Motif ID: SOX21

Z-value: 0.296


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.353.5e-01Click!


Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_61495760 0.166 ENST00000395347.1
 SLC16A9
solute carrier family 16, member 9
chr10_+_5005445 0.161 ENST00000380872.4
 AKR1C1
aldo-keto reductase family 1, member C1
chr2_+_102759199 0.123 ENST00000409288.1
ENST00000410023.1
 IL1R1

interleukin 1 receptor, type I

chr5_-_55529115 0.105 ENST00000513241.2
ENST00000341048.4
 ANKRD55

ankyrin repeat domain 55

chr6_-_112575912 0.100 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
 LAMA4


laminin, alpha 4


chr6_-_112575758 0.089 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4



laminin, alpha 4



chr3_+_186288454 0.085 ENST00000265028.3
 DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr4_+_75174180 0.079 ENST00000413830.1
 EPGN
epithelial mitogen
chr5_+_140579162 0.072 ENST00000536699.1
ENST00000354757.3
 PCDHB11

protocadherin beta 11

chr8_-_142377367 0.072 ENST00000377741.3
 GPR20
G protein-coupled receptor 20
chr8_-_19459993 0.069 ENST00000454498.2
ENST00000520003.1
 CSGALNACT1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

chr20_+_43343886 0.066 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr3_-_186288097 0.066 ENST00000446782.1
 TBCCD1
TBCC domain containing 1
chr7_-_107968999 0.063 ENST00000456431.1
 NRCAM
neuronal cell adhesion molecule
chr20_-_22665932 0.058 ENST00000437696.1
 RP11-359G22.2
RP11-359G22.2
chr5_-_95158644 0.057 ENST00000237858.6
 GLRX
glutaredoxin (thioltransferase)
chr5_-_95158375 0.053 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX



glutaredoxin (thioltransferase)



chr7_-_107968921 0.052 ENST00000442580.1
 NRCAM
neuronal cell adhesion molecule
chr4_+_75174204 0.047 ENST00000332112.4
ENST00000514968.1
ENST00000503098.1
ENST00000502358.1
ENST00000509145.1
ENST00000505212.1
 EPGN





epithelial mitogen





chr9_+_105757590 0.047 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr8_-_50466973 0.046 ENST00000520800.1
 RP11-738G5.2
Uncharacterized protein
chr6_-_154567984 0.045 ENST00000517438.1
 IPCEF1
interaction protein for cytohesin exchange factors 1
chr4_+_69313145 0.045 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr5_-_59668541 0.045 ENST00000514552.1
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_67632083 0.042 ENST00000347310.5
ENST00000371002.1
 IL23R

interleukin 23 receptor

chr5_+_134181755 0.040 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
 C5orf24


chromosome 5 open reading frame 24


chr14_-_102771462 0.040 ENST00000522874.1
 MOK
MOK protein kinase
chr14_+_64565442 0.039 ENST00000553308.1
 SYNE2
spectrin repeat containing, nuclear envelope 2
chr1_+_158901329 0.037 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
 PYHIN1




pyrin and HIN domain family, member 1




chr5_-_124084493 0.037 ENST00000509799.1
 ZNF608
zinc finger protein 608
chr1_-_26394114 0.033 ENST00000374272.3
 TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr6_-_3195981 0.032 ENST00000425384.2
ENST00000435043.2
 RP1-40E16.9

RP1-40E16.9

chr12_-_10588539 0.032 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
 KLRC2

NKG2-E
killer cell lectin-like receptor subfamily C, member 2

Uncharacterized protein
chr10_-_71169031 0.030 ENST00000373307.1
 TACR2
tachykinin receptor 2
chr1_-_217250231 0.029 ENST00000493748.1
ENST00000463665.1
 ESRRG

estrogen-related receptor gamma

chr1_-_151148492 0.028 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr12_+_20522179 0.028 ENST00000359062.3
 PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr18_+_29769978 0.028 ENST00000269202.6
ENST00000581447.1
 MEP1B

meprin A, beta

chr13_-_45048386 0.028 ENST00000472477.1
 TSC22D1
TSC22 domain family, member 1
chr14_-_66471241 0.027 ENST00000554907.1
 CTD-2014B16.3
Uncharacterized protein
chr11_+_114168085 0.027 ENST00000541754.1
 NNMT
nicotinamide N-methyltransferase
chr6_-_121655850 0.026 ENST00000422369.1
 TBC1D32
TBC1 domain family, member 32
chr6_-_154568551 0.026 ENST00000519190.1
 IPCEF1
interaction protein for cytohesin exchange factors 1
chr6_-_112575838 0.025 ENST00000455073.1
 LAMA4
laminin, alpha 4
chr7_+_7196565 0.023 ENST00000429911.1
 C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr8_+_26150628 0.023 ENST00000523925.1
ENST00000315985.7
 PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr6_+_42531798 0.023 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
 UBR2


ubiquitin protein ligase E3 component n-recognin 2


chr7_-_37382683 0.023 ENST00000455879.1
 ELMO1
engulfment and cell motility 1
chr14_-_95922526 0.022 ENST00000554873.1
 SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr6_+_31371337 0.020 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr4_-_83931862 0.019 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
 LIN54



lin-54 homolog (C. elegans)



chr12_-_89746264 0.019 ENST00000548755.1
 DUSP6
dual specificity phosphatase 6
chr12_+_59194154 0.018 ENST00000548969.1
 RP11-362K2.2
Protein LOC100506869
chr4_-_39034542 0.017 ENST00000344606.6
 TMEM156
transmembrane protein 156
chr7_-_73133959 0.016 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A



syntaxin 1A (brain)



chr1_+_199996733 0.016 ENST00000236914.3
 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr12_-_89746173 0.014 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr11_+_114549108 0.014 ENST00000389586.4
ENST00000375475.5
 NXPE2

neurexophilin and PC-esterase domain family, member 2

chr19_+_42381337 0.013 ENST00000597454.1
ENST00000444740.2
 CD79A

CD79a molecule, immunoglobulin-associated alpha

chr12_+_69742121 0.013 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ


lysozyme


chr5_+_67588312 0.012 ENST00000519025.1
 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_2487631 0.012 ENST00000409119.1
 TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr3_-_37034702 0.011 ENST00000322716.5
 EPM2AIP1
EPM2A (laforin) interacting protein 1
chr5_+_175875349 0.011 ENST00000261942.6
 FAF2
Fas associated factor family member 2
chrX_+_52927576 0.011 ENST00000416841.2
 FAM156B
family with sequence similarity 156, member B
chr7_-_142149390 0.010 ENST00000390372.3
 TRBV5-5
T cell receptor beta variable 5-5
chr19_-_20048639 0.010 ENST00000595282.1
 AC007204.1
Uncharacterized protein
chr8_+_101170563 0.009 ENST00000520508.1
ENST00000388798.2
 SPAG1

sperm associated antigen 1

chr22_-_40929812 0.009 ENST00000422851.1
 MKL1
megakaryoblastic leukemia (translocation) 1
chr17_+_60457914 0.008 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
 EFCAB3


EF-hand calcium binding domain 3


chr14_-_92588013 0.008 ENST00000553514.1
ENST00000605997.1
 NDUFB1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa

chr17_-_65235916 0.008 ENST00000579861.1
 HELZ
helicase with zinc finger
chr1_-_169455169 0.008 ENST00000367804.4
ENST00000236137.5
 SLC19A2

solute carrier family 19 (thiamine transporter), member 2

chr4_-_103747011 0.008 ENST00000350435.7
 UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_-_106013207 0.007 ENST00000447958.1
 FHL2
four and a half LIM domains 2
chr3_+_57994127 0.007 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
 FLNB





filamin B, beta





chr14_+_60712463 0.007 ENST00000325642.3
ENST00000529574.1
 PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr4_-_103746924 0.007 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
 UBE2D3


ubiquitin-conjugating enzyme E2D 3


chr14_+_92588281 0.007 ENST00000298875.4
ENST00000553427.1
 CPSF2

cleavage and polyadenylation specific factor 2, 100kDa

chr14_+_50291993 0.006 ENST00000595378.1
 AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr4_-_103746683 0.006 ENST00000504211.1
ENST00000508476.1
 UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr1_-_202776392 0.006 ENST00000235790.4
 KDM5B
lysine (K)-specific demethylase 5B
chr10_-_12084770 0.006 ENST00000357604.5
 UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr7_-_86849836 0.005 ENST00000455575.1
 TMEM243
transmembrane protein 243, mitochondrial
chr4_+_81951957 0.005 ENST00000282701.2
 BMP3
bone morphogenetic protein 3
chr12_+_58087738 0.005 ENST00000552285.1
 OS9
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr14_-_92588246 0.005 ENST00000329559.3
 NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr22_+_39353527 0.004 ENST00000249116.2
 APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr9_+_99690592 0.004 ENST00000354649.3
 NUTM2G
NUT family member 2G
chr6_-_52926539 0.004 ENST00000350082.5
ENST00000356971.3
 ICK

intestinal cell (MAK-like) kinase

chr6_+_151815143 0.004 ENST00000239374.7
ENST00000367290.5
 CCDC170

coiled-coil domain containing 170

chr19_-_54784937 0.004 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
 LILRB2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2


chr3_+_141103634 0.004 ENST00000507722.1
 ZBTB38
zinc finger and BTB domain containing 38
chr11_-_62474803 0.003 ENST00000533982.1
ENST00000360796.5
 BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr14_-_38028689 0.003 ENST00000553425.1
 RP11-356O9.2
RP11-356O9.2
chrX_-_131353461 0.003 ENST00000370874.1
 RAP2C
RAP2C, member of RAS oncogene family
chr7_+_120702819 0.003 ENST00000423795.1
 CPED1
cadherin-like and PC-esterase domain containing 1
chr4_-_69083720 0.002 ENST00000432593.3
 TMPRSS11BNL
TMPRSS11B N-terminal like
chr16_-_15149828 0.002 ENST00000566419.1
ENST00000568320.1
 NTAN1

N-terminal asparagine amidase

chr3_-_164875850 0.002 ENST00000472120.1
 RP11-747D18.1
RP11-747D18.1
chr11_-_57479673 0.001 ENST00000337672.2
ENST00000431606.2
 MED19

mediator complex subunit 19

chr10_-_13276329 0.001 ENST00000378681.3
ENST00000463405.2
 UCMA

upper zone of growth plate and cartilage matrix associated

chr19_+_16308711 0.001 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr15_+_58702742 0.001 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic

chr3_-_141747459 0.001 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chr2_+_217363559 0.001 ENST00000600880.1
ENST00000446558.1
 RPL37A

ribosomal protein L37a

chr12_+_101673872 0.001 ENST00000261637.4
 UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr11_+_35201826 0.000 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0033011 perinuclear theca(GO:0033011)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0047718 androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)