11
keratin associated protein 4-11
chr11_+_2923619 0.033 ENST00000380574.1
 SLC22A18
solute carrier family 22, member 18
chr19_+_55591743 0.032 ENST00000588359.1
ENST00000245618.5
 EPS8L1

EPS8-like 1

chr9_+_131451480 0.032 ENST00000322030.8
 SET
SET nuclear oncogene
chr16_+_22103828 0.032 ENST00000567131.1
ENST00000568328.1
ENST00000389398.5
ENST00000389397.4
 VWA3A



von Willebrand factor A domain containing 3A



chr17_-_40075197 0.031 ENST00000590770.1
ENST00000590151.1
 ACLY

ATP citrate lyase

chr15_+_33010175 0.030 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
 GREM1


gremlin 1, DAN family BMP antagonist


chr3_+_160117418 0.030 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
 SMC4









structural maintenance of chromosomes 4









chr11_+_2923499 0.030 ENST00000449793.2
 SLC22A18
solute carrier family 22, member 18
chr11_+_2923423 0.029 ENST00000312221.5
 SLC22A18
solute carrier family 22, member 18
chr5_-_39424961 0.028 ENST00000503513.1
 DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr11_+_65480222 0.027 ENST00000534681.1
 KAT5
K(lysine) acetyltransferase 5
chr5_-_149535421 0.025 ENST00000261799.4
 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_-_27332931 0.023 ENST00000442608.3
ENST00000335960.6
 SEZ6

seizure related 6 homolog (mouse)

chr9_+_131452239 0.022 ENST00000372688.4
ENST00000372686.5
 SET

SET nuclear oncogene

chr15_-_73075964 0.021 ENST00000563907.1
 ADPGK
ADP-dependent glucokinase
chr1_+_39796810 0.021 ENST00000289893.4
 MACF1
microtubule-actin crosslinking factor 1
chr2_-_26205340 0.020 ENST00000264712.3
 KIF3C
kinesin family member 3C
chr20_+_33464368 0.020 ENST00000484354.1
ENST00000493805.2
ENST00000473172.1
 ACSS2


acyl-CoA synthetase short-chain family member 2


chr5_-_39425068 0.019 ENST00000515700.1
ENST00000339788.6
 DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

chr13_+_24844979 0.018 ENST00000454083.1
 SPATA13
spermatogenesis associated 13
chr11_+_65479702 0.018 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
 KAT5





K(lysine) acetyltransferase 5





chr2_+_27435734 0.017 ENST00000419744.1
 ATRAID
all-trans retinoic acid-induced differentiation factor
chr9_-_117267717 0.017 ENST00000374057.3
 DFNB31
deafness, autosomal recessive 31
chr14_+_56046914 0.016 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
 KTN1



kinectin 1 (kinesin receptor)



chr14_+_56046990 0.016 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
 KTN1


kinectin 1 (kinesin receptor)


chr13_+_24844857 0.016 ENST00000409126.1
ENST00000343003.6
 SPATA13

spermatogenesis associated 13

chr2_-_26205550 0.015 ENST00000405914.1
 KIF3C
kinesin family member 3C
chr9_+_100745615 0.015 ENST00000339399.4
 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr10_-_74856608 0.015 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr19_+_11200038 0.014 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
 LDLR





low density lipoprotein receptor





chr1_-_42384343 0.014 ENST00000372584.1
 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr5_-_139283982 0.013 ENST00000340391.3
 NRG2
neuregulin 2
chr11_+_65479462 0.013 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
 KAT5


K(lysine) acetyltransferase 5


chr13_+_24844819 0.012 ENST00000399949.2
 SPATA13
spermatogenesis associated 13
chr3_-_160117301 0.012 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
 IFT80



intraflagellar transport 80 homolog (Chlamydomonas)



chr11_+_65383227 0.012 ENST00000355703.3
 PCNXL3
pecanex-like 3 (Drosophila)
chr12_+_56495115 0.010 ENST00000548861.1
 RP11-603J24.9
Uncharacterized protein
chr10_-_3827417 0.009 ENST00000497571.1
ENST00000542957.1
 KLF6

Kruppel-like factor 6

chr3_-_98620500 0.008 ENST00000326840.6
 DCBLD2
discoidin, CUB and LCCL domain containing 2
chr9_+_96928516 0.008 ENST00000602703.1
 RP11-2B6.3
RP11-2B6.3
chr2_+_232572361 0.007 ENST00000409321.1
 PTMA
prothymosin, alpha
chr6_-_53213780 0.006 ENST00000304434.6
ENST00000370918.4
 ELOVL5

ELOVL fatty acid elongase 5

chr6_-_53213587 0.006 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
 ELOVL5


ELOVL fatty acid elongase 5


chr10_-_3827371 0.006 ENST00000469435.1
 KLF6
Kruppel-like factor 6
chr19_+_36266417 0.005 ENST00000378944.5
ENST00000007510.4
 ARHGAP33

Rho GTPase activating protein 33

chr15_+_47476275 0.005 ENST00000558014.1
 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr19_-_55791058 0.004 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
 HSPBP1



HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1



chr1_+_231297798 0.003 ENST00000444294.3
 TRIM67
tripartite motif containing 67
chrX_-_153237258 0.003 ENST00000310441.7
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr16_+_50187556 0.003 ENST00000561678.1
ENST00000357464.3
 PAPD5

PAP associated domain containing 5

chr19_-_18392422 0.002 ENST00000252818.3
 JUND
jun D proto-oncogene
chr19_+_36266433 0.002 ENST00000314737.5
 ARHGAP33
Rho GTPase activating protein 33
chr2_+_232573222 0.001 ENST00000341369.7
ENST00000409683.1
 PTMA

prothymosin, alpha

chr19_+_38664224 0.001 ENST00000601054.1
 SIPA1L3
signal-induced proliferation-associated 1 like 3
chr8_+_104512976 0.001 ENST00000504942.2
 RIMS2
regulating synaptic membrane exocytosis 2
chr16_+_31225337 0.001 ENST00000322122.3
 TRIM72
tripartite motif containing 72
chr12_-_48398104 0.000 ENST00000337299.6
ENST00000380518.3
 COL2A1

collagen, type II, alpha 1

chr11_-_73309228 0.000 ENST00000356467.4
ENST00000064778.4
 FAM168A

family with sequence similarity 168, member A

chr11_-_73309112 0.000 ENST00000450446.2
 FAM168A
family with sequence similarity 168, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0014028 notochord formation(GO:0014028)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0 0.1 GO:0046618 drug export(GO:0046618)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0009346 citrate lyase complex(GO:0009346)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:0036435 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.1 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts