Motif ID: SIX6

Z-value: 0.322


Transcription factors associated with SIX6:

Gene SymbolEntrez IDGene Name
SIX6 ENSG00000184302.6 SIX6



Activity profile for motif SIX6.

activity profile for motif SIX6


Sorted Z-values histogram for motif SIX6

Sorted Z-values for motif SIX6



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_71104588 0.471 ENST00000418403.1
 RP11-462G2.1
RP11-462G2.1
chr7_-_81635106 0.270 ENST00000443883.1
 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr10_+_91061712 0.227 ENST00000371826.3
 IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr11_-_104916034 0.212 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
 CARD16


caspase recruitment domain family, member 16


chr6_-_26285737 0.211 ENST00000377727.1
ENST00000289352.1
 HIST1H4H

histone cluster 1, H4h

chr16_+_19467772 0.201 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5


transmembrane channel-like 5


chr9_+_93759317 0.200 ENST00000563268.1
 RP11-367F23.2
RP11-367F23.2
chr3_+_186742464 0.167 ENST00000416235.1
 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_160709076 0.166 ENST00000359331.4
ENST00000495334.1
 SLAMF7

SLAM family member 7

chr12_-_121477039 0.163 ENST00000257570.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr1_+_160709055 0.163 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7



SLAM family member 7



chr12_-_121476959 0.160 ENST00000339275.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr1_+_31885963 0.150 ENST00000373709.3
 SERINC2
serine incorporator 2
chr13_-_62001982 0.146 ENST00000409186.1
 PCDH20
protocadherin 20
chr1_+_160709029 0.142 ENST00000444090.2
ENST00000441662.2
 SLAMF7

SLAM family member 7

chr8_+_32579321 0.136 ENST00000522402.1
 NRG1
neuregulin 1
chr2_+_226273597 0.135 ENST00000409269.2
 NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr12_-_121476750 0.131 ENST00000543677.1
 OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_32579271 0.130 ENST00000518084.1
 NRG1
neuregulin 1
chr11_-_104972158 0.121 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
 CASP1



CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase



caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr8_+_32579341 0.121 ENST00000519240.1
ENST00000539990.1
 NRG1

neuregulin 1

chr8_-_110660975 0.117 ENST00000528045.1
 SYBU
syntabulin (syntaxin-interacting)
chr4_+_57396766 0.111 ENST00000512175.2
 THEGL
theg spermatid protein-like
chr8_+_67405438 0.106 ENST00000305454.3
 C8orf46
chromosome 8 open reading frame 46
chr12_-_10978957 0.102 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr5_+_171621176 0.096 ENST00000398186.4
 EFCAB9
EF-hand calcium binding domain 9
chr2_+_27760247 0.095 ENST00000447166.1
 AC109829.1
Uncharacterized protein
chr10_+_52094298 0.093 ENST00000595931.1
 AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr4_+_74301880 0.085 ENST00000395792.2
ENST00000226359.2
 AFP

alpha-fetoprotein

chrX_-_53350522 0.084 ENST00000396435.3
ENST00000375368.5
 IQSEC2

IQ motif and Sec7 domain 2

chr2_-_100925967 0.079 ENST00000409647.1
 LONRF2
LON peptidase N-terminal domain and ring finger 2
chrX_-_55020511 0.077 ENST00000375006.3
ENST00000374992.2
 PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

chr8_+_1993173 0.076 ENST00000523438.1
 MYOM2
myomesin 2
chr5_+_55147205 0.075 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
 IL31RA



interleukin 31 receptor A



chr8_+_1993152 0.073 ENST00000262113.4
 MYOM2
myomesin 2
chr21_-_43735628 0.068 ENST00000291525.10
ENST00000518498.1
 TFF3

trefoil factor 3 (intestinal)

chr1_-_10003372 0.066 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
 LZIC


leucine zipper and CTNNBIP1 domain containing


chr4_-_42154895 0.062 ENST00000502486.1
ENST00000504360.1
 BEND4

BEN domain containing 4

chr2_+_177134134 0.060 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
 MTX2


metaxin 2


chr1_-_65468148 0.057 ENST00000415842.1
 RP11-182I10.3
RP11-182I10.3
chr2_+_177134201 0.057 ENST00000452865.1
 MTX2
metaxin 2
chr10_-_14614311 0.056 ENST00000479731.1
ENST00000468492.1
 FAM107B

family with sequence similarity 107, member B

chr8_+_26247878 0.055 ENST00000518611.1
 BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr6_+_26204825 0.054 ENST00000360441.4
 HIST1H4E
histone cluster 1, H4e
chr8_+_12809531 0.052 ENST00000532376.2
 KIAA1456
KIAA1456
chr11_+_122709200 0.051 ENST00000227348.4
 CRTAM
cytotoxic and regulatory T cell molecule
chr15_-_51397473 0.047 ENST00000327536.5
 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr4_-_6694189 0.047 ENST00000596858.1
 AC093323.1
Uncharacterized protein
chr8_+_101170134 0.045 ENST00000520643.1
 SPAG1
sperm associated antigen 1
chr8_+_84824920 0.044 ENST00000523678.1
 RP11-120I21.2
RP11-120I21.2
chr3_+_125694347 0.041 ENST00000505382.1
ENST00000511082.1
 ROPN1B

rhophilin associated tail protein 1B

chr19_-_53426700 0.041 ENST00000596623.1
 ZNF888
zinc finger protein 888
chr12_-_11091862 0.037 ENST00000537503.1
 TAS2R14
taste receptor, type 2, member 14
chr9_-_100707116 0.037 ENST00000259456.3
 HEMGN
hemogen
chr5_-_78281775 0.036 ENST00000396151.3
ENST00000565165.1
 ARSB

arylsulfatase B

chr9_-_139642968 0.036 ENST00000341206.4
 LCN6
lipocalin 6
chr21_-_43735446 0.035 ENST00000398431.2
 TFF3
trefoil factor 3 (intestinal)
chr4_+_189321881 0.035 ENST00000512839.1
ENST00000513313.1
 LINC01060

long intergenic non-protein coding RNA 1060

chr18_-_69246167 0.033 ENST00000566582.1
 RP11-510D19.1
RP11-510D19.1
chr1_+_234509186 0.033 ENST00000366615.4
 COA6
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr1_+_63063152 0.032 ENST00000371129.3
 ANGPTL3
angiopoietin-like 3
chr14_-_31926595 0.032 ENST00000547378.1
 RP11-176H8.1
Uncharacterized protein
chr2_-_100939195 0.031 ENST00000393437.3
 LONRF2
LON peptidase N-terminal domain and ring finger 2
chr20_+_34802295 0.031 ENST00000432603.1
 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr10_+_81891416 0.030 ENST00000372270.2
 PLAC9
placenta-specific 9
chr1_+_212738676 0.029 ENST00000366981.4
ENST00000366987.2
 ATF3

activating transcription factor 3

chr5_-_66492562 0.027 ENST00000256447.4
 CD180
CD180 molecule
chr9_-_99382065 0.027 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B


cell division cycle 14B


chr20_+_54987305 0.026 ENST00000371336.3
ENST00000434344.1
 CASS4

Cas scaffolding protein family member 4

chr16_+_22524844 0.026 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
 NPIPB5



nuclear pore complex interacting protein family, member B5



chr8_+_101170257 0.025 ENST00000251809.3
 SPAG1
sperm associated antigen 1
chr16_-_29517141 0.025 ENST00000550665.1
 RP11-231C14.4
Uncharacterized protein
chr16_+_28648975 0.025 ENST00000529716.1
 NPIPB8
nuclear pore complex interacting protein family, member B8
chr7_+_107332334 0.024 ENST00000541474.1
ENST00000544569.1
 SLC26A4

solute carrier family 26 (anion exchanger), member 4

chr2_+_181988560 0.024 ENST00000424170.1
ENST00000435411.1
 AC104820.2

AC104820.2

chr20_-_4990931 0.024 ENST00000379333.1
 SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr18_-_69246186 0.024 ENST00000568095.1
 RP11-510D19.1
RP11-510D19.1
chr12_+_133707570 0.023 ENST00000416488.1
ENST00000540096.2
 ZNF268
CTD-2140B24.4
zinc finger protein 268
Zinc finger protein 268
chr16_-_21436459 0.023 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3


nuclear pore complex interacting protein family, member B3


chr12_+_133614062 0.023 ENST00000540031.1
ENST00000536123.1
 ZNF84

zinc finger protein 84

chr1_+_234509413 0.023 ENST00000366613.1
ENST00000366612.1
 COA6

cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)

chr6_-_26043885 0.023 ENST00000357905.2
 HIST1H2BB
histone cluster 1, H2bb
chr17_+_61271355 0.022 ENST00000583356.1
 TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_-_238305397 0.022 ENST00000409809.1
 COL6A3
collagen, type VI, alpha 3
chr1_+_112016414 0.021 ENST00000343534.5
ENST00000369718.3
 C1orf162

chromosome 1 open reading frame 162

chr12_+_119616447 0.021 ENST00000281938.2
 HSPB8
heat shock 22kDa protein 8
chr4_-_13546632 0.020 ENST00000382438.5
 NKX3-2
NK3 homeobox 2
chr11_+_126262027 0.020 ENST00000526311.1
 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr12_-_15374328 0.019 ENST00000537647.1
 RERG
RAS-like, estrogen-regulated, growth inhibitor
chr1_-_67142710 0.018 ENST00000502413.2
 AL139147.1
Uncharacterized protein
chr19_-_1650666 0.018 ENST00000588136.1
 TCF3
transcription factor 3
chr12_+_40787194 0.018 ENST00000425730.2
ENST00000454784.4
 MUC19

mucin 19, oligomeric

chr16_-_21868739 0.017 ENST00000415645.2
 NPIPB4
nuclear pore complex interacting protein family, member B4
chr15_+_63414760 0.017 ENST00000557972.1
 LACTB
lactamase, beta
chr4_-_139051839 0.017 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
 LINC00616


long intergenic non-protein coding RNA 616


chr1_-_36235559 0.016 ENST00000251195.5
 CLSPN
claspin
chr17_+_60501228 0.016 ENST00000311506.5
 METTL2A
methyltransferase like 2A
chr3_+_8543561 0.016 ENST00000397386.3
 LMCD1
LIM and cysteine-rich domains 1
chr19_-_16008880 0.016 ENST00000011989.7
ENST00000221700.6
 CYP4F2

cytochrome P450, family 4, subfamily F, polypeptide 2

chrX_+_128674213 0.016 ENST00000371113.4
ENST00000357121.5
 OCRL

oculocerebrorenal syndrome of Lowe

chr4_+_113739244 0.015 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
 ANK2


ankyrin 2, neuronal


chr16_-_21868978 0.015 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
 NPIPB4



nuclear pore complex interacting protein family, member B4



chr9_-_67786624 0.014 ENST00000455764.2
 FAM27E3
family with sequence similarity 27, member E3
chr6_+_146348782 0.014 ENST00000361719.2
ENST00000392299.2
 GRM1

glutamate receptor, metabotropic 1

chr1_+_179263308 0.013 ENST00000426956.1
 SOAT1
sterol O-acyltransferase 1
chr18_+_74240610 0.012 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
 LINC00908


long intergenic non-protein coding RNA 908


chr3_+_8543533 0.012 ENST00000454244.1
 LMCD1
LIM and cysteine-rich domains 1
chr17_-_42327236 0.010 ENST00000399246.2
 AC003102.1
AC003102.1
chr12_-_78934441 0.010 ENST00000546865.1
ENST00000547089.1
 RP11-171L9.1

RP11-171L9.1

chr16_+_22524379 0.009 ENST00000536620.1
 NPIPB5
nuclear pore complex interacting protein family, member B5
chr2_-_228497888 0.008 ENST00000264387.4
ENST00000409066.1
 C2orf83

chromosome 2 open reading frame 83

chr20_+_54987168 0.006 ENST00000360314.3
 CASS4
Cas scaffolding protein family member 4
chr3_-_9994021 0.006 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr11_-_102496063 0.006 ENST00000260228.2
 MMP20
matrix metallopeptidase 20
chr21_-_19858196 0.006 ENST00000422787.1
 TMPRSS15
transmembrane protease, serine 15
chr6_-_26018007 0.004 ENST00000244573.3
 HIST1H1A
histone cluster 1, H1a
chr19_+_3136115 0.004 ENST00000262958.3
 GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr1_+_156119798 0.003 ENST00000355014.2
 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chrX_-_18238999 0.003 ENST00000380033.4
ENST00000380030.3
 BEND2

BEN domain containing 2

chr7_+_6121296 0.003 ENST00000428901.1
 AC004895.4
AC004895.4
chr6_-_8102279 0.003 ENST00000488226.2
 EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr11_+_74699942 0.002 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
 NEU3




sialidase 3 (membrane sialidase)




chr1_+_159557607 0.002 ENST00000255040.2
 APCS
amyloid P component, serum
chr22_-_17702729 0.002 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
 CECR1


cat eye syndrome chromosome region, candidate 1


chr11_+_124789146 0.001 ENST00000408930.5
 HEPN1
hepatocellular carcinoma, down-regulated 1
chr1_+_40942887 0.000 ENST00000372706.1
 ZFP69
ZFP69 zinc finger protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.3 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.2 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.0 GO:0061580 colon epithelial cell migration(GO:0061580)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0 0.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling